Use of hormone replacement therapy and risk of breast cancer: nested case-control studies using the QResearch and CPRD databases by Vinogradova, Y, Coupland, C, Hippisley-Cox, J

“…Setting: UK general practices contributing to QResearch or Clinical Practice Research Datalink (CPRD), linked to hospital, mortality, social deprivation, and cancer registry (QResearch only) data. …”

Managing risks to the media from emerging networked technologies by Shere, ARK

“…The countermeasures are linked to phases of the overarching editorial workflow, to ensure that their implementation is feasible and that they are clearly useful by and for specific role categories within the media.…”

Management and outcomes of thoracic sarcomas - a collaboration between Orthopaedic Oncology and cardiothoracic surgery: seven-year clinical data from a tertiary referral centre by Shamsi, ZA, Paraoan, V, Kim, C, Saifuddin, SR, Cosker, TDA, Whitwell, D, Gibbons, CLMH, Stavroulias, D, DiChiara, F

“…Both surgical intervention (p < 0.0001) and clear margins (p = 0.0051) were significantly linked to improved survival. Local recurrence was noted in 28.6% of the 77 surgical cases, and predominantly in the high-grade sarcomas (81.8%). …”

In-silico trials with human modelling and simulation for guiding optimal stratification of atrial fibrillation patients to catheter ablation and pharmacological therapy by Dasí i Martinez, A

“…Different mechanisms of the arrhythmia (i.e., stable micro-re-entries, wavefront meandering, transient rotors and wave breakups) have been linked to specific ionic current dysregulations and their relationship with the structurally-remodelled substrate (i.e., presence of low voltage areas and atrial enlargement).…”

Experimental medicine study with stabilised native-like HIV-1 Env immunogens drives long-term antibody responses, but lacks neutralising breadth by Pollock, K, Cheeseman, H, McFarlane, L, Day, S, Tolazzi, M, Turner, H, Joypooranachandran, J, Shramko, K, Dispinseri, S, Mundsperger, P, Bontjer, I, Lemm, N-M, Coelho, S, Tanaka, M, Cole, T, Korber, B, Katinger, D, Ward, A, Scarlatti, G, Sanders, R, Sattentau, Q, Shattock, R

“…</p> <br> <p><strong>Methods:</strong> Healthy adult volunteers were enrolled into one of five groups (A to E) each receiving a different schedule of one of two consensus Env immunogens (ConM SOSIP, ConS UFO, either unmodified or stabilised by chemical cross-linking, followed by a boost with two mosaic Env immunogens (Mos3·1 and Mos3·2). …”

Multi-colony coral skeletal Ba/Ca from Singapore’s turbid urban reefs : relationship with contemporaneous in-situ seawater parameters by Tanzil, Jani Thuaibah Isa, Goodkin, Nathalie Fairbank, Sin, T. M., Chen, Mengli, Fabbro, Gareth Nicholas, Boyle, E. A., Lee, A. C., Toh, K. B.

“…There was also no clear relationship between Ba/Cacoral and skeletal luminescence G/B (a coral proxy strongly linked with salinity and river runoff). This implies that (1) the incorporation of terrestrially derived humic-like substances into the coral is independent of Ba, and (2) it is likely factors other than freshwater discharge/flood events are driving the poor reproducibility of Ba/Cacoral and disconnect with BaSW at our study sites. …”
Get full text

Formulating a Way Forward Strategy for Malaysia Cross Border Inland Port Using SWOT and TOWS Analysis by Lamsali, Hendrik, Mad Lazim, Halim, Osman, Wan Nadzri, Salleh, Mohamed Najib, Iteng, Rosman, Yiaw, Michael Tio Boon, Abdul Razak, Muhamad Badrul Shah, Ja’afar, Harlina Suzana

“…The development of adequate infrastructure, including well-connected road networks and direct rail links, should be a top priority for the government through NCIA. …”
Get full text

Single-molecule diagnostics to support curative interventions for tuberculosis and HIV by Dougan, Tyler J.

