An epigenetic locus associated with loss of smell in COVID-19 by Aslan, Elif Sibel, White, Kenneth, Meral, Gulsen, Akcay, Zeyneb Nur, Altundag, Aytug, Gur, Savas, Dokur, Mehmet, Baktir, Mehmet Akif, Batur, Lutfiye Karcioglu

“…Previous studies, including genome-wide association studies (GWAS), have identified genetic variants near the UGT2A1 and UGT2A2 genes that are linked to anosmia in COVID-19 patients. However, the role of epigenetic changes in the development and persistence of smell loss has not been well explored. …”
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Cellular studies on the role of OGFOD1, a 2-oxoglutarate-dependent dioxygenase by Attwood, M

“…However, it was not known whether these functions are conserved in mammalian cells or if they are linked.</p> <p>To inform on OGFOD1-dependent cellular phenotypes, OGFOD1 defective cells were generated by genome editing using the CRISPR methodology. …”

Impact of co-morbid common mental disorder symptoms in people with epilepsy in Ethiopia on quality of life and functional disability: cohort study by Tsigebrhan, R, Medhin, G, Belina, M, Newton, C, Hanlon, C

“…Structural equation modelling (SEM) was employed to examine direct and indirect pathways linking co-morbid CMD symptoms with QoL or functional disability.…”

Joint modelling of longitudinal data: a scoping review of methodology and applications for non-time to event data by Ouko, RK, Mukaka, M, Ohuma, EO

“…The random effect was the most commonly applied association structure for linking two sub-models (63 studies; 85%). Estimation of model parameters was commonly done using Markov Chain Monte Carlo with Gibbs sampler algorithm (10 studies; 38%) for the Bayesian approach, whereas maximum likelihood was the most common (33 studies; 68.75%) for the frequentist approach. …”

Health economic aspects of childhood excess weight by Onyimadu, O

“…Additionally, electronic health records extracted from the Clinical Practice Research Datalink (CPRD), linked with Hospital Episode Statistics (HES), were analysed to estimate direct healthcare costs attributable to childhood excess weight.…”

Adverse events of common psychiatric medications: an umbrella review by Bartellas, K

“…Many medications were linked to adverse events through a weak or moderate strength of association and additional factors contributed to the variability in adverse outcome reporting aside from patient characteristics. …”

Human agency and instrumental rationality: applying human capital to gender inequalities and intergenerational stratification by Luo, H

“…</p></br> <p><strong>Contributions</strong></p> <p>Theoretically, this thesis contributes to linking human agency and instrumental rationality to the persistence and transformation of structural inequalities; it also sheds light on education’s potential and limitations as an equalizer. …”

Nutraceuticals silybin B, resveratrol, and epigallocatechin-3 gallate-bind to cardiac muscle troponin to restore the loss of lusitropy caused by cardiomyopathy mutations in vitro,... by Yang, Z, Sheehan, AM, Messer, AE, Tsui, S, Sparrow, A, Redwood, C, Kren, V, Gould, IR, Marston, SB

“…Phosphorylation causes a 2-3 fold decrease of affinity of cTn for Ca2+ associated with a higher rate of Ca2+ dissociation from cTnC leading to a faster relaxation rate of the cardiac muscle (lusitropy). Cardiomyopathy-linked mutations primarily affect Ca2+ regulation or the PKA-dependent modulatory system, such that Ca2+-sensitivity becomes independent of phosphorylation level (uncoupling) and this could be sufficient to induce cardiomyopathy. …”

Enhancement of lentiviral vector production through alteration of virus-cell interactions by Gelinas, J

“…To support this aim, viruses have been modified, with elements linked to viral pathogenicity removed from their genome and replaced by the genetic material to be delivered. …”

Use of hormone replacement therapy and risk of breast cancer: nested case-control studies using the QResearch and CPRD databases by Vinogradova, Y, Coupland, C, Hippisley-Cox, J

“…Setting: UK general practices contributing to QResearch or Clinical Practice Research Datalink (CPRD), linked to hospital, mortality, social deprivation, and cancer registry (QResearch only) data. …”

