The α-globin super-enhancer acts in an orientation-dependent manner by Kassouf, MT, Francis, HS, Gosden, M, Suciu, MC, Downes, DJ, Harrold, C, Larke, M, Oudelaar, M, Cornell, L, Blayney, J, Telenius, J, Xella, B, Shen, Y, Sousos, N, Sharpe, JA, Sloane-Stanley, J, Smith, AJH, Babbs, C, Hughes, JR, Higgs, DR

“…Within mammalian genomes, enhancer-like elements may be found individually or within clusters referred to as locus control regions or super-enhancers (SEs). …”

Centrioles generate two scaffolds with distinct biophysical properties to build mitotic centrosomes by Wong, S-S, Monteiro, JM, Chang, C-C, Peng, M, Mohamad, N, Steinacker, TL, Xiao, B, Saurya, S, Wainman, A, Raff, JW

“…Here, we show that Drosophila Spd-2 (human CEP192) fluxes out from centrioles, recruiting Polo and Aurora A kinases to catalyze the assembly of two distinct mitotic-PCM scaffolds: a Polo-dependent Cnn scaffold, and an Aurora A–dependent TACC scaffold, which exhibit solid- and liquid-like behaviors, respectively. Both scaffolds can independently recruit PCM proteins, but both are required for proper centrosome assembly, with the Cnn scaffold providing mechanical strength, and the TACC scaffold concentrating centriole and centrosome proteins. …”

Universal in-context approximation by prompting fully recurrent models by Petrov, A, Lamb, TA, Paren, A, Torr, PHS, Bibi, A

“…Hence, these findings do not apply to fully recurrent architectures like RNNs, LSTMs, and the increasingly popular SSMs. …”

A regulatory SNP causes a human genetic disease by creating a new transcriptional promoter by De Gobbi, M, Viprakasit, V, Hughes, JR, Fisher, C, Buckle, V, Ayyub, H, Gibbons, RJ, Vernimmen, D, Yoshinaga, Y, de Jong, P, Cheng, J-F, Rubin, EM, Wood, Wg, Bowden, D, Higgs, DR

“…The rSNP creates a new promoterlike element that interferes with normal activation of all downstream α-like globin genes. Thus, our work illustrates a strategy for distinguishing between neutral and functionally important rSNPs, and it also identifies a pathogenetic mechanism that could potentially underlie other genetic diseases.…”

Specialized replication mechanisms maintain genome stability at human centromeres by Scelfo, A, Angrisani, A, Grillo, M, Barnes, BM, Muyas, F, Sauer, CM, Leung, CWB, Dumont, M, Grison, M, Mazaud, D, Garnier, M, Guintini, L, Nelson, L, Esashi, F, Cortés-Ciriano, I, Taylor, SS, Déjardin, J, Wilhelm, T, Fachinetti, D

“…Prolonged stress causes centromeric alterations like ruptures and translocations, as observed in ovarian cancer models experiencing replication stress. …”

A survey of few-shot learning for biomedical time series by Li, C, Denison, T, Zhu, T

“…An emerging approach to overcome the scarcity of labeled data is to augment AI methods with human-like capabilities to leverage past experiences to learn new tasks with limited examples, called few-shot learning. …”

Strike a pose: tracking people by finding stylized poses by Ramanan, D, Forsyth, DA, Zisserman, A

“…Our basic assumption is that people tend to take on certain canonical poses, even when performing unusual activities like throwing a baseball or figure skating. We build a person detector that quite accurately detects and localizes limbs of people in lateral walking poses. …”

Lost in quantization: improving particular object retrieval in large scale image databases by Philbin, J, Chum, O, Isard, M, Sivic, J, Zisserman, A

“…Our results exceed the current state of the art retrieval performance on these datasets, particularly on queries with poor initial recall where techniques like query expansion suffer. Overall we show that soft-assignment is always beneficial for retrieval with large vocabularies, at a cost of increased storage requirements for the index.…”

