Luteolin escape mutants of dengue virus map to prM and NS2B and reveal viral plasticity during maturation by Vasudevan, Subhash G., Peng, Minhua, Swarbrick, Crystall Marie Dawn, Chan, Kitti Wing-Ki, Luo, Dahai, Zhang, Wei, Lai, Xiaoping, Li, Geng

“…On the other hand the SM1 immature virus showed some cleavage while the DM immature virus revealed efficient furin cleavage of prM even in the presence of 50 μM luteolin. Our findings suggest that luteolin inhibition of furin may occur at host/pathogen interface that permits the virus to escape the suppression by mutating key residue that may lead to an altered interface.…”
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Low magnetic field exposure alters prostate cancer cell properties by Lange, Sigrun, Inal, Jameel, Kraev, Igor, Dart, Dafydd Alwyn, Uysal-Onganer, Pinar

“…In addition, 4 h LMF exposure significantly induced cellular invasion of PC3 cells. Overall, our findings suggest that changes in magnetic field exposures modulate EV-mediated and miR-regulatory processes in PCa metastasis, providing a basis for exploring novel therapeutic strategies.…”
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Fiona Patrick - Thesis submitted in partial fulfilment of the degree of Doctor of Clinical Psychology (DClinPsych) by Patrick, F

“…No predictive relationship between ACEs or NSB and BMI was identified, nor any mediating effect of NSB or moderating effect of self-compassion on these relationships. Findings partially support the application of this cognitive model in a general population sample of overweight/obese and indicate the importance of mood. …”

Maternal infections during pregnancy and the risk of childhood leukaemia in the offspring: Evidence from large-scale cohort studies by He, J

“…</p> <p><b>Methods:</b> Three analyses were conducted: (1) A systematic review and meta-analysis was firstly conducted to summarise findings in previous studies on maternal infections during pregnancy and childhood leukaemia. (2) Analyses using data on 312,879 mother-child pairs from the six prospective cohorts in the International Childhood Cancer Cohorts Consortium (I4C) was then performed to assess the association between self-reported maternal infections and childhood leukaemia. (3) A national registry-based investigation was further carried out among 4.9 million mother-child pairs in Denmark and Sweden to examine the association for hospital-diagnosed infections during pregnancy. …”

Chang'E lunar microwave radiometer data analysis and lunar subsurface temperature profile modelling by Zhang, W

“…Hence a heat flow model based on radioactive elements as well as internal cooling was built up to investigate such a finding.</p> <p>In this thesis, a radiative transfer model for the analysis of MRM was developed and proven to be a useful tool for studying the lunar heat flow, as well as subsurface temperature. …”

Financial elites and the spatial variation of inequality: examining the intersection of gender, race and class in Frankfurt, London, and New York by Kaempfer, K

“…Feminist and intersectional theory can also learn from this empirical study, which highlights the importance of contextual factors and provides insights into the intersection of class, gender, and race in the elitist space of finance. In addition, the findings have implications for policies and practitioners.…”

Afiksasi nomina dalam bahasa Indonesia by Denistia, K, Rajeg, GPW

“…The quantitative approach also allows us to describe the word-class preferences of noun-forming affixes. Our findings indicate that the affix ke-/-an tends to be derived from the adjective word, the affix per-/-an has an over-representation for noun-based words, and verbs have an over-representation as a base word for the affixes -an peN-, and peN-/-an. …”

Consensus on current management of endometriosis by Johnson, NP, Hummelshoj, L, World Endometriosis Society Montpellier Consortium

“…</p> <p><strong>Wider implications of the findings:</strong> This is the first time that a large, global, consortium, representing 34 major stakeholding organizations from five continents, has convened to systematically evaluate the best available current evidence on the management of endometriosis, and to reach consensus. …”

Cardiovascular risk factors in childhood and adulthood and cardiovascular disease in Middle Age by Kartiosuo, N, Raitakari, OT, Juonala, M, Viikari, JSA, Sinaiko, AR, Venn, AJ, Jacobs, DR, Urbina, EM, Woo, JG, Steinberger, J, Bazzano, LA, Daniels, SR, Magnussen, CG, Rahimi, K, Dwyer, T

“…<p><strong> Conclusions and Relevance </p></strong> In this cohort study of 10 634 participants, childhood risk factors were found to be associated both directly and indirectly to adult CVD, with the largest direct effect seen for BMI and LDL-C. These findings suggest that intervention for childhood risk factors, in particular BMI, is warranted to reduce incidence of adult CVD as it cannot be fully mitigated by risk factor management in adulthood.…”

Category learning in infants and adults by Sucevic, J

“…</p> <p>In summary, this thesis demonstrates that category learning is a dynamic process shaped by different factors, which determine outcomes of the learning situation. In addition, the findings suggest that similar kinds of statistical category learning are present in infancy and adulthood.…”

Meta-analysis of GHG mitigation potentials of the application of anaerobic digestion in dairy farms by Miranda, N