“…In this thesis, I describe the advancement of digital enzyme-linked immunosorbent assay (ELISA) protein detection methods in service of curing these two deadly infectious diseases. …”
Get full text
Get full text

Multilayered siRNA nanoparticles as a delivery system for extended gene silencing effect by Ng, Alice Jie Ying

“…For instance, an elevated expression of secreted protein acidic and rich in cysteine (SPARC) is linked with fibrosis and the inhibition of SPARC expression reduces fibrosis. …”
Get full text

Unveiling the facade of blog posts to reveal subjective well-being : an exploratory study. by Ou, Zhiqi., Tan, Justine Yi Ting., Tan, Jessie Zi Xi.

“…In this exploratory study to form a bridge between existing methods to gauge the well-being of people and the usage of social media as a data source, we find that there are substantial links between the subjective and objective well-being of people and the feelings expressed by people in blogs. …”
Get full text

Novel nitric oxide donors for the dispersal and control of Pseudomonas aeruginosa biofilms by Poh, Wee Han

“…In the second study, the application of cephalosporin-linked diazeniumdiolate NO donors, which are stable until activation by bacterial specific β-lactamases present within biofilms, were evaluated. …”
Get full text

Lipid-mediated resolution of inflammation and survival in amyotrophic lateral sclerosis by Yildiz, O, Hunt, GP, Schroth, J, Dhillon, G, Spargo, TP, Al-Chalabi, A, Koks, S, Turner, MR, Shaw, PJ, Henson, SM, Iacoangeli, A, Malaspina, A

“…Low levels of resolvins and downregulation of their membrane receptors in blood mononuclear cells are linked to a faster progression of ALS. Higher mononuclear cell expression of resolvin receptors is a predictor of longer survival. …”

Acquisition of musical skills and abilities in older adults—results of 12 months of music training by Losch, H, Altenmüller, E, Marie, D, Passarotto, E, Kretschmer, CR, Scholz, DS, Kliegel, M, Krüger, THC, Sinke, C, Jünemann, K, James, CE, Worschech, F

“…We did not identify any links between individual characteristics, like age, CogTel, CRIq, and musical sophistication, and improvement in musical aptitude tests. …”

Immune Checkpoint Blockade sensitivity and Progression-Free Survival associates with baseline CD8+ T cell clone size and cytotoxicity by Watson, R, Tong, O, Taylor, C, Kumar Sharma, P, Verge De Los Aires, A, Mahe, E, Ruffieux, H, Nassiri, I, Middleton, M, Fairfax, B

“…The cells contained within the expression matrices and Seurat objects have undergone full pre-processing and QC steps and are used for the analysis and figures in the linked manuscript. For raw data, please refer to the FASTQ files which have been deposited in the European Genome–phenome Archive, which is hosted by the European Bioinformatics Institute and the Centre for Genomic Regulation (accession no. …”

Histone lysine and DNA methylation: dynamic marks in the chromatin by Belle, R

“…A common post translational modification is Nε-lysine methylation which is linked to transcriptional silencing or activation depending on the location within the nucleosome. …”

Association between self-reported napping and risk of cardiovascular disease and all-cause mortality: a meta-analysis of cohort studies by Wang, Meng, Xiang, Xin, Zhao, Zhengyan, Liu, Yu, Cao, Yang, Guo, Weiwei, Hou, Linlin, Jiang, Qiuhuan

“…However, napping for 1 hour or more was linked to a 1.37-fold increased risk of CVD (HR: 1.37; 95% CI: 1.09–1.71; I2 = 68.3%; P = 0.007). …”
Get full text

Minimum Wage Policy Effects on Economic Efficiency and Poverty (S/O 12183) by Abd Karim, Mohd Zaini, Hassan, Sallahuddin, Gee, Chan Sok

“…However, there is no study linking minimum wage on efficiency. Hence, the objective of this study is to analyze the effect of minimum wage policy on a country's efficiency and also its effect on poverty. …”
Get full text