Managing risks to the media from emerging networked technologies by Shere, ARK

“…The countermeasures are linked to phases of the overarching editorial workflow, to ensure that their implementation is feasible and that they are clearly useful by and for specific role categories within the media.…”

Securing reform? Post-election power sharing and security sector reform in Zimbabwe, Kenya, and Togo, 2006-2013 by Noyes, A

“…While the power-sharing model continues to be used worldwide and security reform is widely identified by scholars and practitioners as critical to durable peace, the existing literature has generally ignored the potential link between the two.</p> <p>As such, this dissertation seeks to answer the following questions: Does post-election power sharing lead to security sector reform? …”

Magnetic dynamics in iron-based superconductors probed by neutron spectroscopy by Taylor, A

“…The experiments were primarily designed to investigate the link between magnetic dynamics and superconductivity. …”

Management and outcomes of thoracic sarcomas - a collaboration between Orthopaedic Oncology and cardiothoracic surgery: seven-year clinical data from a tertiary referral centre by Shamsi, ZA, Paraoan, V, Kim, C, Saifuddin, SR, Cosker, TDA, Whitwell, D, Gibbons, CLMH, Stavroulias, D, DiChiara, F

“…Both surgical intervention (p &lt; 0.0001) and clear margins (p = 0.0051) were significantly linked to improved survival. Local recurrence was noted in 28.6% of the 77 surgical cases, and predominantly in the high-grade sarcomas (81.8%). …”

In-silico trials with human modelling and simulation for guiding optimal stratification of atrial fibrillation patients to catheter ablation and pharmacological therapy by Dasí i Martinez, A

“…Different mechanisms of the arrhythmia (i.e., stable micro-re-entries, wavefront meandering, transient rotors and wave breakups) have been linked to specific ionic current dysregulations and their relationship with the structurally-remodelled substrate (i.e., presence of low voltage areas and atrial enlargement).…”

Experimental medicine study with stabilised native-like HIV-1 Env immunogens drives long-term antibody responses, but lacks neutralising breadth by Pollock, K, Cheeseman, H, McFarlane, L, Day, S, Tolazzi, M, Turner, H, Joypooranachandran, J, Shramko, K, Dispinseri, S, Mundsperger, P, Bontjer, I, Lemm, N-M, Coelho, S, Tanaka, M, Cole, T, Korber, B, Katinger, D, Ward, A, Scarlatti, G, Sanders, R, Sattentau, Q, Shattock, R

“…</p> <br> <p><strong>Methods:</strong> Healthy adult volunteers were enrolled into one of five groups (A to E) each receiving a different schedule of one of two consensus Env immunogens (ConM SOSIP, ConS UFO, either unmodified or stabilised by chemical cross-linking, followed by a boost with two mosaic Env immunogens (Mos3·1 and Mos3·2). …”

Waste palm leaves-based hydrochar support catalytic esterification of palm fatty acid distillate by Aliyu, Muhammad, Rashid, Umer, Wan Ab Karim Ghani, Wan Azlina, Mohd Salleh, Mohamad Amran, Hazmi, Balkis, Alharthi, Fahad A., Antunes, Elsa, Yu, Jianglong

Identifying erosion risk criteria for coastal city sustainability by using a Hyper-Delphi-hierarchy model: a case study of Kuala Terengganu, Malaysia by Bagheri, Milad, Ibrahim, Zelina Z., Manaf, Latifah Abd, Wolf, Isabelle D., Akhir, M.F., WIAW, Talaat

Dysfunctional cardiac energy transduction, mitochondrial oxidative stress, oncogenic and apoptotic signaling in DiNP-induced asthma in murine model by Kehinde, Samuel Abiodun, Olajide, Abosede Temitope, Fatokun, Tolulope Peter, Faroud, Dalia, Hadi, Najah R., Elgazzar, Ahmed M., James, Adewale Segun, Ashour, Mohamed H. Mazhar

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Model of motivational forces influencing academic achievement among secondary school students through the mediation of flow by Syed Mustafa, Sharifah Muzila

“…However, motivational force alone is not adequately strong to ensure students perform well in their academic tasks. There is a missing link between motivation and academic achievement which can be filled by flow, defined as an optimal state of engagement, concentration and enjoyment when doing a task. …”
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