Treatment options to support the elimination of Hepatitis C: an open label, factorial randomised controlled trial by Cooke, G, Le Manh, H, Flower, B, McCabe, L, Vu Thu Kim, H, Vo Thi, T, Dang Trong, T, Nguyen Thanh, D, Le Thanh, P, Dao Bach, K, Nguyen Thi Chau, A, Pham Ngoc, T, Vu Thu Thu, H, Dang Thi, B, Nguyen Kim, T, Ansari, A, Le Ngoc, C, Vo Minh, Q, Nguyen Thi Ngoc, P, Le Thi, T, Nguyen Bao, T, Kestelyn, E, Kingsley, C, Van Doorn, R, Rahman, M, Pett, S, Thwaites, G, Barnes, E, Day, J, Nguyen Van Vinh, C, Walker, AS

“…</p> <br> <p><strong>Findings:</strong> 624 participants were randomised: 296 (47.4%) genotype 6, 328 (52.6%) genotypes 1-5). …”

The effects and costs of an anti-bullying program (KiVa) in UK primary schools: a multicenter cluster randomized controlled trial by Badger, JR, Bowes, L, Babu, M, Broome, M, Cannings-John, R, Clarkson, S, Coulman, E, Tudor Edwards, R, Ford, T, Hastings, RP, Hayes, R, Lugg-Widger, F, Owen-Jones, E, Patterson, P, Segrott, J, Sydenham, M, Townson, J, Watkins, RC, Whiteley, H, Williams, ME, Stand Together Team, Hutchings, J

“…Outcomes were analyzed using multilevel linear and logistic regression models. <p><b>Findings </b></p> Between 8/11/2019–12/02/2021, 118 primary schools were recruited in four trial sites, 11 111 students in primary analysis (KiVa-intervention: n = 5944; 49.6% female; UP: n = 5167, 49.0% female). …”

Strategies to increase response rate and reduce non-response bias in population health research: a series of randomised controlled trials during a large COVID-19 study by Atchison, CJ, Gilby, N, Pantelidou, G, Clemens, S, Pickering, K, Chadeau-Hyam, M, Ashby, D, Barclay, WS, Cooke, G, Darzi, A, Riley, S, Donnelly, C, Ward, H, Elliott, P

“…<p><strong>Background:</strong> High response rates are needed in population-based studies as non-response reduces effective sample size and bias affects accuracy and decreases generalizability of the study findings.</p> <br> <p><strong>Objectives:</strong> We tested different strategies to improve response rate and reduce non-response bias in a national population-based COVID-19 surveillance programme in England, UK.…”

Microbial communities: network reconstruction and control by Fu, A

“…</p> <p>The thesis concludes with a summary of the research findings, discussing the limitations and potential future directions. …”

Unravelling the degradation pathways and charging mechanism in the Li-O2 battery: the role of singlet oxygen by Zor, C

“…It is demonstrated that ¹O₂ is not the main source of degradation and fresh Li₂O₂ surfaces is the culprit. This finding should redirect the focus of LOB research from avoiding ¹O₂ to developing electrolytes inert towards peroxide and peroxide-derived side products for an electro/chemically stable cell. …”

Frailty trajectories preceding dementia in the US and UK by Ward, DD, Flint, JP, Littlejohns, TJ, Foote, IF, Canevelli, M, Wallace, LMK, Gordon, EH, Llewellyn, DJ, Ranson, JM, Hubbard, RE, Rockwood, K, Stolz, E

“…</p> <p><strong>Conclusions and Relevance: </strong>These findings suggest that frailty measurements may be used to identify high-risk population groups for preferential enrolment into clinical trials for dementia prevention and treatment. …”

The epidemiology of periportal fibrosis and relevance of current Schistosoma mansoni infection within the context of repeated mass drug administration: a population-based, cross-se... by Ajayi, S, Nabatte, B, Mpooya, S, Tinkitina, B, Opio, CK, Kabatereine, NB, Chami, G

“…</p> <br> <p><strong>Findings:</strong> Between Jan 6 and Feb 3, 2022, 342 (12·1%) of 2834 participants were diagnosed with periportal fibrosis. …”

