Induction of z-conformation in ribosomal RNA by Z-DNA binding domain Zα of the human double-stranded RNA deaminase I (ADAR1) by Zhao, Jing

“…We also mapped the binding interfaces of ZαADAR1 to Z-DNA, Z-RNA and E.coli ribosomes, and found them to be identical. Based on this finding, we proposed that the role of ZαADAR1 in binding to ribosomes and inhibiting translation is to recognize potentially Z-forming structures and/or induce localized structural transitions from A- to Z-conformations in ribosomal RNA. …”
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Electrical characterization of bias temperature instability in MOSFETs with the ultrathin SiON and la-doped HfSiO gate dielectrics by Du, Guoan.

“…This phenomenological explanation agrees with the findings of a first-principle simulation study on E'δ centers. …”
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Flexible whispering gallery mode optical microcavities for lasers and sensors by Ta, Van Duong

“…In conclusion, we have contributed promising material compositions and straightforward techniques for creating flexible high Q factor cavities with promising applications as bendable/stretchable microlasers and sensors. Our finding should be also useful for investigation of novel optical nonlinear effects and active/passive components in optical plastic devices/circuits.…”
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Design, development and analysis of a full carbon fibre reinforced composite chassis of an electric vehicle by Khoo, Raymond Rui Xiang

“…Results of the development along side with findings and observations will be documented in the later section of the thesis showing how goals and objectives of a lightweight crashworthy prototype vehicle structure were achieved. …”
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Global response of Vibrio cholerae to predation by heterotrophic protists by Hu, Jie

“…This data may indicate that small molecules, such as amino acids in the protozoal supernatant may act as a trigger for biofilm formation by V. cholerae. These findings will serve as a stepping-stone for further detailed understanding of the interactions between V. cholerae and protozoa, which in turn will lead to a better understanding of how pathogenic bacteria evolve in the environment.…”
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Three physiological responses in fathers and non-fathers’ to vocalizations of typically developing infants and infants with Autism Spectrum Disorder by Esposito, Gianluca, Valenzi, Stefano, Islam, Tanvir, Bornstein, Marc H.

“…Fathers were calmer and acted more promptly than non-fathers while listening to typical cries, perhaps because the fathers had more experience in caring for crying infants. These findings point to similarities and differences in fathers’ and non-fathers’ physiological responsiveness to cries of children with ASD and might guide specific intervention programs for parents of children at risk of ASD.…”
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Semi-closed circulation integrated multi-trophic aquaculture treatment system using aquatic organisms as biofilters to improve shrimp effluent quality by Lavania Baloo

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To what extent and in what ways do communities of practice facilitate learning in the context of professional development for interpreting students and practitioners? by D'Hayer, Danielle

“…It sows the seeds for a CoP mindset that sustains beyond participation and so has the power to transform the ethical values of the interpreting profession. Finally, these findings are transferable to all professional courses (but not only) within and beyond Higher Education.…”
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Lipid-mediated resolution of inflammation and survival in amyotrophic lateral sclerosis by Yildiz, O, Hunt, GP, Schroth, J, Dhillon, G, Spargo, TP, Al-Chalabi, A, Koks, S, Turner, MR, Shaw, PJ, Henson, SM, Iacoangeli, A, Malaspina, A

“…Higher mononuclear cell expression of resolvin receptors is a predictor of longer survival. These findings suggest a lipid-mediated neuroprotective response that could be harnessed to develop novel therapeutic strategies and biomarkers for ALS.…”

Postpartum-specific vital sign reference ranges by Green, L, Pullon, R, Mackillop, L, Gerry, S, Birks, J, Salvi, D, Davidson, S, Loerup, L, Tarassenko, L, Mossop, J, Edwards, C, Gauntlett, R, Harding, K, Knight, M, Chappell, L, Watkinson, P

“…</p> <p><strong>Conclusion: </strong> We present widely relevant, postpartum, day-specific reference ranges which may facilitate early detection of abnormal blood pressure, heart rate, respiratory rate, oxygen saturation and temperature during the puerperium. Our findings could inform construction of an evidence-based modified obstetric early warning system to better identify unwell postpartum women.…”

Granulocyte-macrophage colony-stimulating factor neutralisation in patients with axial spondyloarthritis in the UK (NAMASTE): a randomised, double-blind, placebo-controlled, phase... by Worth, C, Al-Mossawi, MH, MacDonald, J, Fisher, BA, Chan, A, Sengupta, R, Packham, J, Gaffney, K, Gullick, N, Cook, JA, Corn, TH, Teh, J, Machado, PM, Taylor, PC, Bowness, P

“…This trial is registered with ClinicalTrials.gov (NCT03622658). <p><strong>Findings</p></strong> From Sept 6, 2018, to July 25, 2019, 60 patients with moderate-to-severe active axial spondyloarthritis were assessed for eligibility and 42 were randomly assigned to receive namilumab (n=36) or placebo (n=six). …”

