Immune Checkpoint Blockade sensitivity and Progression-Free Survival associates with baseline CD8+ T cell clone size and cytotoxicity by Watson, R, Tong, O, Taylor, C, Kumar Sharma, P, Verge De Los Aires, A, Mahe, E, Ruffieux, H, Nassiri, I, Middleton, M, Fairfax, B

“…The cells contained within the expression matrices and Seurat objects have undergone full pre-processing and QC steps and are used for the analysis and figures in the linked manuscript. …”

Mitofusins Mfn1 and Mfn2 are required to preserve glucose- but not incretin-stimulated β-cell connectivity and insulin secretion by Georgiadou, Eleni, Muralidharan, Charanya, Martinez, Michelle, Chabosseau, Pauline, Akalestou, Elina, Tomas, Alejandra, Yong, Fiona Su Wern, Stylianides, Theodoros, Wretlind, Asger, Legido-Quigley, Cristina, Jones, Ben, Lopez-Noriega, Livia, Xu, Yanwen, Gu, Guoqiang, Alsabeeh, Nour, Cruciani-Guglielmacci, Céline, Magnan, Christophe, Ibberson, Mark, Leclerc, Isabelle, Ali, Yusuf, Soleimanpour, Scott A., Linnemann, Amelia K., Rodriguez, Tristan A., Rutter, Guy A.

“…These findings broaden our understanding of the roles of mitofusins in β-cells, the potential contributions of altered mitochondrial dynamics to diabetes development, and the impact of incretins on this process.…”
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TEOSINTE BRANCHED1/CYCLOIDEA/PROLIFERATING CELL FACTOR4 Interacts with WRINKLED1 to mediate seed oil biosynthesis by Kong, Que, Singh, Sanjay K., Mantyla, Jenny J., Pattanaik, Sitakanta, Guo, Liang, Yuan, Ling, Benning, Christoph, Ma, Wei

“…We screened a TF library using Arabidopsis (Arabidopsis thaliana) WRI1 (AtWRI1) as bait in yeast two-hybrid assays and identified three TEOSINTE BRANCHED1/CYCLOIDEA/PROLIFERATING CELL FACTOR (TCP) family TFs, namely TCP4, TCP10, and TCP24, as AtWRI1-interacting partners. …”
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The role of electronic properties of Pt and Pt alloys for enhanced reformate electro-oxidation in polymer electrolyte membrane fuel cells by Halder, A., Mukerjee, S., Jia, Qingying, Chan, S. H., Ehteshami, Seyyed Mohsen Mousavi

“…One major challenge of PEM fuel cells development is to overcome the activity and durability issues of the current anode materials which are susceptible to hydrogen impurities. …”
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Unveiling the cytotoxic and apoptosis-inducing abilities of an edible bird’s nest extract in human hepatocellular carcinoma Huh-7 cells by Nguyen, Thi-Phuong, Duong, Tang Van, Do, Hoang Dang Khoa, Le, Van Minh, Ta, Kim Nhung, Nguyen, Khoa Thi

“…Edible bird’s nest (EBN) is renowned for diverse pharmacological properties; however, its ability to cause cancer cell death has not been found in recent studies. …”
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Cytotoxicity and apoptotic DNA fragmentation evaluation of ethanolic extract of Phyllanthus niruri L. in Vero and primary feline testicular cells by Roslan, Rasydan Hadi, Choong, Siew Shean, Mohamed, Maizan, Abu Bakar, Md Zuki, Gilbert, Brenda Sabrina, Noralidin, Amalina, Izamin, Izzati, Mohd Sani, Nani Izreen

“…However, in vivo studies are required to confirm these findings.…”
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Neuroprotective effect of tocotrienol-rich fraction and a-tocopherol of vitamin E against glutamate toxicity in neuronal cells and astrocytes by Selvaraju, Thilaga Rati

“…The presence of glutamate in the nerve cells caused DNA or protein damage and chromatin destruction; manipulating these nerve cells to re-enter the cell cycle promoted repair of the damage. …”
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Cytomegalovirus infection is associated with an increase in aortic stiffness in older men which may be mediated in part by CD4 memory T-cells by Kirkham, Frances, Pera, Alejandra, Simanek, Amanda M., Bano, Aalia, Morrow, George, Reus, Bernhard, Caserta, Stefano, Smith, Helen Elizabeth, Davies, Kevin A., Rajkumar, Chakravarthi, Kern, Florian

“…Human Cytomegalovirus (CMV) infection is associated with atherosclerosis, higher cardiovascular disease (CVD) risk, and an increase in memory T-cells (Tmem). T-cells have also been implicated in CVD, independently of CMV infection. …”
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Effects of nnav1.5 expression modulation on mhc I antigen processing machinery and invasion potential of breast cancer cells by Din, Ahmad Hafiz Murtadha Noor

