Peptide asparaginyl ligases—renegade peptide bond makers by Tam, James P., Chan, Ning-Yu, Liew, Heng Tai, Tan, Shaun J., Chen, Yu

“…Here we review the advances in ligases, with a focus on butelase-1, and their applications in engineering bioactive peptides and precision protein modifications, antibody-drug conjugates, and live-cell labeling.…”
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Studies of degradable ureteric stents by Huang, Yun.

“…Further studies to optimize stent design, drug delivery and mechanical properties can be done.…”
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Molecular docking and pharmacokinetics analysis of phytochemicals from Piper caninum as dengue NS2B-NS3 protease inhibitors by Mustafa, Nur Farhana Ajua, Cheng, Kian Kai, Razali, Siti Aisyah, Nadri, Muhammad Helmi

“…Analysis of in silico pharmacokinetics properties revealed that these phytochemicals have good pharmacokinetics profiles and excellent drug-abil-ity, which obeyed Lipinski’s Rule of Five. …”
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Determination of operating point for a propulsive wing UAV using CFD by Chan, Chee Shuan

“…CFD simulations were performed using a 2D RANS k-ε turbulence model and the rotating flow was captured using the moving reference frame method. Lift and drag were obtained for different angle of attacks via a control volume analysis of CFD results. …”
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Synthesis of densely functionalized pyrroles from unprotected carbohydrates by Xia, Mengxin

“…The reaction methodology demonstrates a simple upcycling of carbohydrates to highly functionalized N-heterocyclic compounds. In Chapter Five, the reaction between α-hydroxyketones, oxoacetonitriles, and primary amines selectively gave N-substituted 2,3,5-functionalized 3-cyanopyrroles in up to 90% isolated yields. …”
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Surface modified polymers for controlled macroscopic functions by Chng, S

“…A library of polymers with variation in end group, and with expansion of substrate scope, was characterised in detail for chemical and macroscopic properties. In particular, drug delivery properties were investigated using hole-plate bioassays and HPLC-MS methods, and it was found that the antibiotic, Penicillin V, was still active after being loaded onto the polymer scaffolds, with surface modified polymers binding and releasing more drug than the corresponding controls. …”

Performance cost index in evaluating oil palm stem as alternative fibre material in chain of custody certification of plywood mills in Malaysia by Adnan, Aida

“…Result of the study shows that seven cost components were identified in COC certification; 1) cost of procuring certified raw material (MYR1.24/m³ to MYR2.44/m³); 2) consultancy (plus training) MYR0.41/m³ to MYR0.47/m³); 3) auditing fees (MYR0.99/m³ to MYR1.59/m³); 4) documentation (MYR0.04/m³ to MYR0.27/m³); 5) marketing or promotional (MYR0.35/m³ to MYR0.49/m³); 6) continuous training (MYR0.00/m³ to MYR0.21/m³) and 7) cost for hiring additional staff or reward given (MYR0.00/m³ to MYR0.06/m³). 41% of the certification cost was due to certified raw material which is statistically significant at P≤0.05. …”
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Psychotropic taxonomies: constructing a therapeutic framework for psychiatry by McCutcheon, RA, Cowen, P, Nour, MM, Pillinger, T

“…Disease-based classification systems (e.g., &lsquo;antidepressant&rsquo; and &lsquo;antipsychotic&rsquo;) do not reflect the fact that psychotropic agents are used across diagnostic categories, nor account for the dimensional nature of both the psychopathology and biology of psychiatric illnesses.</p> <p>In this review we discuss the history of psychotropic drug taxonomies and their influence on both clinical practice and drug development. …”

Data for dielectric surface passivation for silicon solar cells: A review by Bonilla, RS, Wilshaw, P, Hamer, P

The durability properties of high volume oil palm biomass waste mortar by Abdul Shukor Lim, Nor Hasanah

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Continuous, high-throughput production of artemisinin-loaded supramolecular cochleates using simple off-the-shelf flow focusing device by Shuddhodana, Wong, Kathy Pooi Wen, Judeh, Zaher

“…It has potential to enable clinical translation of drug-loaded cochleates with predicable drug release, absorption and bioavailability.…”
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Delay-and-pay: prolonging pharmaceutical patent protection without paying the ‘price’ by Foss-Solbrekk, K

