Chronic oxidative stress promotes GADD34-mediated phosphorylation of the TAR DNA-binding protein TDP-43, a modification linked to neurodegeneration by Goh, Catherine Wenhui, Lee, Irene Chengjie, Sundaram, Jeyapriya Rajameenakshi, George, Simi Elizabeth, Yusoff, Permeen, Brush, Matthew Hayden, Sze, Newman Siu Kwan, Shenolikar, Shirish

“…Concomitant with TDP-43 aggregation and proteolysis after prolonged arsenite exposure, GADD34-bound CK1ϵ catalyzed TDP-43 phosphorylations at serines 409/410, which were diminished or absent in GADD34−/− cells. Our findings highlight that the phosphatase regulator, GADD34, also functions as a kinase scaffold in response to chronic oxidative stress and recruits CK1ϵ and oxidized TDP-43 to facilitate its phosphorylation, as seen in TDP-43 proteinopathies.…”
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In situ cross-linked carboxymethyl cellulose-polyethylene glycol binder for improving the long-term cycle life of silicon anodes in Li ion batteries by Lee, Dongsoo, Park, Hyunjung, Goliaszewski, Alan, Byeun, Yun-ki, Song, Taeseup, Paik, Ungyu

“…Through in situ cross-linking during the electrode drying process, the cross-linked CMC-PEG binder is simply prepared without an additional process. …”
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Why are territorial disputes left unresolved? Finding the true utility of ASEAN through a mixed-method analysis on the case of Malaysia and its territorial disputes in Southeast Asia by Chan, Felicia Jia Hui, Ng, Wei Ting

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Modern Game Testing : Learn how to test games like a pro, optimize testing effort, and skyrocket your QA career / by Finska, Nikolina, author 656259

“…This often leads to negative reviews, and in turn, you'll find that demand for your games declines. The solution lies in better quality assurance (QA) - and Modern Game Testing will show you how to achieve just that. …”
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Robust microhoneycomb-like nanofibrous aerogels derived from cellulose and lignin as highly efficient, low-resistant and anti-clogging air filters by Ma, Daphne Xiu Yun, Zeng, Zhihui, Wang, Zhe, Xu, Lulu, Zhang, Youfang, Ang, Jia Ming, Wan, Man Pun, Ng, Bing Feng, Lu, Xuehong

“…In this article, we report highly porous yet robust microhoneycomb-like nanofibrous aerogels (NFAs) with porous cell walls and hierarchical porous structures, and their potential as durable high-performance air filters. …”
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Oral and topical administration of a geranyl acetophenone attenuates DNCB-induced atopic dermatitis-like skin lesions in BALB/c mice by Mohd Kasim, Vivi Nur Khalieda, Lee, Yu Zhao, Bakrin, Ikmal Hisyam, Hussain, Mohd Khairi, Israf, Daud Ahmad, Shaari, Khozirah, Tan, Ji Wei, Lee, Ming Tatt, Tham, Chau Ling

“…There was a minor discrepancy between the two routes of administration, with orally treated tHGA showing significant reductions in Scoring of Atopic Dermatitis (SCORAD), tissue eosinophil infiltration, serum IgE and skin IL-4 levels with treatment of 40 and 80 mg/kg tHGA, whereas topically applied tHGA showed significant reductions in all dosages. These findings suggest that tHGA exhibited therapeutic potential for AD as both oral and topical treatment ameliorates AD-like symptoms in the murine model. © The Author(s) 2024.…”
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Zeolitic imidazolate frameworks activate endosomal Toll-like receptors and potentiate immunogenicity of SARS-CoV-2 spike protein trimer by Alsaiari, Shahad K., Nadeef, Seba, Daristotle, John L., Rothwell, William, Du, Bujie, Garcia, Johnny, Zhang, Linzixuan, Sarmadi, Morteza, Forster, Timothy A., Menon, Nandita, Lin, Stacey Qiaohui, Tostanoski, Lisa H., Hachmann, Nicole, Wang, Erika Yan, Ventura, John D., Barouch, Dan H., Langer, Robert, Jaklenec, Ana

“…In this work, we report the Toll-like receptor agonist activity of a nanoscale adjuvant zeolitic imidazolate framework–8 (ZIF-8). …”
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Testosterone, sex hormone-binding globulin, insulin-like growth factor-1 and endometrial cancer risk: observational and Mendelian randomization analyses by Mullee, A, Dimou, N, Allen, N, O'Mara, T, Gunter, MJ, Murphy, N

“…<p><strong>Background</strong></p> Dysregulation of endocrine pathways related to steroid and growth hormones may modify endometrial cancer risk; however, prospective data on testosterone, sex hormone-binding globulin (SHBG) and insulin-like growth factor (IGF)−1 are limited. To elucidate the role of these hormones in endometrial cancer risk we conducted complementary observational and Mendelian randomization (MR) analyses. …”

The binding interface of kindlin-2 and ILK involves Asp344/Asp352/Thr356 in kindlin-2 and Arg243/Arg334 in ILK by Tan, Hui-Foon, Guan, Si-Yu, Chng, Choon-Peng, Ong, Li-Teng, Tan, Suet-Mien, Law, Alex Sai Kit

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Linking framing analysis and international news communication: a content analysis of newspaper coverage on the Sept. 11 attacks, Bali bombing and Madrid train bombing by Tan, Joann Li Hoeng, Yang, Yanni, Jamaliah Othman

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Experimental medicine study with stabilised native-like HIV-1 Env immunogens drives long-term antibody responses, but lacks neutralising breadth by Pollock, K, Cheeseman, H, McFarlane, L, Day, S, Tolazzi, M, Turner, H, Joypooranachandran, J, Shramko, K, Dispinseri, S, Mundsperger, P, Bontjer, I, Lemm, N-M, Coelho, S, Tanaka, M, Cole, T, Korber, B, Katinger, D, Ward, A, Scarlatti, G, Sanders, R, Sattentau, Q, Shattock, R

