Pleckstrin homology domains bind to phosphatidylinositol-4,5-bisphosphate by Harlan, John E., Hajduk, Philip J., Fesik, Stephen W., Yoon, Ho Sup

“…This suggests that PH domains may be important for membrane localization of proteins through interactions with phosphatidylinositol-4,5-bisphosphate.…”
Get full text
Get full text

The cellular characterization of SARS-CoV-2 spike protein in virus-infected cells using the receptor binding domain binding specific human monoclonal antibodies by Chan, Conrad En-Zuo, Ng, Ching-Ging, Lim, Angeline Pei-Chew, Seah, Shirley Lay-Kheng, Chye, De-Hoe, Wong, Steven Ka-Khuen, Lim, Jie-Hui, Lim, Vanessa Zi-Yun, Lai, Soak-Kuan, Wong, Pui-San, Leong, Kok-Mun, Liu, Yi-Chun, Sugrue, Richard J., Tan, Boon Huan

“…These data suggest that a conformational change in the S protein occurs during its transit through the Golgi complex that enables RBD recognition by the RBD-binders and suggests that these antibodies can be used to monitor S protein RBD formation during the early stages of infection. IMPORTANCE: The SARS-CoV-2 spike (S) protein receptor binding domain (RBD) mediates the attachment of SARS-CoV-2 to the host cell. …”
Get full text

Quantifying conformational changes in the TCR:pMHC-I binding interface by McMaster, B, Thorpe, CJ, Rossjohn, J, Deane, CM, Koohy, H

“…In other protein families, the dynamics of protein-protein interactions have important implications for protein function. …”

The role of the reticulocyte-binding-like protein homologues of Plasmodium in erythrocyte sensing and invasion by Gunalan, Karthigayan, Gao, Xiaohong, Yap, Sally Shu Lin, Huang, Ximei, Preiser, Peter Rainer

“…Two parasite protein families termed reticulocyte-binding-like protein homologues (RBL) and the erythrocyte-binding-like (EBL) protein family are conserved in all Plasmodium species and have been shown to play an important role in host cell recognition and invasion. …”
Get full text
Get full text

G4-PROTAC: targeted degradation of a G-quadruplex binding protein by Patil, Kiran M., Chin, Danielle, Seah, Hui Ling, Shi, Qi, Lim, Kah Wai, Phan, Anh Tuân

“…G-quadruplex (G4)-binding proteins regulate important biological processes, but their interaction networks are poorly understood. …”
Get full text

mAb806 binding to epidermal growth factor receptor: a computational study by Ng, Yao Zong, Kannan, Srinivasaraghavan, Lane, David P., Fuentes, Gloria, Verma, Chandra Shekhar

“…The epidermal growth factor receptor (EGFR) is an important target in the treatment of cancer. A very potent antibody, mAb806, has been developed against overexpressed EGFR and was found to be particularly active in brain tumors. …”
Get full text
Get full text

Mechanistic insights into PTS2-mediated peroxisomal protein import : the co-receptor PEX5L drastically increases the interaction strength between the cargo protein and the receptor... by Kunze, Markus, Wiesinger, Christoph, Schmid, Johannes A., Berger, Johannes, Malkani, Naila, Maurer-Stroh, Sebastian

“…Thus, the sequential formation of a highly stable trimeric complex involving cargo protein, PEX7 and PEX5L stabilizes cargo binding and is a prerequisite for PTS2-mediated peroxisomal import.…”
Get full text
Get full text

Screening for interaction domain in vault nanocapsules. by Loo, Jonathan Yun Haw.

“…This interaction between MVP and mINT is important as researches have shown that the mINT may serves as a protein shuttle to load proteins and nanoparticles into the inner cavity of the vault complex as well as the fact that the interaction site is near the waist of the nanocapsule, where the vault opens up under certain conditions. …”
Get full text

Alternative splicing in the DBD linker region of p63 modulates binding to DNA and iASPP in vitro by Lotz, R, Osterburg, C, Chaikuad, A, Weber, S, Akutsu, M, Machel, AC, Beyer, U, Gebel, J, Löhr, F, Knapp, S, Dobbelstein, M, Lu, X, Dötsch, V

“…Here we characterize the interaction of iASPP with p63 and show that it binds to the linker region between the DNA binding domain and the oligomerization domain. …”

Investigating factors contributing to enhancer-promoter interaction by Cornell, LJ

“…Enhancer promoter interactions usually occur within topologically associated domains (TADs); large regions (200-2000kb) of interacting chromatin delimited by binding sites for the insulating factor CTCF. …”

Structure and interaction of telomeric and telomerase RNA G-quadruplexes. by Martadinata, Herry.

