Structural and molecular characterization of ligands activating the orphan nuclear receptor Nurr1 (NR4A2) by Ng, Xin Yi

“…By employing Surface Plasmon Resonance (SPR) and Nuclear Magnetic Resonance (NMR), C3 was identified to bind to the co-regulator binding pocket and is a strong candidate to be chemically-linked to L1, in hopes of increasing its potency as well as its binding affinity and specificity to Nurr1. …”
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Scaling of the velocity profile in strongly drag reduced turbulent flows over an oscillating wall by Skote, Martin

“…As a result, logarithmic part is influenced by both velocity scales and the slope of the velocity profile is directly linked to the DR. The theoretically obtained results are verified by data from six previously performed direct numerical simulations (DNSs) of boundary layers over spatial and temporal wall oscillations, with a wide range of resulting DR. …”
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The discrete-time second-best dynamic road pricing scheme by Han, Linghui, Wang, David Zhi Wei, Zhu, Chengjuan

“…In this study, we aim to develop a more practical second-best dynamic road pricing scheme implemented on a subset of links, which can drive the traffic evolution towards the desired second-best traffic user equilibrium state from any initial traffic state. …”
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HDSKG: Harvesting domain specific knowledge graph from content of webpages by Zhao, Xuejiao, Xing, Zhenchang, Kabir, Muhammad Ashad, Sawada, Naoya, Li, Jing, Lin, Shang-Wei

“…It integrates structural information of concepts across multiple information sources, and links these concepts together. The extraction of domain specific relation triples (subject, verb phrase, object) is one of the important techniques for domain specific knowledge graph construction. …”
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Investigating circular dorsal ruffles through varying substrate stiffness and mathematical modeling by LeDuc, Philip R., Zeng, Yukai, Lai, Tanny, Koh, Cheng Gee, Chiam, Keng-Hwee

“…We developed a mathematical model of the signaling pathways involved in CDR formation to provide insight into this lifetime and size dependence which is linked to substrate stiffness via Rac-Rho antagonism. …”
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Curvature sensing amphipathic helix in the C-terminus of RTNLB13 is conserved in all endoplasmic reticulum shaping reticulons in Arabidopsis thaliana by Brooks, Rhiannon L., Mistry, Chandni S., Dixon, Ann M.

“…This may facilitate functional flexibility as previous studies have linked these isoforms not only to ER remodeling but other cellular activities.…”
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Deubiquitinases in muscle physiology and disorders by Olie, CS, O'Brien, DP, Jones, HBL, Liang, Z, Damianou, A, Sur-Erdem, I, Pinto-Fernández, A, Raz, V, Kessler, BM

“…Several mutations in DUB encoding genes are linked to human NMDs, such as ATXN3, OTUD7A, UCHL1 and USP14, whilst other NMDs are associated with dysregulation of DUB expression. …”

Disrupted working memory event-related network dynamics in multiple sclerosis by Rossi, C, Vidaurre, D, Costers, L, D’hooghe, MB, Akbarian, F, D’haeseleer, M, Woolrich, M, Nagels, G, Van Schependom, J

“…First, the activation of an early theta prefrontal network linked to stimulus encoding and attentional control significantly decreases in MS compared to HC. …”

Disrupted working memory event-related network dynamics in multiple sclerosis by Rossi, C, Vidaurre, D, Costers, L, D’hooghe, MB, Akbarian, F, D’haeseleer, M, Woolrich, M, Nagels, G, Van Schependom, J

“…First, the activation of an early theta prefrontal network linked to stimulus encoding and attentional control significantly decreases in MS compared to HC. …”

Inherently vulnerable? Ethnic geography and the intensity of violence in the Bosnian civil war by Di Salvatore, J

“…Existing research on ethnic conflict focuses on regional configurations of ethnicity, thus neglecting how local vulnerable pockets of minorities may become primary targets for violence. The mechanism linking minority enclaves to more violence posits that the regional majority group will fight local minorities in order to (i) create ethnically homogeneous areas and (ii) remove potential support for the other group by the local minority. …”

Safety outcomes following COVID-19 vaccination and infection in 5.1 million children in England by Copland, E, Patone, M, Saatci, D, Handunnetthi, L, Hirst, J, Hunt, DPJ, Mills, NL, Moss, P, Sheikh, A, Coupland, CAC, Harnden, A, Robertson, C, Hippisley-Cox, J

