Elucidating the role of metabolic changes in modulating cell fate following treatment with anti-mitotic drugs by Wong, Alex Xing Fah

“…Better understanding of the cellular pathways underlying this escape from antimitotic drug-induced cell death, known as mitotic slippage, is crucial for development of combinatorial therapies that can enhance existing treatment regimen in patients. Mitotic slippage describes a phenomenon where cells escape mitotic arrest and cell death following treatment with anti-mitotic drugs, and "slip" into interphase without proper chromosome segregation and cytokinesis. …”
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Evaluating new malaria vaccine candidates by Noé, A

“…Liver-resident memory CD8+ T cells (TRM) are necessary for protection against rodent malaria by this vaccine regimen. Ultimately, to most faithfully assess immunological responses by these local, specialised, hepatic T cells, periodic liver sampling is necessary. …”

Evaluation of subconjunctival liposomal steroids for the treatment of experimental uveitis by Wong, Chee Wai, Czarny, Bertrand, Metselaar, Josbert M., Ho, Candice, Ng, Si Rui, Barathi, Amutha Veluchamy, Storm, Gert, Wong, Tina T.

“…The current gold standard for treatment is topical steroids, but low ocular bioavailability and compliance issues with the intensive dosing regimen limit the efficacy of this treatment. Liposomes as a drug delivery system may help to overcome these problems. …”
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Exploring the therapeutic potential of 5-fluorouracil-loaded calcium carbonate nanoparticles combined with natural compound thymoquinone for colon cancer treatment by Deng, Xi, Yang, Zhongming, Chan, Kim Wei, Abu Bakar, Md Zuki

“…These results provide evidence for 5FU-CaCO3np as a novel regimen against colon cancer. Combining 5FU-CaCO3np and TQ may offer a new perspective for colon cancer therapy.…”
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Sustaining antimicrobial stewardship in a high-antibiotic resistance setting by Ng, Tat Ming, Heng, Shi Thong, Chua, Boon Hou, Ang, Li Wei, Tan, Sock Hoon, Tay, Hui Lin, Yap, Min Yi, Quek, Jason, Teng, Christine B., Young, Barnaby Edward, Lin, Ray, Ang, Brenda, Lee, Tau Hong, Lye, David C.

“…Design, Setting, and Participants: This cohort study used an interrupted time series with segmented regression analysis of data from January 2007 to December 2018. …”
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Low-power high-performance SAR ADC with redundancy and digital error-correction by Sharma, Sunny

“…The demands for data converters have soared in the last decade with the boom in consumer electronics, smart devices, autonomous vehicles, and automotive segments. The current trend among Nyquist-rate data converters, for example successive approximation register (SAR) analog-to-digital converters (ADC), tends towards high speeds and medium-to-high resolution. …”
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Fedratinib combined with ropeginterferon alfa-2b in patients with myelofibrosis (FEDORA): study protocol for a multicentre, open-label, Bayesian phase II trial by McIlroy, G, Gaskell, C, Jackson, A, Yafai, E, Tasker, R, Thomas, C, Fox, S, Boucher, R, Ghebretinsea, F, Harrison, C, Mead, AJ, McMullin, MF

“…FEDORA uses a within-patient dose escalation regimen to ensure each patient reaches a personalised dose combination that is acceptable. …”

May measurement month 2022: an analysis of blood pressure screening findings from Sierra Leone by Jalloh, MB, Williams, CEE, Jegede, OG, Malijan, GMB, Naveed, A, Kanu, A, Bah, AK, Jalloh, F, Jalloh, A, Faulkner, MMJ, Agboola, K, Baldeh, M, Russell, JBW, Oladapo, OO

“…Notably, 42.9% of the participants with known hypertension did not adhere to their antihypertensive medication regimen, citing cost, availability, side effects, and forgetfulness as common reasons. …”

Repurposing nitroxoline to address antibiotic resistance in the production of poultry for consumption by Zhou, Y

“…<em>In-vivo</em> evaluation (Chapter 5) established an optimal dosage regimen (100 mg/kg of NTX in feed) for treating <em>Salmonella</em> infections in poultry without promoting the development of resistance. …”

Cytisine versus varenicline for smoking cessation in a primary care setting: a randomized non-inferiority trial by Oreskovic, T, Percac-Lima, S, Ashburner, JM, Tiljak, H, Rifel, J, Klemenc Ketiš, Z, Oreskovic, S

“…Given the much lower cost of cytisine treatment, its lower rate of adverse events, and higher feasibility (but its likely lower effectiveness with the standard dosage regimen), future analyses should assess the cost-effectiveness of the two treatments for health policy considerations.…”

Visualization of engine design, simulation and optimization by Wang, Yan Chao

“…Starting from a new distance function and neighborhood relationship between sites, we divide the space by axis-aligned segments. Then a sweepline+skyline based heuristic algorithm is proposed to allocate the partitioned spaces to form an orthogonal Voronoi diagram with orthogonal rectangles. …”
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Synthesizing photorealistic images with deep generative learning by Zheng, Chuanxia

“…To achieve this goal, a new pipeline is presented that interleaves the two tasks of instance segmentation and scene completion through multiple iterations, solving for objects in a layer-by-layer manner. …”
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Discrete differential geometry driven methods for architectural geometry by Yao, Sidan

“…We then trace integral curves with a rounding strategy to encourage them to go through mesh vertices, which can effectively reduce the number of short segments. Finally, we partition the triangle mesh along the integral curves to extract the quadrilateral patches. …”
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Vitamin D3 and carbamazepine protect against Clostridioides difficile infection in mice by restoring macrophage lysosome acidification by Chan, Hung, Li, Qing, Wang, Xiansong, Liu, Wing Yingzhi, Hu, Wei, Zeng, Judeng, Xie, Chuan, Kwong, Thomas Ngai Yeung, Ho, Idy Hiu Ting, Liu, Xiaodong, Chen, Huarong, Yu, Jun, Ko, Ho, Chan, Raphael Chiu Yeung, Ip, Margaret, Gin, Tony, Cheng, Alfred Sze Lok, Zhang, Lin, Chan, Matthew Tak Vai, Wong, Sunny Hei, Wu, William Ka Kei

“…In mice, gavage with TcdB-hyperproducing C. difficile or injection of TcdB into ligated colon segments caused prominent MITF downregulation in macrophages. …”
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Genetic and molecular characterisation of non-tissue culture adapted influenza B viruses detected in Singapore between 2004-2009 by Muhammad Raihan Jumat

“…Only one specimen had both these gene segments from the Yamagata lineage. This finding has resulted in us determining several vaccine mismatches over the six years in focus. …”
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Studies on the assessment of abdominal aortic aneurysm rupture risk by Canchi, Tejas

“…This was done using a combination of in-house segmentation codes and commercial finite element analysis (FEA) software. …”
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Security for automotive electrical/electronic (E/E) architectures by Mundhenk, Philipp

“…These internal networks consist of specialized automotive components, are often not sufficiently segmented or secured, and messages are transmitted unencrypted. …”
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Towards robust sensing and recognition : from statistical learning to transfer learning by Yang, Jianfei

“…These algorithms can be further applied to improving the generalization abilities of deep models for WiFi-based sensing and visual sensing including object recognition, object detection, sentiment segmentation and person re-identification.…”
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