Investigating novel drug delivery systems to enhance tissue regeneration in the central nervous system by Lin, Vincent Po Hen

“…Targeted drug delivery within the central nervous system (CNS) has gained increasing interests in treating neurological diseases, such as neurodegenerative and demyelinating diseases. …”
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Genome-wide gene expression profiling of the Angelman syndrome mice with Ube3a mutation by Low, Daren., Chen, Ken-Shiung.

“…Angelman syndrome (AS) is a human neurological disorder caused by lack of maternal UBE3A expression in the brain. …”
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The cingulum: anatomy, connectivity and what goes beyond by Kollenburg, L, Arnts, H, Green, A, Strauss, I, Vinke, S, Kurt, E

“…For over half a century, the cingulum has been the subject of neuroanatomical and therapeutic investigations owing to its wide range of functions and involvement in various neurological and psychiatric diseases. Recent clinical studies investigating neurosurgical techniques targeting the cingulum, like deep brain stimulation of the anterior cingulate cortex and cingulotomy, have further boosted interests in this central ‘hub’ as a target for chronic intractable pain. …”

Modelling frequency-based neural responses to deep brain stimulation in Parkinson’s disease by Sermon, JJ

“…DBS has been implanted in over 100,000 patients with PD, and is also used in other neurological disorders, such as epilepsy and psychiatric conditions. …”

Functional characterisation of multiple sclerosis-­associated single nucleotide polymorphisms in the Eomesodermin region by Leach, O

“…<p>Multiple sclerosis (MS) is a common inflammatory neurological disease affecting young adults, causing significant disability and increased mortality. …”

Development and validation of outcome prediction models for aneurysmal subarachnoid haemorrhage: the SAHIT multinational cohort study by Jaja, BNR, Saposnik, G, Lingsma, HF, Macdonald, E, Thorpe, KE, Mamdani, M, Steyerberg, EW, Molyneux, A, Manoel, ALDO, Schatlo, B, Hanggi, D, Hasan, D, Wong, GKC, Etminan, N, Fukuda, H, Torner, J, Schaller, KL, Suarez, JI, Stienen, MN, Vergouwen, MDI, Rinkel, GJE, Spears, J, Cusimano, MD, Todd, M

“…In the validation cohort, a core model including patient age, premorbid hypertension, and neurological grade on admission to predict risk of functional outcome had good discrimination, with an area under the receiver operator characteristics curve (AUC) of 0.80 (95% confidence interval 0.78 to 0.82). …”

The metal ion-dependent adhesion site motif of the Enterococcus faecalis EbpA pilin mediates pilus function in catheter-associated urinary tract infection by Nielsen, Hailyn V., Guiton, Pascale S., Kline, Kimberly A., Port, Gary C., Pinkner, Jerome S., Neiers, Fabrice, Normark, Staffan, Henriques-Normark, Birgitta, Caparon, Michael G., Hultgren, Scott J.

“…Inherently resistant to several classes of antibiotics and with a propensity to acquire vancomycin resistance, enterococci are particularly worrisome etiologic agents of CAUTI. A detailed understanding of the molecular basis of Enterococcus faecalis pathogenesis in CAUTI is necessary for the development of preventative and therapeutic strategies. …”
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Cross-reactive dengue human monoclonal antibody prevents severe pathologies and death from Zika virus infections by Kam, Yiu-Wing, Lee, Cheryl Yi-Pin, Teo, Teck-Hui, Howland, Shanshan W., Siti Naqiah Amrun, Lum, Fok-Moon, See, Peter, Kng, Nicholas Qing-Rong, Huber, Roland G., Xu, Mei-Hui, Tan, Heng-Liang, Choo, Andre, Maurer-Stroh, Sebastian, Ginhoux, Florent, Fink, Katja, Wang, Cheng-I, Ng, Lisa F.P., Rénia, Laurent

“…Zika virus (ZIKV) infections have been linked with neurological complications and congenital Zika syndrome. …”
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HELMET: a hybrid machine learning framework for real-time prediction of edema trajectory in large middle cerebral artery stroke by Phillips, E, O'Donoghue, O, Zhang, Y, Tsimpos, P, Mallinger, LA, Chatzidakis, S, Pohlmann, J, Du, Y, Kim, I, Song, J, Brush, B, Smirnakis, S, Ong, CJ, Orfanoudaki, A

“…Our models can provide updated estimations as frequently as every hour, using data from structured time-varying patient records, radiographic text, and human-curated neurological characteristics. Our work resulted in two novel multi-class classification models, collectively named Hybrid Ensemble Learning Models for Edema Trajectory (HELMET), predicting the progression of midline shift over 8-hour (HELMET-8) and 24-hour windows (HELMET-24), respectively. …”

Understanding the molecular mechanism of ion and amino acid transport in neurons by Baroniņa, A

“…EAAT3 malfunction is linked to several neurological diseases and disorders, making it a therapeutic target. …”

Impact of co-morbid common mental disorder symptoms in people with epilepsy in Ethiopia on quality of life and functional disability: cohort study by Tsigebrhan, R, Medhin, G, Belina, M, Newton, C, Hanlon, C

