Scaffold-mediated sustained, non-viral delivery of miR-219/miR-338 promotes CNS remyelination by Milbreta, Ulla, Lin, Junquan, Pinese, Coline, Ong, William, Chin, Jiah Shin, Shirahama, Hitomi, Mi, Ruifa, Williams, Anna, Bechler, Marie E., Wang, Jun, ffrench-Constant, Charles, Hoke, Ahmet, Chew, Sing Yian

“…Using spinal cord injury as a proof-of-concept, we further demonstrate that miR-219/miR-338 could also be delivered non-virally in vivo using an aligned fiber-hydrogel scaffold to enhance remyelination after a hemi-incision injury at C5 level of Sprague-Dawley rats. Specifically, miR-219/miR-338 mimics were incorporated as complexes with the carrier, TransIT-TKO (TKO), together with neurotrophin-3 (NT-3) within hybrid scaffolds that comprised poly(caprolactone-co-ethyl ethylene phosphate) (PCLEEP)-aligned fibers and collagen hydrogel. …”
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Smart education : case study of smart pre-school by Koh, Kai Lun

“…After discussing the SMART Education framework in detail, a SMART Education System Architecture is proposed as a form of design to bring out the intended outcomes of the SMART Education framework. There are 5 key layers to the proposed architecture: Perception layer, Network layer, Edge layer, Cloud layer and Application layer. …”
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Nitrifying niche differentiation in biofilms from full-scale chloraminated drinking water distribution system by Cruz, Mercedes Cecilia, Woo, Yissue, Flemming, Hans-Curt, Wuertz, Stefan

“…Both clusters harbour microorganisms related to nitrification: i) Nitrosomonas (24.9-68.8%), an ammonia oxidising bacterium (AOB) that dominated Cluster LD, and ii) a co-aggregation of genus Nitrospira (9.8-32.5%), a nitrite oxidising bacterium (NOB), and Thaumarchaeota (1.4-10.9%), chemolithotrophic ammonia oxidising (AOA) archaea that were among the most abundant OTUs in Cluster HD. …”
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Whence came these plants most foul? Phylogenomics and biogeography of Lowiaceae (Zingiberales) by Niissalo, Matti A., Gardner, Elliot M., Khew, Gillian S., Šída, Otakar, Poulsen, Axel Dalberg, Leong-Škornicková, Jana

“…In particular, the relatively early isolation between Indochina and Borneo could be explained by the presence of a sea barrier that developed 10–15 MYA, and the continuous movement of plant species between Borneo and Peninsular Malaysia could be explained by a land bridge that existed until c. 5 MYA. The lack of an extensive land bridge with a suitable habitat may explain the absence of this genus from Sumatra and other Indonesian islands aside from Borneo. …”
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Hydrogen as marine fuel – feasibility, prospects, and challenges by Wong, Li Ming

“…The maritime industry currently accounts for at least 2.5% of the overall CO2 emissions. As the maritime industry strives to achieve decarbonisation to comply with IMO 2050, many alternative fuels are being researched and hydrogen is included. …”
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In situ synthesis of silver nanoparticles in poly(vinyl) alcohol layer coated thin film membrane for seawater desalination by Jayavardhana D/o Balaji

“…The best-performed PVA- coated membrane (MPVA1-0.2) was prepared using PVA with the lowest molecular weight of 13-23 kDa and at a concentration of 0.2 w/v%. The permeability of MPVA1-0.2 membrane reduced insignificantly by 8.4% compared to the control membrane without PVA coating layer, achieving PWP of 3.1 L/m2 .h.bar with excellent salt rejection of 99.28%. …”
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Theory-guided machine learning to predict configurational energies of high distortion alloy systems by Huang, Xufa

“…The pipeline is applied to the ten constituent binary alloys of HEA Mo-Nb-V-Ti-Zr, which is known to have large structural distortions, and we discovered that the prediction accuracy significantly improved by an average of 56%, consistent across all ten binary alloy systems. …”
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Characterization of mechanical properties of polyurea by You, Mei Yu

“…The polyureas were allowed to cure until different factors and conditions for up to 5 days. Quasi-static tensile test was conducted on the polyurea samples cut into ASTM-D638 standard. …”
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You must be myths-taken: examining belief in falsehoods during the COVID-19 health crisis by Lwin, May Oo, Sheldenkar, Anita, Tng, Pei Ling

