Glycophorin C (CD236R) mediates vivax malaria parasite rosetting to normocytes by Malleret, Benoit, Lau, Yee-Ling, Lee, Wenn-Chyau, Mauduit, Marjorie, Fong, Mun-Yik, Cho, Jee Sun, Suwanarusk, Rossarin, Zhang, Rou, Albrecht, Letusa, Costa, Fabio T. M., Preiser, Peter, McGready, Rose, Renia, Laurent, Nosten, Francois, Russell, Bruce

“…Rosetting phenomenon has been linked to malaria pathogenesis. While rosetting occurs in all causes of human malaria, most data on this subject has been derived from Plasmodium falciparum. …”
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Leucine-rich α-2-glycoprotein 1 suppresses endothelial cell activation through ADAM10-mediated shedding of TNF-α receptor by Pang, Kuin Tian, Ghim, Mean, Liu, Chenghao, Tay, Hui Min, Fhu, Chee Wai, Chia, Rui Ning, Qiu, Beiying, Sarathchandra, Padmini, Chester, Adrian H., Yacoub, Magdi H., Wilkinson, Fiona L., Weston, Ria, Warboys, Christina M., Hou, Han Wei, Weinberg, Peter D., Wang, Xiaomeng

“…Mechanistically, LRG1 exerted its function by causing the shedding of TNFR1 via the ALK5-SMAD2 pathway and the subsequent activation of ADAM10. …”
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Rifaximin potentiates clarithromycin against Mycobacterium abscessus in vitro and in zebrafish by Goh, Boon Chong, Larsson, Simon, Dam, Linh Chi, Ling, Sharon Yan Han, Chua, Patrina Wei Lin, Abirami, R., Singh, Samsher, Ong, Ernest Jun Long, Teo, Jeanette W. P., Ho, Peiying, Ingham, Philip William, Pethe, Kevin, Dedon, Peter C.

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Counterproductive effects of anti-CD38 and checkpoint inhibitor for the treatment of NK/T cell lymphoma by Lee, Wendy W. L., Lim, Jing Quan, Tang, Tiffany Pooi Ling, Tan, Daryl, Koh, Ser Mei, Puan, Kia Joo, Wang, Liang Wei, Lim, Jackwee, Tan, Kim Peng, Chng, Wee Joo, Lim, Soon Thye, Ong, Choon Kiat, Rotzschke, Olaf

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Detection and characterisation of a sixth Candida auris clade in Singapore: a genomic and phenotypic study by Suphavilai, Chayaporn, Ko, Karrie Kwan Ki, Lim, Kar Mun, Tan, Mei Gie, Boonsimma, Patipan, Chu, Joash Jun Keat, Goh, Sui Sin, Rajandran, Prevena, Lee, Lai Chee, Tan, Kwee Yuen, Bushra Binte Shaik Ismail, Aung, May Kyawt, Yang, Yong, Sim, Jean Xiang Ying, Venkatachalam, Indumathi, Cherng, Benjamin Pei Zhi, Spruijtenburg, Bram, Chan, Kian Sing, Oon, Lynette Lin Ean, Tan, Ai Ling, Tan, Yen Ee, Wijaya, Limin, Tan, Ban Hock, Ling, Moi Lin, Koh, Tse Hsien, Meis, Jacques F., Tsui, Clement Kin Ming, Nagarajan, Niranjan

“…We aimed to characterise three unusual C auris isolates detected in Singapore, and to determine whether they constitute a novel clade distinct from all previously known C auris clades (I–V). Methods: In this genotypic and phenotypic study, we characterised three C auris clinical isolates, which were cultured from epidemiologically unlinked inpatients at a large tertiary hospital in Singapore. …”
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The novel quinoline derivative SKA-346 as a KCa3.1 channel selective activator by Wong, Brandon Han Siang, Shim, Heesung, Goay, Stephanie Shee Min, Ong, Seow Theng, Nur Ayuni Binte Muhammad Taib, Chai, Kelila Xin Ye, Lim, Kerry, Huang, Dachuan, Ong, Choon Kiat, Vaiyapuri, Thamil Selvan, Cheah, Yeong Cheng, Wang, Yulan, Wulff, Heike, Webster, Richard David, Shelat, Vishalkumar G., Verma, Navin Kumar

