Exploring effects of calcitonin and procalcitonin in cardiomyocytes by Moreira, LMF

“…In contrast, I have not observed any evidence of PCT binding to CTRs, but instead uncovered, through PCT interactome studies, a previously unknown direct interaction of PCT with a subunit of L-type calcium channel, LTCC (α2δ3), which was also associated with a decrease in ERK1/2 phosphorylation.</p> <p>These findings suggest that CT and PCT exert opposite effects on the function of atrial CMs. …”

Combining detection dogs and camera traps improves minimally-invasive population monitoring for the cheetah, an elusive and rare large carnivore by Verschueren, S, Hofmann, T, Schmidt-Küntzel, A, Kakove, M, Munyandi, B, Bauer, H, Balkenhol, N, Leirs, H, Neumann, S, Cristescu, B, Marker, L

“…We showed that complementing detection dog surveys with camera trapping can comprehensively and efficiently inform occurrence patterns for an exceptionally wide-ranging terrestrial carnivore. Our findings provide practical guidance for designing effective minimally-invasive monitoring programs, which are important for empirically deriving distribution maps of cheetahs and other carnivores in data-poor regions.…”

Policy design and professional service delivery performance of drinking water services in rural Mali by Wagner, J

“…</p> <br> <p>Guided by contract and consumer demand theories, the findings indicate that any rural water contract is likely to be incomplete due to the inability to guarantee user demand. …”

Exploring population structure, antibiotic resistance and horizontal gene transfer in Neisseria gonorrhoeae by Unitt, A

“…</p> <p>Together, these results provide an improved understanding of <em>N. gonorrhoeae</em> genetics with implications for public health: informing efforts to survey and suppress the evolution of resistance inducing mosaic <em>penA</em> alleles, and describing how gonococcal population structure relates to features such as geographical location and antibiotic resistance, while providing a publicly available lineage nomenclature for future analyses. These findings highlight the advantages of using population-level analysis of bacterial whole genome sequence data to reveal new facets of pathogen biology.…”

Early, very high-titre convalescent plasma therapy in clinically vulnerable individuals with mild COVID-19 (COVIC-19): protocol for a randomised, open-label trial by Desmarets, M, Hoffmann, S, Vauchy, C, Rijnders, BJA, Toussirot, E, Durrbach, A, Körper, S, Schrezenmeier, E, van der Schoot, CE, Harvala, H, Brunotte, G, Appl, T, Seifried, E, Tiberghien, P, Bradshaw, D, Roberts, DJ, Estcourt, LJ, Schrezenmeier, H

“…Signed informed consent will be obtained from all included patients. The findings will be published in peer-reviewed journals and presented at relevant stakeholder conferences and meetings.…”

Canadians' opinions towards COVID-19 data-sharing: a national cross-sectional survey by Savić Kallesøe, SA, Rabbani, T, Gill, EE, Brinkman, F, Griffiths, EJ, Zawati, M, Liu, H, Palmour, N, Joly, Y, Hsiao, WWL

“…<p><strong> Conclusions </p></strong> These findings suggest that the Canadian public is generally favourable to deidentified data-sharing. …”

Identifying falsified COVID-19 vaccines by analysing vaccine vial label and excipient profiles using MALDI-ToF mass spectrometry by Arman, BY, Clarke, R, Bharucha, T, Gomez Fernandez, L, Walsby-Tickle, J, Deats, M, Mosca, S, Lin, Q, Banerjee, S, Chunekar, S, Patil, K, Gairola, S, Dunachie, S, Merchant, H, Stokes, R, Kuwana, R, Maes, A, Charrier, J-P, Probert, F, Caillet, C, Matousek, P, McCullagh, J, Newton, P, Zitzmann, N, Gangadharan, B

“…Furthermore, even if a falsified product contained polysorbate 80 at the same concentration as used in the genuine vaccine, the characteristic spectral profile of polysorbate 80 used in genuine products is a reliable internal marker for vaccine authenticity. Our findings demonstrate that MALDI-ToF MS analysis of extracts from vial labels and the vaccine excipients themselves can be used independently to detect falsified vaccines. …”

An aerodynamic investigation of a high-pressure turbine using rotor casing static pressure measurements at engine representative conditions with different tip designs, tip gaps and... by Singh, D, Beard, PF, Cardwell, D, Staelens, V, Bahulekar, P, Stokes, M, Bather, S, Chana, KS

“…However, the majority of the present findings are based on linear cascade or low-speed rotational studies, due to the high cost of the experiments and difficulty in instrumentation at engine conditions. …”

Intersection between individual, household, environmental and system level factors in defining risk and resilience for children in Kenya’s ASAL: A qualitative study by Chongwo, EJ, Aoko, B, Kaniala, M, Esala, M, Magoma, P, Njoroge, E, Nyamanya, S, Marangu, J, Khamis, A, Ng’asike, J, Huizink, AC, Abubakar, A

“…Results: The mean age of the participants was 44years (SD = 11 years). The findings, viewed through the lens of Bronfenbrenner’s ecological systems theory, reveal a complex interplay of contextual factors impacting children’s development. …”

Technology integration in newborn care: examining communication and decision-making among health professionals in Kenyan hospitals by Ngaiza, GK