“…Integrated management of mental health and neurological conditions is needed to better address the psychosocial needs and improved functioning of people with epilepsy.…”

Adverse events of common psychiatric medications: an umbrella review by Bartellas, K

“…The strongest associations were between amitriptyline and sexual dysfunction (N=442, odds ratio [OR] 16.6; 95% Confidence Intervals [CI] 4.6 to 60.6), aripiprazole and somnolence (N=569, OR 25.8; 95% CI 1.3 to 112.3) and olanzapine and weight gain (N=249, OR 32.0; 95% CI 1.7 to 98.4). Overall, neurological adverse events were reported most frequently for antidepressant, antipsychotic and anxiolytic medication classes. …”

Increased interleukin-6 correlates with myelin oligodendrocyte glycoprotein antibodies in pediatric monophasic demyelinating diseases and multiple sclerosis by Horellou, P, Wang, M, Keo, V, Chrétien, P, Serguera, C, Waters, P, Deiva, K

“…Thirty four children presenting with a first episode of ADS, 17 with monophasic ADS (9 with ADEM, 4 with TM and 4 with ON) and 17 with MS, who had paired blood and CSF samples at onset were included and compared to 12 patients with other non-inflammatory neurological disorders (OND). Cytokines and anaphylatoxins in CSF were measured by Cytometric Bead Array immunoassay. …”

Predicting Outcomes of Preterm Neonates Post Intraventricular Hemorrhage by Vignolle, Gabriel A., Bauerstätter, Priska, Schönthaler, Silvia, Nöhammer, Christa, Olischar, Monika, Berger, Angelika, Kasprian, Gregor, Langs, Georg, Vierlinger, Klemens, Goeral, Katharina

“…In recent years, research has focused on leveraging advanced proteomic technologies and machine learning to improve prediction of neonatal complications, particularly in relation to neurological outcomes. Machine learning (ML) approaches, combined with proteomics, offer a powerful tool to identify biomarkers and predict patient-specific risks. …”
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Toward a neuroscientific understanding of play: a dimensional coding framework for analyzing infant–adult play patterns by Neale, Dave, Clackson, Kaili, Georgieva, Stanimira, Dedetas, Hatice, Scarpate, Melissa, Wass, Sam, Leong, Victoria

“…A challenge for current research is to converge on a common definition and measurement system for play – whether examined at a behavioral, cognitive or neurological level. Combining these different approaches in a multimodal analysis could yield significant advances in understanding the neurocognitive mechanisms of play, and provide the basis for developing biologically grounded play models. …”
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Large-scale profiling of antibody reactivity to glycolipids in patients with Guillain-Barré syndrome by Thomma, RCM, Halstead, SK, de Koning, LC, Fehmi, J, Rinaldi, S, IGOS consortium

“…<br> In total, 1413 patients from the observational International Guillain-Barré syndrome Outcome Study (0-91 years, 60.3% male) and 1061 controls (healthy, family, infectious, vaccination, other neurological disease) were included. Acute-phase sera from patients were screened for IgM, IgG, and IgA reactivity against 15 glycolipids and one phospholipid and their heteromeric complexes, similarly to archived control sera. …”

Discovering genetic modifiers in Niemann-Pick Disease Type C by Rodriguez-Gil, J

“…These subcellular pathologies eventually cause phenotypes of hepatosplenomegaly and neurological degeneration leading to premature death. …”

Changes in cerebrospinal fluid balance of TNF and TNF receptors in naïve multiple sclerosis patients : early involvement in compartmentalised intrathecal inflammation by Magliozzi, Roberta, Pezzini, Francesco, Pucci, Mairi, Rossi, Stefania, Facchiano, Francesco, Marastoni, Damiano, Montagnana, Martina, Lippi, Giuseppe, Reynolds, Richard, Calabrese, Massimiliano

“…In order to explore whether this feature may be present from the early stages of MS and may be associated with the clinical outcome, the protein levels of TNF, sTNF-R1 and sTNF-R2 were assayed in CSF collected from 122 treatment-naïve MS patients and 36 subjects with other neurological conditions at diagnosis. Potential correlations with other CSF cytokines/chemokines and with clinical and imaging parameters at diagnosis (T0) and after 2 years of follow-up (T24) were evaluated. …”
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Preclinical development of antisense conjugates for the treatment of myotonic dystrophy 1 by Stoodley, J

“…However, no therapy has yet been specifically developed that aims to additionally penetrate the CNS and treat the neurological symptoms experienced by patients. Furthermore, cell-penetrating peptide ASO conjugates (CPP-ASOs) can be associated with nephrotoxicity at higher doses, resulting in a trade-off between efficacy and toxicity, highlighting the need for further optimization to broaden their therapeutic window.…”

Molecular detection, risk factor and public awareness of avian bornavirus from captive and non-captive birds in Peninsular Malaysia by Mohd Lutpi, Syamsiah

“…Birds with PDD may show signs of gastrointestinal tract deficit (e.g., weight loss, regurgitation, passage of undigested food in faeces), or neurological dysfunction (e.g., ataxia, abnormal gait, proprioceptive defects) or even both. …”
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