“…In silico analysis using RosettaLigand and GLIDE demonstrated a well-converged pose of SKA-346 in a binding pocket at the interface between the calmodulin N-lobe and the S45A helix in the S4-S5 linker of the KCa3.1 channel. SKA-346 (30 mg kg-1), tolerated by mice after intra-peritoneal administration, exhibited a peak plasma concentration of 6.29 μg mL-1 (29.2 μM) at 15 min and a circulating half-life (t 1/2) of 2.8 h. …”
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Increasing nausea and vomiting of pregnancy is associated with sex-dependent differences in early childhood growth: the GUSTO mother-offspring cohort study by Ong, Judith, Sadananthan, Suresh Anand, Soh, Shu-E, Ng, Sharon, Yuan, Wen Lun, Aris, Izzuddin M., Tint, Mya Thway, Michael, Navin, Loy, See Ling, Tan, Kok Hian, Godfrey, Keith M., Shek, Lynette P., Yap, Fabian, Lee, Yung Seng, Chong, Yap Seng, Chan, Shiao-Yng

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Electrostatic microfiltration (EM) enriches and recovers viable microorganisms at low-abundance in large-volume samples and enhances downstream detection by Liu, Yaoping, Raymond, Joshua J, Wu, Xiaolin, Chua, Patrina Wei Lin, Ling, Sharon Yan Han, Chan, Chia Ching, Chan, Cheryl, Loh, Joanne Xin Yi, Song, Melody Xing Yen, Ong, Matilda Yu Yan, Ho, Peiying, Mcbee, Megan E, Springs, Stacy L, Yu, Hanry, Han, Jongyoon

“…This study develops an efficient electrostatic microfiltration (EM)-based sample preparation technique capable of processing ultra-large-volume (≥500 mL) samples at high throughput (≥10 mL min−1). This approach achieves a significant enrichment (>8000×) of extremely-low-abundance pathogens (down to level of 0.02 CFU mL−1, i.e., 10 CFU in 500 mL). …”
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Alkali additives enable efficient large area (>55 cm²) slot-die coated perovskite solar modules by Rana, Prem Jyoti Singh, Febriansyah, Benny, Koh, Teck Min, Bening Tirta Muhammad, Salim, Teddy, Hooper, Thomas J. N., Kanwat, Anil, Ghosh, Biplab, Kajal, Priyanka, Lew, Jia Haur, Aw, Yeow Chong, Yantara, Natalia, Bruno, Annalisa, Pullarkat, Sumod A., Ager, Joel W., Leong, Wei Lin, Mhaisalkar, Subodh Gautam, Mathews, Nripan

“…The slot-die coated methylammonium-free perovskite module with an active area of 57.5 cm2 shows an efficiency of 16.22% and retains 82% of its initial efficiency after 4800 h under 30% relative humidity without encapsulation.…”
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Remote epitaxial interaction through graphene by Chang, Celesta S, Kim, Ki Seok, Park, Bo-In, Choi, Joonghoon, Kim, Hyunseok, Jeong, Junseok, Barone, Matthew, Parker, Nicholas, Lee, Sangho, Zhang, Xinyuan, Lu, Kuangye, Suh, Jun Min, Kim, Jekyung, Lee, Doyoon, Han, Ne Myo, Moon, Mingi, Lee, Yun Seog, Kim, Dong-Hwan, Schlom, Darrell G, Hong, Young Joon, Kim, Jeehwan

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Comparative analysis of pediatric COVID-19 infection in Southeast Asia, South Asia, Japan, and China by Wong, Judith Ju Ming, Abbas, Qalab, Chuah, Soo Lin, Malisie, Ririe Fachrina, Pon, Kah Min, Katsuta, Tomohiro, Dang, Hongxing, Lee, Pei Chuen, Jayashree, Muralidharan, Sultana, Rehena, Maha, Quratulain, Gan, Chin Seng, Shimizu, Naoki, Xu, Feng, Tang, Swee Fong, Shi, Luming, Lee, Jan Hau, Thoon, Koh Cheng, Yung, Chee Fu

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Longitudinal assessment of antibiotic resistance gene profiles in gut microbiomes of infants at risk of eczema by Loo, Evelyn Xiu Ling, Zain, Amanda, Yap, Gaik Chin, Purbojati, Rikky Wenang, Drautz-Moses, Daniela Isabel, Koh, Yanqing Michelle, Chong, Yap Seng, Tan, Kok Hian, Gluckman, Peter D., Yap, Fabian, Eriksson, Johan Gunnar, Tham, Elizabeth, Shek, Lynette Pei-Chi, Kjelleberg, Staffan, Schuster, Stephan Christoph, Banerjee, Ritu, Lee, Bee Wah

“…Beta-lactam resistant Escherichia coli and Klebsiella pneumoniae were detected in 4 (5.3%) and 32 (42.7%) of subjects respectively. …”
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Persistent symptoms and association with inflammatory cytokine signatures in recovered coronavirus disease 2019 patients by Ong, Sean Wei Xiang, Fong, Siew-Wai, Young, Barnaby Edward, Chan, Yi-Hao, Lee, Bernett, Siti Naqiah Amrun, Chee, Rhonda Sin-Ling, Yeo, Nicholas Kim-Wah, Tambyah, Paul, Pada, Surinder, Tan, Seow Yen, Ding, Ying, Renia, Laurent, Leo, Yee Sin, Ng, Lisa F. P., Lye, David C.

