Investigation into the polishing of brass using flap and fibre grinding disc by Sum, Kar Woh.

“…In this project, the grinding disc will be mounted on the vertical spindle of a 3 axis Computer Numerical Control (CNC) milling machine, with brass mounted at an incline angle. …”
Get full text

Structural characterization of the full-length Hantaan virus polymerase by Keown, JR, Carrique, L, Nilsson-Payant, BE, Fodor, E, Grimes, JM

“…We determine a series of structures at resolutions between 2.7 and 3.3 Å of RNA free polymerase comprising the core, core and endonuclease, and a full-length polymerase. The full-length polymerase structure depicts the location of the cap binding and C-terminal domains which are arranged in a conformation that is incompatible with transcription and in a novel conformation not observed in previous conformations of cap-snatching viral polymerases. …”

Evaluation of keratin templates on dermal regeneration of full-thickness burns by Moay, Zi Kuang

“…Full-thickness burns presents themselves as damages to both epidermis and dermis, and may affect the subcutaneous tissue, muscular, neurovascular, and skeletal structures. …”
Get full text

Structural and functional characterisation of the collagen binding domain of fibronectin by Millard, CJ

“…However, the presence of at least a single GlcNAc sugar residue on the second sugar chain site on 8Fn1 (N- linked to N511) is essential for full affinity binding to collagen. Direct binding of the 8Fn1-9Fn1 module pair to collagen is assessed with a short collagen peptide and the binding is monitored by NMR. …”

Structural basis of RNA binding by leucine zipper GCN4 by Nikolaev, Yaroslav, Pervushin, Konstantin

“…Further studies in the context of full-length bZIP factors are envisaged to address the biological relevance of LZ RNase activity.…”
Get full text
Get full text

Alternative splicing in the DBD linker region of p63 modulates binding to DNA and iASPP in vitro by Lotz, R, Osterburg, C, Chaikuad, A, Weber, S, Akutsu, M, Machel, AC, Beyer, U, Gebel, J, Löhr, F, Knapp, S, Dobbelstein, M, Lu, X, Dötsch, V

“…Here we characterize the interaction of iASPP with p63 and show that it binds to the linker region between the DNA binding domain and the oligomerization domain. …”

Regulation of mRNA abundance by polypyrimidine tract-binding protein-controlled alternate 5′ splice site choice by Hamid, Fursham M., Makeyev, Eugene V.

“…Here we report that polypyrimidine tract-binding protein 1 (Ptbp1/PTB/hnRNP-I) controls alternate 5′ and 3′ splice site (5′ss and 3′ss) usage in a large set of mammalian transcripts. …”
Get full text
Get full text

The SARS-CoV-2 nucleocapsid protein interferes with the full enzymatic activation of UPF1 and its interaction with UPF2 by Nuccetelli, V, Mghezzi-Habellah, M, Deymier, S, Roisin, A, Gérard-Baraggia, F, Rocchi, C, Coureux, P, Gouet, P, Cimarelli, A, Mocquet, V, Fiorini, F

Mapping the structural and dynamical features of multiple p53 DNA binding domains : insights into loop 1 intrinsic dynamics by Lukman, Suryani., Lane, David P., Verma, Chandra S.

“…Loop 1 occupies two major conformational states: extended and recessed; the former but not the latter displays correlations in atomic fluctuations with those of loop 2 (~24 Å apart). Since loop 1 binds to the major groove whereas loop 2 binds to the minor groove of DNA, our results begin to provide some insight into the possible mechanism underpinning the cooperative nature of DBD binding to DNA. …”
Get full text
Get full text

21W.730-2 Expository Writing - Food for Thought: Writing and Reading about Food and Culture, Fall 2005 by Boiko, Karen

Get full text

Structural study of plant cellulose synthase and atypical profilin3 by Qiao, Zhu

“…A low-resolution model of oligomeric full-length cellulose synthase was also obtained by Cryo-EM. …”
Get full text

