Discovering genetic modifiers in Niemann-Pick Disease Type C by Rodriguez-Gil, J

“…Miglustat (Zavesca) is the only approved therapy for NPC, and while it has been shown to improve clinical outcomes it is not a cure. …”

Indicators of Global Climate Change 2023: annual update of key indicators of the state of the climate system and human influence by Forster, PM, Smith, C, Walsh, T, Lamb, WF, Lamboll, R, Hall, B, Hauser, M, Ribes, A, Rosen, D, Gillett, NP, Palmer, MD, Rogelj, J, von Schuckmann, K, Trewin, B, Allen, M, Andrew, R, Betts, RA, Borger, A, Boyer, T, Broersma, JA, Buontempo, C, Burgess, S, Cagnazzo, C, Cheng, L, Friedlingstein, P, Gettelman, A, Gütschow, J, Ishii, M, Jenkins, S, Lan, X, Morice, C, Mühle, J, Kadow, C, Kennedy, J, Killick, RE, Krummel, PB, Minx, JC, Myhre, G, Naik, V, Peters, GP, Pirani, A, Pongratz, J, Schleussner, C-F, Seneviratne, SI, Szopa, S, Thorne, P, Kovilakam, MVM, Majamäki, E, Jalkanen, J-P, van Marle, M

“…Human-induced warming has been increasing at a rate that is unprecedented in the instrumental record, reaching 0.26 [0.2–0.4] °C per decade over 2014–2023. …”

Psychiatric comorbidities in persons with epilepsy compared with persons without epilepsy: a systematic review and meta-analysis by Kwon, C-S, Rafati, A, Ottman, R, Christensen, J, Kanner, AM, Jetté, N, Newton, CR

“…<p><strong>Importance</strong> Several psychiatric disorders have been found to occur more frequently in persons with epilepsy (PWE) than in persons without epilepsy.…”

Collaborative model of care between Orthopaedics and allied healthcare professionals in knee osteoarthritis (CONNACT) : study protocol for an effectiveness-implementation hybrid ra... by Tan, Bryan Yijia, Pereira, Michelle Jessica, Yang, Su-Yin, Hunter, David J., Skou, Soren Thorgaard, Thumboo, Julian, Car, Josip

“…Sample size of 100 patients has been calculated. Discussion: CONNACT MoC is a complex intervention. …”
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ENIGMA CHEK2gether project: a comprehensive study identifies functionally impaired CHEK2 germline missense variants associated with increased breast cancer risk by Stolarova, Lenka, Kleiblova, Petra, Zemankova, Petra, Stastna, Barbora, Janatova, Marketa, Soukupova, Jana, Achatz, Maria Isabel, Ambrosone, Christine, Apostolou, Paraskevi, Arun, Banu K., Auer, Paul, Barnard, Mollie, Bertelsen, Birgitte, Blok, Marinus J., Boddicker, Nicholas, Brunet, Joan, Burnside, Elizabeth S., Calvello, Mariarosaria, Campbell, Ian, Chan, Sock Hoai, Chen, Fei, Chiang, Jian Bang, Coppa, Anna, Cortesi, Laura, Crujeiras-González, Ana, De Leeneer, Kim, De Putter, Robin, DePersia, Allison, Devereux, Lisa, Domchek, Susan, Efremidis, Anna, Engel, Christoph, Ernst, Corinna, Evans, D. Gareth R., Feliubadaló, Lidia, Fostira, Florentia, Fuentes-Ríos, Olivia, Gómez-García, Encarna B., González, Sara, Haiman, Christopher, Hansen, Thomas van Overeem, Hauke, Jan, Hodge, James, Hu, Chunling, Huang, Hongyan, Ishak, Nur Diana Binte, Iwasaki, Yusuke, Konstantopoulou, Irene, Kraft, Peter, Lacey, James, Lázaro, Conxi, Li, Na, Lim, Weng Khong, Lindstrom, Sara, Lori, Adriana, Martinez, Elana, Martins, Alexandra, Matsuda, Koichi, Matullo, Giuseppe, McInerny, Simone, Michailidou, Kyriaki, Montagna, Marco, Monteiro, Alvaro N. A., Mori, Luigi, Nathanson, Katherine, Neuhausen, Susan L., Nevanlinna, Heli, Olson, Janet E., Palmer, Julie, Pasini, Barbara, Patel, Alpa, Piane, Maria, Poppe, Bruce, Radice, Paolo, Renieri, Alessandra, Resta, Nicoletta, Richardson, Marcy E., Rosseel, Toon, Ruddy, Kathryn J., Santamariña, Marta, Dos Santos, Elizabeth Santana, Teras, Lauren, Toland, Amanda E., Trentham-Dietz, Amy, Vachon, Celine M., Volk, Alexander E., Weber-Lassalle, Nana, Weitzel, Jeffrey N., Wiesmuller, Lisa, Winham, Stacey, Yadav, Siddhartha, Yannoukakos, Drakoulis, Yao, Song, Zampiga, Valentina, Zethoven, Magnus, Zhang, Ze Wen, Zima, Tomas, Spurdle, Amanda B., Vega, Ana, Rossing, Maria, Del Valle, Jesús, De Nicolo, Arcangela, Hahnen, Eric, Claes, Kathleen B. M., Ngeow, Joanne, Momozawa, Yukihide, James, Paul A., Couch, Fergus J., Macurek, Libor, Kleibl, Zdenek

“…Besides pathogenic variants, dozens of missense CHEK2 variants of uncertain significance (VUS) have been identified, hampering the clinical utility of germline genetic testing (GGT). …”
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The effect of regularly dosed paracetamol versus no paracetamol on renal function in Plasmodium knowlesi malaria (PACKNOW) : study protocol for a randomised controlled trial by Cooper, Daniel J., Plewes, Katherine, Grigg, Matthew J., Rajahram, Giri S., Piera, Kim A., William, Timothy, Chatfield, Mark D., Yeo, Tsin Wen, Dondorp, Arjen M., Anstey, Nicholas M., Barber, Bridget E.

