Exploring the regulation of myofilament function in the heart using experimental and computational approaches by Folkmanaite, M

“…</p> <p>Altogether, the study advances understanding of cAMP-PKA signalling at the myofilament, identifying distinct cAMP nanodomains and elucidating the role of PKA phase separation in modulating the adrenergic response. These findings provide insights into cardiac cell physiology and have implications for the development of more targeted therapies for cardiac dysfunction. …”

Comparative effectiveness of manual therapy, pharmacological treatment, exercise therapy, and education for neck pain (COMPETE study): protocol of a systematic review with network... by de Oliveira-Souza, AIS, Barbosa-Silva, J, Gross, DP, da Costa, BR, Ballenberger, N, Pereira, TV, Dennett, L, Armijo-Olivo, S

“…NMAs will be conducted to rank interventions according to their effectiveness and safety (when possible), allowing a comprehensive analysis of all available evidence, with different nodes specified for all conservative interventions of interest, placebo, sham therapy, and non-intervention control. Major findings/summary of interpretations/conclusions: This NMA will help clinicians and the scientific community choose the most effective strategy or combinations of strategies for treating neck pain. …”

Investigation into ion channel- and nitric oxide-mediated vasodilation in resistance arteries by Wallis, LE

“…</p> <br> <p>Overall, these findings enhance our understanding of microvascular function and provide a basis for further research which may have significant clinical implications.…”

The role of tumour necrosis factor alpha stimulated gene-6 on bone by Afrough, S

“…</p> <p>Contrary to its previously reported inhibitory effects on osteoblastogenesis, this thesis shows, for the first time, that TSG-6 displays context-specific anabolic properties. This finding implies a therapeutic value for the protein, with possibilities of being used in conjunction with BMP-2 to treat local bone injuries such as fractures.…”

Effect of intra-articular corticosteroid injections for osteoarthritis on the subsequent use of pain medications: a UK CPRD cohort study by Hawley, S, Prats Uribe, A, Matharu, GS, Delmestri, A, Prieto Alhambra, D, Judge, A, Whitehouse, MR

“…</p> <br> <p><strong>Conclusions:</strong> IACI for knee or hand osteoarthritis showed lower incidence of several pain medications over the longer-term relative to no IACI use. Secondary findings suggest IACI may be effective in reducing longer-term use of opioid-nonopioid analgesic combinations for patients with knee, hip, hand, or shoulder osteoarthritis.…”

Global glucose metabolism rate as diagnostic marker for disorder of consciousness of patients: quantitative FDG-PET study by Liu, D, Wang, N, Song, M, Chai, X, He, Q, Cao, T, Kong, D, Song, Z, Zhang, G, Liu, L, Wang, X, Chen, G, Yin, S, Yang, Y, Zhao, J

“…The best classification rate in the derivation cohort was achieved at a metabolic index of 3.32 (41% of the mean cortical metabolic index in healthy controls). Conclusion: Our findings demonstrate that conscious awareness requires a minimum of 41% of normal cortical activity, as indicated by metabolic rates.…”

The impact of psoriatic arthritis on quality of life: a systematic review by James, L, Hailey, L, Suribhatia, R, McGagh, D, Amarnani, R, Bundy, C, Kirtley, S, O'Sullivan, D, Steinkoenig, I, White, J, Vivekanantham, A, Coates, LC

“…</p> <br> <p><strong>Results:</strong> The study included 37 comprehensive studies that examined the impact of PsA on QoL and physical function. The findings revealed that the impact of PsA extends to various aspects of life, including activities of daily living, physical, and emotional aspects, such as fatigue, sleep disturbance, anxiety and depression. …”

Clinical outcomes of patients with unsuccessful mechanical thrombectomy versus best medical management of medium vessel occlusion stroke in the middle cerebral artery territory by Faizy, TD, Yedavalli, V, Salim, HA, Lakhani, DA, Musmar, B, Adeeb, N, Essibayi, MA, Daraghma, M, El Naamani, K, Henninger, N, Sundararajan, SH, Kuhn, AL, Khalife, J, Ghozy, S, Scarcia, L, Yeo, LL, Tan, BY, Regenhardt, RW, Heit, JJ, Cancelliere, NM, Rouchaud, A, Fiehler, J, Sheth, SA, Puri, AS, Dmytriw, AA

“…Conclusion: Unsuccessful MT for MeVO was linked to worse outcomes than best MM. These findings highlight the risks of prolonged attempts and emphasize the importance of efficient procedural decision-making to reduce complications and improve patient outcomes.…”

Exploring effects of calcitonin and procalcitonin in cardiomyocytes by Moreira, LMF

“…In contrast, I have not observed any evidence of PCT binding to CTRs, but instead uncovered, through PCT interactome studies, a previously unknown direct interaction of PCT with a subunit of L-type calcium channel, LTCC (α2δ3), which was also associated with a decrease in ERK1/2 phosphorylation.</p> <p>These findings suggest that CT and PCT exert opposite effects on the function of atrial CMs. …”

Combining detection dogs and camera traps improves minimally-invasive population monitoring for the cheetah, an elusive and rare large carnivore by Verschueren, S, Hofmann, T, Schmidt-Küntzel, A, Kakove, M, Munyandi, B, Bauer, H, Balkenhol, N, Leirs, H, Neumann, S, Cristescu, B, Marker, L

