Multiplexed CRISPR/CAS9‐mediated engineering of pre‐clinical mouse models bearing native human B cell receptors by Wang, Xuesong, Ray, Rashmi, Kratochvil, Sven, Melzi, Eleonora, Lin, Ying‐Cing, Giguere, Sophie, Xu, Liling, Warner, John, Cheon, Diane, Liguori, Alessia, Groschel, Bettina, Phelps, Nicole

“…We validate this technology with the rapid generation of three BCR KI lines expressing native human precursors, instead of computationally inferred germline sequences, to HIV broadly neutralizing antibodies. …”
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Aneuploid senescent cells activate NF-κB to promote their immune clearance by NK cells by Wang, Ruoxi W., Viganò, Sonia, Ben-David, Uri, Amon, Angelika, Santaguida, Stefano

“…Inactivating NF‐κB abolishes NK cell‐mediated clearance of untransformed aneuploid cells. In cancer cell lines, NF‐κB upregulation also correlates with the degree of aneuploidy. …”
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How information about historic carbon emissions affects support for climate aid: evidence from a survey experiment by Charnysh, Volha, Kalow, Jared, Lieberman, Evan, Walk, Erin

“…However, in democratic countries such as the United States, it remains uncertain whether such messages can affect public opinion, especially across partisan lines. We conducted a pre-registered survey from a national online pool (N = 5,002) with a built-in experiment to evaluate the effectiveness of alternative communications strategies associated with historic carbon emissions in increasing support for climate aid. …”
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A novel low-crosstalk driveline based on spoof surface plasmon polaritons by Zhao, Shumin, Zhang, Hao Chi, Liu, Liangliang, Zhao, Jiahao, Yang, Cheng

“…By using traditional drivelines, for example, microstrip lines, the distance between adjacent drivelines should be large enough to reduce the multichannel coupling effects. …”
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Fullwave modeling of coplanar-waveguide discontinuities for applications in filter design and metamaterial characterization by Gao, Jing

“…Coplanar waveguide (CPW) has been finding wide applications in microwave integrated circuit (MIC) and monolithic microwave integrated circuit (MMIC) due to several advantages it offers over microstrip lines. Typical discontinuities characteristics are an integral part of practical circuit design. …”
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Microfluidic platform for negative enrichment of circulating tumor cells by Sajay, Bhuvanendran Nair Gourikutty, Chang, Chia-Pin, Ahmad, Hamizah, Khuntontong, Puttachat, Wong, Chee Chung, Wang, Zhiping, Puiu, Poenar Daniel, Soo, Ross, Rahman, Abdur Rub Abdur

“…Experiments of spiking two cell lines, MCF-7 and NCI-H1975, in the whole blood show an average of >90 % cell recovery over a range of spiked cell numbers. …”
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New techniques for automated architectural reconstruction from photographs by Werner, T, Zisserman, A

“…Second, we develop and refine a technique for piecewise planar model fitting involving sweeping polygonal primitives, and assess the performance of this technique. Third, lines at infinity are constructed from image correspondences and used to sweep planes in the principal directions. …”

Integrative taxonomy clarifies the evolution of a cryptic primate clade by van Elst, T, Sgarlata, GM, Schüßler, D, Tiley, GP, Poelstra, JW, Scheumann, M, Blanco, MB, Aleixo-Pais, IG, Rina Evasoa, M, Ganzhorn, JU, Goodman, SM, Hasiniaina, AF, Hending, D, Hohenlohe, PA, Ibouroi, MT, Iribar, A, Jan, F, Kappeler, PM, Le Pors, B, Manzi, S, Olivieri, G, Rakotonanahary, AN, Rakotondranary, SJ, Rakotondravony, R

“…Here we illustrate best practices for clarifying cryptic diversification processes by presenting an integrative framework that leverages multiple lines of evidence and taxon-informed cut-offs for species delimitation, while placing special emphasis on identifying patterns of isolation by distance. …”

Antitumor polycyclic acridines. 7. Synthesis and biological properties of DNA affinic tetra- and pentacyclic acridines by Stanslas, Johnson, Hagan, Damien J., Ellis, Michael J., Turner, Claire, Carmichael, James, Ward, Wynne, Hammonds, Timothy R., Stevens, Malcolm F. G.

