Optimising investigative pathways in military medicine: operational impact of a military cardiopulmonary exercise testing clinic by Holland, JL, Cowie, P, Gardner, L, Mulae, J, Richards, S, Holdsworth, D

“…Individuals were referred for dyspnoea (22.1%), syncope (11.4%), chest pain (8.1%) (referred to as ‘higher risk’ symptom group), and pre-syncope (8.1%), palpitations (8.1%), and fatigue and/or exercise intolerance (6.0%) (referred to as ‘lower risk’ symptom group). 34% were asymptomatic with incidental findings on cardiac screening investigations. Reduced exercise capacity was rare, affecting only 11% of individuals, which was borderline/mild at worst. …”

Uptake and safety of Sotrovimab for prevention of severe COVID-19 in a cohort and self-controlled case series study by Patone, M, Snelling, AJ, Tibble, H, Coupland, C, Sheikh, A, Hippisley-Cox, J

“…Trials have shown it to have mild to moderate side effects, however, evidence regarding its safety in real-world settings remains insufficient. …”

ECG analysis of ventricular fibrillation dynamics reflects ischaemic progression subject to variability in patient anatomy and electrode location by Martinez-Navarro, H, Bertrand, A, Doste, R, Smith, H, Tomek, J, Ristagno, G, Oliveira, RS, Weber dos Santos, R, Pandit, SV, Rodriguez, B

“…AMSA allowed the precise stratification of VF according to ischaemic severity in the remote myocardium (healthy: 23.62–24.45 mV Hz; mild ischaemia: 10.58–21.47 mV Hz; moderate ischaemia: 4.82–11.12 mV Hz). …”

Pharmacological PPARβ/δ activation upregulates VLDLR in hepatocytes by Zarei, Mohammad, Barroso, Emma, Palomer, Xavier, Escolà-Gil, Joan Carles, Cedó, Lidia, Wahli, Walter, Vázquez-Carrera, Manuel

“…Finally, treatment with another PPARβ/δ agonist increased VLDLR levels in the liver of wild-type mice, but not PPARβ/δ-deficient mice, confirming the regulation of hepatic VLDLR by this nuclear receptor. …”
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Legal translation and ISO standards : a case study by See, Tingting

“…There was no standardized quality assessment for legal translations till April 2020, when the International Organization for Standardization (ISO) published ISO 20771:2020. …”
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Genotype-phenotype maps for gene networks: from evolution to computation by Camargo, FQ

“…For both modelling frameworks, the GRN GP maps exhibit all the structural properties found in the literature, as well as simplicity bias. We also find that the number of genotypes mapping to the wild-type phenotypes for various GRNs is unusually large, and argue that this is evidence that the structure of the GP map plays an important role in determining evolutionary outcomes.…”

Strategies to mitigate establishment under the Wolbachia incompatible insect technique by Soh, Stacy, Ho, Soon Hoe, Ong, Janet, Seah, Annabel, Dickens, Borame Sue, Tan, Ken Wei, Koo, Joel Ruihan, Cook, Alex R., Sim, Shuzhen, Tan, Cheong Huat, Ng, Lee Ching, Lim, Jue Tao

“…Our simulations indicate that these interventions do not override the intended wild type suppression of the IIT approach. These findings will inform policy makers of possible ways to mitigate the potential establishment of Wolbachia using the IIT population control strategy.…”
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Biochemical characterisation of NS2B-NS3 protease from flaviviruses by Nah, Jojo Qian Hui

“…Here, we compared the enzymatic activities of DENV NS2B47- G4SG4 NS3 Wild Type (WT) pro, DENV NS2B47- G4SG4 NS3WTSSpro with DENV NS2B47- G4SG4 NS3WTSS and Zika virus (ZIKV) NS2B-NS3 WT pro. …”
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Methods for the Study of Galactofuranose in Mycobacteria by Taylor, Katherine I.

“…Finally, we characterized the kinetics of a mild electrophile, the squaric ester, and assessed its utility in selectively binding and modifying a key galactofuranosyl transferase involved in mycobacterial cell wall biosynthesis. …”
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新加坡当代社会同志自由的研究 = A study of homosexuals’ liberty in present day Singapore by 陈惠嫔 Tan, Mabel Hui Ping

“…Analysis of credible survey results and reports, as well as gathering personal anecdotes and surveys from respondents was done. Findings were analyzed in an attempt to understand and explain how the tension between the individuals and society at large works. …”
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Clinical and microscopic evaluation of extracapsular stabilisation technique for treatment of cranial cruciate ligament rupture in local dogs by Tahier, Abdullah

