Immunoprofiling of drug-resistant epilepsy with a focus on glutamic acid decarboxylase 65 antibodies by McGinty, R

“…<p>The urgent need to improve therapies for people with drug-resistant epilepsy (DRE) requires improved understanding of the aetiopathophysiology of epilepsy and the mechanisms responsible for pharmacoresistance. …”

The influence of additives on the delivery of paclitaxel from bioresorbable PLGA films by Huang, Charlotte Liwen.

“…The study of the influences of additives on the drug delivery characteristics from PLGA thin films as a coating on angioplasty balloons was reported in this thesis. …”
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RoboCap: Robotic mucus-clearing capsule for enhanced drug delivery in the gastrointestinal tract by Srinivasan, Shriya S., Alshareef, Amro, Hwang, Alexandria V., Kang, Ziliang, Kuosmanen, Johannes, Ishida, Keiko, Jenkins, Joshua, Liu, Sabrina, Madani, Wiam Abdalla Mohammed, Lennerz, Jochen, Hayward, Alison, Morimoto, Josh, Fitzgerald, Nina, Langer, Robert, Traverso, Giovanni

“…Oral drug delivery of proteins is limited by the degradative environment of the gastrointestinal tract and poor absorption, requiring parenteral administration of these drugs. …”
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Dynamic actuation enhances transport and extends therapeutic lifespan in an implantable drug delivery platform by Whyte, William, Goswami, Debkalpa, Wang, Sophie X., Fan, Yiling, Ward, Niamh A., Levey, Ruth E., Beatty, Rachel, Robinson, Scott T., Sheppard, Declan, O’Connor, Raymond, Monahan, David S., Trask, Lesley, Mendez, Keegan L., Varela, Claudia E., Horvath, Markus A., Wylie, Robert, O’Dwyer, Joanne, Domingo-Lopez, Daniel A., Rothman, Arielle S., Duffy, Garry P., Dolan, Eimear B., Roche, Ellen T.

“…Firstly, daily intermittent actuation (cycling at 1 Hz for 5 minutes every 12 hours) preserves long-term, rapid delivery of a model drug (insulin) over 8 weeks of implantation, by mediating local immunomodulation of the cellular FBR and inducing multiphasic temporal FC changes. …”
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Defining proteoform-specific interactions for drug targeting in a native cell signalling environment by Lutomski, CA, Bennett, JL, El-Baba, TJ, Wu, D, Hinkle, JD, Burnap, SA, Liko, I, Mullen, C, Syka, JEP, Struwe, WB, Robinson, CV

“…Given reports of undesirable side-effects involving vision, we characterized the off-target drug binding of two phosphodiesterase 5 inhibitors, vardenafil and sildenafil, to the retina rod phosphodiesterase 6 (PDE6). …”

Application of variational graph encoders as an effective generalist algorithm in computer-aided drug design by Lam, Hilbert Yuen In, Pincket, Robbe, Han, Hao, Ong, Xing Er, Wang, Zechen, Hinks, Jamie, Wei, Yanjie, Li, Weifeng, Zheng, Liangzhen, Mu, Yuguang

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Investigating novel drug delivery systems to enhance tissue regeneration in the central nervous system by Lin, Vincent Po Hen

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Development of high-affinity peptide-drug conjugates for investigating the TRIM24 PHD and bromodomain by Platt, MA

“…Furthermore, by BROMO<em>scan</em> the PDCs demonstrated 13-fold selectivity for TRIM24 (PHD-BRD) over BRPF1 (BRD). PDC5 demonstrated some cell permeability, despite its peptidomimetic structure, and so was evaluated in proliferation assays. …”

Controlled-release nanoencapsulating microcapsules to combat inflammatory diseases by Baek, Jong-Suep, Yeo, Eng Wan, Lee, Yin Hao, Tan, Nguan Soon, Loo, Say Chye Joachim

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Development and in vitro bioevaluation of cockle shell-calcium carbonate (Aragonite) nanoparticles for intracellular drug delivery by Isa, Tijani

“…The mean diameter of inhibition zone was 18.6 ± 0.5 mm, which was better than ciprofloxacin alone (11.7 ± 0.9 mm), while the minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) of the formulation were lower than those of free drugs. …”
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Combined drug delivery and treatment monitoring using a single high frequency ultrasound system by Yildiz, YO, Ruan, J-R, Gray, MD, Bau, L, Mannaris, C, Kiltie, AE, Vojnovic, B, Stride, E, Browning, RJ

