Understanding the disease mechanisms of cerebellar ataxia through induced pluripotent stem cell models by Wong, M

“…Although numerous causative genes have been identified, the underlying pathogenic mechanisms remain incompletely understood, due to the limited availability of human brain tissue and the lack of reliable disease models. …”

Barriers and opportunities for WHO ‘best buys’ non-communicable disease policy adoption and implementation from a political economy perspective: a complexity systematic review by Loffreda, G, Arakelyan, S, Bou-Orm, I, Holmer, H, Allen, LN, Witter, S, Ager, A, Diaconu, K

“…These policies have traditionally been treated as technical solutions, neglecting the critical influence of political economy dynamics. …”

Dental resin monomer enables unique NbO2/carbon lithium-ion battery negative electrode with exceptional performance by Ji, Q, Gao, X, Zhang, Q, Jin, L, Wang, D, Xia, Y, Yin, S, Xia, S, Hohn, N, Zuo, X, Wang, X, Xie, S, Xu, Z, Ma, L, Chen, L, Chen, G, Zhu, J, Hu, B, Müller-Buschbaum, P, Bruce, PG, Cheng, L

“…However, studies on NbO2 based lithium-ion battery negative electrodes have been rarely reported. In the present work, NbO2 4 nanoparticles homogeneously embedded in carbon matrix are synthesized using a dental resin monomer (bisphenol A glycidyl dimethacrylate, Bis-GMA) as solvent and carbon source and niobium ethoxide (NbETO) as the precursor. …”

‘An unimaginable challenge’: a cross-cultural qualitative study of ethics and decision-making around tracheostomy ventilation in patients with amyotrophic lateral sclerosis by Ozeki-Hayashi, R, Wilkinson, D

“…Previous studies have shown that doctors' values may affect decisionmaking. There have been no previous international qualitative comparisons of medical decision-making process for TIV or why practice varies. …”

Identifying falsified COVID-19 vaccines by analysing vaccine vial label and excipient profiles using MALDI-ToF mass spectrometry by Arman, BY, Clarke, R, Bharucha, T, Fernandez, LG, Walsby-Tickle, J, Deats, M, Mosca, S, Lin, Q, Banerjee, S, Chunekar, SR, Patil, KD, Gairola, S, Dunachie, S, Merchant, HA, Stokes, R, Kuwana, R, Maes, A, Charrier, J, Probert, F, Caillet, C, Matousek, P, McCullagh, J, Newton, PN, Zitzmann, N, Gangadharan, B

“…However, these developments are associated with the risk of a surge of substandard and falsified (SF) vaccines, as illustrated by the 184 incidents with SF and diverted COVID-19 vaccines which have been reported during the pandemic in 48 countries, with a paucity of methods for their detection in supply chains. …”

Associations of maternal night shift work during pregnancy with DNA methylation in offspring: a meta-analysis in the PACE consortium by Marques, IF, Domènech-Panicello, C, Geurtsen, ML, Hoang, TT, Richmond, R, Polinski, K, Sirignano, L, Page, CM, Binter, A, Everson, T, Burt, A, Deuschle, M, Gilles, M, Streit, F, Mumford, SL, Magnus, P, Reiss, IKM, Vermeulen, MJ, Witt, SH, Chaves, I, Yeung, E, London, SJ, Guxens, M, Felix, JF

“…Background: Night shift work during pregnancy has been associated with differential DNA methylation in placental tissue, but no studies have explored this association in cord blood. …”

Molecular mechanisms relevant to the maintenance of locomotor control by Guo, F

“…Preferential degeneration of the <em>Penk</em>+ MSNs has been observed at early stage of Huntington disease (HD). …”

A separation-of-powers model for a trustworthy and open cloud computing ecosystem by Ruan, A

“…Trusted Cloud models have been proposed, which establish a Root-of-Trust inside the cloud and vouch for the trustworthiness of the cloud services. …”

Plasma trimethylamine N-oxide (TMAO): associations with cognition, neuroimaging, and dementia by Yaqub, A, Vojinovic, D, Vernooij, MW, Slagboom, PE, Ghanbari, M, Beekman, M, van der Grond, J, Hankemeier, T, van Duijn, CM, Ikram, MA, Ahmad, S

“…<p><b>Background</b></p> The gut-derived metabolite Trimethylamine N-oxide (TMAO) and its precursors - betaine, carnitine, choline, and deoxycarnitine – have been associated with an increased risk of cardiovascular disease, but their relation to cognition, neuroimaging markers, and dementia remains uncertain. …”

From the Andes to the coast: human mobility and diet in the Atacama desert during the late intermediate period (ad 900-1450) by Santana Sagredo, F

“…<p>The Late Intermediate Period in northern Chile has been strongly influenced by the mobility models of vertical archipelago and the gyratory mobility. …”

An aerodynamic investigation of a high-pressure turbine using rotor casing static pressure measurements at engine representative conditions with different tip designs, tip gaps, an... by Singh, D, Beard, PF, Cardwell, D, Staelens, V, Bahulekar, P, Stokes, M, Bather, S, Chana, K

