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    The novel quinoline derivative SKA-346 as a KCa3.1 channel selective activator by Wong, Brandon Han Siang, Shim, Heesung, Goay, Stephanie Shee Min, Ong, Seow Theng, Nur Ayuni Binte Muhammad Taib, Chai, Kelila Xin Ye, Lim, Kerry, Huang, Dachuan, Ong, Choon Kiat, Vaiyapuri, Thamil Selvan, Cheah, Yeong Cheng, Wang, Yulan, Wulff, Heike, Webster, Richard David, Shelat, Vishalkumar G., Verma, Navin Kumar

    Published 2025
    “…SKA-346 (30 mg kg-1), tolerated by mice after intra-peritoneal administration, exhibited a peak plasma concentration of 6.29 μg mL-1 (29.2 μM) at 15 min and a circulating half-life (t 1/2) of 2.8 h. …”
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    Journal Article