Adverse health events associated with antipsychotic use: an umbrella review by Chow, RTS

“…Evidence was of variable quality, given the heterogenous findings, asymmetry in the funnel plots, and the diverse AMSTAR 2 ratings, prediction intervals and excess significance ratios. …”

Accuracy and safety of an autonomous artificial intelligence clinical assistant conducting telemedicine follow-up assessment for cataract surgery by Meinert, E, Milne-Ives, M, Lim, E, Higham, A, Boege, S, de Pennington, N, Bajre, M, Mole, G, Normando, E, Xue, K

“…This study is registered with&nbsp;ClinicalTrials.gov&nbsp;(NCT05213390) and ISRCTN (16038063).</p> <p><strong>Findings:&nbsp;</strong>202 patients were included in the analysis, with data collection completed on 23 March 2022. …”

Mortality rates among patients successfully treated for hepatitis C in the era of interferon-free antivirals: population based cohort study by Hamill, V, Wong, S, Benselin, J, Krajden, M, Hayes, PC, Mutimer, D, Yu, A, Dillon, JF, Gelson, W, Velásquez García, HA, Yeung, A, Johnson, P, Barclay, ST, Alvarez, M, Toyoda, H, Agarwal, K, Fraser, A, Bartlett, S, Aldersley, M, Bathgate, A, Binka, M, Richardson, P, Morling, JR, Ryder, SD, Barnes, E

“…Drug and liver related causes of death were the main drivers of excess mortality. These findings highlight the need for continued support and follow-up after successful treatment for hepatitis C to maximise the impact of direct acting antivirals.…”

Enhanced rice (Oryza sativa L.) plant growth and nutrient contents during the vegetative stage through zinc solubilizing bacterial bead inoculation by Irsyad Sulaimi Ramly, Nur Maizatul Idayu Othman, Aida Soraya Shamsuddin, Tan, Ali Kee Zuan, Nor Hafizah Zakaria, Fadzilah Adibah Abdul Majid, Nur’ Amira Hamid

“…Mixed inoculant also improved soil fertility by increasing the available Zn (6.17 mg kg-1) in the soil, however, it lowered the soil pH to pH 5.8. These findings highlight the potential of ZSB, particularly A. nosocomialis (SR R-10), to improve rice plant’s growth and nutritional quality and increase the bioavailability of zinc in the soil to promote sustainable agricultural practices.…”
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Fabrication and biocompatibility evaluation of hydroxyapatite–polycaprolactone–gelatin composite nanofibers as a bone scaffold by Aminatun, None, Sujak M. K, Aisyah, Izak R, Djony, Hadi, Sofijan, Sari, Yessie Widia, Gunawarman, None, Cahyati, Nilam, Yusuf, Yusril, Che Abdullah, Che Azurahanim

“…The SEM analysis confirmed the biocompatibility of the HA/PCL/gelatin nanofiber scaffold, as osteoblast cells attached and dispersed successfully five days after seeding. Based on these findings, the HA/PCL/gelatin nanofiber scaffold emerges as a very promising candidate for treating bone damage. © 2024 The Royal Society of Chemistry.…”
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A comprehensive study of laser irradiated hydrothermally synthesized 2D layered heterostructure V2O5(1−x)MoS2(x) (X = 1–5%) nanocomposites for photocatalytic application by Jameel, Muhammad Hasnain, Yasin, Aqeela, Samia, Mayzan, Mohd Zul Hilmi, Roslan, Muhammad Sufi, Esa, Fahmiruddin, Agam, Mohd Arif, Mohd Zaid, Mohd Hafiz, Althubeiti, Khaled, Aljohani, Mohammed

“…Furthermore, dielectric findings like the complex dielectric function, tangent loss, electrical conductivity, quality factors, and impedance of V2O5(1−x)MoS2(x) (X = 1–5% w/w) nanocomposites are studied. …”
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Effects of multilingualism on brain structure, cognition and language processing by Yee, Jia’en