“…Since the 1970s, extensive research has been undertaken to understand the over-tip leakage flow and develop mitigation strategies such as novel tip designs, to minimize the losses and heat load. …”

The competing use of perfect and aorist tenses in Old Church Slavonic by MacRobert, C

“…In Old Church Slavonic the distribution of aorist and perfect tenses is problematic: it appears for the most part to be semantically motivated, but the distinction in meaning does not correspond exactly to what is found in modern Slavonic languages and therefore has to be inferred from Old Church Slavonic material. It has sometimes been suggested that in the second and third persons singular, which coincide formally in the aorist tense, variation between aorist and perfect forms may to some extent be correlated with explicitly marked distinctions of person in Greek, and may therefore be a side effect of translation; but such correlations are not regular, and the frequency of second person singular perfect forms is higher in some types of text than in others. …”

Sudden gains in internet cognitive therapy for social anxiety disorder in routine clinical practice by Yim, SH, Clark, DM, Salkovskis, PM, Thew, GR

“…<p><strong>Background:</strong>&nbsp;Sudden gains are large symptom improvements between consecutive therapy sessions. They have been shown to occur in randomised controlled trials of internet-delivered psychological interventions, but little is known about their occurrence when such treatments are delivered in routine clinical practice.…”

Pathway and network analysis of more than 2500 whole cancer genomes by Reyna, MA, Haan, D, Paczkowska, M, Verbeke, LPC, Vazquez, M, Kahraman, A, Pulido-Tamayo, S, Barenboim, J, Wadi, L, Dhingra, P, Shrestha, R, Getz, G, Lawrence, MS, Pedersen, JS, Rubin, MA, Wheeler, DA, Brunak, S, Izarzugaza, JMG, Khurana, E, Marchal, K, von Mering, C, Sahinalp, SC, Valencia, A, PCAWG Drivers and Functional Interpretation Working Group, Reimand, J, Stuart, JM, Raphael, BJ, PCAWG Consortium

“…However, non-coding cancer driver mutations are less well-characterized and only a handful of recurrent non-coding mutations, most notably TERT promoter mutations, have been reported. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2658 cancer across 38 tumor types, we perform multi-faceted pathway and network analyses of non-coding mutations across 2583 whole cancer genomes from 27 tumor types compiled by the ICGC/TCGA PCAWG project that was motivated by the success of pathway and network analyses in prioritizing rare mutations in protein-coding genes. …”

Soft law, hard stakes? State commitment to non-binding international instruments and the case of the UN Declaration on the Rights of Indigenous Peoples by Villeneuve, L

“…Whilst the advantages and appeal of soft law have been widely studied, with its effects explored in both International Relations (IR) and International Law (IL) scholarship, states’ behaviour on commitment to soft law per se has remained underexplored. …”

International healthcare workers’ experiences and perceptions of the 2022 multi-country mpox outbreak by Apea, V, Titanji, BK, Dakin, FH, Hayes, R, Smuk, M, Kawu, H, Waters, L, Levy, I, Kuritzkes, DR, Gandhi, M, Rockstroh, J, Schechter, M, Holt, M, Palich, R, Cortes, CP, Nozza, S, Mussini, C, Calmy, A, Crabtree-Ramirez, BE, Blanco, JL, Bhagani, S, Dewsnap, C, Orkin, C, On Behalf of the Mpox SHARE-NET Writing Group

“…Less than 9% of HCWs in the region of the Caribbean, Central America and South America had been offered a vaccine as compared to almost one-third in the other regions. …”

Spontaneous ventricular tachyarrhythmias in β2-adrenoceptor transgenic mice in relation to cardiac interstitial fibrosis by Nguyen, M-N, Kiriazis, H, Ruggiero, D, Gao, X-M, Su, Y, Jian, A, Han, L-P, McMullen, JR, Du, X-J

“…Myocardial fibrosis is regarded as a pivotal proarrhythmic substrate, but there have been no comprehensive studies showing a correlation between the severity of fibrosis and ventricular tachyarrhythmias (VTAs). …”

A protocol for mobilising novel finance models for collaborative health promotion and disease prevention initiatives: taking a smart capacitating investment approach in the Invest4... by Lane, J, Edwards, RT, Babarczy, B, Whiteley, H, Oruganti, V, Rutten-van Mölken, M, Costongs, C, Jani, AR, Wordsworth, S, Maassen, A, Tsiachristas, A, Davies, J, Stavenow, B, van Vliet, J, Wright, S, Papartyte, L, Camaradou, JC, Koleva-Kolarova, R

“…The term “smart capacitating investment” (SCI) has previously been used to understand how to best boost social infrastructure investment in education, health, transport and housing across the EU. …”

Due regard obligations in the law of the sea convention by Fasia, EE

“…The content and function of these obligations have not been thoroughly and systematically studied and their application in practice can be problematic due to their indeterminate stipulation. …”

BRCA1 regulation of breast cancer cell motility by Hernandez Nuñez, ZE

“…Mutations in BRCA1 have been implicated in the increased risk of developing several cancers. …”