The protocol of a clinical effectiveness trial comparing standard step-up care, early combination DMARD therapy and early use of TNF inhibitors for the treatment of moderate to sev... by Watson, M, Tillett, W, Jadon, D, Massa, MS, Francis, A, Gullick, N, Rombach, I, Sinomati, Y, Tucker, L, Coates, LC

“…Early use of biologics has also been shown to be superior to methotrexate but these drugs are costly and not usually funded first line. However, if a short course of biologics can rapidly suppress inflammation allowing treatment to be withdrawn and response maintained on methotrexate, this may be a cost-effective model for early use.…”

Implementing strategies to improve uptake of patient-reported outcome measures (PROMs) in gender-affirming care: a mixed-methods implementation study by Kamran, R, Jackman, L, Goodwin, C, Laws, A, Stepney, M, Harrison, C, Jain, A, Rodrigues, J

“…</p> <p><strong>Main outcome(s) and measure(s)</strong> Response rates were calculated at 2-week intervals, in line with the deployment of each implementation strategy. …”

Ultra-thin oxide films by Hu, X

“…Various sizes have been found, and sides of these equilateral triangles all show a double-line feature aligned along the 〈 1 ^ˉ<sub style="position: relative; left: -.4em;">1</sub> 0〉 directions of the Au(111) lattice. …”

Tinospora crispa ethanolic extract downregulates Protein Kinase genes expression and activity during Toxoplasma gondii infection: a prospective drug target for lytic cycle inhibiti... by Abdullahi, Sharif Alhassan, Nordin, Norshariza, Unyah, Ngah Zasmy, Basir, Rusliza, Daneji, Isa Muhammad, Nasiru, Wana Mohammed, Majid, Roslaini Abd

“…The aim of this study was to evaluate the in vitro activities of ethanolic extract of Tinospora crispa (EETC) on protein kinases involved in the lytic cycle of T. gondii infection in Vero cell line. The EETC was obtained through the maceration of dried stem powder. …”
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Identification of novel functional compounds from forest onion and its biological activities against breast cancer by Nurkolis, Fahrul, Kurniatanty, Isma, Wiyarta, Elvan, Permatasari, Happy Kurnia, Mayulu, Nelly, Taslim, Nurpudji Astuti, Tjandrawinata, Raymond Rubianto, Hardinsyah, Hardinsyah, Tallei, Trina Ekawati, Tsopmo, Apollinaire, Radu, Son, Hadinata, Edwin, Kim, Bonglee, Ribeiro, Rosy Iara Maciel Azambuja, Syahputra, Rony Abdi

“…Therefore, this study focuses on metabolite profiling, in silico or pharmacoinformatic activity and mechanisms, as well as advanced validation on in vitro cell lines. Ten compounds identified in E. bulbosa bulb ethanolic extract (EBE) showed cancer receptor and radical inhibitory activity via network pharmacology and molecular docking simulation. …”
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Design, synthesis and activity studies of antifreeze peptide derived from type I shorthorn sculpin by Asmawi, Azren Aida

“…Furthermore, these peptides have been proved to be non-cytotoxic on 3T3 cell line with IC50 value >100 μg/mL and have a positive impact on ice crystal growth in ice cream mixes. …”
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Attitudinal Factors of Fishermen Trapped in the B40 Category: an Empirical Study by Mustafar, Mastora, Mat Yamin, Fadhilah, Mohamed Ismail, Risyawati, Mohd Nawi, Nur Syazwani, Abu Bakar, Siti Zakiah, Johari, Ayub

“…However, its importance is not in line with the well-being of key players in the fishing industry itself, especially Zone A fishermen who are mostly in the Bottom 40% (B40) of household income category. …”
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Detection of road markings for advanced driver assistance by Suchitra Sathyanarayana

“…Evaluation of the AHPD on the 101 CMU object database confirms that it can successfully detect the major line features of interest, including lines of close proximity and lines of varying lengths amidst noise. …”
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Mechanism design for internet of things services market by Jiao, Yutao

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Enhanced flotation of high density polyethylene and polyvinyl chloride mixtures based on clean corona modification by Wang, Yinan, Zhao, Yue, Guo, Linyi, Han, Fengrong, Li, Xiaofeng

“…Since the corona modification is reagent-free-addition and rapid in-line process, this work showed great advantages in the total cost of separation (only 450.03 USD/t) and potential environmental benefits, which also paves a clean way for the recycling of HDPE and PVC.…”
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The influence of molasses concentration on the physical and mechanical properties of evaporation boat waste-based crucibles by Rusiyanto, Rusiyanto, Widodo, Rahmat Doni, Prasetyo, Ares Yudi, Fitriyana, Deni Fajar, Bahatmaka, Aldias, Sudiyono, Sudiyono, Setiadi, Rizki, Rengga, Wara Dyah Pita, Ismail, Rifky, Bayuseno, Athanasius Priharyoto, Priyatmojo, Anjar, Ramdhani, Wahyu, Arifiadi, Ferry, Ansori, Chusni, Irawan, Agustinus Purna, Cionita, Tezara, Siregar, Januar Parlaungan

