Energizing solar still efficiency with eco-friendly coconut shell biochar enhanced organic phase change material by Rajamony, Reji Kumar, Suraparaju, Subbarama Kousik, Kalidasan, B., Yadav, Aman, Kumar Pandey, Adarsh Kumar, Nurhanis Sofiah, Abd Ghafar, Siaw Paw, Johnny Koh, Fatehmulla, Amanullah, Samykano, Mahendran, Saidur, Rahman Md

“…Furthermore, cost analysis revealed that the SS-CSePCM system offers a 34.63% reduction in production costs and a 43.58% faster payback period. These findings underscore the scalability and practical applicability of the proposed system, positioning it as a sustainable, cost-efficient, and adaptable solution for clean water production in water-scarce regions globally.…”
Get full text
Get full text

Predictive modeling and optimization of noise emissions in a palm oil methyl ester-fueled diesel engine using response surface methodology and artificial neural network integrated... by Muhammad Zikri, Japri, Mohd Shahrir, Mohd Sani, Mohd Fadzil Faisae, Ab Rashid, Muriban, Jackly, Galang Sandy, Prayogo

“…In summary, the results illustrate that the ANN-GA model outperforms the RSM model in predicting noise emissions under the conditions tested, providing a more accurate and effective method. These findings endorse the feasibility of applying ANN-GA in scenarios where precise noise prediction is crucial, particularly in relation to alternative fuels like POME.…”
Get full text

XFEL serial crystallography reveals the room temperature structure of methyl-coenzyme M reductase by Ohmer, Christopher J, Dasgupta, Medhanjali, Patwardhan, Anjali, Bogacz, Isabel, Kaminsky, Corey, Doyle, Margaret D, Chen, Percival Yang-Ting, Keable, Stephen M, Makita, Hiroki, Simon, Philipp S, Massad, Ramzi, Fransson, Thomas, Chatterjee, Ruchira, Bhowmick, Asmit, Paley, Daniel W, Moriarty, Nigel W, Brewster, Aaron S, Gee, Leland B, Alonso-Mori, Roberto, Moss, Frank, Fuller, Franklin D, Batyuk, Alexander, Sauter, Nicholas K, Bergmann, Uwe, Drennan, Catherine L, Yachandra, Vittal K, Yano, Junko, Kern, Jan F, Ragsdale, Stephen W

“…In celebration of the seminal contributions of inorganic chemist Dick Holm to our understanding of nickel-based catalysis, we are honored to announce our findings in this special issue dedicated to this remarkable pioneer of bioinorganic chemistry.…”
Get full text

Comparative systems biology analysis to study the mode of action of the isothiocyanate compound iberin on pseudomonas aeruginosa by Givskov, Michael, Nielsen, Thomas E., Tolker-Nielsen, Tim, Tan, Sean Yang-Yi, Liu, Yang, Chua, Song Lin, Vejborg, Rebecca Munk, Jakobsen, Tim Holm, Chew, Su Chuen, Li, Yingying, Yang, Liang

“…Taken together, the findings suggest that the mode of QS inhibition in iberin is through downregulation of the Gac/Rsm QS network, which in turn leads to the repression of QS-regulated virulence factors, such as pyoverdine, chitinase, and protease IV. …”
Get full text
Get full text

Omega-3 (ω-3) and social skills interventions for reactive aggression and childhood externalizing behavior problems : a randomized, stratified, double-blind, placebo-controlled, fa... by Raine, Adrian, Ang, Rebecca P., Choy, Olivia, Hibbeln, Joseph R., Ho, Ringo Moon-Ho, Lim, Choon Guan, Lim-Ashworth, Nikki S. J., Ling, Shichun, Liu, Jean C. J., Ooi, Yoon Phaik, Tan, Yi Ren, Fung, Daniel S. S.

“…Effect sizes (d) were small, ranging from 0.17 to 0.31. Conclusions: Findings provide some initial support for the efficacy of ω-3 in reducing reactive aggression over and above standard care (medication and parent training), but yield only preliminary and limited support for the efficacy of ω-3 in reducing overall externalizing behavior in children. …”
Get full text

Maximizing dissimilarity in resting state detects heterogeneous subtypes in healthy population associated with high substance use and problems in antisocial personality by Kashyap, Rajan, Bhattacharjee, Sagarika, Yeo, Thomas B. T., Chen, Annabel Shen-Hsing

“…Gender differences were also significant. Altogether the findings suggested that subtypes exist even in healthy control population, and comparison studies (case vs. control) need to be mindful of it.…”
Get full text

Hippocampal transcriptome profiling reveals common disease pathways in chronic hypoperfusion and aging by Baik, Sang-Ha, Selvaraji, Sharmelee, Fann, David Y., Poh, Luting, Jo, Dong-Gyu, Herr, Deron R., Zhang, Shenpeng R., Kim, Hyun Ah, Silva, Michael De, Lai, Mitchell K. P., Chen, Christopher Li- Hsian, Drummond, Grant R., Lim, Kah-Leong, Sobey, Christopher G., Arumugam, Thiruma V.