“…This study investigates the feasibility of using a single commercial ultrasound imaging transducer operating at 5 MHz for both drug delivery and real-time imaging. …”

Extensively drug-resistant Klebsiella pneumoniae associated with complicated urinary tract infection in Northern India by Kaza, P, Xavier, BB, Mahindroo, J, Singh, N, Baker, S, Nguyen, TNT, Mavuduru, RS, Mohan, B, Taneja, N

“…Klebsiella pneumoniae (Kp), which is associated with hospital-acquired infections, is extensively drug-resistant (XDR), making treatment difficult. …”

A bilayer swellable drug-eluting stent for the treatment of fibrosis-induced ureteral stricture recurrence by Lim, Wei Shan

“…Tunable drug release was demonstrated in the static condition by varying the polymer thickness and drug concentration. …”
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Synergistic antibacterial effect of Persicaria odorata synthesised silver nanoparticles with antibiotics on drug-resistant bacteria. by Abdul Hadi, Atieya, Nik Malek, Nik Ahmad Nizam, Matmin, Juan, Asraf, Muhammad Hariz, Susanto, Hendra, Mohammad Din, Shahrulnizahana, Shamsuddin, Mustaffa

Evaluation of paper spray mass spectrometry for direct analysis of small molecule drugs and hemoglobin constant spring peptide markers by Takyi-Williams, John

“…The studies described in this thesis were undertaken to evaluate the application of paper spray mass spectrometry for direct analysis of small molecule drugs and biomarker in dried matrix spot samples. …”
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Waning of specific antibodies against Delta and Omicron variants five months after a third dose of BNT162b2 SARS-CoV-2 vaccine in elderly individuals by Goh, Yun Shan, Rouers, Angeline, Fong, Siew-Wai, Zhuo, Nicole Ziyi, Hor, Pei Xiang, Loh, Chiew Yee, Huang, Yuling, Neo, Vanessa Kexin, Kam, Isaac Kai Jie, Wang, Bei, Ngoh, Eve Zi Xian, Salleh, Siti Nazihah Mohd, Lee, Raphael Tze Chuen, Pada, Surinder, Sun, Louisa Jin, Ong, Desmond Luan Seng, Somani, Jyoti, Lee, Eng Sing, Maurer-Stroh, Sebastian, Wang, Cheng-I., Leo, Yee Sin, Ren, Ee Chee, Lye, David C., Young, Barnaby Edward, Ng, Lisa F. P., Renia, Laurent

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Characterization and evaluation of bilayer coating for enhanced localization and sustained drug delivery for fibrosis-induced ureteral stricture by Chin, Jia Wen

“…Ureteral stents of various thickness (20um, 50um, 100um) coating and drug concentrations (2.5%, 5.0%, 7.5%) were fabricated using spraycoating, and in vitro drug release studies were analysed using high-performance liquid chromatography. …”
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Roughness-Controlled Self-Assembly of Mannitol/LB Agar Microparticles by Polymorphic Transformation for Pulmonary Drug Delivery by Zhang, Fengying, Ngoc, Nguyen Thi Quynh, Tay, Bao Hui, Mendyk, Aleksander, Shao, Yu-Hsuan, Lau, Raymond

“…SEM images coupled with image analysis software reveal that different surface morphology of the microparticles have different drug adhesion mechanisms. Comparison of ACI results and image analysis of SEM images shows that an increase in the particle surface roughness can increase the fine particle fractions (FPFs) using the rod-covered mannitol microparticles as drug carriers. …”
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Surface modification of smooth poly (L-lactic acid) films for gelatin immobilization by Li, Hai, Xia, Yun, Wu, Jumiati, He, Qiyuan, Zhou, Xiaozhu, Lu, Gang, Shang, Lei, Boey, Freddy Yin Chiang, Venkatraman, Subbu S., Zhang, Hua

“…In this work, we use the oxygen plasma to treat PLLA film followed by modification with organosilanes with different functional groups, such as amine, epoxy, and aldehyde groups. …”
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Antibiotic resistance profile, potential drivers and genotype of Escherichia coli, Salmonella sp. and Vibrio sp. isolated from hybrid red tilapia and Asian seabass in the West Coas... by Dewi, Rita Rosmala

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