Topology surveillance of the lanosterol demethylase CYP51A1 by signal peptide peptidase by Sergejevs, N, Avci, D, van de Weijer, ML, Corey, RA, Lemberg, MK, Carvalho, P

“…Cleavage of transmembrane segments on target proteins by the aspartyl intramembrane protease signal peptide peptidase (SPP, encoded by HM13) has been linked to immunity, viral infection and protein quality control. …”

Blood-stage malaria vaccine candidate RH5.1/Matrix-M in healthy Tanzanian adults and children; an open-label, non-randomised, first-in-human, single-centre, phase 1b trial by Silk, SE, Kalinga, WF, Salkeld, J, Mtaka, IM, Ahmed, S, Milando, F, Diouf, A, Bundi, CK, Balige, N, Hassan, O, Mkindi, CG, Rwezaula, S, Athumani, T, Mswata, S, Lilolime, NS, Simon, B, Msami, H, Mohamed, M, David, DM, Mohammed, L, Nyaulingo, G, Mwalimu, B, Juma, O, Mwamlima, TG, Sasamalo, IA, Mkumbange, RP, Kamage, JJ, Barrett, JR, King, LDW, Hou, MM, Pulido, D, Carnrot, C, Lawrie, AM, Cowan, RE, Nugent, FL, Roberts, R, Cho, J-S, Long, CA, Nielsen, CM, Miura, K, Draper, SJ, Olotu, AI, Minassian, AM

“…Children received either 10 μg RH5.1 at 0, 1, and 2 months (Children 10M) or 10 μg RH5.1 at 0, 1, and 6 months (delayed third dose regimen; Children 10D), and were recruited in parallel, followed by children who received the dose-escalation regimen (Children DFx) and children with higher malaria pre-exposure who also received the dose-escalation regimen (High Children DFx). …”

Rethinking the efficacy of the SEANWFZ treaty by Chew, Alvin

“…ASEAN needs to rethink the purpose of the Southeast Asia Nuclear Weapons-Free Zone as a regime for nuclear non-proliferation.…”
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Pushing the limits of quantifying complexity by Ho, Matthew Shu Hui

“…Then, we shift into the quantum regime to study the analogous counterpart of the classical epsilon machine, known better as the quantum epsilon machine. …”
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Hawking radiation of extended objects by Johnson, G, March-Russell, J

“…We find that in the low-momentum regime, the power emitted is exponentially suppressed for sufficiently large radiated objects, or sufficiently small black holes, though the temperature of emission is unchanged. …”

Characterizing Direct Product Testing via Coboundary Expansion by Bafna, Mitali, Minzer, Dor

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Dynamics of localized waves in one-dimensional random potentials : statistical theory of the coherent forward scattering peak by Lee, Kean Loon, Miniatura, Christian, Grémaud, Benoît

“…Going beyond the perturbative regime, we address here the long-time dynamics of the CFS peak in a one-dimensional random system and we relate this novel interference effect to the statistical properties of the eigenfunctions and eigenspectrum of the corresponding random Hamiltonian. …”
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Confined jet impingement boiling in a chamber with staggered pillars by Qiu, Lu, Dubey, Swapnil, Choo, Fook Hoong, Duan, Fei

“…The reasonable agreements have been reached. Three different regimes are identified based on the captured images. …”
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High-intensity two-frequency photoassociation spectroscopy of a weakly bound molecular state : theory and experiment by Kon, W. Y., Aman, J. A., Hill, J. C., Killian, T. C., Hazzard, Kaden R. A.

“…We investigate two-frequency photoassociation of a weakly bound molecular state, focusing on a regime where the AC Stark shift is comparable to the halo-state energy. …”
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Coherently tunable triangular trefoil phaseonium metamaterial by Soci, Cesare, Nguyen, Duc Minh, Ooi, Raymond C. H.

