Repeat expansion detection in neurodegenerative diseases with CRISPR/Cas9-targeted long read sequencing by Phua, Kimberly

“…I optimised a third-generation long read sequencing strategy by Oxford Nanopore Technologies for targeting the repeat expansion genes HTT, NOTCH2NLC, C9orf72 and RFC1 using CRISPR/Cas9 and applied this to eleven patient samples to determine repeat numbers across these genes. …”
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Spatial organization of long-term depression in mouse hippocampal schaffer collateral : CA1 synapses. by Chan, Jasmine Ee Teng.

“…Long-term depression (LTD) is a form of long-lasting synaptic plasticity that has been postulated to serve as a neural mechanism for memory and learning. …”
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Graph attention informer for long-term traffic flow prediction under the impact of sports events by Song, Yaofeng, Luo, Ruikang, Zhou, Tianchen, Zhou, Changgen, Su, Rong

“…However, due to the complexity of traffic maps and external factors, such as sports events, these models cannot perform well in long-term prediction. In order to enhance the accuracy and robustness of the model on long-term time series prediction, a Graph Attention Informer (GAT-Informer) structure is proposed by combining the graph attention layer and informer layer to capture the intrinsic features and external factors in spatial-temporal correlation. …”
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Centimeter-long and large-scale micropatterns of reduced graphene oxide films : fabrication and sensing applications by He, Qiyuan, Sudibya, Herry Gunadi, Yin, Zongyou, Wu, Shixin, Li, Hai, Boey, Freddy Yin Chiang, Huang, Wei, Chen, Peng, Zhang, Hua

“…In this contribution, we report the fabrication of centimeter-long, ultrathin (1−3 nm), and electrically continuous micropatterns of highly uniform parallel arrays of reduced graphene oxide (rGO) films on various substrates including the flexible polyethylene terephthalate (PET) films by using the micromolding in capillary method. …”
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Automatic and efficient long term arm and hand tracking for continuous sign language TV broadcasts by Pfister, T, Charles, J, Everingham, M, Zisserman, A

“…Our framework replicates the state-of-the-art long term tracker by Buehler et al. (IJCV 2011), but does not require the manual annotation and, after automatic initialisation, performs tracking in real-time. …”

Organizing long duration interdependence in Lloyd’s of London: persistence in a part-whole paradox of organizing by Kilminster, W, Jarzabkowski, P, Giudici, A

“…How interorganizational groups manage these ‘paradoxes of organizing’ to ensure long-term survival remains, however, unclear. We investigate this phenomenon through a historical case study of Lloyd’s of London, arguably the most prominent and long-standing interorganizational group in the global insurance industry. …”

Night flight facilitates late breeding catch-up in a long-distance migratory seabird by Siddiqi-Davies, K, Wynn, J, Padget, O, Bond, S, Danielsen, J, Fayet, AL, Fisher-Reeves, L, Freeman, R, Gillies, N, Kirk, H, Maurice, L, Morgan, G, Syposz, M, Shoji, A, Guilford, T

“…Long-distance migrants must optimise their timing of breeding to capitalise on resources at both breeding and over-wintering sites. …”

In vitro evaluation of oral contraceptives on long-tailed macaque (Macaca fascicularis) primary ovarian cells by Muhammed, Mikail, Tengku Azizan, Tengku Rinalfi Putra, Mohd Noor, Mohd Hezmee, Abu Hassim, Hasliza, Che'Amat, Azlan, Saleh, Annas Bin, Han, Mark Hiew Wen, Ab Latip, Mohd Qayyum

“…Risks of increased zoonosis and conflict are imminent if the population growth of long-tailed macaques is unchecked. However, there's a gap in the literature about the effect of hormonal contraceptives on long-tailed macaque reproductive tissues cell line. …”
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Persistent elevation of intrathecal pro-inflammatory cytokines leads to multiple sclerosis-like cortical demyelination and neurodegeneration by James, Rachel E., Schalks, Renee, Browne, Eleanor, Eleftheriadou, Ioanna, Munoz, Carmen Picon, Mazarakis, Nicholas D., Reynolds, Richard