“…Here we present that protein UP1 binds and unfolds both telomeric DNA and RNA G-quadruplexes. …”
Get full text

Conformational dynamics of capping protein and interaction partners : simulation studies by Wales, David., Verma, Chandra S., Lukman, Suryani., Robinson, Robert C.

“…This interaction is modulated through competitive binding by regulatory proteins such as myotrophin (V-1) and the capping protein interacting (CPI) motif from CARMIL. …”
Get full text
Get full text

Impact of molecular linker size on physicochemical properties of assembled gold nanoparticle mono-/multi-layers and their applicability for functional binding of biomolecules by Krikstolaityte, Vida, Hamit-Eminovski, Jildiz, Abariute, Laura, Niaura, Gediminas, Meskys, Rolandas, Arnebrant, Thomas, Lisak, Grzegorz, Ruzgas, Tautgirdas

“…These characteristics are of great importance for functional binding of biomolecules. Positively charged high or low molecular weight inter-linkers, poly-L-lysine (PLL) or N-(6-mercapto)hexylpyridinium (MHP), were used to attach negatively charged AuNPs on a planar gold surface as well as to further interlink into a multilayer structure via layer-by-layer deposition. …”
Get full text

Synthesis and development of novel small molecule inhibitors of nucleophilic hydrolases by Gayatri

A conserved arginine in NS5 binds genomic 3' stem-loop RNA for primer-independent initiation of flavivirus RNA replication by Wang, Sai, Chan, Kitti Wing Ki, Tan, Min Jie Alvin, Flory, Charlotte, Luo, Dahai, Lescar, Julian, Forwood, Jade K., Vasudevan, Subhash G.

“…We present virological and biochemical data showing the importance of this Arg 888 in virus viability and de novo initiation of RNA polymerase activity in vitro. …”
Get full text

The stress granule protein G3BP1 binds viral dsRNA and RIG-I to enhance interferon-β response by Kim, Susana Soo-Yeon, Sze, Lynette, Lam, Kong-Peng

“…Here, we overexpress G3BP1 with RIG-I in HEK293T cells and found that G3BP1 significantly enhances RIG-I–induced ifn-b mRNA synthesis. More importantly, we demonstrate that G3BP1 binds RIG-I and that this interaction involves the C-terminal RGG domain of G3BP1. …”
Get full text
Get full text

The binding interface of kindlin-2 and ILK involves Asp344/Asp352/Thr356 in kindlin-2 and Arg243/Arg334 in ILK by Tan, Hui-Foon, Guan, Si-Yu, Chng, Choon-Peng, Ong, Li-Teng, Tan, Suet-Mien, Law, Alex Sai Kit

“…Leu353 and Leu357 in kindlin‐2 have been reported to be important for the interaction between kindlin‐2 and ILK. …”
Get full text
Get full text

Sequence- and structure-specific probing of RNAs by short nucleobase-modified dsRNA-binding PNAs incorporating a fluorescent light-up uracil analog by Krishna, Manchugondanahalli Shivakumar, Toh, Desiree-Faye Kaixin, Meng, Zhenyu, Ong, Alan Ann Lerk, Wang, Zhenzhang, Lu, Yunpeng, Xia, Kelin, Prabakaran, Mookkan, Chen, Gang

“…RNAs are emerging as important biomarkers and therapeutic targets. The strategy of directly targeting double-stranded RNA (dsRNA) by triplex-formation is relatively underexplored mainly due to the weak binding at physiological conditions for the traditional triplex-forming oligonucleotides (TFOs). …”
Get full text

Macrobrachium rosenbergii De Man nodavirus recombinant capsid protein production and its interactions with RNA by Goh, Zee Hong

Get full text

Elucidation of functional significance of plasmodium falciparum reticulocyte binding like protein homologues - RH1, RH2A AND RH4 during merozoite invasion. by Karthigayan Gunalan.

“…One major family of ligands involved in these interactions is the Reticulocyte binding like protein Homologues (RHs). …”
Get full text