“…Results showed that 12.7% to 57.5% of the population were unable to identify various myths, such as COVID-19 was manmade, and that three of these myths persisted significantly over time (increases ranging from 3.9% to 9.8%). …”
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Biomarkers and cognition study, Singapore (BIOCIS): protocol, study design, and preliminary findings by Leow, Yi Jin, Wang, J. D. J., Vipin, Ashwati, Sandhu, Gurveen Kaur, Soo, See Ann, Kumar, Dilip, Mohammed, Adnan Azam, Zailan, Fatin Zahra, Lee, Faith Phemie Hui En, Ghildiyal, Smriti, Liew, Shan Yao, Dang, Chao, Tanoto, Pricilia, Tan, Isabelle Yu Zhen, Chong, Wayne Freeman Weien, Kandiah, Nagaendran

“…Design, Setting, Participants: BIOCIS is a 5-year longitudinal study where participants are assessed annually. 2500 participants aged 30 to 95 will be recruited from the community in Singapore. …”
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Molecular interaction of tumor suppressor protein p53 and anti-apoptotic proteins Bcl-2 and Bcl-XL. by Yoon, Ho Sup.

“…Second, to define the binding interface of the molecular interaction, which is not previously characterized, we employed a NMR-based binding study, showing that the binding site on Bel-XL is located in the region including a4, the N- and C-termini of a3, the N-terminus of a5, and the central part of a2. To further probe this observation, we then performed fluorescence resonance energy transfer (FRET) assay in cells. …”
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Report for project A1017-101on hybrid solar PV thermal (PVT) system using a tracking solar trough I by Cheung, Wai Kin.

“…It is also witnessed that the temperature behind the cell with cooling at 0.448 l/min reached 63.7°C, while the water harnessed from the cooling system output reach 57.5°C which is comparable to water temperature in the hot spring. …”
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Three essays on gender wage differentials by Fang, Zheng

“…The objectives of the first chapter of the thesis are to expand the body of evidence, providing an international update from more than 50 countries in 5 continents and to suggest potential explanations to the stylized facts documented across countries. …”
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Cognitive information systems for context-aware decision support by Teng, Teck Hou

“…Our experimental results based on a 1-v-1 PE problem domain have reported improvement to the efficiency of RL using this approach.…”
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Realization of transistors using organic electronics by Ng, Vincent Yi Kai.

“…Using this developed printing method, the performance of the printed circuits is significantly improved – the mobility of the printed transistors (using TIPS-Pentacene as the p-type semiconductor) features a high mobility of ~1.5cm2/Vs, typically ~10x higher than reported additive printed devices of the same design. …”
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Microsoft kinect for early education by Tan, Haiwang.

“…The video can be found at http://www.youtube.com/watch?v=N_TcBL2XpaE This report focuses on the design and development of this interactive learning assistant suite. …”
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Efficient FPGA realization of inner-products of variable vectors by Yan, Yi

“…From the analytical results in this report, it is shown that proposed structures for input word-lengths L = 8 and L = 16, respectively are nearly 5.4% and 36% faster than the reference design (conventional multiplier-based implementation) in average for different inner-product length (N = 8, 16, 32 and 64). …”
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Effect of confining pressure on hysteresis of soil-water characteristic curves by Eng, Ngee Kiang

“…In this project, river sand specimens of different fine contents (5% and 30% fines) were subjected to multi-cycles of drying and wetting at non-zero net confining pressures using the SWCC Apparatus. …”
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Public confidence in the auditing profession by Loh, Mei San, Ng, Meow Ling, Tay, Janice Su-Ting

“…Respondents indicated a more than indifference confidence level of 3.67 (on a scale of 1 to 5) in the profession. Auditors' competence in understanding the clients' businesses received a low rating among all other factors and it is rather highly correlated to public confidence. …”
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Adsorption characteristics of doped MIL-101(Cr) and methane system by Nasirudin Muhammad Tariq

“…The US Department of Energy has set challenging gravimetric target for methane storage at 0.5 g/g under ambient conditions. Synthesising the right MOF is necessary to achieve the DOE target. …”
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