Using Sequenom to identify KRAS mutations in an Asian cohort of ovarian mucinous cancer by Tiong, Wen Ning

“…While there are distinct differences between mucinous epithelial ovarian cancer (mEOC) and the other subtypes of EOC, a standard treatment regimen is followed for all EOC histotypes. KRAS mutations have been observed to occur in relatively high frequencies of 50-60% in mEOC but not in other subtypes of EOC in at least three clinical studies. …”
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Development of a powermeter for a bicycle – I by Pillarisetty Venkata Pranav

“…More than just being a mode of transportation, bicycling has caught on as a competitive sport in many parts of the world and as an exercise regimen by a sizeable fraction of the global population. …”
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First-line chemotherapy for advanced ovarian cancer: paclitaxel, cisplatin and the evidence by Sandercock, J, Parmar, MKB, Torri, V

“…Two of the reported trials (GOG-111 and the Intergroup trial) provide clear evidence that cisplatin combined with paclitaxel is a more effective regimen than one using the same dose of cisplatin combined with cyclophosphamide. …”

Autoinhibition releasing provides a platform for developing p21-activated kinase-1 (PAK1) activators for hypertrophic heart diseases by He, Y

“…PAK1 activators demonstrated substantial efficacy in preventing isoprenaline (ISO)-induced hypertrophy and exhibited the capacity to regress pre-existing cellular hypertrophy following ISO treatment in neonatal rat cardiomyocytes. …”

A systems biology approach to define SARS-CoV-2 correlates of protection in non-human primates by Brady, C

“…Novel predictors of protection included low peripheral intermediate monocyte prevalence during the vaccination regimen and low seasonal coronavirus IgG at baseline - parameters which also predicted high spike IgG titres post- vaccination. …”

Next generation design of floating systems for coastal solar farms by Bi, Cheng

“…In the single-barrier-platform system, the barrier is installed in front of the platform, and significant reduction in platform displacement can be achieved when the barrier is in the membrane-like hydroelastic regime with relatively high rigidity and has a penetration more than 40% of water depth. …”
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Hollow microcapsules as periocular drug depot for sustained release of anti-VEGF protein by Radhakrishnan, Krishna, Vincent, Anita, Joseph, Rini Rachel, Moreno, Miguel, Dickescheid, Andreas, Agrawal, Rupesh, Venkatraman, Subbu S.

“…The current treatment regimen for such diseases involves repeated intravitreal injections of anti- Vascular Endothelial Growth Factor (VEGF) proteins. …”
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Elucidating the role of metabolic changes in modulating cell fate following treatment with anti-mitotic drugs by Wong, Alex Xing Fah

“…Better understanding of the cellular pathways underlying this escape from antimitotic drug-induced cell death, known as mitotic slippage, is crucial for development of combinatorial therapies that can enhance existing treatment regimen in patients. Mitotic slippage describes a phenomenon where cells escape mitotic arrest and cell death following treatment with anti-mitotic drugs, and "slip" into interphase without proper chromosome segregation and cytokinesis. …”
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Evaluating new malaria vaccine candidates by Noé, A

“…Liver-resident memory CD8+ T cells (TRM) are necessary for protection against rodent malaria by this vaccine regimen. Ultimately, to most faithfully assess immunological responses by these local, specialised, hepatic T cells, periodic liver sampling is necessary. …”

Exploring the therapeutic potential of 5-fluorouracil-loaded calcium carbonate nanoparticles combined with natural compound thymoquinone for colon cancer treatment by Deng, Xi, Yang, Zhongming, Chan, Kim Wei, Abu Bakar, Md Zuki

“…These results provide evidence for 5FU-CaCO3np as a novel regimen against colon cancer. Combining 5FU-CaCO3np and TQ may offer a new perspective for colon cancer therapy.…”
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Fedratinib combined with ropeginterferon alfa-2b in patients with myelofibrosis (FEDORA): study protocol for a multicentre, open-label, Bayesian phase II trial by McIlroy, G, Gaskell, C, Jackson, A, Yafai, E, Tasker, R, Thomas, C, Fox, S, Boucher, R, Ghebretinsea, F, Harrison, C, Mead, AJ, McMullin, MF

“…FEDORA uses a within-patient dose escalation regimen to ensure each patient reaches a personalised dose combination that is acceptable. …”