“…We find that, in the metallic regime, the phaseonium metamaterial structure supports extremely large transmission, with optical amplification at large enough intensity of the microwave thanks to strong surface plasmon coupling; while, in the dielectric regime without microwave excitation, the transmission bandwidth can be tuned by varying the control beam intensity. …”
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1-in-3 vs. not-all-equal: dichotomy of a broken promise by Ciardo, L, Kozik, M, Krokhin, A, Nakajima, T-V, Živný, S

“…In the present work, we investigate this constraint satisfaction problem in a regime where the promise is weakened from either side by a rainbow-free structure, and establish a complexity dichotomy for the resulting class of computational problems.…”

Crack densification in drying colloidal suspensions by Lilin, Paul, Ibrahim, Mario, Bischofberger, Irmgard

“…We show that the final spacing between radial cracks is proportional to the local thickness of the deposit, while the aspect ratio of the crack segments depends on the shape of the deposit.…”
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Spin carbon nanotubes into CNT fibers by Lim, Johnathan See Kwan.

“…After densifying, each strand of fiber were tested for their mechanical properties before they were divided into smaller segments and twisted together to form multi-ply fibers, ranging from a 2 ply CNT yarn to a 10 ply CNT yarn. …”
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Multi-linear regression models for traffic prediction in large-scale networks by Zhao, XinYue

“…Various methods have been practice in the traffic forecasting study and some algorithms that used in other fields like In this paper we apply 3 multi-linear regression models on the speed data collected from 266 road segments in Singapore, which are Partial Least Square, High-Order Partial Least Square and N-way Partial Least Square model. …”
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National Day parades : we the citizens of Singapore by Low, Annabel Hui Xin

“…This will be done through the examination of how three segments of the National Day parade – the military showcase, performances and National Day songs – have been used and adapted over the years to further the government’s nation building efforts in Singapore.…”
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Development of a mooring line model for coupled floating structure dynamic analysis by Bai, Ziyi

“…The model should possess the features of adding point buoys, clump weights, different anchor fairlead concepts and multiple line segments to a single mooring line. The model is proposed by National Renewable Energy Laboratory, U.S. as multi-segmented quasi-static modelling. …”
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Fine-scale population structure and widespread conservation of genetic effect sizes between human groups across traits by Hu, S, Ferreira, LAF, Shi, S, Hellenthal, G, Marchini, J, Lawson, DJ, Myers, SR

“…To estimate the similarity of genetic effect sizes between groups, we developed ANCHOR, which estimates changes in the predictive power of an existing PGS in distinct local ancestry segments. ANCHOR infers highly similar (estimated correlation 0.98 ± 0.07) effect sizes between UK Biobank participants of African and European ancestry for 47 of 53 quantitative phenotypes, suggesting that gene–environment and gene–gene interactions do not play major roles in poor cross-ancestry PGS transferability for these traits in the United Kingdom, and providing optimism that shared causal mutations operate similarly in different populations.…”

Instabilities in tidal turbine wakes by Smyth, ASM, Nishino, T, Young, AM

“…Unsteady inflow causes the turbine blades to shed vorticity of time-varying strength into the wake, which in turn leads to a spatial variation in wake vortex strength, such that the vorticity of adjacent returning wake segments can differ. This spatial variation triggers the instability of tip vortices, the characteristics of which are shown to be governed by the ’frequency ratio’ ω/ΩNB (where ω is harmonic inflow frequency, Ω is turbine rotational frequency and NB is the number of blades). …”

Optimising statistical methodologies for estimating antimalarial efficacy for uncomplicated Plasmodium falciparum malaria by Dahal, P

“…For dihydroartemisinin-piperaquine (DP) regimen, a study with 42 day follow-up was estimated to miss 47% [95% CI: 19 – 90%] of the treatment failures in those who were adequately dosed. …”

Analyses of human vaccine-specific circulating and bone marrow-resident B cell populations reveal benefit of delayed vaccine booster dosing with blood-stage malaria antigens by Barrett, JR, Silk, SE, Mkindi, CG, Kwiatkowska, KM, Hou, MM, Lias, AM, Kalinga, WF, Mtaka, IM, McHugh, K, Bardelli, M, Davies, H, King, LDW, Edwards, NJ, Chauhan, VS, Mukherjee, P, Rwezaula, S, Chitnis, CE, Olotu, AI, Minassian, AM, Draper, SJ, Nielsen, CM

“…In contrast, the CD4+ and CD8+ T cell responses were impacted by vaccine platform but not dosing regimen and did not correlate with in vivo growth inhibition in a challenge model. …”