Living with fibrodysplasia ossificans progressiva: radiological images of a patient with extensive heterotopic ossification by Mohammed Mostafa Kotb, Omar, Usama Farghaly, Kaliya-Perumal, Arun-Kumar

“…Here, we present the radiological findings of an 18-year-old female diagnosed with FOP who had severe spinal and right-upper-limb abnormalities. …”
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Bolstering functionality in multilayer and bilayer WS₂ via focused laser micro-engraving by Chan, Si Min, Poh, Eng Tuan, Leong, Jin Feng, Goh, Johnson Kuan Eng, Sow, Chorng Haur

“…Furthermore, we also detail the optical properties of the monolayers obtained from laser thinning, with those acquired from multilayers containing more defect-bound excitons, whereas those lasered from bilayers presenting a trion-dominated profile similar to as-grown monolayers. Together, these findings allow for faster and more efficient multilayer removal and areal shaping of optically active monolayer domains, in comparison to multistep and complex standard lithographic etching (lithography–etch–develop) procedures.…”
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Presence of IgG antibodies is not a reliable marker of Toxoplasma gondii infection in feral mice by Lignereux, Louis, Tong, Wen Han, Tan, Sijie, Vyas, Ajai, O'handley, Ryan

“…The question of the biological mechanisms allowing the chronic infection of wild mice in the absence of a measurable humoral immune response remains. Our findings indicate that serological studies should not be used to measure the level of exposure to T.gondii in feral house mice.…”
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Enhancing implant performance: 20% reduction in Pseudomonas aeruginosa bacterial initial formation with Cu₀.₇₅Ti₀.₂₅O₂ coating by Yadav, Abhishek, Pradhan, Soumen, Khokholva, M., El Khaloufi, Oualyd, Khong, Nicole Zi Jia, Lai, Soak-Kuan, Fouchet, Arnaud, David, Adrian, Lüders, Ulrike, Li, Hoi-Yeung, Rao, Mamidanna Sri Ramachandra, Prellier, Wilfrid

“…The results revealed a 20% reduction in bacterial growth on Cu0.75Ti0.25O2-coated samples, as determined by calculating the biomass of the biofilm. These findings were further discussed in relation to the copper content present on the surface of the coating. …”
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Weakly confined organic–inorganic halide perovskite quantum dots as high-purity room-temperature single photon sources by Wang, Bo, Lim, Melvin Jia Wei, Loh, Siow Mean, Mayengbam, Rishikanta, Ye, Senyun, Feng, Minjun, He, Huajun, Liang, Xiao, Cai, Rui, Zhang, Qiannan, Kwek, Leong Chuan, Demir, Hilmi Volkan, Mhaisalkar, Subodh Gautam, Blundell, Steven A., Sum, Tze Chien

“…Theoretical calculations utilizing a combination of the Bethe-Salpeter (BSE) and k⋅p approaches point towards the modulation of the dielectric constants by the organic cations. Importantly, our findings provide valuable insights into an additional lever for engineering facile-synthesized room-temperature PQD single photon sources.…”
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MTOR modulation induces selective perturbations in histone methylation which influence the anti-proliferative effects of mTOR inhibitors by Kim, HaEun, Lebeau, Benjamin, Papadopoli, David, Jovanovic, Predrag, Russo, Mariana, Avizonis, Daina, Morita, Masahiro, Afzali, Farzaneh, Ursini-Siegel, Josie, Postovit, Lynne-Marie, Witcher, Michael, Topisirovic, Ivan

“…Notably, the ability of mTOR inhibitors to induce H3K27me3 levels was positively correlated with their anti-proliferative effects. Collectively, our findings demonstrate that both activation and inhibition of mTOR selectively increase H3K27me3 by distinct mechanisms, whereby the induction of H3K27me3 may potentiate the anti-proliferative effects of mTOR inhibitors.…”
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Analysis and design recommendations for structures strengthened by prestressed bonded Fe-SMA by Li, Lingzhen, Wang, Sizhe, Chatzi, Eleni, Motavalli, Masoud, Ghafoori, Elyas

