A hydrophilic polyimidazolium antibiotic targeting the membranes of Gram-negative bacteria by Chen, Yahua, Yong, Melvin, Li, Ming, Si, Zhangyong, Koh, Chong Hui, Lau, Pearlyn, Chang, Yi Wei, Teo, Jeanette, Chan-Park, Mary B., Gan, Yunn-Hwen

“…The rise of MDR Gram-negative bacteria (GNB), especially those resistant to last-resort drugs such as carbapenems and colistin, is a global health risk and calls for increased efforts to discover new antimicrobial compounds. …”
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Emergence of spatio-temporal variations in chemotherapeutic drug efficacy : in-vitro and in-silico 3D tumour spheroid studies by Sheraton, Muniraj Vivek, Chiew, Geraldine Giap Ying, Melnikov, Valentin, Tan, E. Y., Luo, K. Q., Verma, N., Sloot, Peter M. A.

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A rapid CRISPR competitive assay for in vitro and in vivo discovery of potential drug targets affecting the hematopoietic system by Shen, Yunbing, Jiang, Long, Iyer, Vaishnavi Srinivasan, Raposo, Bruno, Dubnovitsky, Anatoly, Boddul, Sanjaykumar V., Kasza, Zsolt, Wermeling, Fredrik

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A sustainable approach to individualized disease treatment : The engineering of a multiple use MEMS drug delivery device by Tng, Danny Jian Hang, Song, Peiyi, Hu, Rui, Lin, Guimiao, Yong, Ken-Tye

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Use of peptide asparginyl ligases (PALs) in generating alternative non-Ig protein-drug conjugates for cancer therapy by See, Julia Jing Yi

“…Past research on antibody–drug conjugates (ADCs) focused on protein site-specific modification as chemical conjugation lacks site-selectivity. …”
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Lasting dynamic effects of the psychedelic 2,5-dimethoxy-4- iodoamphetamine ((±)-DOI) on cognitive flexibility by Sabanovic, M, Lazari, A, Blanco Pozo, M, Tisca, C, Tachrount, M, Martins Bach, A, Lerch, J, Walton, M, Bannerman, D

“…Here we show that a single dose of the psychedelic 2,5-dimethoxy-4-iodoamphetamine ((±)-DOI) affects structural brain plasticity and cognitive flexibility in young adult mice beyond the acute drug experience. …”

Exploring the roles of mitochondrial-associated microRNAs of head and neck cancer stem cells in drug resistance and tumor recurrence by Zhu, Xiaoning, Subha, Sethu Thakachy, Fong, Voon Hoong, Tan, Wee Lin, Cheah, Yoke Kqueen

“…Hence, the treatment strategy based on let-7c-5p may provide novel solutions for drug resistance and recurrence in HNC.…”
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CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil by Almqvist, Helena, Axelsson, Hanna, Jafari, Rozbeh, Dan, Chen, Mateus, André, Haraldsson, Martin, Larsson, Andreas, Molina, Daniel Martinez, Artursson, Per, Lundbäck, Thomas, Nordlund, Pär

“…These data distinguished a much slower activation of 5-fluorouracil when compared with nucleoside-based drugs. …”
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Janus particle preparation through UV-induced partial photodegradation of spin-coated particle films by Tan, Jasmine Si Jia, Wong, Chong Hui, Chen, Zhong

“…Photocatalytic titanium dioxide particles prefunctionalized with a surface coating were assembled as particle films via spin-coating on a substrate. The particle films were placed directly under an ultraviolet light source, which induced the photodegradation of the surface coating only on the particle surfaces exposed to the light. …”
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Ocular delivery of predatory bacteria with cryomicroneedles against eye infection by Cui, Mingyue, Zheng, Mengjia, Wiraja, Christian, Chew, Sharon Wan Ting, Mishra, Arti, Mayandi, Venkatesh, Lakshminarayanan, Rajamani, Xu, Chenjie

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Renal-clearable molecular probe for near-infrared fluorescence imaging and urinalysis of SARS-CoV-2 by Liew, Si Si, Zeng, Ziling, Cheng, Penghui, He, Shasha, Zhang, Chi, Pu, Kanyi

