The FGFR inhibitor PD173074 binds to the C-terminus of oncofetal HMGA2 and modulates its DNA-binding and transcriptional activation functions by Ahmed, Syed Moiz, Ragunathan, Priya, Shin, Joon, Peter, Sabrina, Kleissle, Sabrina, Neuenschwander, Martin, Schäfer, Reinhold, Kries, Jens Peter V., Grüber, Gerhard, Dröge, Peter

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Water‐binding‐mediated gelation/crystallization and thermosensitive superchirality by Xing, Pengyao, Li, Yongxin, Wang, Yang, Li, Pei-Zhou, Chen, Hongzhong, Phua, Fiona Soo Zeng, Zhao, Yanli

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The cellular characterization of SARS-CoV-2 spike protein in virus-infected cells using the receptor binding domain binding specific human monoclonal antibodies by Chan, Conrad En-Zuo, Ng, Ching-Ging, Lim, Angeline Pei-Chew, Seah, Shirley Lay-Kheng, Chye, De-Hoe, Wong, Steven Ka-Khuen, Lim, Jie-Hui, Lim, Vanessa Zi-Yun, Lai, Soak-Kuan, Wong, Pui-San, Leong, Kok-Mun, Liu, Yi-Chun, Sugrue, Richard J., Tan, Boon Huan

“…A human monoclonal antibody panel (PD4, PD5, PD7, SC23, and SC29) was isolated from the B cells of convalescent patients and used to examine the S protein in SARS-CoV-2-infected cells. While all five antibodies bound conformational-specific epitopes within SARS-CoV-2 spike (S) protein, only PD5, PD7, and SC23 were able to bind to the receptor binding domain (RBD). …”
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In silico identification of non-chitin binding hevein-like peptides in planta by Kee, Vivian Jie Yi

“…Structural modelling showed the similar conformational fold for all the identified NCB HLPs. Prediction of ligand binding activities using I-TASSER revealed the variety of potential activities each of the NCB HLPs might possess. …”
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Quantifying conformational changes in the TCR:pMHC-I binding interface by McMaster, B, Thorpe, CJ, Rossjohn, J, Deane, CM, Koohy, H

“…Results: In support of some case studies, we demonstrate that all complementarity determining region (CDR) loops move to a certain extent but only CDR3α and CDR3β loops modify their shape when binding pMHC-Is. …”

The role of the reticulocyte-binding-like protein homologues of Plasmodium in erythrocyte sensing and invasion by Gunalan, Karthigayan, Gao, Xiaohong, Yap, Sally Shu Lin, Huang, Ximei, Preiser, Peter Rainer

“…Two parasite protein families termed reticulocyte-binding-like protein homologues (RBL) and the erythrocyte-binding-like (EBL) protein family are conserved in all Plasmodium species and have been shown to play an important role in host cell recognition and invasion. …”
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Post-polymerisation modification of surface chemical functionality and its effect on protein binding by Choong, Cleo Swee Neo, Griffiths, Jon-Paul, Luo, Baiwen, Bora, Meghali, Foord, J. S., Parker, Emily M., Moloney, Mark G.

“…Derivatisation of polystyrene by carbene insertions followed by diazonium coupling permits the introduction of diverse chemical functionality, providing access to materials with similar bulk properties, but in which surface chemical characteristics are systematically varied across a range of surface polarity, hydration and non-bonding interaction behaviour. Protein binding experiments with bovine serum albumin demonstrate that protein adhesion is dependent upon the identity of the surface chemical group, with tert-butyl, hexyl, dimethylamino, amino, and carboxyl modified systems all exhibiting higher levels of binding, while glycol, hydroxyl, and phosphonate give similar or lower levels of binding, relative to the control. …”
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G4-PROTAC: targeted degradation of a G-quadruplex binding protein by Patil, Kiran M., Chin, Danielle, Seah, Hui Ling, Shi, Qi, Lim, Kah Wai, Phan, Anh Tuân

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A comprehensive review of the utilization of alternative binding properties in the construction of asphalt pavements by Ferdaus, R., Khairil Azman, Masri, Hasan, Kamrul, Putra Jaya, Ramadhansyah

