Current data science capacity building initiatives for health researchers in LMICs: global & regional efforts by Kiosia, A, Boylan, S, Retford, M, Marques, LP, Bueno, FTC, Kirima, C, Islam, MS, Naheed, A, Wozencraft, A

“…Articles were screened based on inclusion criteria. Findings: From 212 records, 85 met inclusion criteria, with 20 from PubMed and Scopus, and 65 from grey literature. …”

The SARS-CoV-2 nucleocapsid protein interferes with the full enzymatic activation of UPF1 and its interaction with UPF2 by Nuccetelli, V, Mghezzi-Habellah, M, Deymier, S, Roisin, A, Gérard-Baraggia, F, Rocchi, C, Coureux, P, Gouet, P, Cimarelli, A, Mocquet, V, Fiorini, F

“…Furthermore, we characterized how this interaction affects UPF1’s enzymatic function. Our findings demonstrate that Np inhibits the unwinding activity of UPF1 by physically obstructing its access to structured nucleic acid substrates. …”

Heightened interoception in adults with fibromyalgia by Todd, J, Plans, D, Lee, M, Bird, J, Morelli, D, Cunningham, A, ponzo, S, Murphy, J, Bird, G, Aspell, J

“…Some evidence suggests that people with fibromyalgia syndrome (FMS) – a condition characterised by chronic pain and fatigue – may have altered interoceptive processing. However, extant findings are inconclusive, and some tasks previously used to measure interoception are of questionable validity. …”

An exploratory study on the development of a sensory wheel affiliated with the emotional lexicon for chrysanthemum infusion by Xia, Y, Hou, J, Chen, J, Spence, C, Qian, J, Zhao, F, Dong, G, Zhong, F

“…For this analysis, the emotion lexicon from EsSense25 was clustered into six dimensions: pleasant, tame, warm, active, negative, and bored. Our findings indicate that attributes such as smoothness and chrysanthemum-cucumber flavour induce calm and reassuring emotions (e.g., secure, understanding, calm, and tame). …”

Epigenetic drug screening identifies enzyme inhibitors A-196 and TMP-269 as novel regulators of sprouting angiogenesis by Beter, M, Pulkkinen, HH, Örd, T, Sormunen, A, Kilpeläinen, L, Dunford, JE, Kaikkonen, MU, Aavik, E, Laham-Karam, N, Oppermann, U, Laakkonen, JP, Ylä-Herttuala, S

“…In contrast TMP-269, a selective class IIa HDAC inhibitor, exhibited anti-angiogenic effects by downregulating angiogenesis-related proteins and upregulating pro-inflammatory signaling. These findings highlight the suitability of the modified TeloHAEC fibrin bead assay for drug screening purposes and reveal both pro-angiogenic and anti-angiogenic drug candidates with therapeutic potential.…”

From demonetisation to Covid-19: Insights on the dynamics between informality and financial inclusion from the city of Kolkata, India by Ma, T

“…</p> <p>Empirical research finds that while Demonetisation and Covid-19 managed to reduce some forms of financial informality associated with the use of cash in saving, payment, and borrowing through their catalytic effects on digitalisation, other informal financial practices persisted or even increased, serving as substitutes for or supplements to insufficient and dysfunctional formal ones. …”

Maize monoculture supported pre-Columbian urbanism in southwestern Amazonia by Lombardo, U, Hilbert, L, Bentley, M, Bronk Ramsey, C, Dudgeon, Gaitan-Roca, A, Iriarte, J, Mejía Ramón, AG, Quezada, S, Raczka, M, Watling,JG, Neves, E, Mayle, F

“…Phytolith analyses of 178 samples from 18 soil profiles in drained fields, farm ponds and forested settings record the singular and ubiquitous presence of maize (Zea mays) in pre-Columbian fields and farm ponds, and an absence of evidence for agricultural practices in the forest. Collectively, our findings show how the Casarabe culture managed the savannah landscape for intensive year-round maize monoculture that probably sustained its relatively large population. …”

Ultrafast laser writing of liquid crystal waveguides by Chen, B, Xie, P, Zhao, Z, Salter, PS, Li, M, Xue, L, Qiu, X, Booth, MJ, Elston, SJ, Morris, SM

“…Characteristics of the waveguide are investigated for different fabrication conditions and geometrical configurations, including the dimensions of the waveguide and laser writing power. Our findings reveal that smaller waveguide geometries result in reduced intensity attenuation. …”

Development of HDX-MS methods to further investigate complex protein samples by Smith, L

“…The thesis also includes several case studies of protein complexes analysed using HDX-MS, which had not previously been investigated with this technique. These findings were corroborated with complementary methods and aligned with expectations based on prior research.…”

Words of liberty: the origins and evolution of constitutional ideas by Versteeg, M

“…</p> <p>This thesis's most important finding is that constitutions are inherently “transnational” documents. …”