“…The novel water-soluble agent dihydroindolizino[7,6,5-kl]acridinium chloride 14 has inhibitory activity in a panel of non-small-cell lung and breast tumor cell lines exceeding that of m-AMSA. The salt inhibited the release of minicircle products of kDNA confirming that disorganization of topoisomerase II partly underlies the activity of the compound. …”

Cellular reporter for inflammation. by Yuhanis Abdullah Sunny.

“…Currently, there are commercial green fluorescent protein (GFP) assays available for in vitro cell lines only. There are no in vivo systems that can report NF-B activation in hematopoietic stem cells. …”
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Home automation system using Raspberry Pi by Wang, Yangyang

“…Through out this project, student will gain knowledge in areas such as understand Raspberry Pi’s background; Raspberry Pi’s command lines; how to control GPIO pins; how to use PuTTY to remotely access the Raspberry Pi; understand web server Apache and PHP; understand WinSCP and how to transfer files with it; have the knowledge of web interface design, understand HTML5, CSS, PHP and JavaScript and be able to do electrical wiring and mechanical modification for the equipment required in the project.…”
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Laser surface treatment of 50CrMo4 steel by Chew, Han Xin

“…The speed of laser is significance in affecting the width and depth of the laser treated lines. When the speed is too high, the change is not visible, thus, the hardness test cannot be done on the cross section area.…”
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Database and Application Programming Interface Development for Rotational Spectroscopy by Cheung, Jasmine So Yee

“…A database of spectroscopic data serves as the foundation of the automation pipeline for assigning spectral lines to species. While there are existing databases available for use, we developed our custom database, named SAAGAdb, and an application programming interface (API) to access the database to fulfill the needs of SAAGA. …”
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Cytotoxic triosmium carbonyl clusters : a structure-activity relationship study by Top, Siden, Vessières, Anne, Leong, Weng Kee, Lee, Shirley Hui Zhi

“…In vitro evaluation of these new compounds showed that some are selectively active against estrogen receptor (ER)-independent MDA-MB-231 breast cancer cell lines relative to ER-dependent MCF-7 breast cancer cells, suggesting that the compounds have a different biological target specific to MDA-MB-231 cells. …”
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An iGlu receptor antagonist and its simultaneous use with an anticancer drug for cancer therapy by Luo, Zhong, Li, Peizhou, Tan, Si Yu, Ang, Chung Yen, Nguyen, Kim Truc, Zhao, Yanli

“…In vitro studies on B16F10 and NIH3T3 cell lines revealed that the iGlu receptor antagonist L1 exhibited therapeutic as well as targeting effects. …”
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Investigating the content and function of stress-induced extracellular vesicles in colorectal cancer by Mason, J

“…Therefore, my DPhil focussed on investigating the potential pro-tumorigenic properties of these “switched” EVs in CRC cell lines in vitro and also assessing the composition of EVs in CRC patient plasma.…”

Neuroprotective effect of tocotrienol-rich fraction and a-tocopherol of vitamin E against glutamate toxicity in neuronal cells and astrocytes by Selvaraju, Thilaga Rati

“…In this study, the effects of vitamin E when supplemented before (pre-treatment) and after (post-treatment) glutamate insult were elucidated in neuronal and astrocyte cell lines. The neuroprotective effect of TRF and α-TCP were investigated. …”
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Serial interconnections of 1-contracting and 2-contracting systems by Ofir, Ron, Margaliot, Michael, Levron, Yoash, Slotine, Jean-Jacques

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Assessing the financial performance of container shipping companies by Shen, Wanling.

“…Five companies were shortlisted from the top 30 container shipping lines, where trends and changes in five selected indicators were analyzed over a specified timeframe before and after integration. …”
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Targeted therapy to gastric cancer by Hou, Qian.

“…In this study, 17 gastric cancer cell lines were used to screen a library of 60 small molecule inhibitors and chemotherapy drugs for discovery of potential therapeutic agent by methyl thiazole tetrazolium (MTT) assays. 8 effective drugs which include Docetaxel, Paclitaxel, 17-DMAG, Bortezomib, Calyculin A, Okadaic acid, Staurosporine and Bafilomycin A1 were identified and subject to further characterization by IC50 calculation, cell migration assay, morphology study and cell cycle analysis by FACS. …”
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