Antigen presentation dynamics shape the antibody response to variants like SARS-CoV-2 Omicron after multiple vaccinations with the original strain by Yang, Leerang, Van Beek, Matthew, Wang, Zijun, Muecksch, Frauke, Canis, Marie, Hatziioannou, Theodora, Bieniasz, Paul D, Nussenzweig, Michel C, Chakraborty, Arup K

“…After the first dose, limited antigen availability in germinal centers (GCs) results in a response dominated by B cells that target immunodominant epitopes that are mutated in an Omicron-like variant. After the second dose, these memory cells expand and differentiate into plasma cells that secrete antibodies that are thus ineffective for such variants. …”
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Enriching the methanol generation via CO2 photoconversion over the cockscomb-like fibrous silica copper by Mahadi, Bahari, Che Rozid, Mamat, Aishah, Abdul Jalil, Shing, Lo Sook, Nurul Sahida, Hassan, F. F.A., Aziz, Alhassan, Mansur, Mohd Ghazali, Mohd Nawawi, Kamarizan, Kidam, Herma Dina, Setiabudi

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Toward a crystal-clear view of the viral RNA sensing and response by RIG-I-like receptors by Luo, Dahai

“…The RIG-I-like receptors (RLRs)—RIG-I, MDA5, and LGP2—detect intracellular pathogenic RNA and elicit an antiviral immune response during viral infection. …”
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Persistent elevation of intrathecal pro-inflammatory cytokines leads to multiple sclerosis-like cortical demyelination and neurodegeneration by James, Rachel E., Schalks, Renee, Browne, Eleanor, Eleftheriadou, Ioanna, Munoz, Carmen Picon, Mazarakis, Nicholas D., Reynolds, Richard

“…Here we tested the hypothesis that persistent production of these cytokines in the meningeal compartment and diffusion into underlying GM can drive chronic MS-like GM pathology. Lentiviral transfer vectors were injected into the sagittal sulcus of DA rats to deliver continuous expression of TNF + IFNγ transgenes in the meninges and the resulting neuropathology analysed after 1 and 2 months. …”
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Chrysanthemum-like Au@Polydopamine synthesized using one-pot method and its advantage in immunochromatographic assay by Zhang, Gang-gang, Lai, Xiao-cui, Ding, Neng-shui, Xiong, Qirong, Hou, Shuai, Duan, Hongwei, Lai, Wei-hua

“…Flower-like gold nanoparticle (AuNF) is widely used as a probe. …”
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Functional characterization of plasmodium falciparum reticulocyte binding like protein homologue 1 (PfRH1) by Yap, Sally Shu Lin

“…One of the protein families involved in invasion, reticulocyte binding like protein homologues (PfRHs) has been suggested to be involved in host cell selection. …”
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Genes for carnivory : a comparative study on the local duplication of papain-like cysteine proteases in carnivorous plants by Tan, Qiao Wen

“…Thus, the presence of protein degrading enzymes such as papain-like cysteine proteases (PLCPs) in trap fluids is not surprising. …”
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Functional comparison of human Adenomatous Polyposis Coli (APC) and APC-like in targeting beta-catenin for degradation by Schneikert, Jean, Chandra, Shree Harsha Vijaya, Ruppert, Jan Gustav, Ray, Suparna, Wenzel, Eva Maria, Behrens, Jürgen

“…Using RNA interference and domain swapping experiments, we show that APCL benefits from the 15R of truncated APC to target β-catenin for degradation, in a process likely involving heterodimerization of the two partners. …”
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Local rainfall is more likely than distant thunderstorms to affect movement behaviour in Northern Kenyan elephants by Mulder, T, Mortimer, B, Ferwerda, J, Vollrath, F

“…We conclude that climate change makes a strong case for studying elephant behaviours in response to environmental cues during the day and night, especially in dry-land study sites like Northern Kenya.…”

GOLDEN2-like1 is sufficient but not necessary for chloroplast biogenesis in mesophyll cells of C4 grasses by Lambret-Frotte, J, Smith, G, Langdale, J

“…In land plants, chloroplast biogenesis is regulated by a family of transcription factors named GOLDEN2-like (GLK). In C4 grasses, it has been hypothesized that genome duplication events led to the sub-functionalization of GLK paralogs (GLK1 and GLK2) to control chloroplast biogenesis in two distinct cell types: mesophyll and bundle sheath cells. …”