“…However, important methodologies such as the Intergovernmental Panel on Climate Change (IPCC) Guidelines, rely only on a small sample of the accumulated scientific findings in the field. This thesis improves the robustness of these methodologies by applying data-driven techniques to estimate values of the energy output of AD systems and their consequent effect in GHG emissions.…”

Internet tool to support self-assessment and self-swabbing of sore throat: development and feasibility study by Lown, M, Smith, KA, Muller, I, Woods, C, Maund, E, Rogers, K, Becque, T, Hayward, G, Moore, M, Little, P, Glogowska, M, Hay, A, Stuart, B, Mantzourani, E, Wilcox, CR, Thompson, N, Francis, NA

“…Of these, 35 (78%) and 32 (71%) participants completed all scoring elements for FeverPAIN and Centor scores, respectively, and most (30/45, 67%) of them reported finding self-assessment relatively easy. No valid response was provided for swollen lymph nodes, throat inflammation, and pus on the throat by 11 (24%), 9 (20%), and 13 (29%) participants respectively. …”

Association of nucleoside reverse transcriptase inhibitors with adverse perinatal outcomes in pregnant women living with HIV: systematic review and meta-analysis by Cowdell, I, Beck, K, Hey, M, Portwood, C, Sexton, H, Kumarendran, M, Brandon, Z, Kirtley, S, Hemelaar, J

“…Abacavir is not associated with adverse perinatal outcomes. Our findings support current WHO guidelines.</p>…”

Psychiatric comorbidities in persons with epilepsy compared with persons without epilepsy: a systematic review and meta-analysis by Kwon, C-S, Rafati, A, Ottman, R, Christensen, J, Kanner, AM, Jetté, N, Newton, CR

“…</p> <p><strong>Conclusions and Relevance</strong> In this comprehensive study, most psychiatric comorbidities examined were significantly more prevalent in PWE than in those without epilepsy. These findings show the high burden of psychiatric comorbidities in PWE. …”

Circadian rhythm and misalignment in the pathogenesis of metabolic dysfunction-associated steatotic liver disease (MASLD): an experimental medicine approach by Marjot, T

“…Despite global improvements in metabolic health after weight loss, diurnal differences persist, suggesting that night-time metabolic dysfunction may represent a unique risk factor for MASLD. These findings will help establish the optimal window for energy intake in patients with MASLD, and help guide the best time-of-day to deliver medications currently in development.…”

Molecular characterisation of methicillin-resistant Staphylococcus aureus and Staphylococcus pseudintermedius in cats, dogs and pet owners in a Veterinary Hospital by Afshar, Mohammad Farzad

“…In brief, both MRSA and MRSP that were detected in the current study were multidrug resistant and molecularly related to other Southeast Asian countries. The findings from this study have brought new insights into the current status of antimicrobial resistance and molecular characteristics of both S. aureus and S. …”
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Effectiveness of King’s theory of goal attainment in blood glucose management for newly diagnosed patients with type 2 diabetes: randomized controlled trial by Yan, Man, Yu, Yingchun, Li, Shuping, Zhang, Peiling, Yu, Jiaxiang

“…Conversely, the control group maintained relatively higher values for these metrics at the same time point (P<.05). These findings underscore the efficacy of online feedback in managing glycemic control and reducing psychological distress associated with hypoglycemia. …”
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Prevalence and risk factors of long covid and its associated adverse work outcomes among workers in the manufacturing sector in Malaysia – a mixed-methods study protocol by Mohd Yusoff, Hanizah, Che Mohamed, Norfariha, Yew, Sheng Qian, Mohammed Nawi, Azmawati, Rashidah Ismail, Ohnmar Htwe, Mohd Tohit, Noorlaili, Mohamed, Zuraida, Muhamad Noordin, Muhamad Ariff, Mohd, Fazlin Hazirah, Shariff, Mohammad Izzat Akmal, Shaharum, Muaz Haqim, Abd. Rahman, Anita, Dapari, Rahmat

“…The aim of the FGDs is to explore the understanding, experience, and potential risk factors of Long Covid-19 among manufacturing workers. Findings from the FGDs will be analysed thematically. …”
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Factors influencing career success of women managers in Malaysian public sector by Abdul Manaf, Saidatul Hizam

“…Three groups of variables were identified in predicting women managers’ objective and subjective career success; i) individual related variables (self-efficacy, proactive personality and extraversion), ii) human capital variables (work experience and sense of competence) and iii) organizational related variables (organizational culture and perceived organizational justice). The findings of this study revealed that individual, human capital and organizational factors have significant effect on women managers’ objective and subjective career success. …”
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Qualitative and quantitative accuracy evaluation of 18f-fdg PET/CT with TOF and NON-TOF system on beta value in BPL reconstruction by Hui, Ng Suk

“…Conclusion: Our study findings suggested that a beta value of 450 was optimal for TOF acquisition, while a beta value of 300 was recommended for non-TOF acquisition. …”
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