Elucidating the role of metabolic changes in modulating cell fate following treatment with anti-mitotic drugs by Wong, Alex Xing Fah

“…Better understanding of the cellular pathways underlying this escape from antimitotic drug-induced cell death, known as mitotic slippage, is crucial for development of combinatorial therapies that can enhance existing treatment regimen in patients. Mitotic slippage describes a phenomenon where cells escape mitotic arrest and cell death following treatment with anti-mitotic drugs, and "slip" into interphase without proper chromosome segregation and cytokinesis. …”
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Evaluating new malaria vaccine candidates by Noé, A

“…Liver-resident memory CD8+ T cells (TRM) are necessary for protection against rodent malaria by this vaccine regimen. Ultimately, to most faithfully assess immunological responses by these local, specialised, hepatic T cells, periodic liver sampling is necessary. …”

Exploring the therapeutic potential of 5-fluorouracil-loaded calcium carbonate nanoparticles combined with natural compound thymoquinone for colon cancer treatment by Deng, Xi, Yang, Zhongming, Chan, Kim Wei, Abu Bakar, Md Zuki

“…These results provide evidence for 5FU-CaCO3np as a novel regimen against colon cancer. Combining 5FU-CaCO3np and TQ may offer a new perspective for colon cancer therapy.…”
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Fedratinib combined with ropeginterferon alfa-2b in patients with myelofibrosis (FEDORA): study protocol for a multicentre, open-label, Bayesian phase II trial by McIlroy, G, Gaskell, C, Jackson, A, Yafai, E, Tasker, R, Thomas, C, Fox, S, Boucher, R, Ghebretinsea, F, Harrison, C, Mead, AJ, McMullin, MF

“…FEDORA uses a within-patient dose escalation regimen to ensure each patient reaches a personalised dose combination that is acceptable. …”

May measurement month 2022: an analysis of blood pressure screening findings from Sierra Leone by Jalloh, MB, Williams, CEE, Jegede, OG, Malijan, GMB, Naveed, A, Kanu, A, Bah, AK, Jalloh, F, Jalloh, A, Faulkner, MMJ, Agboola, K, Baldeh, M, Russell, JBW, Oladapo, OO

“…Notably, 42.9% of the participants with known hypertension did not adhere to their antihypertensive medication regimen, citing cost, availability, side effects, and forgetfulness as common reasons. …”

Evaluation of subconjunctival liposomal steroids for the treatment of experimental uveitis by Wong, Chee Wai, Czarny, Bertrand, Metselaar, Josbert M., Ho, Candice, Ng, Si Rui, Barathi, Amutha Veluchamy, Storm, Gert, Wong, Tina T.

“…The current gold standard for treatment is topical steroids, but low ocular bioavailability and compliance issues with the intensive dosing regimen limit the efficacy of this treatment. Liposomes as a drug delivery system may help to overcome these problems. …”
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Repurposing nitroxoline to address antibiotic resistance in the production of poultry for consumption by Zhou, Y

“…<em>In-vivo</em> evaluation (Chapter 5) established an optimal dosage regimen (100 mg/kg of NTX in feed) for treating <em>Salmonella</em> infections in poultry without promoting the development of resistance. …”

Investigating the impact of growth arrest mechanisms on tumour growth and responses to radiotherapy and hyperthermia by Colson, C

“…In each regime, we determine the biological processes that may underpin positive and negative treatment outcomes and assess which treatment (RT, HT or RT + HT) and dosing regimen maximise the reduction in tumour burden. This work enables us to generate a set of hypotheses that may explain some of the widely varying tumour behaviours observed experimentally and clinically.…”

Cytisine versus varenicline for smoking cessation in a primary care setting: a randomized non-inferiority trial by Oreskovic, T, Percac-Lima, S, Ashburner, JM, Tiljak, H, Rifel, J, Klemenc Ketiš, Z, Oreskovic, S

“…Given the much lower cost of cytisine treatment, its lower rate of adverse events, and higher feasibility (but its likely lower effectiveness with the standard dosage regimen), future analyses should assess the cost-effectiveness of the two treatments for health policy considerations.…”