Treatment options to support the elimination of Hepatitis C: an open label, factorial randomised controlled trial by Cooke, G, Le Manh, H, Flower, B, McCabe, L, Vu Thu Kim, H, Vo Thi, T, Dang Trong, T, Nguyen Thanh, D, Le Thanh, P, Dao Bach, K, Nguyen Thi Chau, A, Pham Ngoc, T, Vu Thu Thu, H, Dang Thi, B, Nguyen Kim, T, Ansari, A, Le Ngoc, C, Vo Minh, Q, Nguyen Thi Ngoc, P, Le Thi, T, Nguyen Bao, T, Kestelyn, E, Kingsley, C, Van Doorn, R, Rahman, M, Pett, S, Thwaites, G, Barnes, E, Day, J, Nguyen Van Vinh, C, Walker, AS

“…</p> <br> <p><strong>Findings:</strong> 624 participants were randomised: 296 (47.4%) genotype 6, 328 (52.6%) genotypes 1-5). …”

The effects and costs of an anti-bullying program (KiVa) in UK primary schools: a multicenter cluster randomized controlled trial by Badger, JR, Bowes, L, Babu, M, Broome, M, Cannings-John, R, Clarkson, S, Coulman, E, Tudor Edwards, R, Ford, T, Hastings, RP, Hayes, R, Lugg-Widger, F, Owen-Jones, E, Patterson, P, Segrott, J, Sydenham, M, Townson, J, Watkins, RC, Whiteley, H, Williams, ME, Stand Together Team, Hutchings, J

“…Outcomes were analyzed using multilevel linear and logistic regression models. <p><b>Findings </b></p> Between 8/11/2019–12/02/2021, 118 primary schools were recruited in four trial sites, 11 111 students in primary analysis (KiVa-intervention: n = 5944; 49.6% female; UP: n = 5167, 49.0% female). …”

Strategies to increase response rate and reduce non-response bias in population health research: a series of randomised controlled trials during a large COVID-19 study by Atchison, CJ, Gilby, N, Pantelidou, G, Clemens, S, Pickering, K, Chadeau-Hyam, M, Ashby, D, Barclay, WS, Cooke, G, Darzi, A, Riley, S, Donnelly, C, Ward, H, Elliott, P

“…<p><strong>Background:</strong> High response rates are needed in population-based studies as non-response reduces effective sample size and bias affects accuracy and decreases generalizability of the study findings.</p> <br> <p><strong>Objectives:</strong> We tested different strategies to improve response rate and reduce non-response bias in a national population-based COVID-19 surveillance programme in England, UK.…”

Immune Checkpoint Blockade sensitivity and Progression-Free Survival associates with baseline CD8+ T cell clone size and cytotoxicity by Watson, R, Tong, O, Taylor, C, Kumar Sharma, P, Verge De Los Aires, A, Mahe, E, Ruffieux, H, Nassiri, I, Middleton, M, Fairfax, B

“…We identify seven subsets with divergent responses to ICB, finding the effector cluster demonstrates the most pronounced changes. …”

Imagined futures and relational agency in nurses' writing transitions: a qualitative study across two writing group interventions in a higher education setting by Waite, M

“…Becoming an active agent was contingent on supervisory support and cultivating and enacting know-who to align what mattered with others to develop common knowledge about disciplinary writing concepts. The findings revealed the potential to develop writers’ identities to help them change the status quo towards an imagined future. …”

Microbial communities: network reconstruction and control by Fu, A

“…</p> <p>The thesis concludes with a summary of the research findings, discussing the limitations and potential future directions. …”

Unravelling the degradation pathways and charging mechanism in the Li-O2 battery: the role of singlet oxygen by Zor, C

“…It is demonstrated that ¹O₂ is not the main source of degradation and fresh Li₂O₂ surfaces is the culprit. This finding should redirect the focus of LOB research from avoiding ¹O₂ to developing electrolytes inert towards peroxide and peroxide-derived side products for an electro/chemically stable cell. …”

Frailty trajectories preceding dementia in the US and UK by Ward, DD, Flint, JP, Littlejohns, TJ, Foote, IF, Canevelli, M, Wallace, LMK, Gordon, EH, Llewellyn, DJ, Ranson, JM, Hubbard, RE, Rockwood, K, Stolz, E

“…</p> <p><strong>Conclusions and Relevance: </strong>These findings suggest that frailty measurements may be used to identify high-risk population groups for preferential enrolment into clinical trials for dementia prevention and treatment. …”

The epidemiology of periportal fibrosis and relevance of current Schistosoma mansoni infection within the context of repeated mass drug administration: a population-based, cross-se... by Ajayi, S, Nabatte, B, Mpooya, S, Tinkitina, B, Opio, CK, Kabatereine, NB, Chami, G

“…</p> <br> <p><strong>Findings:</strong> Between Jan 6 and Feb 3, 2022, 342 (12·1%) of 2834 participants were diagnosed with periportal fibrosis. …”