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2841
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2842
Dysregulation of the Pdx1/Ovol2/Zeb2 axis in dedifferentiated β-cells triggers the induction of genes associated with epithelial-mesenchymal transition in diabetes
Published 2022“…We carried out loss- and gain-of-function experiments in MIN6 and EndoC-bH1 cell lines. We analysed previously published mouse andhuman T2D data sets.Results:Bulk RNA-seq revealed thatb-cell dedifferentiation is associated with the induction of genes associated with epithelial-to-mesenchymal transition (EMT) in prediabetic (2-week-old) and diabetic (12-week-old) Tg7 mice. …”
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Journal Article -
2843
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2844
Conformational design characterization of a truncated diamine oxidase
Published 2014“…By maintaining the native protein’s pH profile, the mini protein was highly active at 40 °C and stable at pH 7, with a half-life of 80 min at 50 °C. Results from the kinetic studies showed that the Km value for native diamine oxidase was 0.274 mM and 1.3 mM for the mini protein. …”
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Thesis -
2845
Tropical peat subsidence, nutrient losses and oil palm seedling growth due to different water table depths
Published 2018“…The system was made of exchange chamber of air pump with the flow rate ranges between 1 and 3.5 L min-1, exchange chamber of (2670 mL plastic container) and a trap (250 mL Erlenmeyer flask). …”
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Thesis -
2846
The prospective associations of 24-hour movement behaviors and domain-specific activities with executive function and academic achievement among school-aged children in Singapore
Published 2024“…Background: Physical activity (PA), sedentary behavior (SB), and sleep are collectively referred to as 24-h movement behaviors, which may be linked to cognitive development in children. However, most of the evidence was based on cross-sectional studies and/or solely relied on parent-reported information on children’s behaviors, and it remains uncertain whether all domains/contexts of PA and SB are similarly associated with executive function and academic achievement. …”
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Journal Article -
2847
Understanding the role of Enterococcus faecalis in polymicrobial wounds
Published 2023“…Since E. faecalis T7SS encodes toxins involved in bacterial competition, but not the MPT and EET systems, I hypothesized that a link between the energy metabolism systems and the T7SS may exist. …”
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Thesis-Doctor of Philosophy -
2848
Integrative genomic analyses in adipocytes implicate DNA methylation in human obesity and diabetes
Published 2023Get full text
Journal Article -
2849
An omics-based machine learning approach to predict diabetes progression: a RHAPSODY study
Published 2024Get full text
Journal Article -
2850
Using brain structural neuroimaging measures to predict psychosis onset for individuals at clinical high-risk
Published 2024Get full text
Journal Article -
2851
The effects of atmosphere-ocean-wave coupling during tropical cyclone
Published 2018“…This transfer of momentum (from atmosphere to ocean) is not a one-way link, i.e., there are feedback effects from ocean (both in terms of enthalpy and momentum) on the atmospheric boundary layer. …”
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Thesis-Doctor of Philosophy -
2852
HiPIMS deposition of VO2 thermochromic coating for enhanced optical properties
Published 2022“…In chapter 4, a HiPIMS deposition technique for VO2(M) thin film on a commercial material, such as soda-lime glass substrate, was established with a high deposition rate of 5.7 nm/min. The VO2(M) deposited on soda-lime glass exhibits excellent crystallinity and thermochromic properties (highest luminous transmission Tlum ≈ 30.4%, and solar modulation ΔTsol ≈ 12%) in comparison with similarly prepared VO2 on high temperature glass and quartz substrates. …”
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Thesis-Doctor of Philosophy -
2853
Evaluation of paper spray mass spectrometry for direct analysis of small molecule drugs and hemoglobin constant spring peptide markers
Published 2016“…Further application of the PS-MS assay to preclinical pharmacokinetic (PK) study found that, the assay was simple and rapid with overall analysis time of 1 min and a full plasma concentration vs. time profile of sunitinib could be obtained from a single mouse. …”
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Thesis -
2854
Antimicrobial activity, phytochemical and toxicity analyses of salam [Syzygium polyanthum (Wight) Walp.] leaf extract and its application in food
Published 2018“…Generally the significant reduction of natural microflora in tested food samples were started at 0.50% (v/v) of extract at 5 min. During storage, 5% (v/v) showed better effect in controlling the microbial survival throughout the storage time. …”
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Thesis -
2855
High p16 expression and heterozygous RB1 loss are biomarkers for CDK4/6 inhibitor resistance in ER+ breast cancer
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Journal Article -
2856
Observation of flat bands and Dirac cones in a pyrochlore lattice superconductor
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Journal Article -
2857
A machine-learned approach for reducing airborne delays and environmental impact in terminal manoeuvring area using extended arrival management
Published 2024“…Air traffic management divides the airspace into three sections: the airport control zone (taxiing, takeoff, landing), the terminal manoeuvring area (TMA, for climbs and descents), and the en-route airspace (cruise). The TMA, a critical link between en-route airspace and the airport, is a major source of airborne delays. …”
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Thesis-Doctor of Philosophy -
2858
Health monitoring, lifetimes estimation, and thermal management of IGBT-based power converters
Published 2017“…Reliability of a power converter is mainly verbalized by the failure rate of power semiconductor device and dc-link capacitor. For instance, in applications demanding higher reliability, electrolytic capacitors are swapped with film capacitors, since they exhibit lower equivalent series resistance (ESR) with increased reliability. …”
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Thesis -
2859
论阮籍诗文中的逃避主义 = Escapism in the literary works of Ruan Ji
Published 2014“…Next, this thesis will introduce Ruan Ji and seek to link the concept of escapism with Ruan Ji’s literary works. …”
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Final Year Project (FYP) -
2860
Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits
Published 2020Get full text
Journal Article