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    Platform architecture for sustainable product family design by Tan, Melvin Joseph Hong Thye

    Published 2016
    “…Platform architectures require design factors and processes which contribute to the sustainability of the product family over an entire life cycle. Product life cycles are increasingly overlapping with one another as part commonality becomes a design objective for greater re use. …”
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    Final Year Project (FYP)
  10. 3190

    Culture of human pluripotent stem cells and neural networks in 3D using an optogenetic approach and a hydrogel model by Lee, S

    Published 2016
    “…Investigation of cell response reveals that a flow rate of 3 ml/min and an alginate concentration of 1.8% (w/v) are optimal and that stem cell survival is significantly improved through incorporation of RGD and ROCKi. …”
    Thesis
  11. 3191

    Burden of disease scenarios for 204 countries and territories, 2022-2050: a forecasting analysis for the Global Burden of Disease Study 2021 by Vollset, SE, Ababneh, HS, Abate, YH, Lacey, BWH, GBD 2021 Forecasting Collaborators

    Published 2024
    “…At the super-region level, forecasted healthy life expectancy patterns were similar to those of life expectancies. …”
    Journal article
  12. 3192

    Use of smartphones to detect diabetic retinopathy : scoping review and meta-analysis of diagnostic test accuracy studies by Tan, Choon Han, Kyaw, Bhone Myint, Smith, Helen, Tan, Colin Siang Hui, Car, Lorainne Tudor

    Published 2021
    “…This review is reported in line with the Preferred Reporting Items for a Systematic Review and Meta-analysis of Diagnostic Test Accuracy Studies guidelines. …”
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    Journal Article
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    Development of reconstructed intestinal micronucleus cytome (RICyt) assay in 3D human gut model for genotoxicity assessment of orally ingested substances by Lim, Hui Kheng, Hughes, Christopher Owen, Lim, Michelle Jing Sin, Li, Jia'En Jasmine, Rakshit, Moumita, Yeo, Calvin, Chng, Kern Rei, Li, Angela, Chan, Joanne Sheot Harn, Ng, Kee Woei, Leavesley, David Ian, Smith, Benjamin Paul Chapman

    Published 2022
    “…Micronucleus assays typically utilise homogenous in vitro cell lines which poorly recapitulate the physiology, biochemistry and genomic events in the gut, the site of first contact for ingested materials. …”
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    Journal Article
  16. 3196

    Signalling inhibition by ponatinib disrupts productive alternative lengthening of telomeres (ALT) by Kusuma, Frances Karla, Prabhu, Aishvaryaa, Tieo, Galen, Syed Moiz Ahmed, Dakle, Pushkar, Yong, Wai Khang, Pathak, Elina, Madan, Vikas, Jiang, Yan Yi, Tam, Wai Leong, Kappei, Dennis, Dröge, Peter, Koeffler, H. Phillip, Jeitany, Maya

    Published 2023
    “…By performing anti-cancer compound library screen on isogenic cell lines and using extrachromosomal telomeric C-circles, as a bona fide marker of ALT activity, we identify a receptor tyrosine kinase inhibitor ponatinib that deregulates ALT mechanisms, induces telomeric dysfunction, reduced ALT-associated telomere synthesis, and targets, in vivo, ALT-positive cells. …”
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    Journal Article
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