Ligand substitutions between ruthenium–cymene compounds can control protein versus DNA targeting and anticancer activity by Davey, Curt Alexander, Adhireksan, Zenita, Davey, Gabriela E., Campomanes, Pablo, Groessl, Michael, Clavel, Catherine M., Yu, Haojie, Nazarov, Alexey A., Yeo, Charmian Hui Fang, Ang, Wee Han, Dröge, Peter, Rothlisberger, Ursula, Dyson, Paul J.

“…Using a novel ‘atom-to-cell’ approach, we establish the basis for the surprisingly site-selective adduct formation behaviour and distinct cellular impact of these two chemically similar anticancer agents, which suggests that the cytotoxic effects arise largely from DNA lesions, whereas the protein adducts may be linked to the other therapeutic activities. Our study shows promise for developing new ruthenium drugs, via ligand-based modulation of DNA versus protein binding and thus cytotoxic potential, to target distinguishing epigenetic features of cancer cells.…”
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Loss of NnT increases expression of oxidative phosphorylation complexes in C57BL/6J hearts by Williams, Jack L., Hall, Charlotte L., Meimaridou, Eirini, Metherell, Louise A.

“…A number of studies have linked NNT dysfunction to cardiomyopathies and increased risk of atherosclerosis; however, biallelic mutations in humans commonly cause a phenotype of adrenal insufficiency, with rare occurrences of cardiac dysfunction and testicular tumours. …”
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A principles-led approach to information assurance and governance in local government by Brett, Mark

“…This practice-based paper explores a principles-led approach to cyber information governance for local authorities (LAs) in England and Wales, while linking it to a corporate information governance regime to support cyber security and resilience. …”

Distinct immune cell infiltration patterns in pancreatic ductal adenocarcinoma (PDAC) exhibit divergent immune cell selection and immunosuppressive mechanisms by Sivakumar, S, Jainarayanan, A, Arbe-Barnes, E, Sharma, PK, Leathlobhair, MN, Amin, S, Reiss, DJ, Heij, L, Hegde, S, Magen, A, Tucci, F, Sun, B, Wu, S, Anand, NM, Slawinski, H, Revale, S, Nassiri, I, Webber, J, Hoeltzel, GD, Frampton, AE, Wiltberger, G, Neumann, U, Charlton, P, Spiers, L, Elliott, T, Middleton, MR, Peppa, D, Fairfax, B, Dustin, ML, Abu-Shah, E, Bashford-Rogers, R

“…Adaptive immune cell-enriched is intrinsically linked with highly distinct B and T cell clonal selection, diversification, and differentiation. …”

Learning from the community: iterative co-production of a programme to support the development of attention, regulation and thinking skills in toddlers at elevated likelihood of au... by Hendry, A, Hulks, V, Murphy, S, Radford, H, Smith, S, Charman, T, Mathers, S, Rhodes, S, Scerif, G

“…The logic model for the resultant programme—Supporting Toddlers with a connection to autism or ADHD to develop strong Attention, Regulation and Thinking skills (START)—involves three mechanisms of change: The child has appropriate play-based opportunities to practise EF skills; Parenting behaviours linked to strong EFs are encouraged; Parents are empowered to improve environmental-fit for their child so that EF stressors are reduced.…”

‘Urge, urge, urge, dogs gnawing’: pain, play and the material text in Jonathan Swift's Journal to Stella by Williams, A

“…This chapter explores how Swift uses his text to record the physical ailments of the public figures who dominate his working life, linking these very public bodies to Swift’s own physical experiences. …”

The association between adverse childhood experiences and adult cardiac function in the UK Biobank by Quiroz, JC, Cooper, J, McCracken, C, Khanji, MY, Laranjo, L, Aung, N, Lee, AM, Simon, J, Murphy, T, Biasiolli, L, Piechnik, SK, Maurovich-Horvat, P, Petersen, SE, Raisi-Estabragh, Z

“…Numerous studies have shown the links between adverse experiences and trauma in childhood and physical and mental well-being in adulthood. …”

Wide-bandgap perovskite-inspired materials: defect-driven challenges for high-performance optoelectronics by Grandhi, GK, Hardy, D, Krishnaiah, M, Vargas, B, Al-Anesi, B, Suryawanshi, MP, Solis-Ibarra, D, Gao, F, Hoye, RH, Vivo, P

“…The remarkable success of lead halide perovskites (LHPs) in photovoltaics and other optoelectronics is significantly linked to their defect tolerance, although this correlation remains not fully clear. …”

