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2261
Tumor cell-intrinsic signals promoting tolerance and adaptation to oncogenic kinase inhibition
Published 2024“…The work described in both parts was aided by two MS software solutions I developed: one to automate the generation of targeted acquisition methods for protein phosphosites and pathways of interest, and the other to retain quantitative information from fragment ion spectra with missing values. Together, this thesis reports new connections between cell signaling and kinase inhibitor response, and offers the intriguing hypothesis that SFK signaling may be a conserved barrier for maximally effective targeted cancer therapy.…”
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Thesis -
2262
Neuronal control of cardiac excitability in pro-hypertensive states
Published 2016“…Restoring the cGMP cyclic nucleotide dysfunction seen in these cells, rescues the ion channel phenotype and bring the Ca<sup>2+</sup> down to levels seen in the normotensive WKY neuron. …”
Thesis -
2263
Mechanistic Studies of Interfacial Proton-Coupled Electron Transfer to Molecularly Defined Surface Sites
Published 2024“…With these observations we construct a mechanistic model in which I-PCET is not a single step, but a multi-step reaction sequence in which elementary I-PCET is gated by an ion exchange reaction between proton donor/acceptor species and proton-neutral supporting electrolyte at the electrode-electrolyte interface. …”
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Thesis -
2264
Cardiac-sympathetic dysfunction in hypertension
Published 2018“…The over-represented molecular function gene ontology families included ligand-gated ion channels and regulation of phosphodiesterase signalling. …”
Thesis -
2265
Purification of miraculin from miracle fruit [Synsepalum dulcifium (Schumach. & Thonn.) Daniell]
Published 2015“…However, optimization of efficient purification method of miraculin from miracle fruit has not been reported in the literature. Immobilized metal ion affinity chromatography (IMAC) with nickel-NTA was employed for miraculin purification from the extract of the pulp with optimization. …”
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Thesis -
2266
Development of novel electrospun nanofibrous scaffold with nanomaterials for target adsorption in different applications
Published 2023“…With the concerning rise in pollution of waters threatening the critical sources of clean water, tremendous amounts of efforts had been put into the research and development of water treatment technologies, inexhaustive of conventional municipal water treatment, to ion-exchange, electrolysis or biological treatment, membrane technology is one of the most energy efficient processes to remove targeted solutes from water. …”
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Thesis-Doctor of Philosophy -
2267
Developing metallic cathode for low-temperature solid oxide fuel cell applications
Published 2017“…This GDC capping layer could reduce the ohmic resistance due to the extra ion conduction pathways, while the polarization resistance increased since the GDC capping impeded oxygen surface exchange on Ag. …”
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Thesis -
2268
Establishment of optimise strategies in production of recombinant Hepatitis B surface antigen for chip-based antibody detection approach
Published 2015“…Following the release of HBsAg from cell disruption, univariate screening approaches on factors affecting the purification performance of HBsAg on ion exchange chromatography (IEC) and size exclusion chromatography (SEC) techniques and the establishment of a two-step purification strategy were performed. …”
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Thesis -
2269
Fabrication and characterization of Algan/Gan high electron mobility transistors on silicon
Published 2016“…In addition, the fabricated MISHEMTs exhibit excellent ION/IOFF ratio and good sub threshold swing characteristics, which reflects on the good quality of our gate stack approach. …”
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Thesis -
2270
抒情作家莫河的地方经验 : 故土、历史与文化的记忆 = Lyrical writer Mo He's local experiences : the memories of homeland, history and culture
Published 2021“…Mo He, a Singaporean Chinese author, had been publishing Chinese literary works for more than 50 years (1950s to 2010s). His long-spanning writing career was a result of his deep passion in the subject. …”
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Thesis-Master by Research -
2271
Scheduling and resource optimization in rail operations : models and algorithms
Published 2016“…Countries such as China and India have the railway network span over 120,000 and 64,000 track kilometres respectively, and are rapidly expanding their rail network. …”
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Thesis -
2272
Modulating electronic and geometric structure of transition metal compounds for efficient water splitting
Published 2020“…Subsequently, the CoMoO6 sample undergoes an ion exchange reaction in additional hydrothermal process to obtain CoMo2S4. …”
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Thesis-Doctor of Philosophy -
2273
Growth of vanadium oxides nanostructures by chemical vapour deposition
Published 2015“…However, the commercial application of V2O5 in energy storage devices is limited due to its poor cycling stability, Li ion diffusion and electric conductivity. Two-dimensional (2-D) nanostructures have demonstrated better stability, more active sites for lithium insertion/deinsertion than zero-dimensional and onedimensional (1-D) structure, making them attractive in energy storage devices. …”
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Thesis -
2274
Bis(imino)phenyl group 13 - 14 complexes
Published 2018“…However, the reaction of bis(imino)phenyl pincer ligand with tBu substituents and indium(I) bromide in toluene afforded a separated ion pair of bis(imino)phenylindium(III) bromide complex, [LtBu2In]Br (1.1, LtBu = C6H3-2,6-(HC=NtBu)2). …”
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Thesis -
2275
Ag3XO4 (X = P, As, V)电子结构及光催化性质的第一性原理计算 = First-principles study on the electronic and photocatalytic properties of Ag3XO4 (X = P, As, V)
Published 2018“…In comparison to Ag3PO4, Ag3VO4 shows better photocatalytic stability, mainly due to the enhanced Ag―O bonds and improved Ag ion stability, but poorer photocatalytic activity in the visible light region mainly due to the presence of d orbital character at the conduction band minimum (CBM) and lower valence band maximum (VBM) potentials (2.335 V, vs NHE). …”
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Journal Article -
2276
Evaluation of paper spray mass spectrometry for direct analysis of small molecule drugs and hemoglobin constant spring peptide markers
Published 2016“…Potential analytical liabilities, such as carryover and ion suppression were systematically evaluated using structurally diverse test compounds. …”
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Thesis -
2277
50 Years of quantum chromodynamics
Published 2024“…The calculated jet production rates (using perturbative QCD) are shown to agree precisely with data, for jet energies spanning more than five orders of magnitude. The production of jets recoiling against a vector boson, $$W^\pm $$ W ± or Z, is shown to be well understood. …”
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