Colonic mucosal microbiota and association of bacterial taxa with the expression of host antimicrobial peptides in pediatric ulcerative colitis by Jalanka, Jonna, Cheng, Jing, Hiippala, Kaisa, Ritari, Jarmo, Salojärvi, Jarkko, Ruuska, Tarja, Kalliomäki, Marko, Satokari, Reetta

“…Inflammatory bowel diseases (IBD), ulcerative colitis (UC) and Crohn's disease (CD), are chronic debilitating disorders of unknown etiology. Over 200 genetic risk loci are associated with IBD, highlighting a key role for immunological and epithelial barrier functions. …”
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A Review of Oxytocin and Arginine-Vasopressin Receptors and Their Modulation of Autism Spectrum Disorder by Cataldo, Ilaria, Azhari, Atiqah, Esposito, Gianluca

“…Although these genes did not surface in genome-wide association studies, evidence supports the hypothesis that these receptors and their polymorphisms are widely involved in the regulation of social behavior, and in modulating neural and physiological pathways contributing to the etiology of ASD. With a specific focus on variants considered to be among the most prevalent in the development of ASD, these issues will be discussed in-depth and suggestions to approach inconsistencies in the present literature will be provided. …”
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Influence of initial micro-crack damage on strength and micro-cracking behavior of an intrusive crystalline rock by Peng, Jun, Wong, Louis Ngai Yuen, Liu, Guang, Teh, Cee Ing

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Revealing the potential role of hsa-miR-663a in modulating the PI3K-Akt signaling pathway via miRNA microarray in spinal muscular atrophy patient fibroblast-derived iPSCs by Gandhi, Gayatri, Kodiappan, Radha, Abdullah, Syahril, Teoh, Hoon Koon, Tai, Lihui, Cheong, Soon Keng, Yeo, Wendy Wai Yeng

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Comparative spatial predictions of the locations of soil-rock interface by Qi, Xiaohui, Pan, Xiaohua, Chiam, Kiefer, Lim, Yong Siang, Lau, Sze Ghiong

“…The spatial trend of the geological interface cannot be captured by the polynomial regression method with a relatively high (i.e., 10) order of the polynomial when faults and folds exist. …”
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Seroepidemiology of COVID-19 in pregnant women and their infants in Uganda and Malawi across multiple waves 2020-2022 by Hookham, L, Cantrell, L, Cose, S, Freyne, B, Gadama, L, Imede, E, Kawaza, K, Lissauer, S, Musoke, P, Nankabirwa, V, Sekikubo, M, Sommerfelt, H, Voysey, M, PeriCOVID Consortium, Le Doare, K

“…Overall, 63% of pregnant women had a SARS-CoV-2 positive serology. Over subsequent waves (delta and omicron), in the absence of vaccination, seropositivity rose from 20% to over 80%. …”

Distinctive antibody responses to Mycobacterium tuberculosis in pulmonary and brain infection by Spatola, M, Nziza, N, Irvine, EB, Cizmeci, D, Jung, W, Van, LH, Nhat, LTH, Ha, VTN, Phu, NH, Nghia, HDT, Thwaites, GE, Lauffenburger, DA, Fortune, S, Thuong, NTT, Alter, G

“…<br> Using a high throughput systems serology approach, we deeply profiled the antibody responses against 10 different <i>M. tuberculosis</i> antigens, including lipoarabinomannan (LAM) and purified protein derivative (PPD), in HIV-negative adults with pulmonary TB (n = 10) versus TBM (n = 60). …”

Vitamin B12 ameliorates the pathological phenotypes of multiple Parkinson’s disease models by alleviating oxidative stress by Wu, Yue, Zhao, Zhongting, Yang, Naidi, Xin, Chenqi, Li, Zheng, Xu, Jiajia, Ma, Bo, Lim, Kah-Leong, Li, Lin, Wu, Qiong, Yu, Changmin, Zhang, Chengwu

“…Parkinson's disease (PD) is the second most common neurodegenerative disease characterized by progressive loss of dopaminergic neurons in the substantia nigra of the midbrain. The etiology of PD has yet to be elucidated, and the disease remains incurable. …”
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Multipsychiatric comorbidity in people with epilepsy compared with people without epilepsy: a systematic review and meta-analysis by Kwon, C-S, Rafati, A, Gandy, M, Scott, A, Newton, CR, Jette, N

From 2D to 3D: development of monolayer dopaminergic neuronal and midbrain organoid cultures for Parkinson's disease modeling and regenerative therapy by Yeap, Yee Jie, Tng, Teddy J. W., Lee, Mok Jung, Goh, Micaela, Lim, Kah-Leong

“…Despite intensive research, the etiology of PD is currently unresolved, and the disease remains incurable. …”
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PARP1 resolves DNA replication defects in PCNA-associated DNA repair disorder by Wang, L

“…</p> <p>Overall, these data have implications both for the etiology of PCNA-associated repair disorder as well as suggesting novel circumstances in which PARP-inhibition might be of use in the cancer clinic. …”