“…Immunoblot analyses confirmed these findings. Finally, relative to young sham mice the cell type-specific profile of genes in both young BCAS and old sham animals further revealed common cell-specific genes. …”
Get full text

Monolayer tungsten disulfide in photonic environment : angle-resolved weak and strong light-matter coupling by Zhang, Xuewen, Wu, Lishu, Wang, Xu, He, Silin, Hu, Hanwei, Shi, Guangchao, Zhang, Xingwang, Shang, Jingzhi, Yu, Ting

“…By embedding 1L-WS2 into a dielectric microcavity, strong exciton-photon coupling results in the formation of lower and upper polariton branches with an appreciable Rabi splitting of 34 meV at room temperature, where the observed blueshift of the lower polariton branch is indicative of the enhanced polariton-polariton scattering. Our findings highlight the effect of dielectric environment on angle-resolved optical response of exciton-photon interactions in a two-dimensional semiconductor, which is helpful to develop practical TMD-based architectures for photonic and polaritonic applications. …”
Get full text

Graphdiyne/graphene heterostructure: a universal 2D scaffold anchoring monodispersed transition-metal phthalocyanines for selective and durable CO₂ electroreduction by Gu, Huoliang, Zhong, Lixiang, Shi, Guoshuai, Li, Jiaqiang, Yu, Ke, Li, Jiong, Zhang, Shuo, Zhu, Chenyuan, Chen, Shaohua, Yang, Chunlei, Kong, Ya, Chen, Chen, Li, Shuzhou, Zhang, Jin, Zhang, Liming

“…The usage of the GDY/G heterostructure as a scaffold can be further extended to other organometallic complexes beyond CoPc. Our findings lend credence to the prospect of the GDY/G hybrid contributing to the design of single-molecule dispersed CO2R catalysts for sustainable energy conversion.…”
Get full text

Nanoparticle-induced chemoresistance: the emerging modulatory effects of engineered nanomaterials on human intestinal cancer cell redox metabolic adaptation by Wu, Zhuoran, Setyawati, Magdiel Inggrid, Lim, Hong Kit, Ng, Kee Woei, Tay, Chor Yong

“…Transcriptome profiling, bioinformatics analysis and siRNA gene knockdown experiments revealed the nuclear factor erythroid 2-related factor 2 (Nrf2) as the key modulator of the ZnO NP-induced drug resistance. Our findings suggest that a ROS-inducing ENM can emerge as a nano-stressor, capable of regulating the chemosensitivity of colon cancer cells.…”
Get full text

Super-resolution imaging of photogenerated charges on CdS/g-C₃N₄ heterojunctions and its correlation with photoactivity by Wu, Shuyang, Lee, Jinn-Kye, Lim, Pei Chong, Xu, Rong, Zhang, Zhengyang

“…The photoactive species (i.e., e- and h+) were found to be preferentially distributed at the two end segments of CdS nanorods and the edge boundaries of g-C3N4. Therefore, our findings shed more light on the charge distribution and photocatalytic heterogeneity of composite materials at the nanoscale. …”
Get full text

Time-restricted feeding modulates the DNA methylation landscape, attenuates hallmark neuropathology and cognitive impairment in a mouse model of vascular dementia by Selvaraji, Sharmelee, Efthymios, Motakis, Foo, Roger Sik Yin, Fann, David Y., Lai, Mitchell Kim Peng, Chen, Christopher Li Hsian, Lim, Kah-Leong, Arumugam, Thiruma V.

“…Modulation of DNA methylation patterns in the cortex of AL CCH mice was re-modelled and signs of reversal was observed in IF CCH mice across all three timepoints. Conclusions: These findings provide an understanding of how IF may protect the brain against damage caused by CCH and show promise in offering potential beneficial effects in mitigating the neuropathology and cognitive deficits in VaD.…”
Get full text

Parent-infant affect synchrony during social and solo play by Kidby, Sayaka, Neale, Dave, Wass, Sam, Leong, Victoria

“…While our sample was small and from a homogeneous population (e.g. white, highly educated parents), limiting the implications of the findings, these results demonstrate that maternal active engagement in playful interaction with her infant affords, increases, and extends infant positive affect and parent-infant positive affect synchrony, providing insights into how the social context modulates infants' affective experiences. …”
Get full text

2D-3D perovskite memristor with low energy consumption and high stability for neural morphology calculation by Sun, Kaixuan, Wang, Qingrui, Zhou, Long, Wang, Jingjuan, Chang, Jingjing, Guo, Rui, Tay, Beng Kang, Yan, Xiaobing

