Transcriptomic changes in oligodendrocytes and precursor cells associate with clinical outcomes of Parkinson’s disease by Dehestani, Mohammad, Kozareva, Velina, Blauwendraat, Cornelis, Fraenkel, Ernest, Gasser, Thomas, Bansal, Vikas

“…We found a significant association of oligodendrocytes (ODCs) and oligodendrocyte precursor cells (OPCs) with PD-linked risk loci and report several dysregulated genes and pathways, including regulation of tau-protein kinase activity, regulation of inclusion body assembly and protein processing involved in protein targeting to mitochondria. …”
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Inter-laboratory comparison of eleven quantitative or digital PCR assays for detection of proviral bovine leukemia virus in blood samples by Pluta, Aneta, Jaworski, Juan P., Droscha, Casey, VanderWeele, Sophie, Taxis, Tasia M., Valas, Stephen, Brnić, Dragan, Jungić, Andreja, Ruano, María J., Sánchez, Azucena, Murakami, Kenji, Nakamura, Kurumi, Puentes, Rodrigo, De Brun, MLaureana

“…Agreement amongst different assays was linked to BLV copy numbers present in samples and the characteristics of each assay (i.e., BLV target sequence). …”
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ProtAgents: Protein discovery via large language model multi-agent collaborations combining physics and machine learning by Ghafarollahi, Alireza, Buehler, Markus J.

“…Current methodologies for protein design often rely on AI-based models, such as surrogate models that address end-to-end problems by linking protein structure to material properties or vice versa. …”
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Hidden Influence in Dynamic Networks by Erhardt, Keeley Donovan

“…These networks consist of nodes (entities) and edges (connections) that dynamically evolve, reflecting changes in relationships, the emergence of new entities, and the dissolution of old links. Unlike static networks, which offer a snapshot of connections at a specific time, dynamic networks allow for modeling processes and system-level changes over time. …”
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Skeletal myotubes expressing ALS mutant SOD1 induce pathogenic changes, impair mitochondrial axonal transport, and trigger motoneuron death by Martínez, Pablo, Silva, Mónica, Abarzúa, Sebastián, Tevy, María F., Jaimovich, Enrique, Constantine-Paton, Martha, Bustos, Fernando J., van Zundert, Brigitte

“…A large body of evidence shows that astrocytes expressing ALS-linked mutant proteins cause non-cell autonomous toxicity of MNs. …”
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Rectified and Salt Concentration Dependent Wetting of Hydrophobic Nanopores by Polster, Jake W, Aydin, Fikret, de Souza, J Pedro, Bazant, Martin Z, Pham, Tuan Anh, Siwy, Zuzanna S

“…Molecular dynamics simulations together with continuum models provided a multiscale explanation of the observed phenomena and linked the salt concentration dependence of wetting with an electrowetting model. …”
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Site-specific chemical and topological modifications to augment mRNA therapeutic potential by Aditham, Abhishek J.

“…We developed QRNAs, which are circRNAs that possess an unnaturally-linked inverted 7-methylguanosine (m7G) cap. QRNAs substantially outperform conventional circRNAs, given the low translation initiation efficiency of IRES compared to cap-dependent initiation. …”
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3D carbon/cobalt-nickel mixed-oxide hybrid nanostructured arrays for asymmetric supercapacitors by Zhu, Jianhui, Jiang, Jian, Sun, Zhipeng, Luo, Jingshan, Fan, Zhanxi, Huang, Xintang, Zhang, Hua, Yu, Ting

“…Two such supercapacitors linked in series can simultaneously power four distinct light-emitting diode indicators; they can also drive the motor of remote-controlled model planes. …”
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Simultaneous binding of hybrid molecules constructed with dual DNA-binding components to a G-quadruplex and its proximal duplex by Asamitsu, Sefan, Obata, Shunsuke, Phan, Anh Tuân, Hashiya, Kaori, Bando, Toshikazu, Sugiyama, Hiroshi

“…By means of circular dichroism (CD), fluorescence resonance energy transfer (FRET), surface plasmon resonance (SPR), and NMR techniques, we showed the dual and simultaneous recognition of the respective segment via hybrid molecules, and the synergistic and mutual effect of each binding component that was appropriately linked on higher binding affinity and modest sequence specificity. …”
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Ultracompact high-sensitivity biosensing based on regenerable laminated bio-conjugation in integrated photonic circuits by Li, Z. Y., Chen, Y. Y., Xiong, S., Truc, N. K., Xiong, Q. H., Liu, Ai Qun