Part I Targeting RNA duplexes with modified triplex-forming oligonucleotides Part II Allostery within a Watson-Crick RNA duplex and its application in studying RNA recognition by R... by Zhou, Yuan

“…Binding of full-length RIG-I and a triplex-forming oligonucleotide (TFO) also induces 2AP fluorescence enhancement. …”
Get full text

Identification of novel functional compounds from forest onion and its biological activities against breast cancer by Nurkolis, Fahrul, Kurniatanty, Isma, Wiyarta, Elvan, Permatasari, Happy Kurnia, Mayulu, Nelly, Taslim, Nurpudji Astuti, Tjandrawinata, Raymond Rubianto, Hardinsyah, Hardinsyah, Tallei, Trina Ekawati, Tsopmo, Apollinaire, Radu, Son, Hadinata, Edwin, Kim, Bonglee, Ribeiro, Rosy Iara Maciel Azambuja, Syahputra, Rony Abdi

“…A natural resource with potential activity against breast cancer is forest onion, Eleutherine bulbosa (Mill.) Urb., but the identity of its active constituents and their mechanisms of action remain unexplored. …”
Get full text

Identification of RNA-Tis11b complexes in activated B cells. by Tang, Ngang Heok.

“…RNA-binding proteins (RBPs) play important roles in regulating gene expression at post-transcriptional level. …”
Get full text

Spontaneous emission of a quantum emitter near a Chern insulator : interplay of time-reversal symmetry breaking and Van Hove singularity by Lu, Bing-Sui, Arifa, Kathee Zathul, Hong, Xing Ru

“…To this end, we obtain the full real-frequency behavior of the conductivity tensor by performing a tight-binding calculation based on the Qi-Wu-Zhang model and using a Kubo formula, and derive the full electromagnetic Green tensor of the system, which breaks Onsager reciprocity. …”
Get full text

The LBP gene and its association with resistance to Aeromonas hydrophila in Tilapia by Xia, Jun Hong, Fu, Gui Hong, Liu, Feng, Yue, Gen Hua

“…In immune-related genes, the lipopolysaccharide-binding protein (LBP) gene is an important mediator of the inflammatory reaction. …”
Get full text
Get full text

Digital keywords for China: perceptions and portrayals in English-language novels by Matthews, Graham, Cheung, Cally Hiu Tung

“…To date, we have collected 12,186 passages that include the words china or chinese with full metadata (author, title, country of origin, year of publication) for the years 1900–2017. …”
Get full text

Structural and biochemical mechanisms of NLRP1 inhibition by DPP9 by Huang, Menghang, Zhang, Xiaoxiao, Toh, Gee Ann, Gong, Qin, Wang, Jia, Han, Zhifu, Wu, Bin, Zhong, Franklin, Chai, Jijie

“…Nucleotide-binding domain, leucine-rich repeat receptors (NLRs) mediate innate immunity by forming inflammasomes. …”
Get full text

Investigation of Synthetic Proteins Produced via Automated Fast-Flow Peptide Synthesis by Cowfer, Amanda Elizabeth

“…I will discuss the iterative steps my team took to vary both chemical and mechanical and control variables to improve per-coupling yield enough to enable access to full-length single-domain proteins. On this journey, we utilized test peptides to validate synthesis quality and later synthesized a suite of full-length single-domain biologically active proteins. …”
Get full text

High-resolution HDX-MS reveals distinct mechanisms of RNA recognition and activation by RIG-I and MDA5 by Liu, Chuan-Fa, Zheng, Jie, Yong, Hui Yee, Panutdaporn, Nantika, Tang, Kai, Luo, Dahai

“…RIG-I and MDA5 are the major intracellular immune receptors that recognize viral RNA species and undergo a series of conformational transitions leading to the activation of the interferon-mediated antiviral response. However, to date, full-length RLRs have resisted crystallographic efforts and a molecular description of their activation pathways remains hypothetical. …”
Get full text
Get full text