“…Moreover, this perovskite-based artificial synapse has ultra-low power consumption due to the switchable p-i-n structure in organic-inorganic halide perovskites. Our finding highlights the immense application potential of the 2D-3D perovskite memristor in the future neuromorphic computing system.…”
Get full text

LKAW: a robust watermarking method based on large kernel convolution and adaptive weight assignment by Zhang, Xiaorui, Jiang, Rui, Sun, Wei, Song, Aiguo, Wei, Xindong, Meng, Ruohan

“…Robust watermarking requires finding invariant features under multiple attacks to ensure correct extraction. …”
Get full text

Waste to wealth: near-infrared/pH dual-responsive copper-humic acid hydrogel films for bacteria-infected cutaneous wound healing by Zha, Kangkang, Xiong, Yuan, Zhang, Wenqian, Tan, Meijun, Hu, Weixian, Lin, Ze, Cheng, Peng, Lu, Li, Cai, Kaiyong, Mi, Bobin, Feng, Qian, Zhao, Yanli, Liu, Guohui

“…This PVA@Cu-HAs NPs@SEW hydrogel film improves tissue regeneration by promoting M2 macrophage polarization, alleviating oxidative stress, enhancing angiogenesis, and facilitating collagen deposition. These findings highlight the therapeutic potential of PVA@Cu-HAs NPs@SEW hydrogel film for the treatment of bacterially infected cutaneous wound healing.…”
Get full text

Imprinting of IgA responses in previously infected individuals receiving bivalent mRNA vaccines (WT and BA.4/BA.5 or WT and BA.1) by Goh, Yun Shan, Fong, Siew-Wai, Hor, Pei Xiang, Loh, Chiew Yee, Tay, Matthew Zirui, Wang, Bei, Salleh, Siti Nazihah Mohd, Ngoh, Eve Zi Xian, Lee, Raphael Tze Chuen, Poh, Xuan Ying, Lee, I. Russel, Rao, Suma, Chia, Po Ying, Maurer-Stroh, Sebastian, Wang, Cheng-I, Leo, Yee Sin, Lye, David C., Young, Barnaby Edward, Ng, Lisa F. P., Renia, Laurent

“…The relative fold change in serum binding IgA response was more skewed towards WT over variant (BA.1, BA.5 or EG.5.1) spike in previously infected bivalent-booster-vaccinees, as compared with previously infected monovalent-(WT)-booster-vaccinees. Conclusion: The findings suggest imprinting of antibody responses that is shaped by the first vaccination (WT spike). …”
Get full text

Early Prediction of Skin Viability Using Visible Diffuse Reflectance Spectroscopy and Autofluorescence Spectroscopy by Zhu, Caigang, Chen, Shuo, Chui, Christopher Hoe-Kong, Tan, Bien-Keem, Liu, Quan

“…Meanwhile, several physiologically relevant parameters including hemoglobin oxygenation, total hemoglobin concentration, and redox ratio indicators estimated from diffuse reflectance and autofluorescence spectra show distinctively different trends over time for nonviable and viable skin. Conclusions: These findings will be helpful to clinicians for making a precise judgment on flap viability. …”
Get full text
Get full text

Heme-Regulated eIF2α Kinase Modulates Hepatic FGF21 and is Activated by PPARβ/δ Deficiency by Zarei, Mohammad, Barroso, Emma, Leiva, Rosana, Barniol-Xicota, Marta, Pujol, Eugènia, Escolano, Carmen, Vázquez, Santiago, Palomer, Xavier, Pardo, Virginia, González-Rodríguez, Águeda, Valverde, Ángela M., Quesada-López, Tania, Villarroya, Francesc, Wahli, Walter, Vázquez-Carrera, Manuel

“…Moreover, pharmacological activation of HRI increased Fgf21 expression and reduced lipid-induced hepatic steatosis and glucose intolerance and these effects were not observed in Fgf21-null mice. Overall, these findings suggest that HRI is a potential target for regulating hepatic FGF21 levels.…”
Get full text
Get full text

Hypoxia-inducible factor-2 alpha up-regulates CD70 under hypoxia and enhances anchorage-independent growth and aggressiveness in cancer cells by Kitajima, Shojiro, Lee, Kian Leong, Fujioka, Masaki, Sun, Wendi, You, Jia, Chia, Grace Sushin, Wanibuchi, Hideki, Tomita, Shuhei, Araki, Marito, Kato, Hiroyuki, Poellinger, Lorenz

“…In addition, the expression of CD70 and colony forming efficiency in soft agar were decreased by knockdown of HIF-2α. These findings indicate that CD70 expression and an aggressive phenotype of cancer cells is driven under hypoxic conditions and mediated by HIF-2α functions and epigenetic modifications. …”
Get full text
Get full text