May measurement month 2022: an analysis of blood pressure screening findings from Sierra Leone by Jalloh, MB, Williams, CEE, Jegede, OG, Malijan, GMB, Naveed, A, Kanu, A, Bah, AK, Jalloh, F, Jalloh, A, Faulkner, MMJ, Agboola, K, Baldeh, M, Russell, JBW, Oladapo, OO

“…Notably, 42.9% of the participants with known hypertension did not adhere to their antihypertensive medication regimen, citing cost, availability, side effects, and forgetfulness as common reasons. …”

Evaluation of subconjunctival liposomal steroids for the treatment of experimental uveitis by Wong, Chee Wai, Czarny, Bertrand, Metselaar, Josbert M., Ho, Candice, Ng, Si Rui, Barathi, Amutha Veluchamy, Storm, Gert, Wong, Tina T.

“…The current gold standard for treatment is topical steroids, but low ocular bioavailability and compliance issues with the intensive dosing regimen limit the efficacy of this treatment. Liposomes as a drug delivery system may help to overcome these problems. …”
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Repurposing nitroxoline to address antibiotic resistance in the production of poultry for consumption by Zhou, Y

“…<em>In-vivo</em> evaluation (Chapter 5) established an optimal dosage regimen (100 mg/kg of NTX in feed) for treating <em>Salmonella</em> infections in poultry without promoting the development of resistance. …”

Cytisine versus varenicline for smoking cessation in a primary care setting: a randomized non-inferiority trial by Oreskovic, T, Percac-Lima, S, Ashburner, JM, Tiljak, H, Rifel, J, Klemenc Ketiš, Z, Oreskovic, S

“…Given the much lower cost of cytisine treatment, its lower rate of adverse events, and higher feasibility (but its likely lower effectiveness with the standard dosage regimen), future analyses should assess the cost-effectiveness of the two treatments for health policy considerations.…”

STandards for reporting interventions in clinical trials of tuina/massage (STRICTOTM): extending the CONSORT statement by Zhang, Xuan, Liang, Feng, Lau, Chung Tai, Chan, Jacky C. P., Wang, Nana, Deng, Jiashuai, Wang, Juan, Ma, Yanfang, Zhong, Linda Lidan, Zhao, Chen, Yao, Liang, Wu, Taixiang, Lyu, Aiping, Tian, Guihua, Shang, Hongcai, Miao, Jiangxia, Bian, Zhaoxiang

“…Results: A checklist of seven items (namely Tuina/Massage rationale, details of Tuina/Massage, intervention regimen, other components of the intervention, Tuina/Massage provider background, control or comparator interventions, and precaution measures), and 16 subitems were developed. …”
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Investigations into femtosecond laser hybrid manufacturing for 3D power sources by Tham, Nicholas Cheng Yang

“…A thermally localised laser graphitisation (LLG) regime can then be identified to achieve in-situ PG integration. …”
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A comparative analysis of missing data imputation techniques on sedimentation data by Loh, Wing Son, Ling, Lloyd, Chin, Ren Jie, Lai, Sai Hin, Loo, Kar Kuan, Seah, Choon Sen

“…A comparative analysis on the missing fine sediment data imputation performance was made based on four different techniques, namely the k-Nearest Neighbourhood (k-NN), Support Vector Regression (SVR), Multiple Regression (MR), and Artificial Neural Network (ANN), under the single imputation (SI) and multiple imputation (MI) regimes. …”
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Modelling the rheology of living cell cytoplasm: poroviscoelasticity and fluid-to-solid transition by Thekkethil, Namshad, Köry, Jakub, Guo, Ming, Stewart, Peter S., Hill, Nicholas A., Luo, Xiaoyu

“…Baseline simulations (neglecting the viscosity of the cytosol) indicate that the system exhibits seven different regimes across the parameter space spanned by the viscoelastic relaxation timescale of the cytoskeleton and the poroelastic diffusion timescale; these regimes agree qualitatively with experimental measurements. …”
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An investigation of friction-based tendon sheath model appropriate for control purposes by Tjahjowidodo, Tegoeh, Lau, Michael Wai Shing, Phee, Soo Jay, Do, T. N.

“…A new dynamic friction model that allows accurate description of friction lag and hysteresis behavior in two regimes, i.e. presliding and sliding regimes, for a sheath in arbitrary configuration such as helical and spatial shape has been developed. …”
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