Investigating ERO1α, IDO1 and MHC Class I : potential proteins that can be manipulated to change the tumour microenvironment from ‘cold’ to ‘hot’ by Peck, Jia Yi

“…ERO1α, a cancer-associated protein, and IDO1, an immunomodulatory enzyme, have been shown to be associated with the expression of MHC Class I proteins. …”
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Reconstructing prehistoric lifeways using multi-Isotope analyses of human enamel, dentine, and bone from Legaire Sur, Spain by Griffith, JI, James, HF, Ordoño, J, Fernández-Crespo, T, Gerritzen, CT, Cheung, C, Spros, R, Claeys, P, Goderis, S, Veselka, B, Snoeck, C

“…Oxygen and strontium isotope analysis suggest all individuals come from a similar, likely local, geological region, aside from one biological female who presents a notably different geographical birthplace, weaning, and dietary life history than the rest of the burial population. …”

Electrical stimulation therapy and HA/TCP composite scaffolds modulate the Wnt pathways in bone regeneration of critical-sized defects by Helaehil, Júlia Venturini, Helaehil, Luiza Venturini, Alves, Laryssa Fernanda, Huang, Boyang, Santamaria-Jr, Milton, Bartolo, Paulo, Caetano, Guilherme Ferreira

“…Critical bone defects are the most difficult challenges in the area of tissue repair. …”
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Thermal management and biocompatibility in dry machining: An experimental study of ZrO2-based cutting tool for bone machining by Addepalli, Phanindra, Sawangsri, Worapong, Saiful Anwar, Che Ghani

“…This paper aims to assess the thermal properties and biocompatibility of zirconia-based bio ceramic cutting tools for bone surgery compared to stainless steel (SS316L) tools. …”
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Sheep as a Large-Animal Model for Otology Research: Temporal Bone Extraction and Transmastoid Facial Recess Surgical Approach by Waring, Nicholas A., Chern, Alexander, Vilarello, Brandon J., Lang, Jeffrey H., Olson, Elizabeth S., Nakajima, Hideko H.

“…Results Temporal bone extraction was successful in 10/10 temporal bones. …”
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Synthesis and characterization of poly (Ethylene Glycol) dimethacrylate-based bionanocomposites with hydroxyapatite from rohu fish (Labeo rohita) bones by Inam, Bushra, Jamila, Nargis, Khan, Naeem, Nishan, Umar, Rauf, Aleesha, Shujah, Shaukat, Shah, Azhar Ul Haq Ali, Ibrahim, Mohamed A., Kim, Kyong Su

“…The present study was aimed to isolate hydroxyapatite from rohu fish bones and integrate it into biomaterials with the potential for use in dentistry. …”
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Harnessing 3D microarchitecture of pterosaur bone using multi-scale X-ray CT for aerospace material design by Pili, N, Lowe, TJ, Margetts, L, Pickup, K, Sellers, WI, Nicholls, EL, Withers, PJ, Manning, PL

“…This microarchitecture of bone offers a unique geometry where self-healing materials with internal monitoring systems can be developed. …”

Structural characterization of vaccinia-related kinase 1 (VRK1), a histone mitotic kinase by Ngow, Yeen Shian

“…To-date, the structural basis of VRK1-ATP interaction is not available, hindering the progress toward designing VRK1 specific Type I inhibitors. …”
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Novel modulo multipliers for moduli 2^n-1, 2^n and 2^n+1. by Ramya Muralidharan

“…In this thesis, special modulo 2^n-1, modulo 2^n and modulo 2^n+1 multipliers are studied. …”
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Topological phase transition in quasi-one-dimensional bismuth iodide Bi 4 I 4 by Zhao, WX, Yang, M, Du, X, Li, YD, Zhai, KY, Hu, YQ, Han, JF, Huang, Y, Liu, ZK, Yao, YG, Zhuang, JC, Du, Y, Zhou, JJ, Chen, YL, Yang, LX

“…Quasi-one-dimensional (quasi-1D) bismuth iodide Bi4I4 exhibits versatile topological phases of matter including weak topological insulator (WTI) and higher-order topological insulator (HOTI) phases with high tunability in response to external parameters. …”

Inhibiting IP6K1 confers atheroprotection by elevating circulating apolipoprotein A-I by Liu, X, Zhang, Z, Aguirre, T, Shipton, ML, Fu, L, Du, J, Furkert, D, Qi, J, Chin, AC, Riley, AM, Liu, T, Zhang, X, Potter, BVL, Fiedler, D, Zhu, Y, Fu, C

“…Depleting 5PP-InsP₅ by deleting IP6K1 or blocking IP6K1 activity disrupts the interaction between UBE4A and apoA-I, preventing apoA-I degradation, leading to increased production of apoA-I. …”