“…Combining inductive and deductive coding, the thematic data analysis identified key themes and built explanations.</p> <p>Findings reveal that physical context elements, such as adequate staffing, patient rooms in close proximity and health professionals’ communal congregation area promote more frequent and in-depth communication among health professionals using CPAP and phototherapy. …”

Combined electron imaging and diffraction methods for understanding disordered rocksalt cathodes by Hedley, E

“…</p> <br> <p>The aforementioned digression into optimising the handling of 4D-STEM data involves an in-depth investigating the feasibility of ptychographyic reconstructions from event-based binary data. The investigation finds the method effectively reduces the data storage and processing memory requirements. …”

Associations between snoring, body mass index and coronary artery diseases: observational and mendelian randomization study in Asia by Zhu, Y, Lan, Y, Lv, J, Sun, D, Pei, P, Yang, L, Millwood, IY, Walters, RG, Chen, Y, Du, H, Wang, J, Yang, X, Stevens, R, Chen, J, Chen, Z, Li, L, Yu, C

“…The causal associations were independent of BMI. These findings indicated that snoring intervention might contribute to the decrease of CAD risk among Asians.…”

CipherTrace: automatic detection of ciphers from execution traces by Hassanin, MA

“…Finally, we report the findings, observations, limitations, and assert the feasibility and scalability of the concept, the dynamic analysis approach, as well as the technique applied to identify cryptographic (crypto) elements to classify a cipher. …”

Distinct Circle of Willis anatomical configurations in healthy preterm born adults: a 3D time-of-flight magnetic resonance angiography study by Greggio, J, Malamateniou, C, Baruteau, KP, Reyes-Aldasoro, CC, Huckstep, OJ, Francis, JM, Williamson, W, Leeson, P, Lewandowski, AJ, Lapidaire, W

“…Future work should focus on larger prospective studies and explore the implications of these findings for normal development and cerebrovascular disease. …”

Assessing the kinetics of oxygen-unloading from red cells using FlowScore, a flow-cytometric proxy of the functional quality of blood by Rabcuka, J, Smethurst, P, Dammert, K, Saker, J, Aran, G, Walsh, G, Tan, J, Codinach, M, McTaggart, K, Marks, D, Bakker, S, McMahon, A, Di Angelantonio, E, Roberts, D, Blonski, S, Korczyk, P, Shirakami, A, Cardigan, R, Swietach, P

“…Experiments compared freshly-drawn RBCs with stored RBCs, wherein metabolic run-down and spherical remodelling hinder oxygen unloading. <p><strong> Findings: </p></strong>Multivariable regression related τ to a ratio of side- and forward-scatter, referred to herein as FlowScore. …”

Effectiveness of fludrocortisone plus hydrocortisone versus hydrocortisone alone in septic shock: a systematic review and network meta-analysis of randomized controlled trials by Teja, B, Berube, M, Pereira, TV, Law, AC, Schanock, C, Pang, B, Wunsch, H, Walkey, AJ, Bosch, NA

“…Although we undertook several sensitivity analyses and assessments, these findings should be considered while also acknowledging the heterogeneity of included trials.…”

Profiling the growth conditions and persistent organic pollutants (POPS) tolerance of Phenoliferia glacialis USM-PSY62 by Ain Nur Afifah Azman, Shazilah Kamaruddin, Quay, Doris Huai Xia, Farah Diba Abu Bakar, Noor Haza Fazlin Hashim, Abdul Munir Abdul Murad, Izwan Bharudin

“…Interestingly, the psychrophilic yeast presented growth in media supplemented with Persistent Organic Pollutants (POPs) such as dichlorophenyldichloroethylene (DDE) and polychlorinated biphenyl (PCB). These preliminary findings suggest that P. glacialis USM-PSY62 has tremendous potential for bioremediation application in polluted cold regions, as well as deepening our knowledge of its optimal growth conditions.…”
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Association between gestational bisphenol a exposure and maternofoetal outcomes: a cohort study in a single tertiary hospital in Klang Valley by Juliana Yusof, Sarah Zulkifli, Mohd Shahril Ahmad Saman, Danial Efendy Goon, Nurliana Abd Mutalib, Nur Izzaty Yusnazery, Izzuan Khirman Adnan, Siti Hamimah Sheikh Abdul Kadir

“…Babies who need NICU admission were born to mothers who exhibited significantly different urinary BPA levels compared to those whose babies were not admitted (p=0.049). Finding from this study suggestive of further investigation on level of gestational urinary BPA with NICU admission, ideally with a larger sample size to validate these results.…”
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Comparative study of modeling, drying kinetics and specific energy consumption of desiccated coconut during convective and infrared drying by S., Yahya, A., Mohd Shamsul, A.G., Nur Hamizah, M.N., Mohd Zuhair

“…Experimental drying curves displayed only a falling drying rate period. The experimental findings demonstrated that drying temperature, air velocity, and drying techniques had a substantial impact on drying kinetics. …”
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Exploring critical components of physician-patient communication: a qualitative study of lay and professional perspectives by Mohd Salim, Nurul, Roslan, Nurhanis, Hod, Rafidah, Zakaria, Syahiera, Adam, Siti

“…We also found that the patients and relatives had a lack of awareness on confidentiality issues. These findings provide an insight on the improvement of medical training and patient education to improve patient care. …”
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