Cell-derived nanovesicles from mesenchymal stem cells as extracellular vesicle-mimetics in wound healing by Neupane, Yub Raj, Handral, Harish K., Syed Abdullah Alkaff, Chng, Wei Heng, Venkatesan, Gopalakrishnan, Huang, Chenyuan, Lee, Choon Keong, Wang, Jiong-Wei, Sriram, Gopu, Dienzo, Rhonnie Austria, Lu, Wen Feng, Yusuf Ali, Czarny, Bertrand, Pastorin, Giorgia

“…Of note, MSC-CDNs enhanced angiogenesis in human dermal microvascular endothelial cells in a 3D PEG-fibrin scaffold and animal model, accelerating wound healing in vitro and in vivo. These findings suggest that MSC-CDNs could replace both whole cells and EVs in promoting wound healing and tissue regeneration.…”
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Living with fibrodysplasia ossificans progressiva: radiological images of a patient with extensive heterotopic ossification by Mohammed Mostafa Kotb, Omar, Usama Farghaly, Kaliya-Perumal, Arun-Kumar

“…Here, we present the radiological findings of an 18-year-old female diagnosed with FOP who had severe spinal and right-upper-limb abnormalities. …”
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Presence of IgG antibodies is not a reliable marker of Toxoplasma gondii infection in feral mice by Lignereux, Louis, Tong, Wen Han, Tan, Sijie, Vyas, Ajai, O'handley, Ryan

“…The question of the biological mechanisms allowing the chronic infection of wild mice in the absence of a measurable humoral immune response remains. Our findings indicate that serological studies should not be used to measure the level of exposure to T.gondii in feral house mice.…”
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Enhancing implant performance: 20% reduction in Pseudomonas aeruginosa bacterial initial formation with Cu₀.₇₅Ti₀.₂₅O₂ coating by Yadav, Abhishek, Pradhan, Soumen, Khokholva, M., El Khaloufi, Oualyd, Khong, Nicole Zi Jia, Lai, Soak-Kuan, Fouchet, Arnaud, David, Adrian, Lüders, Ulrike, Li, Hoi-Yeung, Rao, Mamidanna Sri Ramachandra, Prellier, Wilfrid

“…The results revealed a 20% reduction in bacterial growth on Cu0.75Ti0.25O2-coated samples, as determined by calculating the biomass of the biofilm. These findings were further discussed in relation to the copper content present on the surface of the coating. …”
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Judging a book by its cover: cultural differences in inference of the inner state based on the outward appearance by Ji, Li-Jun, Lee, Albert, Zhang, Zhiyong, Li, Ye, Wang, Xin-Qiang, Torok, Debra, Rosenbaum, Sam

“…By focusing on the assumed relationship between the outward appearance and inner state, these findings provide a unique angle for understanding cross-cultural phenomena and have practical implications in daily life.…”
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On the robustness of average losses for partial-label learning by Lv, Jiaqi, Liu, Biao, Feng, Lei, Xu, Ning, Xu, Miao, An, Bo, Niu, Gang, Geng, Xin, Sugiyama, Masashi

“…Experimentally, we have two promising findings: ABS using bounded losses can match/exceed state-of-the-art performance of IBS using unbounded losses; after using robust APLLs to warm start, IBS can further improve upon itself. …”
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Physics-informed neural network for fast prediction of temperature distributions in cancerous breasts as a potential efficient portable AI-based diagnostic tool by Mukhmetov, Olzhas, Zhao, Yong, Mashekova, Aigerim, Zarikas, Vasilios, Ng, Eddie Yin Kwee, Aidossov, Nurduman

“…The utilization of deep learning and physical principles in a diagnostic tool provides a non-invasive and safer alternative for breast self-examination compared to traditional methods such as mammography. These findings hold promise for the ongoing development of a new portable Artificial Intelligence (AI) tool for the early detection of breast cancer in breast self-examination as promoted by WHO, which is crucial for reducing mortality rates of breast cancer in the world.…”
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Suppressing condensation frosting using micropatterned ice walls by Zuo, Zichao, Zhao, Yugang, Li, Kang, Zhang, Hua, Yang, Chun