Beyond symbolism: the roles of action planning and case-making in immigrant integration policymaking by Allen, WL, Broadhead, J

“…This serves as a micro-foundation for the action planning mechanism, which links symbolic statements about immigrant integration with substantive intended actions.…”

Exploring crystal methamphetamine use among school-going learners: a qualitative case study in South African schools by Singwane, Thembinkosi Peter, Ramoshaba, Dillo Justin

“…Persistent substance abuse among students is linked to various negative outcomes, including poor academic performance, strained relationships, physical injuries, violence, heightened sexual activity, and suicidal ideation. …”
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Overall quality of life perception among occupants of green and non-green office buildings in Malaysia by Laiche, Abdelfatah Bousbia, Dahlan, Nur Dalilah, Shari, Zalina, Zaky Jaafar, Mohamad Fakri

“…Several missing factors linked to the Green Building Index (GBI) criteria were significantly correlated with the QoL experience of occupants.…”
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Preserving Mojiang Hani hand weaving techniques: understanding complexity for culture and sustainable development by Mingquan, Liu, Yahaya, Siti Rohaya, Chunli, Guo, Yan, Huang

“…The findings illuminate that the gradual disappearance of these techniques is intricately linked to their inherent complexity, manifesting across five dimensions: classification, materials, process, patterns, and forms. …”
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Notes on Thermodynamics : Hot Oolong Cools / by Kang, Hway Chuan, author 655469, World Scientific (Online service) 655444

“…The book draws upon the idea of microstates where that clarifies the macroscopic ideas: entropy of mixing of gases is linked to Boltzmann and Gibbs' entropy formulations, thus motivating the formulation of the chemical potential of non-ideal systems in terms of their activities. …”
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How Stories Change Us : A Developmental Science of Stories from Fiction and Real Life / by Reese, Elaine, author 655966

“…Likewise, imagined stories and imagined friendships can promote learning, creativity, and well-being, but at the extremes, imaginative processes can be linked to psychopathology. The gender differences observed in women's and men's fiction reading may be due in part to individual differences in mental imagery from practices dating back to early childhood. …”
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The stalks of the motor A1A0 ATP synthase come into the focus : structural insight into subunits E, F and H by Gayen, Shovanlal

“…NMR analysis together with cross-linking and mutagenesis experiments has shown that subunit H is divided into a C-terminal coiled-coil domain and an N-terminal domain formed by adjacent helices. …”
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Extreme Water Uptake of Hygroscopic Hydrogels through Maximized Swelling‐Induced Salt Loading by Graeber, Gustav, Díaz‐Marín, Carlos D, Gaugler, Leon C, Zhong, Yang, El Fil, Bachir, Liu, Xinyue, Wang, Evelyn N

“…By tuning the salt concentration of the swelling solutions and the cross‐linking properties of the gels, hygroscopic hydrogels with extremely high salt loadings are synthesized, which enable unprecedented water uptakes of 1.79 and 3.86 gg<jats:sup>−1</jats:sup> at relative humidity (RH) of 30% and 70%, respectively. …”
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Modelling the rheology of living cell cytoplasm: poroviscoelasticity and fluid-to-solid transition by Thekkethil, Namshad, Köry, Jakub, Guo, Ming, Stewart, Peter S., Hill, Nicholas A., Luo, Xiaoyu

“…Experiments indicate that cell cytoplasm can exhibit both elastic and viscous characteristics in different regimes, while the transport of fluid (cytosol) through the cross-linked filamentous scaffold (cytoskeleton) is reminiscent of mass transfer by diffusion through a porous medium. …”
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On Power: How Colombia’s National Oil Company Can Support the Country’s Energy Transition by Beron, David

“…I show how the power supply crisis of 1992 revealed inseparable links between climate, energy, capital, and policy. …”
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Exploring the Internet Celebrity City: Social Media and Urban Space in China by Chen, Yufei

“…The term "Internet celebrity," or wanghong in Chinese, is utilized in modern Chinese media to refer to celebrities and the specific cultural and consumption trends linked to them. This concept has surfaced alongside the growth of e-commerce platforms, with the recognition that wanghong often engages in promoting products, services, or lifestyles to their followers. …”
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Controlling the thermally-driven crystallization of DNA-coated nanoparticles with formamide by Hueckel, Theodore, Woo, Seungyeon, Macfarlane, Robert J

“…While various design handles such as particle size, DNA design, and salt concentration influence the stability of the DNA duplexes linking PAEs in a lattice, their influence on the system's melting temperature (Tm) often follows complicated trends that make rational tuning of self-assembly challenging. …”
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