Nanoparticle-induced chemoresistance: the emerging modulatory effects of engineered nanomaterials on human intestinal cancer cell redox metabolic adaptation by Wu, Zhuoran, Setyawati, Magdiel Inggrid, Lim, Hong Kit, Ng, Kee Woei, Tay, Chor Yong

“…Transcriptome profiling, bioinformatics analysis and siRNA gene knockdown experiments revealed the nuclear factor erythroid 2-related factor 2 (Nrf2) as the key modulator of the ZnO NP-induced drug resistance. Our findings suggest that a ROS-inducing ENM can emerge as a nano-stressor, capable of regulating the chemosensitivity of colon cancer cells.…”
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Super-resolution imaging of photogenerated charges on CdS/g-C₃N₄ heterojunctions and its correlation with photoactivity by Wu, Shuyang, Lee, Jinn-Kye, Lim, Pei Chong, Xu, Rong, Zhang, Zhengyang

“…The photoactive species (i.e., e- and h+) were found to be preferentially distributed at the two end segments of CdS nanorods and the edge boundaries of g-C3N4. Therefore, our findings shed more light on the charge distribution and photocatalytic heterogeneity of composite materials at the nanoscale. …”
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Time-restricted feeding modulates the DNA methylation landscape, attenuates hallmark neuropathology and cognitive impairment in a mouse model of vascular dementia by Selvaraji, Sharmelee, Efthymios, Motakis, Foo, Roger Sik Yin, Fann, David Y., Lai, Mitchell Kim Peng, Chen, Christopher Li Hsian, Lim, Kah-Leong, Arumugam, Thiruma V.

“…Modulation of DNA methylation patterns in the cortex of AL CCH mice was re-modelled and signs of reversal was observed in IF CCH mice across all three timepoints. Conclusions: These findings provide an understanding of how IF may protect the brain against damage caused by CCH and show promise in offering potential beneficial effects in mitigating the neuropathology and cognitive deficits in VaD.…”
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LKAW: a robust watermarking method based on large kernel convolution and adaptive weight assignment by Zhang, Xiaorui, Jiang, Rui, Sun, Wei, Song, Aiguo, Wei, Xindong, Meng, Ruohan

“…Robust watermarking requires finding invariant features under multiple attacks to ensure correct extraction. …”
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Waste to wealth: near-infrared/pH dual-responsive copper-humic acid hydrogel films for bacteria-infected cutaneous wound healing by Zha, Kangkang, Xiong, Yuan, Zhang, Wenqian, Tan, Meijun, Hu, Weixian, Lin, Ze, Cheng, Peng, Lu, Li, Cai, Kaiyong, Mi, Bobin, Feng, Qian, Zhao, Yanli, Liu, Guohui

“…This PVA@Cu-HAs NPs@SEW hydrogel film improves tissue regeneration by promoting M2 macrophage polarization, alleviating oxidative stress, enhancing angiogenesis, and facilitating collagen deposition. These findings highlight the therapeutic potential of PVA@Cu-HAs NPs@SEW hydrogel film for the treatment of bacterially infected cutaneous wound healing.…”
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Topography-incorporated adjoint-state surface wave Traveltime tomography: method and a case study in Hawaii by Hao, Shijie, Chen, Jing, Xu, Mijian, Tong, Ping

“…Additionally, our model reveals a high-velocity anomaly to the South of Hualalai's summit, which may be related to a buried rift zone. Our findings further demonstrate that including topography can lead to a correction of up to 0.8% in the shear wave velocity model of Hawaii, an island spanning approximately 100 km with volcanoes reaching elevations exceeding 4 km.…”
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Electrocatalytic reduction of simulated industrial CO2 and CO mixtures: revising chronoamperometry to enable selective gas mixture reduction via cyclic voltammetry by Chen, Wen Qian, Foo, Cyrus Jit Loong, Ge, Liya, Veksha, Andrei, Chan, Wei Ping, Shen, Yafei, Lisak, Grzegorz