Expediting treatments in the 21st century: orphan drugs and accelerated approvals by Domike, Reuben, Raju, G. K., Sullivan, Jamie, Kennedy, Annie

“…The re-use of surrogate markers for oncological diseases has been an advantage in a way that may not be scientifically feasible in many other disease areas that have greater differentiation across disease etiology. For non-oncological diseases, applicability of AA is, in part, dependent upon greater focus on characterization and acceptance of novel surrogate markers.…”
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First international conference on RASopathies and neurofibromatoses in Asia : identification and advances of new therapeutics by Rauen, Katherine A, Alsaegh, Abeer, Ben-Shachar, Shay, Berman, Yemima, Blakeley, Jaishri, Cordeiro, Isabel, Elgersma, Ype, Evans, D Gareth, Fisher, Michael J, Frayling, Ian M, George, Joshi, Huson, Susan M, Kerr, Bronwyn, Khire, Uday, Korf, Bruce, Legius, Eric, Messiaen, Ludwine, van Minkelen, Rick, Nampoothiri, Sheela, Ngeow, Joanne, Parada, Luis F, Phadke, Shubha, Pillai, Ashok, Plotkin, Scott R, Puri, Ratna, Raji, Anup, Ramesh, Vijaya, Ratner, Nancy, Shankar, Suma P, Sharda, Sheetal, Tambe, Anant, Vikkula, Miikka, Widemann, Brigitte C, Wolkenstein, Pierre, Upadhyaya, Meena

“…Due to their common underlying pathogenetic etiology, all these syndromes have significant phenotypic overlap of which one common feature include a predisposition to tumors, which may be benign or malignant. …”
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Hippocampal transcriptome profiling reveals common disease pathways in chronic hypoperfusion and aging by Baik, Sang-Ha, Selvaraji, Sharmelee, Fann, David Y., Poh, Luting, Jo, Dong-Gyu, Herr, Deron R., Zhang, Shenpeng R., Kim, Hyun Ah, Silva, Michael De, Lai, Mitchell K. P., Chen, Christopher Li- Hsian, Drummond, Grant R., Lim, Kah-Leong, Sobey, Christopher G., Arumugam, Thiruma V.

“…Vascular dementia (VaD) is a progressive cognitive impairment of vascular etiology. VaD is characterized by cerebral hypoperfusion, increased blood-brain barrier permeability and white matter lesions. …”
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On Power: How Colombia’s National Oil Company Can Support the Country’s Energy Transition by Beron, David

“…Ecopetrol sells green hydrogen — instead of fossil fuels — to Europe and Asia. It has shifted from geology to geography, from offshore drilling to offshore wind. …”
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Remote digital cognitive assessment reveals cognitive deficits related to hippocampal atrophy in autoimmune limbic encephalitis: a cross-sectional validation study by Shibata, K, Attaallah, B, Tai, X-Y, Trender, W, Hellyer, PJ, Hampshire, A, Irani, SR, Manohar, SG, Husain, M

“…<p><strong>Background:</strong> Autoimmune limbic encephalitis (ALE) is a neurological disease characterised by inflammation of the limbic regions of the brain, mediated by pathogenic autoantibodies. …”

Tectono-stratigraphic evolution of the foreland fold-and-thrust belt of the United Arab Emirates by Abdelmaksoud, A, Ali, MY, Searle, MP

“…The subsurface and surface structural geometries of the United Arab Emirates (UAE) fold-and-thrust belt (FTB) and foreland basins are interpreted from seismic, well data, and surface geology. Twelve horizons ranging in age from Miocene to Lower Jurassic were interpreted and mapped. …”

Shale oil in Russia – commercial catalyst required by Henderson, J

“…It is becoming increasingly clear that the answer to this will be less to do with geology and technology than with the commercial environment in Russia and the corporate mind set of the companies that currently control the majority of the relevant licences.…”

Science Overview of the Europa Clipper Mission by Pappalardo, Robert T., Buratti, Bonnie J., Korth, Haje, Senske, David A., Blaney, Diana L., Blankenship, Donald D., Burch, James L., Christensen, Philip R., Kempf, Sascha, Kivelson, Margaret G., Mazarico, Erwan, Retherford, Kurt D., Turtle, Elizabeth P., Westlake, Joseph H.

“…The mission’s objectives are to investigate Europa’s interior (ice shell and ocean), composition, and geology; the mission will also search for and characterize any current activity including possible plumes. …”
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The Mapping Imaging Spectrometer for Europa (MISE) by Blaney, Diana L., Hibbitts, Karl, Diniega, Serina, Davies, Ashley G., Clark, Roger N., Green, Robert O., Hedman, Matthew, Langevin, Yves, Lunine, Jonathan, McCord, Thomas B., Murchie, Scott, Paranicas, Chris, Seelos, Frank, Soderblom, Jason M., Cable, Morgan L.

“…MISE, combined with observations collected by the rest of the Europa Clipper payload, will enable significant advances in our understanding of how the large-scale structure of Europa’s surface is shaped by geological processes and inform our understanding of the surface at microscale. …”
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