“…A self-controlled case-series study was conducted using linked data of 5.1 million children in England to compare risks of hospitalisation from vaccine safety outcomes after COVID-19 vaccination and infection. …”

Immune correlates of early clearance of Mycobacterium tuberculosis among tuberculosis household contacts in Indonesia by Setiabudiawan, TP, Apriani, L, Verrall, AJ, Utami, F, Schneider, M, Indrati, AR, Halim, PP, Kaplonek, P, Malca, H, Lee, JS, Moorlag, SJCFM, de Bree, LCJ, Mourits, VP, Joosten, LAB, Netea, MG, Alisjahbana, B, McNamara, RP, Alter, G, van Laarhoven, A, Ussher, JE, Sharples, K, Koeken, VACM, Hill, PC, van Crevel, R

“…The protective effect of BCG vaccination against Mtb infection may be linked to innate immune priming, also termed ‘trained immunity’.…”

Adherence to the eatwell guide and population and planetary health: a rank prize forum report by Shannon, OM, Townsend, O, Malcolmson, FC, Matu, J, Griffiths, A, Jennings, A, Ward, N, Papier, K, Best, N, French, C, Scheelbeek, P, Kim, C, Ochieng, B, Jay, F, Shepherd, K, Corfe, B, Fairley, A, McEnvoy, CT, Minihane, A-M, Sim, YJ, Stevenson, E, Gregory, S

“…The 1.5-day Forum highlighted the limited, albeit promising evidence linking higher adherence to the Eatwell Guide with favourable health outcomes, including reduced overall mortality risk, lower abdominal obesity in postmenopausal women, and improved cardiometabolic health markers. …”

Transforming CCTV cameras into NO 2 sensors at city scale for adaptive policymaking by Ibrahim, MR, Lyons, T

“…Air pollution in cities, especially NO2, is linked to numerous health problems, ranging from mortality to mental health challenges and attention deficits in children. …”

Strain-tuning of nematicity and superconductivity in single crystals of FeSe by Ghini, M, Bristow, M, Prentice, JCA, Sutherland, S, Sanna, S, Haghighirad, AA, Coldea, AI

“…Close to the critical temperature, all resistivity curves at constant strain cross in a single point, indicating a universal critical exponent linked to a strain-induced phase transition. Our results indicate that the superconducting state is enhanced under compressive strain and suppressed under tensile strain, in agreement with the trends observed in FeSe thin films and overdoped pnictides, whereas the nematic phase seems to be affected in the opposite way by the uniaxial strain. …”

Dynamics of classified forests in the urban district of Bobo-Dioulasso in Burkina Faso by Francoise, Valea, Karambiri, Bienvenue Lawankilea Chantal Noumpoa, Sanou, Korotimi

“…The results show that the agricultural production system, the cutting of wood for energy, pastoral practices, and water stress linked to rising temperatures have a negative impact on the development of peri-urban forests. …”
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Prevalence of smartphone addiction and the impact on sleep quality among undergraduate students at School of Health Sciences, USM by Othman, Nurul Aina

“…Numerous studies have been done on sleep quality, but very few have linked it to smartphone addiction. A cross-sectional survey was carried out to study Prevalence of Smartphone Addiction and the Impact on Sleep Quality Among Undergraduate Students at School of Health Sciences, USM using a set of self-administered online questionnaire that adopted the Smartphone Addiction Scale (SAS) and Pittsburgh Sleep Quality Index. …”
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The Accident / by Pavone, Chris, author 656312

“…This manuscript - printed out, hand-delivered, totally anonymous - is full of shocking revelations and disturbing truths linked to a car accident that occurred years ago, things which could compromise national security. …”

Talking careers: using interviews with learner stakeholders to understand the graduate outcome gap. Stakeholder internal report. Autumn 2024. by Conroy, Dom, Poku, Mary-Jane, Patel, Jade, Diop, Leah, Huda, Nahid, Benn, Jade, Olasope, Awesome

“…‘What are students of colour’s viewpoints on factors that help explain, and may help mitigate, the ethnicity linked graduate outcome gap? This report will provide provisional evidence to help address research questions 1, 2 and 3.…”
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A Lagrangian perspective on the lifecycle and radiative effect of deep convective clouds by Jones, WK

“…A major limit in our understanding of DCCs is a lack of observations linking convective processes to anvil cloud properties. …”