“…Meanwhile, the results underscored the dependency of performance enhancement on the scan rate of cycling, revealing plausible correlations with mass transfer and electrode surface dynamics. Furthermore, the findings indicated that the selectivity towards HCOOH and C2H4 is closely related to the CO2/CO ratios of gas sources. …”
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Early Prediction of Skin Viability Using Visible Diffuse Reflectance Spectroscopy and Autofluorescence Spectroscopy by Zhu, Caigang, Chen, Shuo, Chui, Christopher Hoe-Kong, Tan, Bien-Keem, Liu, Quan

“…Meanwhile, several physiologically relevant parameters including hemoglobin oxygenation, total hemoglobin concentration, and redox ratio indicators estimated from diffuse reflectance and autofluorescence spectra show distinctively different trends over time for nonviable and viable skin. Conclusions: These findings will be helpful to clinicians for making a precise judgment on flap viability. …”
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Heme-Regulated eIF2α Kinase Modulates Hepatic FGF21 and is Activated by PPARβ/δ Deficiency by Zarei, Mohammad, Barroso, Emma, Leiva, Rosana, Barniol-Xicota, Marta, Pujol, Eugènia, Escolano, Carmen, Vázquez, Santiago, Palomer, Xavier, Pardo, Virginia, González-Rodríguez, Águeda, Valverde, Ángela M., Quesada-López, Tania, Villarroya, Francesc, Wahli, Walter, Vázquez-Carrera, Manuel

“…Moreover, pharmacological activation of HRI increased Fgf21 expression and reduced lipid-induced hepatic steatosis and glucose intolerance and these effects were not observed in Fgf21-null mice. Overall, these findings suggest that HRI is a potential target for regulating hepatic FGF21 levels.…”
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Hypoxia-inducible factor-2 alpha up-regulates CD70 under hypoxia and enhances anchorage-independent growth and aggressiveness in cancer cells by Kitajima, Shojiro, Lee, Kian Leong, Fujioka, Masaki, Sun, Wendi, You, Jia, Chia, Grace Sushin, Wanibuchi, Hideki, Tomita, Shuhei, Araki, Marito, Kato, Hiroyuki, Poellinger, Lorenz

“…In addition, the expression of CD70 and colony forming efficiency in soft agar were decreased by knockdown of HIF-2α. These findings indicate that CD70 expression and an aggressive phenotype of cancer cells is driven under hypoxic conditions and mediated by HIF-2α functions and epigenetic modifications. …”
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Ethnic differences in knowledge, attitudes, and practices related to dietary salt intake and association with hypertension in Malaysia: a multi-centre cross-sectional study by Chia, Yook Chin, Ching, Siew Mooi, Chew, Ming Tsuey, Devaraj, Navin Kumar, Oui, Jethro Ee Keat, Lim, Hooi Min, Chew, Bee Nah, Mohamed, Mohazmi, Ooi, Pei Boon, Cheng, Maong Hui, Beh, Hooi Chin, Chung, Felicia Fei-Lei

“…Those who were unaware of the difference between salt and sodium and who reported not reading salt labels had higher odds of having elevated blood pressure. These findings demonstrate that while there is a suboptimal translation of salt knowledge into practice in Malaysia, with significant differences in KAP observed between ethnic groups, the potential of improving health outcomes by improving the clarity and awareness of salt labels is substantial. …”

Global incidence, prevalence, years lived with disability (YLDs), disability-adjusted life-years (DALYs), and healthy life expectancy (HALE) for 371 diseases and injuries in 204 co... by Ferrari, AJ, Santomauro, DF, Aali, A, Lacey, BWH, Rodriguez, JAB

“…A global epidemiological transition remains underway. Our findings suggest that prioritising non-communicable disease prevention and treatment policies, as well as strengthening health systems, continues to be crucially important. …”

Halal beauty supply chain and sustainable operational excellence: A moderator of the post-SARS-CoV-2 mitigation strategy by Fernando, Yudi, Mergeresa, Fineke, Ika Sari, Wahyuni-TD, Nurul Sabrina, Hazarasim

“…This study used a structural equation modeling technique to test the validity of the research model and hypotheses. Findings: This study found that halal transportation, halal manufacturing, halal packaging and post-SARS-CoV-2 mitigation strategies had a significant and direct effect on SOE. …”
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Performance-based identity in a BIM environment : An architect’s perceptions and experiences by Syafizal, Shahruddin, Mohd, Zairul, Ahmad Tarmizi, Haron, Meor Mohammad, Fared

