The English National Lynch Syndrome transformation project: an NHS Genomic Medicine Service Alliance (GMSA) programme by Monahan, KJ, Ryan, N, Monje-Garcia, L, Armstrong, R, Church, DN, Cook, J, Elghobashy, A, Lalloo, F, Lane, S, McDermott, FD, Miles, T, Hardy, SA, Tyson, A, Wang, VYW, Kim, A, Gelinas, S, Faravelli, F, Elmslie, F, Shaw, AC

“…Results: Survey and baseline testing data illustrated variation, and a disparity between practice and perception, in levels of testing. The main reported barriers related to funding streams and systematic approaches. …”

A parametric version of the Hilbert Nullstellensatz by Ait El Manssour, R, Balaji, N, Nosan, K, Shirmohammadi, M, Worrell, J

“…</p> <p>We observe that Koiran’s proof that DIM lies in AM can be interpreted as a randomised polynomial-time reduction of DIM to HNP, followed by an argument that HNP lies in AM. Our main contribution is a self-contained proof that HNP lies in AM that follows the same basic idea as Koiran’s argument - namely random instantiation of the parameters - but whose justification is purely algebraic, relying on a parametric version of Hilbert’s Nullstellensatz, and avoiding recourse to semi-algebraic geometry.…”

Contagious McKean–Vlasov systems with resets: integrate-and-fire neuron models with common noise by Petronilia, AAFM

“…</p> <p>Our study progresses through three main stages. First, we examine the limiting behaviour of a simplified McKean--Vlasov system with a smoothed feedback mechanism as the smoothing becomes singular. …”

Statistical analysis plan for a cluster randomised controlled trial to compare screening, feedback and intervention for child anxiety problems to usual school practice: identifying... by Ball, S, Reardon, T, Creswell, C, Taylor, L, Brown, P, Ford, T, Gray, A, Hill, C, Jasper, B, Larkin, M, Macdonald, I, Morgan, F, Pollard, J, Sancho, M, Sniehotta, FF, Spence, SH, Stainer, J, Stallard, P, Violato, M, Ukoumunne, OC

“…This article describes the following: trial objectives and outcomes; statistical analysis principles, including detailed estimand information necessary for aligning trial objectives, conduct, analyses and interpretation when there are different analysis populations and outcome measures to be considered; and planned main analyses, sensitivity and additional analyses. …”

Multidecadal Morphodynamic evolution of shorelines and coral reefs along the Arabian Sea Coast of Oman: Bar Al Hikman Peninsula by Teillet, T, Bois, P, Homewood, P, Mettraux, M, Samimi-Namin, K, Vahrenkamp, V

“…The findings reveal a dramatic 60% reduction in the surface area of Bar Al Hikman’s main coral reefs. A significant consequence of this reef shrinkage is the rapid shoreline erosion on the leeward side of the disappearing reefs. …”

Understanding the role of transporters and ion channels in lysosomal homeostasis by Salphati, S

“…The lysosome is a key regulator of cellular activity as it acts as a signaling hub for metabolic regulation and is the main site of biomolecule degradation. Following the degradation of biomolecules, including proteins, glycans, nucleic acids and lipids, nutrients are exported out of the lysosome by efflux transporters, which provide nutrients for cellular anabolic activity. …”

A random-key genetic algorithm-based method for transportation network vulnerability envelope analysis under simultaneous multi-link disruptions by Gu, Y, Ryu, S, Xu, Y, Chen, A, Chan, H-Y, Xu, X

“…This study aims to develop an efficient method based on the random key genetic algorithm (RKGA) for determining the TNVE under simultaneous multi-link disruptions. The main features and benefits of the proposed method include: (a) it simultaneously solves the upper- and lower-bound problems at the same time while guaranteeing the feasibility of all solutions in the solution procedure; (b) it improves the computational efficiency to ensure the applicability to real transportation networks; and (c) it can provide a variety of alternative solutions in addition to the single optimal one, which facilitates the derivation of TNVE buffer and identification of sub-important links. …”

Impact of the COVID-19 pandemic and a supertyphoon: A quantitative study in Cebu, Philippines by Ylade, M, Adhikari, B, Crisostomo, MV, Daag, JV, Cuachin, AM, Lopez, MH, Macasero, A, Agrupis, KA, Deen, J

“…Pandemics and natural disasters are recognized to cause major disruptions. The main objective of this study was to explore the impacts of COVID-19 and supertyphoon Odette in Cebu, Philippines. …”

Iranian and Saudi mutual (mis)representations: a study of the relationship between discourses of othering, political confrontation and sectarian strife by Mohammad, T