“…<p>This thesis argues that actors use the patent system as part of a ‘delay-and-pay’ strategy to preserve drug prices for as long as possible by delaying generic/biosimilar market entry – and that they have a significant incentive to do so. …”

Using GO supporting catalyst to convert biomass into DFF by Li, Haopeng

“…In this paper, two different kinds of Catalytic reaction system were prepared for the purpose of producing DFF, and the target products were obtained from using different kinds of biomass as raw materials. In the first part, a highly efficient multifunctional catalytic process is developed to convert cellulose into 2,5-diformylfuran (DFF).In presence of GO@MoO3 as the catalyst and DMSO as the solvent, a remarkable yield of DFF 24.6% is obtained. …”
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Development of immunomodulatory RNA therapeutics for immune disorders by Iyer, Vaishnavi Srinivasan

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Comparison of different deep learning object detection algorithms on fruit drying characterization by Umair, Mohammad Yamin, Norazlianie, Sazali, Kettner, Maurice, Mohd Azraai, Mohd Razman, Weiβ, Robert

“…This study employs three deep learning object detection models: You Only Look Once v5m (YOLOv5m), Single Shot Detector (SSD) MobileNet and EfficientDet. …”
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Clinical sub-phenotypes of Staphylococcus aureus bacteraemia by Swets, MC, Bakk, Z, Westgeest, AC, Berry, K, Cooper, G, Sim, W, Lee, RS, Gan, TY, Donlon, W, Besu, A, Heppenstall, E, Tysall, L, Dewar, S, de Boer, M, Fowler, VG, Dockrell, DH, Thwaites, GE, Pujol, M, Pallarès, N, Tebé, C, Carratalà, J, Szubert, A, Groeneveld, GH, Russell, CD

“…</p> <br> <p><Strong>Results:</strong> Included patients had predominantly methicillin-susceptible SAB (1366/1430,95.5%). We identified five distinct, reproducible clinical sub-phenotypes: (A) SAB associated with older age and comorbidity, (B) nosocomial intravenous catheter-associated SAB in younger people without comorbidity, (C) community-acquired metastatic SAB, (D) SAB associated with chronic kidney disease, and (E) SAB associated with injection drug use. …”

Integrated Assessment of Diclofenac Biotransformation, Pharmacokinetics, and Omics-Based Toxicity in a Three-Dimensional Human Liver-Immunocompetent Coculture System by Large, Emma, Hughes, David J., Sarkar, Ujjal, Ravindra, Kodihalli C., Young, Carissa L., Rivera-Burgos, Dinelia, Yu, Jiajie, Cirit, Murat, Wishnok, John S, Lauffenburger, Douglas A, Griffith, Linda G, Tannenbaum, Steven R

“…Kupffer cell–mediated cytokine release recapitulated an in vivo proinflammatory response exemplified by a cohort of 11 cytokines that were differentially regulated after lipopolysaccharide induction, including interleukin (IL)-1β, IL-1Ra, IL-6, IL-8, IP-10, tumor necrosis factor-α, RANTES (regulated on activation normal T cell expressed and secreted), granulocyte colony-stimulating factor, macrophage colony-stimulating factor, macrophage inflammatory protein-1β, and IL-5. In summary, our findings indicate that three-dimensional liver microphysiological systems may serve as preclinical investigational platforms from the perspective of the discovery of a set of clinically relevant biomarkers including potential reactive metabolites, endogenous bile acids, excreted proteins, and cytokines to predict early drug-induced liver toxicity in humans.…”
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The effects of different solubilizing agents on the transport and pharmacokinetic profiles of indomethacin: in vitro and in vivo approach by Siti Aisyah Zainuddin, Abdul Latip Ab Hamid, Aqila Iman Rafandi, Mashani Mohamad, Khuriah Abdul Hamid, Syed Haroon Khalid

“…Solubilizing agents, including propylene glycol, Transcutol P, Labrasol, PEG 400, and Tween 80, were separately added at 10% (v/v) to 1 mg/5 mL for in vitro diffusion chamber and 10 mg/kg body weight for in vivo oral absorption studies of indomethacin. …”
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A grid-based HIV expert system by Sloot, Peter M. A., Boukhanovsky, Alexander V., Boucher, Charles A. B., Keulen, Wilco.

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Quenched nematic criticality separating two superconducting domes in an iron-based superconductor under pressure by Coldea, A, Reiss, P