“…The proposed surface shows reasonable durability when exposed to varying substrate supercooling, and frost coverage may increase due to covering and fracturing of the out-of-plane growth of feather-like ice clusters at large substrate supercooling. Our findings provide an effective anti-frosting surface design that doesn't require any chemical or mechanical modifications on the targeted surfaces, showing great advantages compared to conventional icephobic surface designs.…”
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MTOR modulation induces selective perturbations in histone methylation which influence the anti-proliferative effects of mTOR inhibitors by Kim, HaEun, Lebeau, Benjamin, Papadopoli, David, Jovanovic, Predrag, Russo, Mariana, Avizonis, Daina, Morita, Masahiro, Afzali, Farzaneh, Ursini-Siegel, Josie, Postovit, Lynne-Marie, Witcher, Michael, Topisirovic, Ivan

“…Notably, the ability of mTOR inhibitors to induce H3K27me3 levels was positively correlated with their anti-proliferative effects. Collectively, our findings demonstrate that both activation and inhibition of mTOR selectively increase H3K27me3 by distinct mechanisms, whereby the induction of H3K27me3 may potentiate the anti-proliferative effects of mTOR inhibitors.…”
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Analysis and design recommendations for structures strengthened by prestressed bonded Fe-SMA by Li, Lingzhen, Wang, Sizhe, Chatzi, Eleni, Motavalli, Masoud, Ghafoori, Elyas

“…A parametric study and a sensitivity analysis are then conducted to assess the impact of the four influential features on the final prestress level, and their impact is ranked in the following order: recovery stress ≈ Fe-SMA width > activation length > bonded anchorage length. Based on these findings, a design strategy, in line with Eurocode 0, for the bonded/embedded Fe-SMA strengthening system is proposed. …”
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Does the peer review mode make a difference? An exploratory look at undergraduates' performances and preferences in a writing course by Hsieh, Yi-Chin, Leong, Alvin Ping, Lin, Yu-Ju, Aryadoust, Vahid

“…Focus group discussions (FGDs) were administered to investigate students’ perceptions of the peer review modes, including their perceived usefulness of the feedback and the review processes. The findings show that the students’ writing performances significantly improved after the peer review session in all three peer review modes, with the anonymous CMPR and the blended mode showing stronger effectiveness as compared to the F2F mode. …”
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Low-velocity impact response of sandwich structures with cores made from entangled metallic wire material - silicone rubber composites by Zheng, Xiaoyuan, Xiao, Zhongmin, Ren, Zhiying, Zi, Bao, Bai, Hongbai, Wu, Yiwan, Yao, Liming

“…Finally, the superiority of the EMWM-SRC sandwich structure in enhancing impact resistance was validated by comparing it with individual EMWM and SR sandwich structures. These findings of this work offer valuable guidance for designing novel sandwich structures with excellent impact resistance.…”
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Mass spectrometry imaging highlights dynamic patterns of lipid co-expression with Aβ plaques in mouse and human brains by Huang, Helen Xuexia, Inglese, Paolo, Tang, Jiabin, Yagoubi, Riad, Correia, Gonçalo D. S., Horneffer-van der Sluis, Verena M., Camuzeaux, Stephane, Wu, Vincen, Kopanitsa, Maksym V., Willumsen, Nanet, Jackson, Johanna S., Barron, Anna M., Saito, Takashi, Saido, Takaomi C., Gentlemen, Steve, Takats, Zoltan, Matthews, Paul M.