Dynamic liquid-liquid interface: applying a spinning interfacial microreactor to actively converge biphasic reactants for the enhanced interfacial reaction by Ng, Li Shiuan, Chong, Carice, Lok, Xin Yi, Pereira, Veronica, Ang, Zhi Zhong, Han, Xuemei, Li, Haitao, Lee, Hiang Kwee

“…Herein, we achieve an efficient interfacial reaction by creating a magnetic-responsive, microscale liquid-liquid interface and exploit its dynamic spinning motion to generate vortex-like hydrodynamic flows that rapidly converge biphasic reactants to the point-of-reaction. …”
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Characterization on three-dimensional trajectory of disk-like gold-nickel-platinum nanomotor using digital holographic imaging by Hu, Liangxing, Rehman, Shakil, Tao, Kai, Miao, Jianmin

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Ligand-specific factors influencing GLP-1 receptor post-endocytic trafficking and degradation in pancreatic beta cells by Fang, Zijian, Chen, Shiqian, Manchanda, Yusman, Bitsi, Stavroula, Pickford, Philip, David, Alessia, Shchepinova, Maria M., Corrêa, Ivan R., Jr., Hodson, David J., Broichhagen, Johannes, Tate, Edward W., Reimann, Frank, Salem, Victoria, Rutter, Guy A., Tan, Tricia, Bloom, Stephen R., Tomas, Alejandra, Jones, Ben

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Intensity of stress singularity for the circumferential V-shape corner front of a three-dimensional diamond-like defect by Ping, X. ., Zhang, Y. X., Guo, Y. B., Xiao, Z. M., Jalde, J., Chen, M. C.

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Effect of solvent state and isothermal conditions on gelation of methylcellulose hydrogels by Joshi, Sunil Chandrakant, Liang, C. M., Lam, Yee Cheong

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In situ Kerr and harmonic measurement in determining current-induced effective fields in MgO/CoFeB/Ta by Wong, Qi Ying, Gan, Weiliang, Luo, Fanglin, Lim, Gerard Joseph, Ang, Calvin Ching Ian, Tan, Funan, Law, Wai Cheung, Lew, Wen Siang

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Zeolitic imidazolate frameworks activate endosomal Toll-like receptors and potentiate immunogenicity of SARS-CoV-2 spike protein trimer by Alsaiari, Shahad K., Nadeef, Seba, Daristotle, John L., Rothwell, William, Du, Bujie, Garcia, Johnny, Zhang, Linzixuan, Sarmadi, Morteza, Forster, Timothy A., Menon, Nandita, Lin, Stacey Qiaohui, Tostanoski, Lisa H., Hachmann, Nicole, Wang, Erika Yan, Ventura, John D., Barouch, Dan H., Langer, Robert, Jaklenec, Ana

“…In this work, we report the Toll-like receptor agonist activity of a nanoscale adjuvant zeolitic imidazolate framework–8 (ZIF-8). …”
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Conditional knock out of N-WASP in keratinocytes causes skin barrier defects and atopic dermatitis-like inflammation by Kalailingam, Pazhanichamy, Tan, Hui Bing, Jain, Neeraj, Sng, Ming Keat, Chan, Jeremy Soon Kiat, Tan, Nguan Soon, Thanabalu, Thirumaran

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A wearable circulator‐like circularly polarised antenna for full‐duplex wireless body area network applications by Thakur, Ajeet, Sharma, Ashwani, Garcia Zuazola, Ignacio Julio

“…A circulator‐like high gain, unidirectional, dual circularly polarised (DCP) wearable antenna with a low specific absorption rate of 0.088 W/kg for 5.8 GHz industrial, scientific, and medical (ISM) band (5.725 − 5.875 GHz) full‐duplex wireless body area network (WBAN) applications is proposed. …”
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Experimental investigation on mode-I fracture properties of magnesium-based wood-like material using DIC technique by Li, C, Chen, H, Zhang, H, Marrow, TJ

“…To understand the fracture behaviors of a new environmentally friendly building material, namely magnesium-based wood-like material (MWM), three-point bending tests were carried out on single-edge notched beams to study its fracture properties. …”