“…Finally, by investigating three main Iranian and Saudi spheres/discourses, namely the political (speeches of the elite), religious (Friday prayer sermons) and media (newspaper editorials) discourses, this study will try to explain how <em>Othering</em> is understood and functions in the Iranian-Saudi discourse, its relationship to political rivalry and religious conflict and how they are understood as cases of political propaganda or religious polemics.…”

The amygdala and the pursuit of future rewards by Johnson, ST, Grabenhorst, F

“…Here we review evidence from single-neuron recordings and neuroimaging studies that implicate the amygdala—a brain structure long associated with cue-reactivity and emotion—in decision-making and the planned pursuit of future rewards (Grabenhorst et al., 2012, 2016, 2019, 2023; Hernadi et al., 2015; Zangemeister et al., 2016). The main findings are that, in behavioral tasks in which future rewards can be pursued through planning and stepwise decision-making, amygdala neurons prospectively encode the value of anticipated rewards and related behavioral plans. …”

Decision-making under flood predictions: a risk perception study of coastal real estate by Seenath, A, Mahadeo, SMR, Blackett, M

“…Here, we evaluate the influence of coastal flood predictions on real estate decision-making in the United Kingdom by adopting an interdisciplinary approach, involving flood modeling, novel experimental willingness-to-pay real estate surveys of UK residents in response to flood predictions, statistical modeling, and geospatial analysis. Our main findings show that access to multiple sources of flood predictions dominates real estate decisions relative to preferences for location aesthetics, reflecting a shift in demand toward risk averse locations. …”

The role of ADAM10 and mucin-like molecules in modulating cell-cell interactions by Drexhage, L

“…The mechanism underlying mucin regulation during efferocytic clearance and T cell activation remain unclear. The main theme of this study explores a novel efferocytic pathway centered around the cleavage of specific mucins on apoptotic T cells, which otherwise function as a don’t eat-me barrier for macrophages. …”

The role of SPRTN protease in colorectal cancer chemotherapy by Peron, C

“…To address SPRTN potential role in the repair of DPCs induced by irinotecan and oxaliplatin, two main approaches have been attempted in this thesis. …”

Feasibility of an undergraduate academic fellowship in global health system development by Pine, H, Mayoras, BR, Klapow, MC, Smith, NJ, Delaney, PG, Eisner, ZJ

“…The curriculum encompasses four main educational components: (1) professional development and networking, (2) global health education, (3) scientific research, and (4) internationally engaged collaboration. …”

Artifacts for "Synthesis of Code-Reuse Attacks from p-code Programs" by DenHoed, M, Melham, TF

“…<br> <br> Our artifacts are composed of four main folders: <br> <ul> <li>jingle: The implementation of our logical modeling of p-code. …”

A landscape of conflict? Rural fortifications in the Argolid (400 – 146 BC) by Blomley, AM

“…</p> <br> <p><strong>Chapter 8</strong> concludes the study with a summary of the main results, before discussing their significance for the wider field of research and exploring the future potential of GIS-based methods of data analysis in the Argolid and beyond.…”

Pharmaceutical applications of layered double hydroxides by Fisher, H

“…The <b>Appendices</b> contain supplementary characterisation and analytical data that are referred to in the main text.</p>…”

Modelling Malaysia air quality data using Bayesian Structural Time Series models by Aeshah Mohammed, Mohd Aftar Abu Bakar, Mahayaudin M. Mansor, Noratiqah Mohd Ariff

“…The BSTS model integrates three main techniques: The structural model, which employs the Kalman filter approach to model trend and seasonality components; spike and slab regression for variable selection; and Bayesian model averaging to estimate the best-performing prediction model while accounting for uncertainty. …”
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Disasterprep: gamified mobile edutainment for future disaster preparedness and resilience by Sakinah Ali Pitchay, Farida Ridzuan, Azni Haslizan Ab Halim, Najwa Hayaati Mohd Alwi

“…Users can explore four main menus—training, flood, earthquake, and disaster outbreak—offering realistic preparation, response, and recovery scenarios. …”
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Assessment of gut microbiome variations in the mother and twin infant of captive white-handed gibbons (Hylobates lar) reveals the presence of beneficial and nonpathogenic bacteria by Badrul Munir Md-Zain, Siti Hajar Azmi, Roberta Chaya Tawie Tingga, Millawati Gani, Mohamad Khairulmunir, Abd Rahman Mohd-Ridwan

“…Knowledge of the gut microbiota of endangered captive Malaysian Hylobatidae primates is important for health assessment and conservation management. Thus, the main objective of this study was to determine the gut microbiota profile of captive white-handed gibbons using the metabarcode 16S rRNA gene. …”
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