Organic donor-acceptor cocrystals for multiferroic applications by Wang, Zongrui, Zhang, Qichun

“…The cocrystallization strategy has provided an efficient route to fulfill room temperature magnetoelectricity in single phase owing to the long-range ordered π-π stacking (donor-acceptor assembled) network, long-lived excitons (with μs lifetime), spin orders (±1/2 s pin) and charge transfer (CT) dipoles in the assembled crystal lattice. …”
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The Portevin-Le Chatelier effect of Cu-2.0Be alloy during hot compression by Zhu, Daibo, Wu, Na, Liu, Yang, Liu, Xiaojin, Jiang, Chaohua, Jiang, Yanbin, Zhao, Hongyun, Cui, Shuhui, Xie, Guilan

“…As the strain rate increases, the dislocations outpace the diffusion speed of the solute atoms, limiting their ability to effectively pin the dislocations, resulting in lower dislocation density and serration amplitude. …”
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Compatability and equilibrium approach to slender concrete column design (dual project) by Toh, Yi Hui

“…This report evaluates and compares the proposed design method with the Australian code AS3600-2001 for slender concrete column. The failure loads of pin-end columns under short term loading and uniaxial bending are used as a pre-determined factor to analyse the data. …”
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Mendelian randomization identifies proteins involved in neurodegenerative diseases by Belbasis, L, Morris, S, Van Duijn, C, Bennett, D, Walters, R

“…The newly-associated proteins indicated the involvement of complement (C1S, C1R), microglia (SIRPA, SIGLEC9, PRSS8) and lysosomes (CLN5) in AD, interleukin-6 pathway (CTF1) in PD, lysosomes (TPP1), blood–brain barrier integrity (MFAP2) and astrocytes (TNFSF13) in ALS, and blood–brain barrier integrity (VEGFB), oligodendrocytes (PARP1), node of Ranvier and dorsal root ganglion (NCS1, FLRT3, CDH15), and innate immune system (CR1, AHSG, WARS) in MS. Our study demonstrates how harnessing large-scale genomic and proteomic data can yield novel insights into the role of plasma proteome in the pathogenesis of neurodegenerative diseases.…”

Evolutionary explanations and the debunking of moral beliefs by Cofnas, N

“…According to the debunkers, natural selection does not track mind-independent moral truth, so the discovery that our moral beliefs (realistically construed) were caused by natural selection renders them unjustified. I argue that our innate moral faculty is likely not the product of natural selection, but rather social selection. …”

Conformable ultrasound breast patch for deep tissue scanning and imaging by Du, Wenya, Zhang, Lin, Suh, Emma, Lin, Dabin, Marcus, Colin, Ozkan, Lara, Ahuja, Avani, Fernandez, Sara, Shuvo, Ikra Iftekhar, Sadat, David, Liu, Weiguo, Li, Fei, Chandrakasan, Anantha P., Ozmen, Tolga, Dagdeviren, Canan

“…The in vitro studies and clinical trials reveal that the array using a piezoelectric crystal [Yb/Bi-Pb(In <jats:sub>1</jats:sub> <jats:sub>/2</jats:sub> Nb <jats:sub>1/2</jats:sub> )O <jats:sub>3</jats:sub> -Pb(Mg <jats:sub>1/</jats:sub> <jats:sub>3</jats:sub> Nb <jats:sub>2/3</jats:sub> )O <jats:sub>3</jats:sub> -PbTiO <jats:sub>3</jats:sub> ] (Yb/Bi-PIN-PMN-PT) exhibits a sufficient contrast resolution (~3 dB) and axial/lateral resolutions of 0.25/1.0 mm at 30 mm depth, allowing the observation of small cysts (~0.3 cm) in the breast. …”
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Piezoelectric single crystal based one-dimensional phased array for breast tissue imaging by Du, Wenya

“…In this thesis, I propose a conformable ultrasound breast patch (cUSBr-Patch) consisting of a one-dimensional (1D) phased array and a nature-inspired patch design, which offers large-area, deep tissue scanning and multi-angle, repeatable breast imaging while avoiding the drawbacks of conventional ultrasound imaging technologies. I used a Yb/Bi-doped PIN-PMN-PT single crystal as the active element due to its superior piezoelectric properties (d33 = 2,800 pC/N, εr = 7,000, k33 = 0.93). …”
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Two-phase immersion cooling for power dense printed circuit board converters by Ristic-Smith, A

“…A theoretical model and numerical solution method for boiling on pin fins is developed and used to design heat spreaders to increase the power dissipation per unit semiconductor area with minimal penalty on the converter volume. …”

Metformin alters human host responses to Mycobacterium tuberculosis in healthy subjects by Lachmandas, Ekta, Eckold, Clare, Böhme, Julia, Koeken, Valerie A. C. M., Mardiana Marzuki, Blok, Bastiaan, Arts, Rob J. W., Chen, Jinmiao, Teng, Karen W. W., Ratter, Jacqueline, Smolders, Elise J., Van den Heuvel, Corina, Stienstra, Rinke, Dockrell, Hazel M., Newell, Evan, Netea, Mihai G., Singhal, Amit, Cliff, Jacqueline M., Van Crevel, Reinout

“…Conclusion: Metformin has a range of potentially beneficial effects on cellular metabolism, immune function, and gene transcription involved in innate host responses to M. tuberculosis.…”
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ZAP isoforms regulate unfolded protein response and epithelial- mesenchymal transition by Ly, Phuong Thao, Xu, Shaohai, Wirawan, Melissa, Luo, Dahai, Roca, Xavier

