Investigation of Synthetic Proteins Produced via Automated Fast-Flow Peptide Synthesis by Cowfer, Amanda Elizabeth

“…I will discuss the iterative steps my team took to vary both chemical and mechanical and control variables to improve per-coupling yield enough to enable access to full-length single-domain proteins. On this journey, we utilized test peptides to validate synthesis quality and later synthesized a suite of full-length single-domain biologically active proteins. …”
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High-resolution HDX-MS reveals distinct mechanisms of RNA recognition and activation by RIG-I and MDA5 by Liu, Chuan-Fa, Zheng, Jie, Yong, Hui Yee, Panutdaporn, Nantika, Tang, Kai, Luo, Dahai

“…RIG-I and MDA5 are the major intracellular immune receptors that recognize viral RNA species and undergo a series of conformational transitions leading to the activation of the interferon-mediated antiviral response. However, to date, full-length RLRs have resisted crystallographic efforts and a molecular description of their activation pathways remains hypothetical. …”
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Amplifying signals in the tumor microenvironment for drug development and diagnostics by Martin Alonso, Maria Carmen

“…At the same time, improving the sensitivity of ctDNA-based tests, that remains limited by the scarcity of ctDNA in blood, holds the key to unlock the full potential of liquid biopsy across many important clinical applications. …”
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Crack healing in reactive MgO-slag system via bacteria induced carbonate precipitation by Zheng, Yanying

“…In the Concrete industry, the most widely used binding ingredient for concrete, portland cement (PC), is accountable for around 8% of global anthropogenic carbon dioxide (CO2) emissions. …”
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Synthesis of Au@Pd core/shell nanomaterials for high-performance ethanol oxidation reactions by Xu, Weichang

“…During CV scans, the onset potential and peak current density of backward peak reveals the binding affinity of –OH group and the catalytic activity, respectively. …”
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PESI: paratope-epitope set interaction for SARS-CoV-2 neutralization prediction by Wan, Zhang, Lin, Zhuoyi, Rashid, Shamima, Ng, Shaun Yue Hao, Yin, Rui, Senthilnath, J., Kwoh, Chee Keong

“…Traditional methods rely on features based on first principles derived from the binding interface. However, they are burdened by arduous data preprocessing from a limited quantity of protein structures. …”
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Targeted hematopoietic stem cell depletion through SCF-blockade by Chan, Yan Y., Ho, Pui Y., Dib, Carla, Swartzrock, Leah, Rayburn, Maire, Willner, Hana, Ko, Ethan, Ho, Katie, Down, Julian D., Wilkinson, Adam C., Nakauchi, Hiro, Denis, Morgane, Cool, Taylor, Czechowicz, Agnieszka

“…Results We confirm that only ACK2 inhibits SCF binding fully and prevents HSC proliferation in vitro. …”
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Purification of miraculin from miracle fruit [Synsepalum dulcifium (Schumach. & Thonn.) Daniell] by He, Zuxing

“…The effect of optimizing crude extract was more important than optimizing the binding buffer. In elution stage, the effect of imidazole was more important than acetic acid. …”
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Conformational changes involved in signal transduction in avian cryptochromes by Gehrckens, AS

“…</p> <p>Finally, by mapping conformational changes found in molecular dynamics simulations onto changes observed in a previous HDX-MS data set on the <em>Drosophila</em> cryptochrome, a few gaps left by the incomplete coverage of the current experimental data were filled by acquiring information on the phosphate-binding loop and the protrusion motif, two regions which have also been found to undergo light-induced structural changes for the avian cryptochromes investigated. …”

Layer-by-Layer Nanoparticles for Cytokine Delivery by Pires, Ivan S.

“…We also find that the LbL film conformation is key to maintaining therapeutic efficacy as thicker films hinder IL-12 delivery. …”
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Core level shift of diamond and graphite upon Ar+ ion bombardment by Geng, Han He.