“…This is despite multilingualism being a common phenomenon in many parts of the world. Findings from past bilingual studies have shown patterns of volumetric expansions that are followed with reductions as language experience increases; possibly signifying renormalisation. …”
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Infection patterns of scabies and tinea between inland and resettled indigenous Negrito communities in peninsular Malaysia by Er, Yi Xian, Than, Leslie Thian Lung, Muslim, Azdayanti, Yap, Nan Jiun, Tee, Mian Zi, Abdull-Majid, Nurmanisha, Lee, Soo Ching, Shahrizal, Shezryna, Lim, Yvonne Ai Lian

“…Risk analysis revealed specific associations: scabies with Kensiu subtribe (P = 0.002), high income (P = 0.001) and underweight individuals (P = 0.009); tinea versicolor with Bateq subtribe (P = 0.003), resettled villagers (P < 0.001), males (P = 0.040), and overweight/obese individuals (P = 0.015); and tinea imbricata with Bateq (P = 0.011) and smokers (P = 0.004). These findings highlight a complex interplay between environment and lifestyle in skin infection prevalence. …”
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Determination of octreotide acetate as radiosensitizer in breast cancer cell lines by Alkhansa, Salih Mahmoud Abdalla

“…While MCF7 cell line was resistant to radiation, there was no difference between the irradiated and non-irradiated cells, however, SSTR1, SSTR2, SSTR3 and SSTR4 mRNA expression were significantly higher in MDA-MB231 cell line as compared to MCF-7 cell line (P=0.02, 0.002, 0.001, 0.01) respectively. These findings showed that MCF7 is a radio- resistant cell line expressed low levels of SSTRs 1-5 which considered a suitable model for study the effects of octreotide acetate agonist as radiosensitizer in breast cancer. …”
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Enhanced rice (Oryza sativa L.) plant growth and nutrient contents during the vegetative stage through zinc solubilizing bacterial bead inoculation by Ramly, Irsyad Sulaimi, Othman, Nur Maizatul Idayu, Shamsuddin, Aida Soraya, Zuan, Ali Tan Kee, Zakaria, Nor Hafizah, Abdul Majid, Fadzilah Adibah, Hamid, Nur’ Amira

“…Mixed inoculant also improved soil fertility by increasing the available Zn (6.17 mg kg-1) in the soil, however, it lowered the soil pH to pH 5.8. These findings highlight the potential of ZSB, particularly A. nosocomialis (SR R-10), to improve rice plant’s growth and nutritional quality and increase the bioavailability of zinc in the soil to promote sustainable agricultural practices.…”
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Phytochemical analysis and cytotoxic effects of mango (Mangifera indica L) kernel on breast cancer cell lines by Abdullah, Al-Shwyeh Hussah

“…It is suggested that the anticancer effect of the M.indica extract is via modulation of redox status through its antioxidant constituents and induction of apoptosis. These findings suggest that M. indica kernel extract, with antiproliferative properties towards cancer cells, while relatively innocuous to normal cells, is a good candidate as an alternative to or for supplementation for current chemotherapies in the treatment of breast cancers, without showing the side-effects associated with these anticancer drugs.…”
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Tea leaf [Camellia sinensis (L.) Kuntze] extract-synthesized silver nanoparticles as antimicrobial agent against foodborne pathogens by Loo, Yuet Ying

“…This is the first report to demonstratethat the application of AgNPs in washing-up liquid has significant antibacterial activity against foodborne pathogens. Overall, the findings show that AgNPs have strong antibacterial activity and can be an alternative antimicrobial agent.…”
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Development of superhydrophobic ceramic membrane decorated with flake-like structure by two-step synthesis for seawater desalination by membrane distillation by Omar, Najib Meftah Almukhtar, Othman, Mohd. Hafiz Dzarfan, Tai, Zhong Sheng, Puteh, Mohd. Hafiz, Wong, Keng Yinn, Tan, Huiyi, Tonni Agustiono Kurniawan, Tonni Agustiono Kurniawan, Ooi, Boon Seng, Nomura, Mikihiro, Iwamoto, Yuji

“…A seawater desalination experiment by a membrane distillation (MD) system evaluated the performance of MK-SS HFM for 500 min. Significant findings: The results revealed that the MK-SS/4 h HFM, characterized by its flake-like structure, exhibited optimal superhydrophobic behavior. …”