Fine-scale genetic structure and natural selection signatures of southwestern Hans inferred from patterns of genome-wide allele, haplotype, and haplogroup lineages by Wang, Mengge, Yuan, Didi, Zou, Xing, Wang, Zheng, Yeh, Hui-Yuan, Liu, Jing, Wei, Lan-Hai, Wang, Chuan-Chao, Zhu, Bofeng, Liu, Chao, He, Guanglin

“…Generally, we provided a case and ideal strategy to reconstruct the detailed demographic evolutionary history of Guizhou Hans, which provided new insights into the fine-scale genomic formation of one ethnolinguistically specific targeted population from the comprehensive perspectives of the shared unlinked alleles, linked haplotypes, and paternal and maternal lineages.…”
Get full text

Changes in cerebrospinal fluid balance of TNF and TNF receptors in naïve multiple sclerosis patients : early involvement in compartmentalised intrathecal inflammation by Magliozzi, Roberta, Pezzini, Francesco, Pucci, Mairi, Rossi, Stefania, Facchiano, Francesco, Marastoni, Damiano, Montagnana, Martina, Lippi, Giuseppe, Reynolds, Richard, Calabrese, Massimiliano

“…Finally, the CSF TNFR2-associated pattern (encompassing high CSF levels of IFN-β, IFN-λ2, sIL-6Rα) was linked to Th cell differentiation and regulatory cytokine signalling. …”
Get full text

Spatial, temporal, and demographic patterns in prevalence of smoking tobacco use and attributable disease burden in 204 countries and territories, 1990–2019: a systematic analysis... by Reitsma, M. B., Kendrick, P. J., Ababneh, E., Abbafati, C., Abbasi-Kangevari, M., Abdoli, A., Abedi, A., Abhilash, E. S., Abila, D. B., Aboyans, V., Abu-Rmeileh, N. M., Adebayo, O. M., Advani, S. M., Aghaali, M., Ahinkorah, B. O., Ahmad, S., Ahmadi, K., Ahmed, H., Aji, B., Akunna, C. J., Al-Aly, Z., Alanzi, T. M., Alhabib, K. F., Ali, L., Alif, S. M., Alipour, V., Aljunid, S. M., Alla, F., Allebeck, P., Alvis-Guzman, N., Amin T. T., Amini, S., Amu, H., Amul, G. G. H., Ancuceanu, R., Anderson, J. A., Ansari-Moghaddam, A., Antonio, C. A. T., Antony, B., Anvari, D., Arabloo, J., Arian, N. D., Arora, M., Asaad, M., Ausloos, M., Awan, A. T., Ayano, G., Aynalem, G. L., Azari, S., B, D.B., Badiye, A. D., Baig, A. A., Bakhshaei, M. H., Banach, M., Banik, P.C., Barker-Collo, S. L., Bärnighausen, T. W., Barqawi, H. J., Basu, S., Bayati, M., Bazargan-Hejazi, S., Behzadifar, M., Bekuma, T. T., Bennett, D. A., Bensenor, I. M., Berfield, K. S. S., Bhagavathula, A. S., Bhardwaj, N., Bhardwaj, P., Bhattacharyya, K., Bibi, S., Bijani, A., Bintoro, B. S., Biondi, A., Birara, S., Braithwaite, D., Brenner, H., Brunoni, A. R., Burkart, K., Butt, Z. A., Caetano dos Santos, F. L., Car, Josip, Cárdenas, R., Carreras, G., Carrero, J. J., Castaldelli-Maia, J. M., Cattaruzza, M. S. S., Chang, J. C., Chen, S., Chu, D. T., Chung, S. C., Cirillo, M., Costa, V. M., Couto, R. A. S., Dadras, O., Dai, X., Damasceno, A. A. M., Damiani, G., Dandona, L.

“…We completed systematic reviews and did Bayesian meta-regressions for 36 causally linked health outcomes to estimate non-linear dose-response risk curves for current and former smokers. …”
Get full text