Centrioles generate two scaffolds with distinct biophysical properties to build mitotic centrosomes by Wong, S-S, Monteiro, JM, Chang, C-C, Peng, M, Mohamad, N, Steinacker, TL, Xiao, B, Saurya, S, Wainman, A, Raff, JW

“…Here, we show that Drosophila Spd-2 (human CEP192) fluxes out from centrioles, recruiting Polo and Aurora A kinases to catalyze the assembly of two distinct mitotic-PCM scaffolds: a Polo-dependent Cnn scaffold, and an Aurora A–dependent TACC scaffold, which exhibit solid- and liquid-like behaviors, respectively. Both scaffolds can independently recruit PCM proteins, but both are required for proper centrosome assembly, with the Cnn scaffold providing mechanical strength, and the TACC scaffold concentrating centriole and centrosome proteins. …”

Universal in-context approximation by prompting fully recurrent models by Petrov, A, Lamb, TA, Paren, A, Torr, PHS, Bibi, A

“…Hence, these findings do not apply to fully recurrent architectures like RNNs, LSTMs, and the increasingly popular SSMs. …”

A regulatory SNP causes a human genetic disease by creating a new transcriptional promoter by De Gobbi, M, Viprakasit, V, Hughes, JR, Fisher, C, Buckle, V, Ayyub, H, Gibbons, RJ, Vernimmen, D, Yoshinaga, Y, de Jong, P, Cheng, J-F, Rubin, EM, Wood, Wg, Bowden, D, Higgs, DR

“…The rSNP creates a new promoterlike element that interferes with normal activation of all downstream α-like globin genes. Thus, our work illustrates a strategy for distinguishing between neutral and functionally important rSNPs, and it also identifies a pathogenetic mechanism that could potentially underlie other genetic diseases.…”

Specialized replication mechanisms maintain genome stability at human centromeres by Scelfo, A, Angrisani, A, Grillo, M, Barnes, BM, Muyas, F, Sauer, CM, Leung, CWB, Dumont, M, Grison, M, Mazaud, D, Garnier, M, Guintini, L, Nelson, L, Esashi, F, Cortés-Ciriano, I, Taylor, SS, Déjardin, J, Wilhelm, T, Fachinetti, D

“…Prolonged stress causes centromeric alterations like ruptures and translocations, as observed in ovarian cancer models experiencing replication stress. …”

Lost in quantization: improving particular object retrieval in large scale image databases by Philbin, J, Chum, O, Isard, M, Sivic, J, Zisserman, A

“…Our results exceed the current state of the art retrieval performance on these datasets, particularly on queries with poor initial recall where techniques like query expansion suffer. Overall we show that soft-assignment is always beneficial for retrieval with large vocabularies, at a cost of increased storage requirements for the index.…”

Ant, spider and DNA: letting mindless generative mechanisms speak by Bråten, E

“…ANT and SPIDER share a blindness with respect to invisible beings like itself, DNA argues. Their privileging of spatiotemporal immediacy entails a one-dimensional (flat) ontology that tends to push mindless generative mechanisms out of view. …”

Baturaja inscription: a threats to Miańga by Andhifani, Wahyu Rizky, Tedjowasono, Ninny Susanti

“…This inscription, if seen from its paleographic form, most likely originates from around the VII century, like the early inscriptions of the Sriwijaya Kingdom, namely: the Kedukan Bukit inscription, the Talang Tuwo inscription, the Telaga Batu inscription, the Kota Kapur inscription, the Karang Brahi inscription, the Palas Pasemah inscription, and some the short Siddhayatra inscription. …”
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Thismia perlisensis (Thismiaceae), a new red-annulus Thismia species from Peninsular Malaysia by Besi, Edward Entalai, Mad Jabar, Qistina Anis, Abd Rahman, Syamil, Saad, Mohd Zulkifly, Ag Ahmadni, Ag Shaffie, Go, Rusea

“…The new species is easily distinguished from the similar species, T. arachnites, T. javanica, T. tentaculata, and T. kenyirensis by the prominent reddish dome-shaped annulus instead of ring-like with rim, deeply trilobed stigma with bifid and subulate lobes, and claviform apices of the inner tepals.…”
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The Role of Institutional Trust and Political Accountability in Pakistan: An Empirical Study by Sadiq, Saiqa, Mohd. Zain, Zawiyah, Ajis, Mohd Na'eim