“…Here we tested the hypothesis that persistent production of these cytokines in the meningeal compartment and diffusion into underlying GM can drive chronic MS-like GM pathology. Lentiviral transfer vectors were injected into the sagittal sulcus of DA rats to deliver continuous expression of TNF + IFNγ transgenes in the meninges and the resulting neuropathology analysed after 1 and 2 months. …”
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Local rainfall is more likely than distant thunderstorms to affect movement behaviour in Northern Kenyan elephants by Mulder, T, Mortimer, B, Ferwerda, J, Vollrath, F

“…We conclude that climate change makes a strong case for studying elephant behaviours in response to environmental cues during the day and night, especially in dry-land study sites like Northern Kenya.…”

Zeolitic imidazolate frameworks activate endosomal Toll-like receptors and potentiate immunogenicity of SARS-CoV-2 spike protein trimer by Alsaiari, Shahad K., Nadeef, Seba, Daristotle, John L., Rothwell, William, Du, Bujie, Garcia, Johnny, Zhang, Linzixuan, Sarmadi, Morteza, Forster, Timothy A., Menon, Nandita, Lin, Stacey Qiaohui, Tostanoski, Lisa H., Hachmann, Nicole, Wang, Erika Yan, Ventura, John D., Barouch, Dan H., Langer, Robert, Jaklenec, Ana

“…In this work, we report the Toll-like receptor agonist activity of a nanoscale adjuvant zeolitic imidazolate framework–8 (ZIF-8). …”
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Enriching the methanol generation via CO2 photoconversion over the cockscomb-like fibrous silica copper by Mahadi, Bahari, Che Rozid, Mamat, Aishah, Abdul Jalil, Shing, Lo Sook, Nurul Sahida, Hassan, F. F.A., Aziz, Alhassan, Mansur, Mohd Ghazali, Mohd Nawawi, Kamarizan, Kidam, Herma Dina, Setiabudi

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Toward a crystal-clear view of the viral RNA sensing and response by RIG-I-like receptors by Luo, Dahai

“…The RIG-I-like receptors (RLRs)—RIG-I, MDA5, and LGP2—detect intracellular pathogenic RNA and elicit an antiviral immune response during viral infection. …”
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Chrysanthemum-like Au@Polydopamine synthesized using one-pot method and its advantage in immunochromatographic assay by Zhang, Gang-gang, Lai, Xiao-cui, Ding, Neng-shui, Xiong, Qirong, Hou, Shuai, Duan, Hongwei, Lai, Wei-hua

“…Flower-like gold nanoparticle (AuNF) is widely used as a probe. …”
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Genes for carnivory : a comparative study on the local duplication of papain-like cysteine proteases in carnivorous plants by Tan, Qiao Wen

“…Thus, the presence of protein degrading enzymes such as papain-like cysteine proteases (PLCPs) in trap fluids is not surprising. …”
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Bio-inspired Flow Sensing and Prediction for Fish-like Undulating Locomotion: A CFD-aided Approach by Zhou, Han, Hu, Tianjiang, Low, Kin Huat, Shen, Lincheng, Ma, Zhaowei, Wang, Guangming, Xu, Haijun

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Functional comparison of human Adenomatous Polyposis Coli (APC) and APC-like in targeting beta-catenin for degradation by Schneikert, Jean, Chandra, Shree Harsha Vijaya, Ruppert, Jan Gustav, Ray, Suparna, Wenzel, Eva Maria, Behrens, Jürgen

“…Using RNA interference and domain swapping experiments, we show that APCL benefits from the 15R of truncated APC to target β-catenin for degradation, in a process likely involving heterodimerization of the two partners. …”
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GOLDEN2-like1 is sufficient but not necessary for chloroplast biogenesis in mesophyll cells of C4 grasses by Lambret-Frotte, J, Smith, G, Langdale, J

“…In land plants, chloroplast biogenesis is regulated by a family of transcription factors named GOLDEN2-like (GLK). In C4 grasses, it has been hypothesized that genome duplication events led to the sub-functionalization of GLK paralogs (GLK1 and GLK2) to control chloroplast biogenesis in two distinct cell types: mesophyll and bundle sheath cells. …”

Finding and performing an efficient rigging production workflow for 3D which can be transferred to different aspects apart from character rigging by Oen, Nicholas Weng Wah

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Re-thinking arts engagement in COVID-19: findings from a hybrid-delivered participatory arts intervention for Singapore's older adults by Yam, Jodie

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