“…We showed that complementing detection dog surveys with camera trapping can comprehensively and efficiently inform occurrence patterns for an exceptionally wide-ranging terrestrial carnivore. Our findings provide practical guidance for designing effective minimally-invasive monitoring programs, which are important for empirically deriving distribution maps of cheetahs and other carnivores in data-poor regions.…”

Policy design and professional service delivery performance of drinking water services in rural Mali by Wagner, J

“…</p> <br> <p>Guided by contract and consumer demand theories, the findings indicate that any rural water contract is likely to be incomplete due to the inability to guarantee user demand. …”

Exploring population structure, antibiotic resistance and horizontal gene transfer in Neisseria gonorrhoeae by Unitt, A

“…</p> <p>Together, these results provide an improved understanding of <em>N. gonorrhoeae</em> genetics with implications for public health: informing efforts to survey and suppress the evolution of resistance inducing mosaic <em>penA</em> alleles, and describing how gonococcal population structure relates to features such as geographical location and antibiotic resistance, while providing a publicly available lineage nomenclature for future analyses. These findings highlight the advantages of using population-level analysis of bacterial whole genome sequence data to reveal new facets of pathogen biology.…”

Early, very high-titre convalescent plasma therapy in clinically vulnerable individuals with mild COVID-19 (COVIC-19): protocol for a randomised, open-label trial by Desmarets, M, Hoffmann, S, Vauchy, C, Rijnders, BJA, Toussirot, E, Durrbach, A, Körper, S, Schrezenmeier, E, van der Schoot, CE, Harvala, H, Brunotte, G, Appl, T, Seifried, E, Tiberghien, P, Bradshaw, D, Roberts, DJ, Estcourt, LJ, Schrezenmeier, H

“…Signed informed consent will be obtained from all included patients. The findings will be published in peer-reviewed journals and presented at relevant stakeholder conferences and meetings.…”

Canadians' opinions towards COVID-19 data-sharing: a national cross-sectional survey by Savić Kallesøe, SA, Rabbani, T, Gill, EE, Brinkman, F, Griffiths, EJ, Zawati, M, Liu, H, Palmour, N, Joly, Y, Hsiao, WWL

“…<p><strong> Conclusions </p></strong> These findings suggest that the Canadian public is generally favourable to deidentified data-sharing. …”

Identifying falsified COVID-19 vaccines by analysing vaccine vial label and excipient profiles using MALDI-ToF mass spectrometry by Arman, BY, Clarke, R, Bharucha, T, Gomez Fernandez, L, Walsby-Tickle, J, Deats, M, Mosca, S, Lin, Q, Banerjee, S, Chunekar, S, Patil, K, Gairola, S, Dunachie, S, Merchant, H, Stokes, R, Kuwana, R, Maes, A, Charrier, J-P, Probert, F, Caillet, C, Matousek, P, McCullagh, J, Newton, P, Zitzmann, N, Gangadharan, B

“…Furthermore, even if a falsified product contained polysorbate 80 at the same concentration as used in the genuine vaccine, the characteristic spectral profile of polysorbate 80 used in genuine products is a reliable internal marker for vaccine authenticity. Our findings demonstrate that MALDI-ToF MS analysis of extracts from vial labels and the vaccine excipients themselves can be used independently to detect falsified vaccines. …”

Intersection between individual, household, environmental and system level factors in defining risk and resilience for children in Kenya’s ASAL: A qualitative study by Chongwo, EJ, Aoko, B, Kaniala, M, Esala, M, Magoma, P, Njoroge, E, Nyamanya, S, Marangu, J, Khamis, A, Ng’asike, J, Huizink, AC, Abubakar, A

“…Results: The mean age of the participants was 44years (SD = 11 years). The findings, viewed through the lens of Bronfenbrenner’s ecological systems theory, reveal a complex interplay of contextual factors impacting children’s development. …”

Quality and outcomes of diabetes care in patients diagnosed with cancer by Griffiths, R

“…<b>Conclusions and Implications</b>: Overall, the findings indicate that diabetes is not overlooked in older breast, colorectal, or prostate cancer patients. …”

Technology integration in newborn care: examining communication and decision-making among health professionals in Kenyan hospitals by Ngaiza, GK

“…Combining inductive and deductive coding, the thematic data analysis identified key themes and built explanations.</p> <p>Findings reveal that physical context elements, such as adequate staffing, patient rooms in close proximity and health professionals’ communal congregation area promote more frequent and in-depth communication among health professionals using CPAP and phototherapy. …”

Combined electron imaging and diffraction methods for understanding disordered rocksalt cathodes by Hedley, E

“…</p> <br> <p>The aforementioned digression into optimising the handling of 4D-STEM data involves an in-depth investigating the feasibility of ptychographyic reconstructions from event-based binary data. The investigation finds the method effectively reduces the data storage and processing memory requirements. …”

Associations between snoring, body mass index and coronary artery diseases: observational and mendelian randomization study in Asia by Zhu, Y, Lan, Y, Lv, J, Sun, D, Pei, P, Yang, L, Millwood, IY, Walters, RG, Chen, Y, Du, H, Wang, J, Yang, X, Stevens, R, Chen, J, Chen, Z, Li, L, Yu, C

“…The causal associations were independent of BMI. These findings indicated that snoring intervention might contribute to the decrease of CAD risk among Asians.…”