Multiple independent genetic code reassignments of the UAG stop codon in phyllopharyngean ciliates by McGowan, J, Richards, TA, Hall, N, Swarbreck, D

“…Furthermore, we show that the function of UAA is firmly fixed as the preferred stop codon. These findings shed light on the evolvability of the genetic code in understudied microbial eukaryotes.…”

A multimodal neural signature of face processing in autism within the fusiform gyrus by Floris, DL, Llera, A, Zabihi, M, Moessnang, C, Jones, EJH, Mason, L, Haartsen, R, Holz, NE, Mei, T, Elleaume, C, Vieira, BH, Pretzsch, CM, Forde, NJ, Baumeister, S, Dell’Acqua, F, Durston, S, Banaschewski, T, Ecker, C, Holt, RJ, Baron-Cohen, S, Bourgeron, T, Charman, T, Loth, E, Murphy, DGM, Beckmann, CF

“…In autistic individuals, multimodal components were associated with cognitive and clinical features linked to social, but not nonsocial, functioning. These findings underscore the importance of elucidating multimodal neural associations of social functioning in autism, offering potential for the identification of mechanistic and prognostic biomarkers.…”

Friend request accepted: fundamental features of social environments determine social affiliation decisions by Garud, S

“…Taken together, these findings suggest that the human brain takes background statistics of an environment into account while making social decisions and that such decisions can be explained by personality or psychiatric factors.…”

Image segmentation with minimal human supervision by Shin, G

“…</p> <br> <p>In the first part, we demonstrate that considering a model's uncertainty in predictions can significantly reduce the number of annotations required to train a segmenter that performs nearly as well as a fully-supervised one. This finding underscores the critical role of pixels around semantic boundaries in helping the model to learn representations suitable for segmentation.…”

Implications of human-nature interactions for livelihoods and conservation in Kasungu, Malawi by Mandoloma, L, Clark, M, Hughes, K, Coad, L, Milner-Gulland, E

“…However, certain factors including proximity to the park, women, food insecurity, and crop and livestock loss were linked to negative attitudes. Our findings offer valuable insights for the design and implementation of conservation initiatives and policies, particularly in communities heavily dependent on natural resources for their livelihoods. …”

Clinical presentation and outcome of ribavirin treated RT-PCR confirmed Lassa fever patients in ISTH Irrua: a pilot study by Asogun, AD, Ochei, O, Moody, V, Abejegah, C, Okoh, E

“…</p> <p><b>Aim:</b> To review the clinical features, laboratory findings of Lassa fever and the outcome of confirmed cases treated with Ribavirin.…”

SARS-CoV-2 human challenge reveals biomarkers that discriminate early and late phases of respiratory viral infections by Rosenheim, J, Gupta, RK, Thakker, C, Mann, T, Bell, LCK, Broderick, CM, Madon, K, Papargyris, L, Dayananda, P, Kwok, AJ, Greenan-Barrett, J, Wagstaffe, HR, Conibear, E, Fenn, J, Hakki, S, Lindeboom, RGH, Dratva, LM, Lemetais, B, Weight, CM, Venturini, C, Kaforou, M, Levin, M, Kalinova, M, Mann, AJ, Knight, JC

“…Another ISG, IFI27, shows a delayed but sustained response restricted to myeloid cells, attributable to gene and cell-specific epigenetic regulation. These findings are reproducible in experimental and naturally acquired infections with influenza, respiratory syncytial virus and rhinovirus. …”

Screening for pathogenic neuronal autoantibodies in serum and CSF of patients with first-episode psychosis by Theorell, J, Ramberger, M, Harrison, R, Mgbachi, V, Jacobson, L, Waters, P, Erhardt, S, Sellgren, CM, Cervenka, S, Piehl, F, Irani, SR

“…In conclusion, formes frustes of autoimmune encephalitis are not prevalent among FEP patients admitted to psychiatric care. Our findings do not support screening for neuronal surface autoantibodies in unselected psychotic patients.…”

Rhetoric on trial: an aristotelian insight into Najib Razak’s corruption case by Syaza Fuhat, Juliana Abdul Wahab

“…Through a qualitative content analysis of 21 news broadcasts from ASTRO Awani, the study applies Aristotle’s triadic model of persuasion—ethos, pathos, and logos. The findings indicate that Najib predominantly relies on logos and pathos, strategically leveraging logical reasoning and emotional appeal while minimising the use of ethos¾ethical credibility. …”
Get full text

Communication in the workplace: request mitigations in Instant Messaging (IM) among native Malay speakers by Petani Mohd Noor, Marlyna Maros, Kesumawati Abu Bakar, Normalis Amzah

“…We analysed the data using strategy types of supportive moves by Fukushima (1996), supplemented with additional categories from Blum-Kulka and Olshtain (1984) and Konakahara (2011). Our findings revealed a preference for deferential supportive moves, with grounders being the most favoured type for mitigating requests. …”
Get full text