“…Diamond-like films (DLF) and highly oriented pyrolytic graphite (HOPG) are made of two allotropes of carbon, diamond and graphite. …”
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High-density lipoprotein function is modulated by the SARS-CoV-2 spike protein in a lipid-type dependent manner by Correa, Yubexi, Del Giudice, Rita, Waldie, Sarah, Thépaut, Michel, Micciula, Samantha, Gerelli, Yuri, Moulin, Martine, Delaunay, Clara, Fieschi, Franck, Pichler, Harald, Haertlein, Michael, Forsyth, V. Trevor, Le Brun, Anton, Moir, Michael, Russell, Robert A., Darwish, Tamim, Brinck, Jonas, Wodaje, Tigist, Jansen, Martin, Martín, César, Roosen-Runge, Felix, Cárdenas, Marité

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Three-component Friedel-Crafts-type difunctionalization of ynamides with (hetero)arenes and iodine(iii) electrophile by Kikuchi, Jun, Nagata, Toya, Ito, Shingo, Yoshikai, Naohiko

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Theoretical Modelling and Facile Synthesis of a Highly Active Boron-Doped Palladium Catalyst for the Oxygen Reduction Reaction by Vo Doan, Tat Thang, Wang, Jingbo, Poon, Kee Chun, Tan, Desmond Chun Long, Khezri, Bahareh, Webster, Richard David, Su, Haibin, Sato, Hirotaka

“…Our theoretical modelling reveals that B-doped Pd (Pd-B) weakens the absorption of ORR intermediates with nearly optimal binding energy by lowering the barrier associated with O2 dissociation, suggesting Pd-B should be highly active for ORR. …”
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‘On-demand’ soft tissue adhesives by Mogal, Vishal Tukaram

“…Various plasma parameters were investigated for controlling model drug release and soft-tissue adhesion of polyester thin films. When compared to non-treated polyester thin films, plasma intensity could give rise to a ~ 6-fold (for 100 W, 5 min.) increase in shear adhesion strength (157 ± 24 mN/cm2). …”
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Influence of post-deposition annealing on interfacial properties between GaN and ZrO2 grown by atomic layer deposition by Ye, Gang, Wang, Hong, Ng, Serene Lay Geok, Ji, Rong, Arulkumaran, Subramaniam, Ng, Geok Ing, Li, Yang, Liu, Zhi Hong, Ang, Kian Siong

“…Influence of post-deposition annealing on interfacial properties related to the formation/annihilation of interfacial GaOx layer of ZrO2 grown by atomic layer deposition (ALD) on GaN is studied. ZrO2 films were annealed in N2 atmospheres in temperature range of 300 °C to 700 °C and analyzed by X-ray photoelectron spectroscopy and high-resolution transmission electron microscopy. …”
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Optical properties of semi-conductive MXene Sc2COx, CsPbBr3 nanoplatelets and quantum dots by Chen, Qiran

“…For any given NPL with a certain thickness, there is a slight blue shift in the peak position of optical gain as the carrier density increases because of band filling effect. The maximum optical gain of thinner NPLs needs higher carrier density to reach saturation. …”
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Controlling the assembly of proteins and cells on SiO₂ surfaces by Seong, Jiehyun, 1973-

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A hand-targeted auxiliary personal protective equipment for intervention of fomite transmission of viruses by Tan, Justin Kok Soon, Song, Shang Wei, Zeng, Jialiu, Lo, Chih Hung

“…Importantly, FlexiPalm was found to bind significantly less viral protein and VLP than artificial human skin, confirming its ability to reduce viral contamination. …”
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Exciton Dynamics and Anisotropy in 2D Metal Organochalcogenolate Semiconductors by Lee, Woo Seok

“…From a fundamental science perspective, AgSePh provides an excellent platform for exploring many-body interactions among quasiparticles (such as excitons, phonons, and photons) due to its large exciton binding energy, strong exciton-lattice interactions, and natural photonic cavity structure. …”
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