Potent antimyeloma activity of the novel bromodomain inhibitors I-BET151 and I-BET762 by Chaidos, A, Caputo, V, Gouvedenou, K, Liu, B, Marigo, I, Chaudhry, M, Rotolo, A, Tough, DF, Smithers, NN, Bassil, AK, Chapman, TD, Harker, NR, Barbash, O, Tummino, P, Al-Mahdi, N, Haynes, AC, Cutler, L, Le, B, Rahemtulla, A, Roberts, I, Kleijnen, M, Witherington, J, Parr, NJ, Prinjha, RK, Karadimitris, A

“…In contrast, transcriptional upregulation of HEXIM1 is BRD2-4 independent. Finally, preclinical studies show that I-BET762 has a favorable pharmacologic profile as an oral agent and that it inhibits myeloma cell proliferation, resulting in survival advantage in a systemic myeloma xenograft model. …”

China : one year after September 11 by Tang, Shiping

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One-step disposable optical waveguide immunosensors by Zhou, Yan, Lam, Yee Loy

“…To develop one-step disposable optical waveguide immunosensors.…”
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Singapore One : multimedia broadband infrastructure for everyone by Tan, Chin Tuan.

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Free-standing one-dimensional plasmonic nanostructures by Jiang, Lin, Sun, Yinghui, Huo, Fengwei, Zhang, Hua, Qin, Lidong, Li, Shuzhou, Chen, Xiaodong

“…In this feature article, a category of chemically nanofabricated, unique free-standing one-dimensional (1D) plasmonic nanostructures has been summarized. …”
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Evaluation of population immunity against SARS-CoV-2 variants, EG.5.1, FY.4, BA.2.86, JN.1, JN.1.4, and KP.3.1.1 using samples from two health demographic surveillance systems in Kenya by Lugano, D, Kutima, B, Kimani, M, Sigilai, A, Gitonga, J, Karani, A, Akech, D, Karia, B, Ziraba, AK, Maina, A, Lambisia, A, Omuoyo, D, Mugo, D, Lucinde, R, Owuor, S, Konyino, G, Newman, J, Bailey, D, Nduati, E, Githinji, G, Agoti, CN, Bejon, P, Scott, JAG, Agweyu, A, Warimwe, GM

“…Our data show that antibodies from individuals in the general population in Kenya were less effective against the recent prevalent SARS-CoV-2 omicron variants (i.e. EG.5.1, FY.4, BA.2.86, JN.1, JN.1.4, and KP.3.1.1) compared to the ancestral wildtype strain. …”

Temperature-dependent ultrafast carrier and phonon dynamics of topological insulator Bi1.5Sb0.5Te1.8Se1.2 by Cheng, Liang, La-o-vorakiat, Chan, Tang, Chi Sin, Nair, Saritha K., Xia, Bin, Wang, Lan, Zhu, Jian-Xin, Chia, Elbert E. M.

“…Using ultrafast optical pump-probe technique, we studied the temperature-dependent carrier and phonon dynamics of the topological insulator Bi1.5Sb0.5Te1.8Se1.2 single-crystal from 10 K to 300 K. …”
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Preparation of 1T′-phase ReS2xSe2(1‑x) (x = 0−1) nanodots for highly efficient electrocatalytic hydrogen evolution reaction by Lai, Zhuangchai, Chaturvedi, Apoorva, Wang, Yun, Tran, Thu Ha, Liu, Xiaozhi, Tan, Chaoliang, Luo, Zhimin, Chen, Bo, Huang, Ying, Nam, Gwang-Hyeon, Zhang, Zhicheng, Chen, Ye, Hu, Zhaoning, Li, Bing, Xi, Shibo, Zhang, Qinghua, Zong, Yun, Gu, Lin, Kloc, Christian, Du, Yonghua, Zhang, Hua

“…Here, by combining chemical vapor transport and Li-intercalation, we have prepared a series of 1T′-phase ReS2xSe2(1-x) (x = 0–1) nanodots to achieve high-performance HER in acid medium. …”
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The combined activation of KCa3.1 and inhibition of Kv11.1/hERG1 currents contribute to overcome Cisplatin resistance in colorectal cancer cells by Pillozzi, Serena, D'Amico, Massimo, Bartoli, Gianluca, Gasparoli, Luca, Petroni, Giulia, Crociani, Olivia, Marzo, Tiziano, Guerriero, Angela, Messori, Luigi, Severi, Mirko, Udisti, Roberto, Wulff, Heike, Chandy, Kanianthara George, Becchetti, Andrea, Arcangeli, Annarosa

“…The effect was maximal when KCa3.1 activation and Kv11.1 inhibition were combined. …”
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