“…The study was conducted in a Malaysian architectural consultancy practice (ACP) setting. Findings: The data analysis resulted in the following five performance identity themes that revolve around the core identity of a successful designer: “performing as a design strategist”, “performing as a design translator”, “performing as a design facilitator”, “reinstating the identity of a design coordinator” and “performing as a design innovator”. …”
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Heat transfer and energy performance analysis of photovoltaic thermal system using functionalized carbon nanotubes enhanced phase change material by Rajamony, Reji Kumar, Pandey, A. K., Mahendran, Samykano, Johnny Koh, Siaw Paw, Kareri, Tareq, Laghari, Imtiaz Ali, Tyagi, V. V.

“…Furthermore, the total efficiency of the PVT system, phase change materials integrated PVT system, and NePCM integrated PVT system were determined to be 81.9 %, 84.5 %, and 85.05 %, respectively. These findings underscore the potential of NePCM-integrated PVT systems for enhancing performance and expanding their practical application.…”
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Evaluating the rheological, chemical and mechanical properties of hybrid asphalt binders and mixtures for enhanced performance by Wan Noor Hin, Mior Sani, Putra Jaya, Ramadhansyah, Khairil Azman, Masri, Amar, Dulaimi

“…Consequently, the hybrid asphalt mixture demonstrated favourable outcomes in improving the hot mix asphalt characteristics. These findings suggested that the hybrid contents (0% as control, 3%, 6%, and 9%) produced a significant performance impact on the hybrid asphalt mixture. …”
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Measuring ethical behavior of accounting graduates in Malaysia: Comparison between perceptual statements and vignettes by Hasnah, Hj Haron, Nurul Nazlia, Jamil, Nathasa Mazna, Ramli, Fatin Arissa, Parsimin, Azim Azuan, Osman

“…This study involved 344 samples of accounting graduates from MIA-accredited universities, and path analysis was performed to test the hypotheses. The findings demonstrate a positive relationship between the ethical workplace culture and ethical behavior among accounting graduates, regardless of whether the ethical behavior was measured using vignette scenarios or perceptual statements. …”
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Data-driven brain emotional learning-based intelligent controller-PID control of MIMO systems based on a modified safe experimentation dynamics algorithm by Shahrizal, Saat, Mohd Ashraf, Ahmad, Mohd Riduwan, Ghazali

“…The comparative results demonstrated that the MSEDA-BELBIC-PID consistently performed better than the original approach and had improved fitness function values, reduced total integral square error, and lower total integral square input. These findings underscored the MSEDA suitability as a data-driven tool for controller design parameter optimization. …”
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Depletion of lamins B1 and B2 promotes chromatin mobility and induces differential gene expression by a mesoscale-motion-dependent mechanism by Pujadas Liwag, Emily M., Wei, Xiaolong, Acosta, Nicolas, Carter, Lucas M., Yang, Jiekun, Almassalha, Luay M., Jain, Surbhi, Daneshkhah, Ali, Rao, Suhas S. P., Seker-Polat, Fidan, MacQuarrie, Kyle L., Ibarra, Joe, Agrawal, Vasundhara, Aiden, Erez Lieberman, Kanemaki, Masato T., Backman, Vadim, Adli, Mazhar

“…Conclusions Our findings suggest that, while B-type lamin degradation does not significantly change genome topology, it has major implications for three-dimensional chromatin conformation at the single-cell level both at the lamina-associated periphery and the non-LAD-associated nuclear interior with concomitant genome-wide transcriptional changes. …”
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Rheo-PIV of yield-stress fluids in a 3D-printed fractal vane-in-cup geometry by Medina-Bañuelos, Esteban F., Marín-Santibáñez, Benjamín M., Chaparian, Emad, Owens, Crystal E., McKinley, Gareth H., Pérez-González, José

“…We describe the velocity distributions in all cases and show that the fVIC produces an almost axisymmetric flow field and rotation rate-independent “effective radius” when used with both the Newtonian fluid and the microgel. These findings are supported by 2D simulation results and enable the safe use of both the Couette analogy and the torque-to-stress conversion scheme for a 24-arm fVIC as well as validate it as a reliable rheometrical tool for characterization of a variety of complex fluids. …”
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