“…Likewise, in human donors with varying Braak stages, similar studies of cortical sections revealed co-expression of lysophospholipids and ceramides around Aβ plaques in AD (Braak stage V/VI) but not in earlier Braak stage controls. Our findings in mice provide evidence of temporally and spatially heterogeneous differences in lipid composition as local and global Aβ-related pathologies evolve. …”
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Empowering student self-regulated learning and science education through ChatGPT: a pioneering pilot study by Ng, Davy Tsz Kit, Tan, Chee Wei, Leung, Jac Ka Lok

“…SRLbot's adaptability and personalized approach distinguished it from rule-based chatbots. The findings offer valuable evidence for AI developers and educators to consider generative AI settings and chatbot design, facilitating greater success in online science learning.…”
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Selective photoelectrochemical oxidation of glycerol to glyceric acid on (002) facets exposed WO3 nanosheets by Xiao, Yonghao, Wang, Mengran, Liu, Dong, Gao, Jiajian, Ding, Jie, Wang, Huan, Yang, Hong Bin, Li, Fuhua, Chen, Mengxin, Xu, Yangsen, Xu, Danyun, Zhang, Yun-Xiao, Fang, Shaofan, Ao, Xin, Wang, Jingyu, Su, Chenliang, Liu, Bin

“…Compared to (200) facets exposed WO3 , a combination of experiments and theoretical calculations indicates that the superior performance of selective glycerol oxidation mainly originates from the better charge separation and prolonged carrier lifetime resulted from the plenty of surface trapping states, lower energy barrier of the glycerol-to-GLYA reaction pathway, more abundant active sites and stronger oxidative ability of photogenerated holes on the (002) facets exposed WO3 . Our findings show great potential to significantly contribute to the sustainable and environmentally friendly chemical processes via designing high performance photoelectrochemical cell via facet engineering for renewable feedstock transformation.…”
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Profiling pro-inflammatory proteases as biomolecular signature of material-induced subcutaneous host response in immuno-competent mice by Tran, Nam M. P., Truong, Anh T. H., Nguyen, Dang T., Dang, Tram Thuy

“…This study also demonstrates the predictive utility of protease activity as a non-invasive, pro-inflammatory parameter for evaluation of the anti-inflammatory effects of model bioactive compounds on material-induced host response. Overall, our findings provide new insights into protease presence in material-induced immune responses, facilitating future biomaterial assessment to evoke appropriate host responses for implant applications.…”
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Optical quantum sensing for agnostic environments via deep learning by Zhou, Zeqiao, Du, Yuxuan, Yin, Xu-Fei, Zhao, Shanshan, Tian, Xinmei, Tao, Dacheng

“…Extensive experiments are conducted to investigate the performance of DQS under different settings up to eight photons. Our findings not only offer a different lens through which to accelerate optical quantum sensing tasks but also catalyze future research integrating deep learning and quantum mechanics.…”
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Customer co-creation in B2C e-commerce: does it lead to better new products? by Pee, Loo Geok

“…This is also one of the earliest studies to report empirical evidence for the impact of customer co-creation in e-commerce. The findings offer specific insights into the co-creation tasks and NPD stages to open for customer co-creation in practice.…”
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p27 is regulated independently of Skp2 in the absence of Cdk2 by Kaldis, Philipp, Kotoshiba, Shuhei, Gopinathan, Lakshmi, Pfeiffenberger, Elisabeth, Rahim, Anisa, Vardy, Leah Karen Anne, Nakayama, Keiko, Nakayama, Keiichi I.

“…Ablation of other ubiquitin ligases for p27 such as KPC1, DDB1, and Pirh2 did not restore stability of p27 in Cdk2−/−Skp2−/− MEFs. Our findings point towards novel and alternate pathways for p27 regulation.…”
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Virus-specific T lymphocytes home to the skin during natural dengue infection by Rivino, Laura, Kumaran, Emmanuelle A., Thein, Tun-Linn, Too, Chien Tei, Gan, Victor Chih Hao, Hanson, Brendon J., Wilder-Smith, Annelies, Bertoletti, Antonio, Gascoigne, Nicholas R. J., Lye, David Chien, Leo, Yee Sin, Akbar, Arne N., Kemeny, David M., MacAry, Paul A.

“…The juxtaposition of dengue-specific T cells with virus-permissive cell types at sites of possible dengue exposure represents a previously uncharacterized form of immune surveillance for this virus. These findings suggest that vaccination strategies may need to induce dengue-specific T cells with similar homing properties to provide durable protection against dengue viruses.…”
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