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Management of adult sepsis in resource-limited settings: global expert consensus statements using a Delphi method by Thwaites, L, Nasa, P, Abbenbroek, B, Dat, VQ, Finfer, S, Kwizera, A, Ling, L, Lobo, SM, Sinto, R, Aditianingsih, D, Antonelli, M, Arabi, YM, Argent, A, Azevedo, L, Bennett, E, Chakrabarti, A, De Asis, K, De Waele, J, Divatia, JV, Estenssoro, E, Evans, L, Faiz, A, Hammond, NE, Hashmi, M

Charting the path forward in Southeast Asia: Learning from the COVID-19 vaccination challenges in six ASEAN countries by Fu, Jolene Yin Ling, Pukhari, Muhammad Harith, Cruz, Kristine Alvarado-Dela, Soebandrio, Amin, Tan, Le Van, Jantarabenjakul, Watsamon, Sawitri, Anak Agung Sagung, Chantasrisawad, Napaporn, Yee, Sidney, Weng, Ruifen, Sundar, Raghav, Tan, Chee Wah, Wang, Lin-Fa, Sam, I-Ching, Young, Barnaby Edward, Sutarsa, I Nyoman, Chan, Yoke Fun

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High with low: harnessing the power of demand-side solutions for high wellbeing with low energy and material demand by Sugiyama, M, Wilson, C, Wiedenhofer, D, Boza-Kiss, B, Cao, T, Chatterjee, JS, Chatterjee, S, Hara, T, Hayashi, A, Ju, Y, Krey, V, Godoy León, MF, Martinez, L, Masanet, E, Mastrucci, A, Min, J, Niamir, L, Pelz, S, Roy, J, Saheb, Y, Schaeffer, R, Ürge-Vorsatz, D, van Ruijven, B, Shimoda, Y, Verdolini, E, Wiese, F, Yamaguchi, Y, Zell-Ziegler, C, Zimm, C

Profiling microbial communities in idiopathic granulomatous mastitis by Ong, Seeu Si, Xu, Jia, Sim, Choon Kiat, Khng, Alexis Jiaying, Ho, Peh Joo, Kwan, Philip Kam Weng, Ravikrishnan, Aarthi, Tan, Benita Kiat-Tee, Tan, Qing Ting, Tan, Ern Yu, Tan, Su-Ming, Putti, Thomas Choudary, Lim, Swee Ho, Tang, Serene Ee Ling, Nagarajan, Niranjan, Karnani, Neerja, Li, Jingmei, Hartman, Mikael

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Modifiable risk factor score and fecundability in a preconception cohort in Singapore by Loy, See Ling, Ku, Chee Wai, Tiong, Michelle Mei Ying, Ng, Carissa Shi Tong, Cheung, Yin Bun, Godfrey, Keith M., Lim, Shan Xuan, Colega, Marjorelee T., Lai, Jun Shi, Chong, Yap-Seng, Shek, Lynette Pei-Chi, Tan, Kok Hian, Chan, Shiao-Yng, Chong, Mary Foong-Fong, Yap, Fabian, Chan, Jerry Kok Yen

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Correlates of lifestyle patterns among children in Singapore aged 10 years: the growing up in Singapore towards healthy outcomes (GUSTO) study by Tan, Sarah Yi Xuan, Chia, Airu, Tai, Bee Choo, Toh, Jia Ying, Colega, Marjorelee, Padmapriya, Natarajan, Setoh, Peipei, Kee, Michelle Zhi Ling, Yuan, Wen Lun, Lee, Yung Seng, Loo, Benny Kai Guo, Yap, Fabian Kok Peng, Tan, Kok Hian, Godfrey, Keith M., Chong, Yap Seng, Eriksson, Johan, Müller-Riemenschneider, Falk, Chong, Mary Foong-Fong

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Graphene nanopattern as a universal epitaxy platform for single-crystal membrane production and defect reduction by Kim, Hyunseok, Lee, Sangho, Shin, Jiho, Zhu, Menglin, Akl, Marx, Lu, Kuangye, Han, Ne Myo, Baek, Yongmin, Chang, Celesta S., Suh, Jun Min, Kim, Ki Seok, Park, Bo-In, Zhang, Yanming, Choi, Chanyeol, Shin, Heechang, Yu, He, Meng, Yuan, Kim, Seung-Il, Seo, Seungju, Lee, Kyusang, Kum, Hyun S., Lee, Jae-Hyun, Ahn, Jong-Hyun, Bae, Sang-Hoon, Hwang, Jinwoo, Shi, Yunfeng, Kim, Jeehwan

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