“…Transcriptomic analysis of ZAP-isoform-specific knockout cells revealed uncharacterized host mRNAs targeted by ZAPL/S with broad cellular functions such as unfolded protein response (UPR), epithelial-mesenchymal transition (EMT), and innate immunity. We established that endogenous ZAPL and ZAPS localize to membrane compartments and cytosol, respectively, and that the differential localization correlates with their target-RNA specificity. …”
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Viral proteases activate the CARD8 inflammasome in the human cardiovascular system by Nadkarni, Rhea, Chu, Wern Cui, Lee, Cheryl Q. E., Mohamud, Yasir, Yap, Lynn, Toh, Gee Ann, Beh, Sheryl, Lim, Radiance, Fan, Michelle Yiyun, Zhang, Lyanne Yizhuo, Robinson, Kim, Tryggvason, Karl, Luo, Honglin, Zhong, Franklin, Ho, Lena

“…Nucleotide-binding oligomerization domain (NBD), leucine-rich repeat (LRR) containing protein family (NLRs) are intracellular pattern recognition receptors that mediate innate immunity against infections. The endothelium is the first line of defense against blood-borne pathogens, but it is unclear which NLRs control endothelial cell (EC) intrinsic immunity. …”
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Induction of z-conformation in ribosomal RNA by Z-DNA binding domain Zα of the human double-stranded RNA deaminase I (ADAR1) by Zhao, Jing

“…The Z-DNA/Z-RNA binding domain Zα of the human RNA editing enzyme double-stranded RNA deaminase I (ADAR1) is found to influence various biological functions, such as the DNA-mediated innate immune response, and transcriptional modulation of gene expression. …”
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Distinctive antibody responses to Mycobacterium tuberculosis in pulmonary and brain infection by Spatola, M, Nziza, N, Irvine, EB, Cizmeci, D, Jung, W, Van, LH, Nhat, LTH, Ha, VTN, Phu, NH, Nghia, HDT, Thwaites, GE, Lauffenburger, DA, Fortune, S, Thuong, NTT, Alter, G

“…Antibody studies included analysis of immunoglobulin isotypes (IgG, IgM, IgA) and subclass levels (IgG1–4) and the capacity of <i>M. tuberculosis</i>-specific antibodies to bind to Fc receptors or C1q and to activate innate immune effector functions (complement and natural killer cell activation; monocyte or neutrophil phagocytosis). …”

Metagenetic analysis of gut microbial community of Malaysian mahseer Tor tambroides (Bleeker, 1854) (Cyprinidae) and its probiotics potential by Tan, Chun Keat

“…Bacillus sp. could enhance the innate immune system of fishes by increase lysozyme activity in blood serum. …”
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Effects of thrombin and its related peptide fragments on neutrophils by Lim, Chun Hwee

“…In addition, these peptides were shown to have immunomodulatory effects on monocytes, but whether they have any effects on the other major innate immune cells, neutrophils, was not known. Hence, we aimed to address the immunomodulatory potential of these C-terminal truncations on neutrophil functions. …”
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Local-flexural interactive buckling of S690 high strength steel slender welded I-section columns: testing, modelling and design by Sun, Yao, Liang, Yating, Su, Andi, Zhao, Ou

“…A testing programme, adopting two S690 high strength steel slender welded I-sections, was firstly conducted and included initial geometric imperfection measurements and ten pin-ended column tests. The testing programme was accompanied by a numerical modelling programme, where finite element models were developed and validated against the test results and then employed to perform parametric studies to generate further numerical data over a wide range of cross-section dimensions and member effective lengths. …”
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Changes in cerebrospinal fluid balance of TNF and TNF receptors in naïve multiple sclerosis patients : early involvement in compartmentalised intrathecal inflammation by Magliozzi, Roberta, Pezzini, Francesco, Pucci, Mairi, Rossi, Stefania, Facchiano, Francesco, Marastoni, Damiano, Montagnana, Martina, Lippi, Giuseppe, Reynolds, Richard, Calabrese, Massimiliano

“…Combined correlation and pathway analysis (ingenuity) of the CSF protein pattern associated with TNF expression (encompassing elevated levels of BAFF, IFN-γ, IL-1β, IL-10, IL-8, IL-16, CCL21, haptoglobin and fibrinogen) showed a particular relationship to the interaction between innate and adaptive immune response. The CSF sTNF-R1-associated pattern (encompassing high levels of CXCL13, TWEAK, LIGHT, IL-35, osteopontin, pentraxin-3, sCD163 and chitinase-3-L1) was mainly related to altered T cell and B cell signalling. …”
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Structural and biochemical mechanisms of NLRP1 inhibition by DPP9 by Huang, Menghang, Zhang, Xiaoxiao, Toh, Gee Ann, Gong, Qin, Wang, Jia, Han, Zhifu, Wu, Bin, Zhong, Franklin, Chai, Jijie

“…Nucleotide-binding domain, leucine-rich repeat receptors (NLRs) mediate innate immunity by forming inflammasomes. Activation of the NLR protein NLRP1 requires autocleavage within its function-to-find domain (FIIND)1-7. …”
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Experimental and numerical studies of S960 ultra-high strength steel welded I-section columns by Su, Andi, Liang, Yating, Zhao, Ou

“…A testing programme, including initial geometric imperfection measurements and ten pin-ended column tests, was conducted. The testing programme was accompanied by a numerical modelling programme, where finite element models were firstly developed and validated against the test results, and then employed to perform parametric studies to generate further numerical data. …”
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Structure-activity relationships of photo-activated soft tissue Adhesive by Wicaksono, Gautama

“…Soft tissue fixation relies on mechanical means such as sutures, pins, and screws, with potential complications such as concentrated tissue damage, perforation, and the need for secondary surgeries. …”
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