Ant, spider and DNA: letting mindless generative mechanisms speak by Bråten, E

“…ANT and SPIDER share a blindness with respect to invisible beings like itself, DNA argues. Their privileging of spatiotemporal immediacy entails a one-dimensional (flat) ontology that tends to push mindless generative mechanisms out of view. …”

Baturaja inscription: a threats to Miańga by Andhifani, Wahyu Rizky, Tedjowasono, Ninny Susanti

“…This inscription, if seen from its paleographic form, most likely originates from around the VII century, like the early inscriptions of the Sriwijaya Kingdom, namely: the Kedukan Bukit inscription, the Talang Tuwo inscription, the Telaga Batu inscription, the Kota Kapur inscription, the Karang Brahi inscription, the Palas Pasemah inscription, and some the short Siddhayatra inscription. …”
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Thismia perlisensis (Thismiaceae), a new red-annulus Thismia species from Peninsular Malaysia by Besi, Edward Entalai, Mad Jabar, Qistina Anis, Abd Rahman, Syamil, Saad, Mohd Zulkifly, Ag Ahmadni, Ag Shaffie, Go, Rusea

“…The new species is easily distinguished from the similar species, T. arachnites, T. javanica, T. tentaculata, and T. kenyirensis by the prominent reddish dome-shaped annulus instead of ring-like with rim, deeply trilobed stigma with bifid and subulate lobes, and claviform apices of the inner tepals.…”
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The Role of Institutional Trust and Political Accountability in Pakistan: An Empirical Study by Sadiq, Saiqa, Mohd. Zain, Zawiyah, Ajis, Mohd Na'eim

“…However, data is thematically analyzed, that is expedient technique for multiethnic country like Pakistan. Therefore, it is find out that weak political accountability and lower government performance have robust trust eroding effects in Pakistan.Thus the overall results are categorical about people lacking trust over political accountability institutions…”
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The Role of Social Media Towards Political Accountability in Pakistan: A Literature Review by Sadiq, Saiqa, Mohd. Zain, Zawiyah, Ajis, Mohd Na'eim

“…However, an emerging democracy like Pakistan, where social media trend is up surging and accountability condition is destitute. …”
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Developing Animation Projects that Foster Student's Creativity: An Application of Design Thinking Process (S/O 14722) by Mohd Suki, Norbayah, Mohd Suki, Norazah, Ahmad, Rosliza

“…Minimal research has been investigated on nurturing students' behavioural intention and actual usage of creative animation using design thinking as the digital social innovation agent to foster creativity at tertiary level within Malaysia context, particularly from the aspects like performance expectancy, effort expectancy, social influence, and facilitating conditions. …”
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Kesan persekitaran pekerjaan terhadap penglibatan wanita dalam STEM by Nurhamizah Rashid, Norain Mod Asri, Azrina Abdullah Al-Hadi, Norshamliza Chamhuri, Hazrul Izuan Shahiri

“…Objektif kajian ini adalah untuk mengenalpasti kesan persekitaran pekerjaan terhadap penglibatan wanita dalam bidang sains, teknologi, kejuruteraan dan matematik (STEM). …”
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Kesan keadaan tinggi karbon dioksida dan kandungan nutrien media terhadap pertumbuhan dan kandungan nutrien Wolffia arrhiza by Farhannah Azhar, Babul Airianah Othman, Mohamad Yusof Maskat

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A longitudinal qualitative study on lived experience of oral cancer patients during covid-19 pandemic in khyber pakhtunkhwa Pakistan by Khattak, Maria Ishaq

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Development, validation and the effects of culturally specific guided imagery and progressive muscle relaxation audio for patients with functional abdominal bloating by Shen, Vincent Tee Wei

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Effects of ifenprodil treatment on pain behaviour, inflammation, and nociceptive responses in the spinal cord of complete freund’s adjuvant-induced chronic polyarthritis rat by Noh, Ain’ Sabreena Mohd

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Studies on the physicochemical, biomechanical and biological properties of novel decellularized bovine scaffold for bone regeneration by Qabbani, Ali Abdul Qader Hameed Al

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