“…<p><strong>Background:</strong> We report findings from an experimental medicine study of rationally designed prefusion stabilised native-like HIV envelope glycoprotein (Env) immunogens, representative of global circulating strains, delivered by sequential intramuscular injection.…”

Nanofiltration-like forward osmosis membranes with graphene oxide modified polymer-blended subtrate for aerobically-treated palm oil mill effluent treatment / by Wan Nur Ain Shuhada Abdullah, 1994-, author 655804, Lau, Woei Jye, 1983-, supervisor 483710, Farhana Aziz, supervisor 638316, Fakulti Kejuruteraan Kimia Dan Kejuruteraan Tenaga 599090

Nanofiltration-like forward osmosis membranes with graphene oxide modified polymer-blended subtrate for aerobically-treated palm oil mill effluent treatment / by Wan Nur Ain Shuhada Abdullah, 1994-, author 655804

Rapid and Scalable Production of Functional SARS-CoV-2 Virus-like Particles (VLPs) by a Stable HEK293 Cell Pool by Puarattana-aroonkorn, Sitthiphol, Tharakaraman, Kannan, Suriyawipada, Disapan, Ruchirawat, Mathuros, Fuangthong, Mayuree, Sasisekharan, Ram, Artpradit, Charlermchai

“…We employed the membrane, envelope, and highly immunogenic spike proteins of SARS-CoV-2 to produce virus-like particles (VLPs) using the HEK293-F cell line as a host system with an economical transfection reagent. …”
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Antigen presentation dynamics shape the antibody response to variants like SARS-CoV-2 Omicron after multiple vaccinations with the original strain by Yang, Leerang, Van Beek, Matthew, Wang, Zijun, Muecksch, Frauke, Canis, Marie, Hatziioannou, Theodora, Bieniasz, Paul D, Nussenzweig, Michel C, Chakraborty, Arup K

“…After the first dose, limited antigen availability in germinal centers (GCs) results in a response dominated by B cells that target immunodominant epitopes that are mutated in an Omicron-like variant. After the second dose, these memory cells expand and differentiate into plasma cells that secrete antibodies that are thus ineffective for such variants. …”
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One Plus One is More than Two: A Practical Combination of Power and Fault Analysis Attacks on PRESENT and PRESENT-Like Block Ciphers by Patranabis, Sikhar, Mukhopadhyay, Debdeep, Breier, Jakub, Bhasin, Shivam

“…Our attack sheds light on a hitherto unexplored vulnerability of PRESENT and PRESENT-like block ciphers that use bit-permutations instead of maximum distance separable (MDS) layers for diffusion.…”
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When a test is more than just a test: findings from patient interviews and survey in the trial of a technology to measure antidepressant medication response (the PReDicT Trial) by Brown, S, Ploeger, C, Guo, B, Petersen, JJ, Beckenstrom, AC, Browning, M, Dawson, GR, Deckert, J, Dias, R, Dourish, CT, Gorwood, P, Kingslake, J, Menke, A, Sola, VP, Reif, A, Ruhe, H, Simon, J, Stäblein, M, van Schaik, A, Veltman, DJ, Morriss, R, PReDicT Group

Linking digital leadership and employee digital performance in SMEs in China: The chain-mediating role of high-involvement human resource management practice and employee dynamic capability by Wang, Guifang, Dato Mansor, Zuraina, Leong, Yee Choy

“…Conclusion: In the digital market, digital leadership improves employee digital performance by boosting HI-HRMP and enhancing employee dynamic capabilities. The findings support studies on practical applications and link between digital leadership and employee digital performance. …”
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‘Russian military censorship, like the Russian warship, can go f*** itself.’ An analysis of Russian independent media response to wartime media freedom restrictions by Raspopina, Aleksandra

“…It examines editorials published by six independent online media outlets on their websites and social media. This chapter finds that journalists use editorials as spaces to provide practical information to their audiences, to explain editorial decisions, to discuss the laws restricting coverage of the war as military censorship, and to emphasize the professional norms and values of journalism. …”
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Search for single-production of vector-like quarks decaying into Wb in the fully hadronic final state in pp collisions at s = 13 TeV with the ATLAS detector by Aad, G, Aakvaag, E, Abbott, B, Abdelhameed, S, Abeling, K, Abicht, NJ, Abidi, SH, Aboelela, M, Aboulhorma, A, Abramowicz, H, Abreu, H, Abulaiti, Y, Acharya, BS, Ackermann, A, Adam Bourdarios, C, Adamczyk, L, Addepalli, SV, Addison, MJ, Adelman, J, Adiguzel, A, Adye, T, Affolder, AA, Afik, Y, Agaras, MN, Barr, AJ, Bortoletto, D, Bruckler, TL, Celli, F, Chen, M, Conroy, EI, Cooper-Sarkar, AM, Dingley, T, Draguet, MA, Eberwein, GH, Frost, JA, Gallas, EJ, Grabarczyk, RP, Gwenlan, C, Haslbeck, F, Hays, CP, Hodkinson, BH, Huffman, TB, Iizawa, T, Karava, K, Koch, SF, Li, Z, Moser, B, Nagai, K, Nedic, L, Nickerson, RB, Pacey, HA, Rossi, E, Ruggiero, A, Schopf, E, Shipsey, IPJ, Sultan, DMS, Viehhauser, GHA, Weidberg, AR, Yildirim, TP

“…A search for T and Y vector-like quarks produced in proton-proton collisions at a centre-of-mass energy of 13 TeV and decaying into Wb in the fully hadronic final state is presented. …”