“…The effects of modulating nNav1.5 were assessed by profiling all target genes using real-time PCR and on spheroid invasion ability using Cultrex kit. …”
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DOK3 promotes atopic dermatitis by enabling the phosphatase PP4C to inhibit the T cell signaling mediator CARD11 by Loh Jia Tong, Teo, Joey Kay Hui, Kannan, Srinivasaraghavan, Verma, Chandra Shekhar, Andiappan, Anand Kumar, Lim, Hong-Hwa, Lam, Kong-Peng

“…Hypomorphic (partial loss-of-function) mutations in CARD11 are associated with the development of severe atopic dermatitis, in which T cell receptor signaling is reduced and helper T cell differentiation is skewed to an allergy-associated type 2 phenotype. …”
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Roseburia intestinalis generated butyrate boosts anti-PD-1 efficacy in colorectal cancer by activating cytotoxic CD8⁺ T cells by Kang, Xing, Liu, Changan, Ding, Yanqiang, Ni, Yunbi, Ji, Fenfen, Lau, Harry Cheuk Hay, Jiang, Lanping, Sung, Joseph Jao Yiu, Wong, Sunny Hei, Yu, Jun

“…Mechanistically, butyrate directly bound to toll-like receptor 5 (TLR5) receptor on CD8(+) T cells to induce its activity through activating nuclear factor kappa B (NF-& kappa;B) signalling. …”
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Insights on the characteristics and therapeutic potential of mesenchymal stem cell-derived exosomes for mitigation of Alzheimer’s disease’s pathogenicity: a systematic review by Mohammed Yousuf Abdi, Sarah, Mustaffa Al-Bakri, Siti Sarah, Nordin, Norshariza

“…Delivery of exosomal micro-RNAs was also found to reduce neuroinflammation. Findings from this review provided convincing systematic evidence highlighting the therapeutic properties of MSC-derived exosomes as a prospective source for cell-free (acellular) therapy in treating AD.…”

The rickettsial effector Sca4 has a conserved interaction with host clathrin and a tick cell specific role in infection by Vondrak, Cassandra Joan

“…Intracellular bacterial pathogens secrete effectors to manipulate the host cell environment, create a hospitable niche, and promote infection. …”
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Elucidating the non-apoptotic role of the caspases in the Drosophila intestinal system by Arthurton, L

“…<p>The deregulation of caspase activity and stem cell properties are often correlated with the appearance and propagation of cancer, including colorectal cancer. …”

Enviro-toons : what do parents think about it? by Goh, Jeannette

“…With children’s methods of learning growing increasingly dependent on media, it comes as no surprise that when academics needed to find out what children know about nature, they would turn to that outlet. …”
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Investigation of nonlinear ultrasonic guided waves in open waveguides based on perfectly matched layers by Zuo, Peng, Liu, Yang, Zhou, Yu, Fan, Zheng

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Studies on the antioxidant mechanisms of betacyanins from improved fermented red dragon fruit (Hylocereus polyrhizus) drink in HepG2 cells by Lim, Teck Wei, Lim, Renee Lay Hong, Pui, Liew Phing, Tan, Chin Ping, Ho, Chun Wai

“…Red dragon fruit (RDF, Hylocereus polyrhizus) is high in betacyanins content but is understudied for its antioxidant mechanisms in liver cells. The present study aimed to investigate the antioxidant mechanisms of the stabilised betacyanins in a novel RDF functional drink, Improved-FRDFD-dH2O (produced from mild, sustainable approaches) using HepG2 cell line. …”
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Unraveling microglial spatial organization in the developing human brain with DeepCellMap, a deep learning approach coupled with spatial statistics by Perochon, T, Krsnik, Z, Massimo, M, Ruchiy, Y, Romero, AL, Mohammadi, E, Li, X, Long, KR, Parkkinen, L, Blomgren, K, Lagache, T, Menassa, DA, Holcman, D

“…This pipeline is designed to map microglial organization during normal and pathological brain development and has the potential to be adapted to any cell type. Using DeepCellMap, we capture the morphological diversity of microglia, identify strong coupling between proliferative and phagocytic phenotypes, and show that distinct spatial clusters rarely overlap as human brain development progresses. …”

The hollow fiber bioreactor as a stroma-supported, serum-free ex vivo expansion platform for human umbilical cord blood cells by Xue, Cao, Kwek, Kenneth Y. C., Chan, Jerry Kok Yen, Chen, Qingfeng, Lim, Mayasari

“…These findings demonstrate the feasibility of utilizing the HFBR for creating a complex cell matrix architecture, which may provide good in vitro mimicry of the bone marrow, supporting large-scale expansion of HSCs.…”
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Influence Of Different Ratios Of Gdc-Sdc On Ssc/Gdc–Sdc Dual Composite Cathode For Intermediate-Temperature Solid Oxide Fuel Cells by Roslan, Mohammad Fikrey, Abd Rahman, Hamimah, Azmi, Mohd Azham, MohdTukimon, Mohd Faizal, Jaidi, Zolhafizi, Abdul Ghani, Muhammad Zul Idzham

“…Solid oxide fuel cells (SOFCs) have emerged as highly promising contenders in the field of energy conversion, offering enhanced efficiency and environmental sustainability. …”
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