“…A parametric study and a sensitivity analysis are then conducted to assess the impact of the four influential features on the final prestress level, and their impact is ranked in the following order: recovery stress ≈ Fe-SMA width > activation length > bonded anchorage length. Based on these findings, a design strategy, in line with Eurocode 0, for the bonded/embedded Fe-SMA strengthening system is proposed. …”
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Low-velocity impact response of sandwich structures with cores made from entangled metallic wire material - silicone rubber composites by Zheng, Xiaoyuan, Xiao, Zhongmin, Ren, Zhiying, Zi, Bao, Bai, Hongbai, Wu, Yiwan, Yao, Liming

“…Finally, the superiority of the EMWM-SRC sandwich structure in enhancing impact resistance was validated by comparing it with individual EMWM and SR sandwich structures. These findings of this work offer valuable guidance for designing novel sandwich structures with excellent impact resistance.…”
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Mass spectrometry imaging highlights dynamic patterns of lipid co-expression with Aβ plaques in mouse and human brains by Huang, Helen Xuexia, Inglese, Paolo, Tang, Jiabin, Yagoubi, Riad, Correia, Gonçalo D. S., Horneffer-van der Sluis, Verena M., Camuzeaux, Stephane, Wu, Vincen, Kopanitsa, Maksym V., Willumsen, Nanet, Jackson, Johanna S., Barron, Anna M., Saito, Takashi, Saido, Takaomi C., Gentlemen, Steve, Takats, Zoltan, Matthews, Paul M.

“…Likewise, in human donors with varying Braak stages, similar studies of cortical sections revealed co-expression of lysophospholipids and ceramides around Aβ plaques in AD (Braak stage V/VI) but not in earlier Braak stage controls. Our findings in mice provide evidence of temporally and spatially heterogeneous differences in lipid composition as local and global Aβ-related pathologies evolve. …”
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Empowering student self-regulated learning and science education through ChatGPT: a pioneering pilot study by Ng, Davy Tsz Kit, Tan, Chee Wei, Leung, Jac Ka Lok

“…SRLbot's adaptability and personalized approach distinguished it from rule-based chatbots. The findings offer valuable evidence for AI developers and educators to consider generative AI settings and chatbot design, facilitating greater success in online science learning.…”
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Selective photoelectrochemical oxidation of glycerol to glyceric acid on (002) facets exposed WO3 nanosheets by Xiao, Yonghao, Wang, Mengran, Liu, Dong, Gao, Jiajian, Ding, Jie, Wang, Huan, Yang, Hong Bin, Li, Fuhua, Chen, Mengxin, Xu, Yangsen, Xu, Danyun, Zhang, Yun-Xiao, Fang, Shaofan, Ao, Xin, Wang, Jingyu, Su, Chenliang, Liu, Bin

“…Compared to (200) facets exposed WO3 , a combination of experiments and theoretical calculations indicates that the superior performance of selective glycerol oxidation mainly originates from the better charge separation and prolonged carrier lifetime resulted from the plenty of surface trapping states, lower energy barrier of the glycerol-to-GLYA reaction pathway, more abundant active sites and stronger oxidative ability of photogenerated holes on the (002) facets exposed WO3 . Our findings show great potential to significantly contribute to the sustainable and environmentally friendly chemical processes via designing high performance photoelectrochemical cell via facet engineering for renewable feedstock transformation.…”
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Profiling pro-inflammatory proteases as biomolecular signature of material-induced subcutaneous host response in immuno-competent mice by Tran, Nam M. P., Truong, Anh T. H., Nguyen, Dang T., Dang, Tram Thuy

“…This study also demonstrates the predictive utility of protease activity as a non-invasive, pro-inflammatory parameter for evaluation of the anti-inflammatory effects of model bioactive compounds on material-induced host response. Overall, our findings provide new insights into protease presence in material-induced immune responses, facilitating future biomaterial assessment to evoke appropriate host responses for implant applications.…”
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Optical quantum sensing for agnostic environments via deep learning by Zhou, Zeqiao, Du, Yuxuan, Yin, Xu-Fei, Zhao, Shanshan, Tian, Xinmei, Tao, Dacheng