“…The inexpensive and widely available drug paracetamol inhibits CFHb-induced lipid peroxidation via reduction of ferryl haem to the less toxic Fe3+ state, and has been shown to reduce oxidative damage and improve renal function in patients with sepsis complicated by haemolysis as well as in falciparum malaria. …”
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Understanding lived experiences of bereaved parents of children with chronic life-threatening Illness : towards a culture-specific and meaning-oriented narrative E-writing interven... by Dutta, Oindrila

“…In Singapore, while deaths among children and youths (age<19) have been steadily declining over the past decade, the number of child deaths caused by chronic conditions has increased by about 27% from 120 in 2014 to 152 in 2016. …”
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Effects of "Thursdays at the Museum" at the Montreal Museum of Fine Arts on the mental and physical health of older community dwellers : the art-health randomized clinical trial pr... by Beauchet, Olivier, Cooper-Brown, Liam, Hayashi, Yoko, Galery, Kevin, Vilcocq, Christine, Bastien, Thomas

“…Discussion: Art-based activities carried out at museums have been receiving increased interest from researchers and policy-makers because of their benefits to mental and physical health. …”
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SARS-CoV-2 accessory protein 7b forms homotetramers in detergent by Surya, Wahyu, Queralt-Martin, Maria, Mu, Yuguang, Aguilella, Vicente M., Torres, Jaume

“…Also, anti-p7b antibodies have been found in the sera of SARS-CoV convalescent patients. …”
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Exploring and Exploiting Ribonuclease 1: from Protein Biochemistry to Protein Engineering by Wralstad, Evans Christian

“…RNase 1 and its bovine homologue RNase A exhibit ubiquitous expression across tissues, a catalytic efficiency within the diffusion-limited regime, and minimal substrate sequence requirements. RNase A has been a favorite model protein of biochemists for over half a century; due to the high level of sequence conservation between RNase A and RNase 1, many observations made for RNase A have corollaries for RNase 1. …”
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Smart window for tuning transparency and noise absorption by Shrestha, Milan

“…Recently, a tunable acoustic membrane absorber has been developed based on a membrane DEA. Its resonant frequency is tunable by controlling membrane tension through voltage activation. …”
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Self-assembled structures using CABC multi-block copolymers by Zheng, Jie

“…Controlled radical polymerizations, especially the reversible complexation mediated polymerization (RCMP), have been introduced. I also introduced the motivations and purposes of Chapters 2, 3 and 4. …”
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Dynamic swimming pattern of Pseudomonas aeruginosa near a vertical wall during initial attachment stages of biofilm formation by Khong, Nicole Zi-Jia, Zeng, Yukai, Lai, Soak-Kuan, Koh, Cheng-Gee, Liang, Zhao-Xun, Chiam, Keng-Hwee, Li, Hoi-Yeung

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Inclusions in calcite phantom crystals suggest role of clay minerals in dolomite formation by Farsang, Stefan, Pekker, Péter, Lampronti, Giulio I., Molnár, Zsombor, Milovský, Rastislav, Pósfai, Mihály, Ozdín, Daniel, Raub, Timothy D., Redfern, Simon Anthony Turner

“…Micro- and nano-inclusions embedded in calcite phantom crystals from Gemerská Ves, Slovak Republic, have been characterized by a combination of Raman spectroscopy, scanning and transmission electron microscopy, X-ray powder difraction, and C and O isotope analysis. …”
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Exploring dependence structures among European electricity markets: static and dynamic copula-GARCH and dynamic state-space approaches by Ly, Sel, Sriboonchitta, Songsak, Tang, Jiechen, Wong, Wing-Keung

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Robust incentive mechanisms for efficient and secure coded edge intelligence by Ng, Jer Shyuan

“…To mitigate the challenges of distributed computing, coded distributed computing (CDC), i.e., a combination of coding theoretic techniques and distributed computing, has been proposed. In particular, CDC systems reduce communication load and alleviate the straggler effects. …”
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Defect chemistry in 2D atomic layers for energy photocatalysis by Di, Jun, Hao, Gazi, Jiang, Wei, Liu, Zheng

“…Numerous efforts have been dedicated to the reasonable design of photocatalytic materials to improve the photocatalytic efficiency. …”
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The stalks of the motor A1A0 ATP synthase come into the focus : structural insight into subunits E, F and H by Gayen, Shovanlal

“…In order to get a detailed picture, structural characterization has been done for the central stalk subunit F and the peripheral stalk subunits H and E. …”
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Layer-by-layer assembled micro and nano carriers for drug delivery applications by Mutukumaraswamy Shaillender

“…In particular, the characterization and applications of biodegradable, biocompatible carriers, coated with polyelectrolyte multilayers, have not been extensively studied to date The objective is to fabricate, characterize and evaluate specific applications of polyelectrolyte multilayered carriers for drug delivery applications. …”
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Photo-driven smart polymers and their molecular self-assembly by Hu, Jinhua

“…This photo-driven vesicle is a typical example of pulsating self-assemblies reported for the first time. Other examples have been reported are pH-responsive1 and thermo-responsive2 pulsating vesicles, respectively. …”
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