Autoinhibition releasing provides a platform for developing p21-activated kinase-1 (PAK1) activators for hypertrophic heart diseases by He, Y

“…In addition, mutagenesis and structural studies unveiled an allosteric site, termed the 'DEK' (encompassing the key structural elements DFG motif, Glu315 on the αC helix, and kinase inhibitory segment), crucial in modulating kinase activity.</p> <p>To gain a deeper understanding of the action mechanism underlying PAK1 small molecule activators, fluorescence resonance energy transfer (FRET), superresolution single molecular imaging, and mass photometry were applied to illustrate the conformational changes and alterations in PAK1 dimerization upon the binding of small molecule activators. …”

Localization and motion planning of mobile robots by Dai, Yunxiang

“…Afterward, a novel reference path segment generation and switching mechanism are proposed to bridge the perception with the low-level controller. …”
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Structural and mechanistic insights into the Rel protein of Mycobacterium tuberculosis by Singal, Bharti

“…The MtRel NTD in the presence of TGS domain showed almost similar synthetic activity as of MtRel NTD and approximately 3 fold higher than that of MtRel showing auto-inhibition by rest of the C-terminus MtRel segment. The MtRel ACT structure was determined as a dimer and the oligomeric state was further confirmed using SAXS. …”
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Associations between health literacy and health care utilization and mortality in patients with coexisting diabetes and end-stage renal disease : a prospective cohort study by Griva, Konstantina, Loong, Russel K. L., Nandakumar, Mooppil, Rajeswari, Moothathamby, Khoo, Eric Y. H., Lee, Vanessa Y. W., Kang, Augustine W. C., Osborne, Richard H., Brini, Stefano, Newman, Stanton P.

“…Patients with diabetes (DM) comprise the fastest growing segment of patients with end-stage renal disease (ESRD). …”
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Sustaining antimicrobial stewardship in a high-antibiotic resistance setting by Ng, Tat Ming, Heng, Shi Thong, Chua, Boon Hou, Ang, Li Wei, Tan, Sock Hoon, Tay, Hui Lin, Yap, Min Yi, Quek, Jason, Teng, Christine B., Young, Barnaby Edward, Lin, Ray, Ang, Brenda, Lee, Tau Hong, Lye, David C.

“…Design, Setting, and Participants: This cohort study used an interrupted time series with segmented regression analysis of data from January 2007 to December 2018. …”
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Synthesizing photorealistic images with deep generative learning by Zheng, Chuanxia

“…To achieve this goal, a new pipeline is presented that interleaves the two tasks of instance segmentation and scene completion through multiple iterations, solving for objects in a layer-by-layer manner. …”
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Mechanically durable and damage resilient dielectric elastomer actuators by Tan, Matthew Wei Ming

“…By tuning hard-to-soft segment ratios and molecular weights of polydiols, carboxyl polyurethanes (PULM0) attained large mechanical toughness (96.5 MJ m-3) and puncture resistance. …”
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Studies on the assessment of abdominal aortic aneurysm rupture risk by Canchi, Tejas

“…This was done using a combination of in-house segmentation codes and commercial finite element analysis (FEA) software. …”
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Tracking and detecting objects in image sequence by Wang, Li

“…Then, a so-called “split-merge” approach is proposed to over-segment a foreground region into subregions and then cluster them into a number of object regions by using the proposed boundary based similarity metric. …”
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Security for automotive electrical/electronic (E/E) architectures by Mundhenk, Philipp

“…These internal networks consist of specialized automotive components, are often not sufficiently segmented or secured, and messages are transmitted unencrypted. …”
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Pnictogen-halide semiconductors for photovoltaics by Liu, P

“…Convolutional Neural Network (CNN) models were used to evaluate the density of pinholes in the scanning electron microscopy images, and the Segment Anything Model (SAM) was used to separate different regions within the images. …”

Towards robust sensing and recognition : from statistical learning to transfer learning by Yang, Jianfei

“…These algorithms can be further applied to improving the generalization abilities of deep models for WiFi-based sensing and visual sensing including object recognition, object detection, sentiment segmentation and person re-identification.…”
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