“…However, data is thematically analyzed, that is expedient technique for multiethnic country like Pakistan. Therefore, it is find out that weak political accountability and lower government performance have robust trust eroding effects in Pakistan.Thus the overall results are categorical about people lacking trust over political accountability institutions…”
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The Role of Social Media Towards Political Accountability in Pakistan: A Literature Review by Sadiq, Saiqa, Mohd. Zain, Zawiyah, Ajis, Mohd Na'eim

“…However, an emerging democracy like Pakistan, where social media trend is up surging and accountability condition is destitute. …”
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Developing Animation Projects that Foster Student's Creativity: An Application of Design Thinking Process (S/O 14722) by Mohd Suki, Norbayah, Mohd Suki, Norazah, Ahmad, Rosliza

“…Minimal research has been investigated on nurturing students' behavioural intention and actual usage of creative animation using design thinking as the digital social innovation agent to foster creativity at tertiary level within Malaysia context, particularly from the aspects like performance expectancy, effort expectancy, social influence, and facilitating conditions. …”
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An analysis of heavy silicone oil treatment for inferior proliferative vitreoretinopathy by Hammer, M, Ie, A, Eibenberger, K, Auffarth, GU, Xue, K

“…In 20% of cases, an increased medication was continued long-term after Densiron removal. Significant cataract progression occurred in all phakic patients. …”

Mobility and community at Mesolithic Lake Onega, Karelia, north-west Russia: insights from strontium isotope analysis by Eckelmann, R, Arppe, L, Tarasov, A, Pospieszny, Ł, Ackerman, L, Heyd, V, Gerasimov, D, Moiseyev, V, Fairbanks, V, Hyland, C, Mannermaa, K

“…Only two individuals had strontium values indicating time spent outside of Lake Onega’s northern shores, where the majority of the burial population is likely to have resided. These results suggest that the YOO cemetery predominantly served as a burial place for those with semi-permanent residence in this area, with no significant evidence for gender-based relocation patterns indicative of patri- or matrilocal residency. …”

Young adolescents’ experiences and views on eating and food by Gilmour, A, Gill, S, Loudon, G

“…<p><strong>Purpose: </strong>Poor eating habits established during adolescence are likely to lead to negative long-term health consequences. …”

Capitalizing on a crisis: a computational analysis of all five million British firms during the Covid-19 pandemic by Muggleton, N, Rahal, C, Reeves, A

“…In this respect, the pandemic will likely impact future wealth inequalities. Our work offers methodological guidance for future policymakers during economic crises and highlights the long-term consequences for capital and wealth inequality.…”

Swimming in Data by Douglass, Katherine, Lamb, Augustus, Lu, Jerry, Ono, Ken, Tenpas, William

“…Ladies and Gentlemen, this is the Olympic Final,” thunders from the loudspeakers, yet it is barely audible over the deafening roar of a crowd ten thousand strong. One long blast of the referee’s whistle summons eight of the world’s fastest swimmers to the starting blocks. …”
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Interpreting Photoactive Fluorescence Microscopy Measurements of Steady-State Actin Dynamics by Tardy, Y., McGrath, J.L., Hartwig, J.H., Dewey, C.F.

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Highly reliable carbon nanotube-based composite fibers cross-linked by a 3D polymer network by Sun, Gengzhi, Zheng, Lianxi, Zhan, Zhaoyao, Jiang, Chunbo, Hansen, Reinack V., Khor, Yengpeng, Pang, John Hock Lye

“…However, CNTs inside a CNT fiber slide considerably during static and cyclic tensile tests, which is unfavorable for long-term performances. In this study, a second phase has been introduced into CNT fiber in order to enhance its reliability.…”
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Foreign exchange prediction and trading using low-shot machine learning by Faris Ahmad Ishak

“…A comparison study has also been done using a built meta-learner Long Short Term Memory(LSTM) to forecast the same exchange rate. …”
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Suitability of TCLP for cement-based products by Shen, Aldwin Weishun.

“…This is particularly important for the assessment of the long term leaching characteristic after the ANC of the waste is exhausted. …”
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