“…Extensive experiments are conducted to investigate the performance of DQS under different settings up to eight photons. Our findings not only offer a different lens through which to accelerate optical quantum sensing tasks but also catalyze future research integrating deep learning and quantum mechanics.…”
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Customer co-creation in B2C e-commerce: does it lead to better new products? by Pee, Loo Geok

“…This is also one of the earliest studies to report empirical evidence for the impact of customer co-creation in e-commerce. The findings offer specific insights into the co-creation tasks and NPD stages to open for customer co-creation in practice.…”
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Adsorption of hyaluronic acid on solid supports: Role of pH and surface chemistry in thin film self-assembly by Choi, Jae-Hyeok, Kim, Seong-Oh, Linardy, Eric, Dreaden, Erik C., Zhdanov, Vladimir P., Hammond, Paula T., Cho, Nam-Joon

“…The observed specifics of the kinetics of HA adsorption, including a short initial linear phase and subsequent long non-linear phase, were described by using a mean-field kinetic model taking HA diffusion limitations and reconfiguration in the adsorbed state into account. The findings extend the physicochemical background of design strategies for improving the use of passive HA adsorption for surface modification applications.…”
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p27 is regulated independently of Skp2 in the absence of Cdk2 by Kaldis, Philipp, Kotoshiba, Shuhei, Gopinathan, Lakshmi, Pfeiffenberger, Elisabeth, Rahim, Anisa, Vardy, Leah Karen Anne, Nakayama, Keiko, Nakayama, Keiichi I.

“…Ablation of other ubiquitin ligases for p27 such as KPC1, DDB1, and Pirh2 did not restore stability of p27 in Cdk2−/−Skp2−/− MEFs. Our findings point towards novel and alternate pathways for p27 regulation.…”
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Virus-specific T lymphocytes home to the skin during natural dengue infection by Rivino, Laura, Kumaran, Emmanuelle A., Thein, Tun-Linn, Too, Chien Tei, Gan, Victor Chih Hao, Hanson, Brendon J., Wilder-Smith, Annelies, Bertoletti, Antonio, Gascoigne, Nicholas R. J., Lye, David Chien, Leo, Yee Sin, Akbar, Arne N., Kemeny, David M., MacAry, Paul A.

“…The juxtaposition of dengue-specific T cells with virus-permissive cell types at sites of possible dengue exposure represents a previously uncharacterized form of immune surveillance for this virus. These findings suggest that vaccination strategies may need to induce dengue-specific T cells with similar homing properties to provide durable protection against dengue viruses.…”
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High expression of MnSOD promotes survival of circulating breast cancer cells and increases their resistance to doxorubicin by Fu, Afu, Ma, Shijun, Wei, Na, Tan, Blanche Xiao Xuan, Tan, Ern Yu, Luo, Kathy Qian

“…Specific siRNA-mediated MnSOD knockdown reversed all three phenotypes. Our findings therefore suggest that MnSOD plays an important integrative role in supporting cancer cell survival in circulation, metastasis, and doxorubicin resistance. …”
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Robust design of LCL filters for single-current-loop-controlled grid-connected power converters with unit PCC voltage feedforward by Li, Xiaoqiang, Fang, Jingyang, Tang, Yi, Wu, Xiaojie

“…Moreover, another interesting finding is that the feedforward control can help maintain a high current control bandwidth under grid impedance variation. …”
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Geometric shapes effect of in-duct perforated orifices on aeroacoustics damping performances at low Helmholtz and Strouhal number by Zhao, Dan, Ji, Chenzhen, Wang, Bing

“…The measured minimum reflection coefficient Rmin occurs at Ma ≈ 0.024. This experimental finding is consistent with the quasi-steady prediction.…”
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