“…The use of evaporation vessel waste and molasses in the production of crucibles in this study is in line with Sustainable Development Goals (SDGs) 3, 7, 14, and 15, which relate to improving excellent health and well-being, ensuring access to affordable energy, and conserving marine and terrestrial ecosystems.…”
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Positive innovative thinking based on the integration of spiritual knowledge through the subjects of design and technology by Zaipah, Ismail, Aede Hatib, Musta’amal @ Jamal, Nornazira, Suhairom, Rohana, Hamzah

“…However, the teaching and learning process and the existing curriculum often ignore the spiritual element, which can play an important role in forming positive innovative thinking and student morals. This research is in line with the Sustainable Development Goals (SDG), especially SDG 4 (Quality Education) and SDG 9 (Industry, Innovation, and Infrastructure), by emphasizing the integration of intellectual and spiritual knowledge education to produce students with positive innovative thinking and noble character. …”
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Mental-LLM: Leveraging Large Language Models for Mental Health Prediction via Online Text Data by Xu, Xuhai, Yao, Bingsheng, Dong, Yuanzhe, Gabriel, Saadia, Yu, Hong, Hendler, James, Ghassemi, Marzyeh, Dey, Anind K., Wang, Dakuo

“…We highlight the important ethical risks accompanying this line of research.…”
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Intermittent actuation attenuates fibrotic behaviour of myofibroblasts by Ward, Niamh A., Hanley, Shirley, Tarpey, Ruth, Schreiber, Lucien H.J., O'Dwyer, Joanne, Roche, Ellen T., Duffy, Garry P., Dolan, Eimear B.

“…Here, we use analytical, computational, and in vitro models to understand the response of human myofibroblasts (WPMY-1 stromal cell line) to intermittent actuation using soft robotics and investigate how actuation can alter the secretion of collagen and pro/anti-inflammatory cytokines by these cells. …”
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Device and material investigations of GaN enhancement-mode transistors for Venus and harsh environments by Xie, Qingyun, Niroula, John, Rajput, Nitul S., Yuan, Mengyang, Luo, Shisong, Fu, Kai, Isamotu, Mohamed Fadil, Palash, Rafid Hassan, Sikder, Bejoy, Eisner, Savannah R., Surdi, Harshad, Belanger, Aidan J., Darmawi-Iskandar, Patrick K., Aksamija, Zlatan, Nemanich, Robert J., Goodnick, Stephen M., Senesky, Debbie G., Hunter, Gary W., Chowdhury, Nadim, Zhao, Yuji, Palacios, Tomás

“…Through transistor, Transmission Line Method (TLM), and Hall-effect measurements vs temperature, it is revealed that the mobility decrease is the primary cause of reduction of on-state performance of this GaN transistor at high temperature. …”
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Using shock tube species time-histories in Bayesian parameter estimation: Effective independent-data number and target selection by Chen, Huaibo, Ji, Weiqi, Cassady, Séan J, Ferris, Alison M, Hanson, Ronald K, Deng, Sili

“…This further implies that several critical points can represent the entire line for point estimation. This paper can provide a reference both for modelers about reasonable utilization of species time-histories, and for experimentalists about the importance of a detailed probability distribution of measurement error, as well as experiment design with emphasis on critical points.…”
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Structure and dynamics of magnetic domain walls in multi-sublattice magnetic oxides by Huang, Siying

“…In EuIG(110) thin film with strong in-plane anisotropy, we demonstrate bistable Néel DW states interchangeable by in-plane field pulse-driven incoherent DW reversal, from which we extract for the first time the Bloch line energetics. Besides the above DW Néel character stabilization, we also provide a DW position stabilization on the racetracks by the exchange bias effect in Pt/Co/Pt/Co₀.₈Ni₀.₂O thin films. …”
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Orbital stability in a classical pilot-wave system by Liu, Nicholas Z.

“…Finally, we show that the instability of large circular orbits is related to the in-line speed oscillations of free walking droplets in a manner that is independent of the external force.…”
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FrED Manufacturing - A Study in Affordable Manufacturing to Scale using Desktop Sized Fiber Extrusion Device by Rosko, Rachael S.

“…In 2024, the aim for the lab was to implement design refinements, design for manufacturing, design the assembly line, design packaging, develop supply chain using Tulip, develop educational content, perform user testing, and execute pilot runs. …”
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The Europa Imaging System (EIS) Investigation by Turtle, E. P., McEwen, A. S., Patterson, G. W., Ernst, C. M., Elder, C. M., Slack, K. A., Hawkins, S. E., McDermott, J., Meyer, H., DeMajistre, R., Espiritu, R., Seifert, H., Niewola, J.

“…The WAC is designed to acquire three-line pushbroom stereo and color swaths along flyby ground-tracks.…”
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