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Ultra-fast all-optical switching based on nanoantenna coupled to monolayer TMDs by Song, Qige

“…In the dissertation, a spatial all-optical switch based on dimer and monolayer TMDs is designed. …”
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Validating the ratio of insulin like growth factor binding protein 4 to sex hormone binding globulin as a prognostic predictor of preterm birth in Viet Nam: a case-cohort study by Hirst, JE, Boniface, JJ, Le, DP, Polpitiya, AD, Fox, AC, Vu, TTK, Dang, TT, Fleischer, TC, Bui, NTH, Hickok, DE, Kearney, PE, Thwaites, G, Kennedy, SH, Kestelyn, E, Le, TQ

“…Relative insulin-like growth factor binding protein 4 (IGFBP4) and sex hormone binding globulin (SHBG) abundances were measured by mass spectrometry and their ratio compared between PTB cases and term controls. …”

Investigation on chemical protease, nuclease and catecholase activity of two copper complexes with flexidentate Schiff base ligands by Das, Mriganka, Kundu, Bidyut Kumar, Tiwari, Ritudhwaj, Mandal, Poulami, Nayak, Debasis, Ganguly, Rakesh, Mukhopadhyay, Suman

“…Screening tests were conducted to quantify the binding ability of complexes (1 and 2) towards BSA and DNA as well as the protease and nuclease activity of these complexes using gel electrophoresis technique. …”
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Impact of pyridyl moieties on the inhibitory properties of prominent acyclic metal chelators against metallo-β-lactamase-producing Enterobacteriaceae : investigating the molecular... by Sosibo, Sphelele C., Somboro, Anou M., Amoako, Daniel G., Osei Sekyere, John, Bester, Linda A., Ngila, Jane C., Sun, Darren Delai, Kumalo, Hezekiel M.

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Identification and application of self-binding zipper-like sequences in SARS-CoV spike protein by Zhang, Si Min, Liao, Ying, Neo, Tuan Ling, Lu, Yanning, Liu, Ding Xiang, Vahlne, Anders, Tam, James Pingkwan

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Use of ladle furnace slag containing heavy metals as a binding material in civil engineering by Xu, Bo, Yi, Yaolin

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Persistent spectral hypergraph based machine learning (PSH-ML) for protein-ligand binding affinity prediction by Liu, Xiang, Feng, Huitao, Wu, Jie, Xia, Kelin

“…We test our PSH-GBT model on three most commonly used datasets, including PDBbind-2007, PDBbind-2013 and PDBbind-2016. Our results, for all these databases, are better than all existing machine learning models with traditional molecular descriptors, as far as we know.…”
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Structural analysis of protein tyrosine phosphatase 1B reveals potentially druggable allosteric binding sites by Kumar, Ammu Prasanna, Nguyen, Minh Nhan, Verma, Chandra, Lukman, Suryani

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Analysis of the role played by ligand-induced folding of the cocaine-binding aptamer in the photochrome aptamer switch assay by Shoara, Aron A., Churcher, Zachary R., Steele, Terry W. J., Johnson, Philip E.

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Alternative splicing in the DBD linker region of p63 modulates binding to DNA and iASPP in vitro by Lotz, R, Osterburg, C, Chaikuad, A, Weber, S, Akutsu, M, Machel, AC, Beyer, U, Gebel, J, Löhr, F, Knapp, S, Dobbelstein, M, Lu, X, Dötsch, V

“…Here we characterize the interaction of iASPP with p63 and show that it binds to the linker region between the DNA binding domain and the oligomerization domain. …”

Characterizing the conformational landscape of MDM2-binding p53 peptides using molecular dynamics simulations by Yadahalli, Shilpa, Li, Jianguo, Lane, David P., Gosavi, Shachi, Verma, Chandra Shekhar

“…The conformational landscapes of p53 peptide variants and phage derived peptide (12/1) variants, all known to bind to MDM2, are studied using hamiltonian replica exchange molecular dynamics simulations. …”
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