“…Mild to moderate osteoarthritis was seen, however there was no obvious different in the presence of inflammatory cells between the operated and non-operated joint fluid. …”
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Barnacle cement protein as an efficient bioinspired corrosion inhibitor by Bui, My Hanh, Hiew, Shu Hui, Salim, Teddy, Saw, Wan Geok, Webster, Richard David, Grüber, Gerhard, Mu, Yuguang, Miserez, Ali

“…Here, we present an alternative green inhibitor, the recombinant protein rMrCP20 derived from the adhesive cement of the barnacle Megabalanus rosa and show that it efficiently protects mild steel against corrosion under high salt conditions mimicking the marine environment. …”
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DOK3 promotes atopic dermatitis by enabling the phosphatase PP4C to inhibit the T cell signaling mediator CARD11 by Loh Jia Tong, Teo, Joey Kay Hui, Kannan, Srinivasaraghavan, Verma, Chandra Shekhar, Andiappan, Anand Kumar, Lim, Hong-Hwa, Lam, Kong-Peng

“…A subset of hypomorphic CARD11 variants found in patients with atopic dermatitis bound more strongly than wild-type CARD11 to DOK3. Our findings suggest that the strength of the interaction of DOK3 with CARD11 may predispose individuals to developing atopic dermatitis.…”
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A multi-view context-aware approach to Android malware detection and malicious code localization by Narayanan, Annamalai, Chandramohan, Mahinthan, Chen, Lihui, Liu, Yang

“…Subsequently, it employs Multiple Kernel Learning (MKL) to find a weighted combination of the views which yields the best detection accuracy. …”
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Treatment options to support the elimination of Hepatitis C: an open label, factorial randomised controlled trial by Cooke, G, Le Manh, H, Flower, B, McCabe, L, Vu Thu Kim, H, Vo Thi, T, Dang Trong, T, Nguyen Thanh, D, Le Thanh, P, Dao Bach, K, Nguyen Thi Chau, A, Pham Ngoc, T, Vu Thu Thu, H, Dang Thi, B, Nguyen Kim, T, Ansari, A, Le Ngoc, C, Vo Minh, Q, Nguyen Thi Ngoc, P, Le Thi, T, Nguyen Bao, T, Kestelyn, E, Kingsley, C, Van Doorn, R, Rahman, M, Pett, S, Thwaites, G, Barnes, E, Day, J, Nguyen Van Vinh, C, Walker, AS

“…</p> <br> <p><strong>Findings:</strong> 624 participants were randomised: 296 (47.4%) genotype 6, 328 (52.6%) genotypes 1-5). …”

PPARβ/δ prevents endoplasmic reticulum stress-associated inflammation and insulin resistance in skeletal muscle cells through an AMPK-dependent mechanism by Salvadó, Laia, Barroso, Emma, Gómez-Foix, Anna Maria, Palomer, Xavier, Michalik, Liliane, Wahli, Walter, Vázquez-Carrera, Manuel

“…Methods Studies were conducted in mouse C2C12 myotubes, in the human myogenic cell line LHCN-M2 and in skeletal muscle from wild-type and PPARβ/δ-deficient mice and mice exposed to a high-fat diet. …”
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Application of in vitro erythropoiesis from bone marrow derived progenitors to detect and study genotoxicity by Shuga, Joseph F. (Joseph Francis)

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Global response of Vibrio cholerae to predation by heterotrophic protists by Hu, Jie

“…Indeed, a pigmented mutant, disrupted in VC1345 (hmgA), survived 100-fold better intracellularly in amoebae than did the wild type. The biomass of V. cholerae biofilms increased when the cell-free supernatant from a T. pyriformis culture was added, indicating that there may be chemical cues involved. …”
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Comparison of diabetic and non-diabetic human leukocytic responses to different capsule types of klebsiella pneumoniae responsible for causing pyogenic liver abscess by Lee, I. Russel, Sng, Ethel, Lee, Kok-Onn, Molton, James S., Chan, Monica, Kalimuddin, Shirin, Izharuddin, Ezlyn, Lye, David C., Archuleta, Sophia, Gan, Yunn-Hwen

“…Furthermore, type 2 DM PBMCs have a mild defect in its ability to control hvKP replication relative to healthy PBMCs. …”
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Wage premium in Singapore. by Tan, Ruo Hui., Tan, Yan Yu., Lee, Wai Meng.

“…In a broader picture, wage-risk premiums could also be used to derive the value of a statistical life, which till today is widely debated and is a highly controversial topic. …”
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