“…LOD can be improved to 30 ng/mL after linking the detection antibody. After associating with the layer-by-layer structure composed by HRP and anti-HRP antibody on the sandwich assay, LOD can be improved to several pg/mL. …”
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Insight into the lateral ride discomfort thresholds of young-adult bus passengers at multiple postures : case of Singapore by Nguyen, Teron, NguyenDinh, Nen, Lechner, Bernhard, Wong, Yiik Diew

“…Lateral ride discomfort thresholds were thus established for bus negotiating roundabouts, intersections and along links. The three levels of ride discomfort are Uncomfortable, Very Uncomfortable and Extremely Uncomfortable with average lateral accelerations of ay = 1.5, 1.75 and 2.0 m/s2, respectively. …”
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NaTi₂(PO₄)₃ hollow nanoparticles encapsulated in carbon nanofibers as novel anodes for flexible aqueous rechargeable sodium-ion batteries by He, Bing, Yin, Kuibo, Gong, Wenbin, Xiong, Yuwei, Zhang, Qichong, Yang, Jiao, Wang, Zhixun, Wang, Zhe, Chen, Mengxiao, Man, Ping, Coquet, Philippe, Yao, Yagang, Sun, Litao, Wei, Lei

“…Herein, hollow-structure NTP evenly encapsulated in cross-linked porous N-doped carbon nanofiber (HNTP@PNC) is prepared through electrospinning technology and subsequent carbonization treatment, directly acting as binder-free anode for flexible ARSIBs. …”
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Identification of RNA-Tis11b complexes in activated B cells. by Tang, Ngang Heok.

“…Our data suggest that Tis11b may play a role during B cell activation processes and SB1/56.6 antibody could be used in cross-linking immunoprecipitation (CLIP) experiment to identify full spectrum of RNA targets of Tis11b. …”
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The relationship between self-perceived burden, depression, medication adherence, and health-related quality of life in coronary heart disease patients by Lim, Benjamin Chee Chong

“…Although self-perceived burden has been consistently linked to health-related quality of life (HRQOL), its underlying mechanisms remain unexplored, particularly in coronary heart disease (CHD) patients. …”
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Continuous treatment of the organic fraction of municipal solid waste in an anaerobic two-stage membrane process with liquid recycle by Trzcinski, A.P., Stuckey, David Campbell

“…The operation was not sustainable below this HRT due to a membrane flux limitation at 0.5–0.8 L/m2 h (LMH), which was linked to the increasing MLTSS. SCOD in the recycled permeate did not build up indicating a slow degradation of recalcitrants over time. …”
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MEG Insight into the Spectral Dynamics Underlying Steady Isometric Muscle Contraction by Bourguignon, Mathieu, Piitulainen, Harri, Smeds, Eero, Zhou, Guangyu, Jousmäki, Veikko, Hari, Riitta

“…Thus, ∼20 Hz coherence between cortex and periphery is tightly linked to the presence of ∼20 Hz bursts in SM1 and peripheral activity. …”
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Taste and see: real presence as revelation in Heideggerian perspective by Olson, JW

“…Heidegger’s notion of Being-in-the-world opens up a new definition of understanding, where what is primary is praxis in the form of worldly involvement, so that understanding in the form of habits, mood, and know-how becomes foundational for any knowledge of the beings with which we interact. Language is then linked up with this pre-reflective understanding, first as discourse and then later as poetry, both of which disclose a fundamental world-orientation to language.…”

Mapping the extent and exploring the drivers of cocoa agroforestry in Nigeria, insights into trends for climate change adaptation by Koralewicz, A, Vlcek, J, Oliveras-Menor, I, Hirons, M, Akinyugha, A, Sikiru Olowoyo, O, Oluyemi, M, Owen, O

“…In Nigeria, modernization efforts promoting full-sun cocoa have been linked to deforestation and biodiversity loss. The promotion of traditional cocoa agroforestry methods are regaining interest as an approach to climate adaptation and forest restoration. …”

An exploratory study on the development of a sensory wheel affiliated with the emotional lexicon for chrysanthemum infusion by Xia, Y, Hou, J, Chen, J, Spence, C, Qian, J, Zhao, F, Dong, G, Zhong, F

“…However, sensory attributes such as bitterness, astringency, and vegetal aroma were linked to negative emotions and were sometimes associated with feelings of activity. …”

Two for tau: automated model discovery reveals two-stage tau aggregation dynamics in Alzheimer’s disease by Stockman, CA, Goriely, A, Kuhl, E, Jerusalem, A, Alzheimer’s Disease Neuroimaging Initiative

“…Our method reveals previously overlooked two-stage aggregation dynamics by uncovering a twoterm ordinary differential equation that links the local accumulation rate to the tau concentration. …”