“…Such a design not only allows sensitive detection of Mpro in the lungs of living mice after intratracheal administration but also permits optical urinalysis of SARS-CoV-2 infection. Thus, this study presents an in vivo sensor that holds potential in preclinical high-throughput drug screening and clinical diagnostics for respiratory viral infections.…”
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Determining targets for antiretroviral drug concentrations: a causal framework illustrated with pediatric efavirenz data from the CHAPAS-3 trial by Schomaker, M, Denti, P, Bienczak, A, Burger, D, Díaz, I, Gibb, DM, Walker, AS, McIlleron, H

“…<p><strong>Background:&nbsp;</strong>Determining a therapeutic window for maintaining antiretroviral drug concentrations within an appropriate range is required for identifying effective dosing regimens. …”

Human genomic diversity, viral genomics and proteomics, as exemplified by human papillomaviruses and H5N1 influenza viruses by Sakharkar, Meena Kishore, Sakharkar, Kishore R., Chow, Vincent T.K.

“…This paper discusses specific examples illustrating the phenomenon of diversity of hosts and pathogens, with special reference to human papillomaviruses and H5NI influenza viruses. We also review the influence of diverse host-pathogen interactions that determine the pathophysiology of infections, and their responses to drugs or vaccines.…”
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Identification of potent new brain cancer EGFR inhibitor from usimine A and usimine B: computer-aided drug design perspective by Roney, Miah, Issahaku, Abdul Rashid, Wilhelm, Anke, Mohd Fadhlizil Fasihi, Mohd Aluwi

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Exploring population structure, antibiotic resistance and horizontal gene transfer in Neisseria gonorrhoeae by Unitt, A

Artemisinin resistance in the malaria parasite, Plasmodium falciparum, originates from its initial transcriptional response by Zhu, Lei, van der Pluijm, Rob W., Kucharski, Michal, Nayak, Sourav, Tripathi, Jaishree, White, Nicholas J., Day, Nicholas P. J., Faiz, Abul, Phyo, Aung Pyae, Amaratunga, Chanaki, Lek, Dysoley, Ashley, Elizabeth A., Nosten, François, Smithuis, Frank, Ginsburg, Hagai, von Seidlein, Lorenz, Lin, Khin, Imwong, Mallika, Chotivanich, Kesinee, Mayxay, Mayfong, Dhorda, Mehul, Nguyen, Hoang Chau, Nguyen, Thuy Nhien Thanh, Miotto, Olivo, Newton, Paul N., Jittamala, Podjanee, Tripura, Rupam, Pukrittayakamee, Sasithon, Peto, Thomas J., Hien, Tran Tinh, Dondorp, Arjen M., Bozdech, Zbynek

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Knowledge and attitude toward elder abuse among adult attendees at Hospital Universiti Sains Malaysia (USM) by Zakaria, Ainul Mardhiah

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Exploring the therapeutic potential of 5-fluorouracil-loaded calcium carbonate nanoparticles combined with natural compound thymoquinone for colon cancer treatment by Deng, Xi, Yang, Zhongming, Chan, Kim Wei, Abu Bakar, Md Zuki

“…A shaking incubator and a high-speed homogenizer were used to prepare the optimal 5FU-CaCO3np, with characterizations of physicochemical properties, in vitro drug release profile, and biocompatibility. …”
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Current trends in additive manufacturing of selective laser melting for biomedical implant applications by Nazari, Aufa Adlia, Hassan, Mohamad Zaki, Ismail, Zarini, Ramlie, Faizir, Jamaludin, Khairur Rijal, Md. Daud, Mohd. Yusof, Ren, James

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The effect of manufacturing method: direct compression, hot-melt extrusion, and 3D printing on polymer stability and drug release from polyethylene oxide tablets by Nashed, Nour, W. Greenland, Barnaby, Majumder, Mridul, Lam, Matthew, Ghafourian, Taravat, Nokhodchi, Ali

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