STandards for reporting interventions in clinical trials of tuina/massage (STRICTOTM): extending the CONSORT statement by Zhang, Xuan, Liang, Feng, Lau, Chung Tai, Chan, Jacky C. P., Wang, Nana, Deng, Jiashuai, Wang, Juan, Ma, Yanfang, Zhong, Linda Lidan, Zhao, Chen, Yao, Liang, Wu, Taixiang, Lyu, Aiping, Tian, Guihua, Shang, Hongcai, Miao, Jiangxia, Bian, Zhaoxiang

“…Results: A checklist of seven items (namely Tuina/Massage rationale, details of Tuina/Massage, intervention regimen, other components of the intervention, Tuina/Massage provider background, control or comparator interventions, and precaution measures), and 16 subitems were developed. …”
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The role of SPRTN protease in colorectal cancer chemotherapy by Peron, C

“…The first-line treatment of metastatic colorectal cancer (mCRC) is frequently based on combination chemotherapeutic regimens, where 5-fluorouracil is either associated with irinotecan (FOLFIRI) or oxaliplatin (FOLFOX). …”

Quality of life and compliance with fluid restriction among hemodialysis patients in Hospital Universiti Sains Malaysia by Mohamad, Siti Aniza

“…In conclusion, patients’ knowledge and practice of treatment regimens has to be enhanced and improved so they will be knowledgeable and able to comply to treatment regimens thus increasing their quality of life.…”
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Efficacy of cannabinoids for the prophylaxis of chemotherapy-induced nausea and vomiting—a systematic review and meta-analysis by Chow, R, Basu, A, Kaur, J, Hui, D, Im, J, Prsic, E, Boldt, G, Lock, M, Eng, L, Ng, TL, Zimmermann, C, Scotte, F

“…However, there was no difference between cannabinoid and active treatment alternatives (most using dated single-agent regimens) for any outcomes. A recent phase II/III trial demonstrated superior efficacy of THC:CBD for secondary prevention of CINV when used as adjunctive therapy alongside modern antiemetic regimens, albeit mostly without olanzapine. …”

Advancing the chemotherapy of tuberculous meningitis: a consensus view by Wasserman, S, Donovan, J, Kestelyn, E, Watson, JA, Aarnoutse, RE, Barnacle, JR, Boulware, DR, Chow, FC, Cresswell, FV, Davis, AG, Dooley, KE, Figaji, AA, Gibb, DM, Huynh, J, Imran, D, Marais, S, Meya, DB, Misra, UK, Modi, M, Raberahona, M, Ganiem, AR, Rohlwink, UK, Ruslami, R, Seddon, JA, Skolimowska, KH, Solomons, RS, Stek, CJ, Thuong, NTT, van Crevel, R, Whitaker, C, Thwaites, GE, Wilkinson, RJ

“…Antimicrobial treatment is based on regimens used for pulmonary tuberculosis, which overlooks important differences between lung and brain drug distributions. …”

Rifaximin potentiates clarithromycin against Mycobacterium abscessus in vitro and in zebrafish by Goh, Boon Chong, Larsson, Simon, Dam, Linh Chi, Ling, Sharon Yan Han, Chua, Patrina Wei Lin, Abirami, R., Singh, Samsher, Ong, Ernest Jun Long, Teo, Jeanette W. P., Ho, Peiying, Ingham, Philip William, Pethe, Kevin, Dedon, Peter C.

“…Because of its extensive innate resistance to numerous antibiotics, treatment options are limited, often resulting in poor clinical outcomes. Current treatment regimens usually involve a combination of antibiotics, with clarithromycin being the cornerstone of NTM treatments.…”
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From private entrepreneurship to state monopoly: contracting Swiss soldiers for Dutch Service under Ancien Régime Fiscal- Military Practices (1693–1829) by Depreter, M

“…This contribution examines Dutch contracting practices to hire Swiss troops during the Ancien Régime, from the first contracts directly negotiated in the Protestant cantons by Petrus Valckenier (1693-1694) during the Nine Years’ War, seizing opportunities arisen from Louis XIV’s revocation of the Edict of Nantes (1685) after a period during which the Dutch seem to have relied on uncertain access to Swiss manpower through French intercession, up to the end of a short-lived revival of Swiss foreign regiments in the newly-instated Kingdom of the Netherlands (1814-1829). …”

Determining targets for antiretroviral drug concentrations: a causal framework illustrated with pediatric efavirenz data from the CHAPAS-3 trial by Schomaker, M, Denti, P, Bienczak, A, Burger, D, Díaz, I, Gibb, DM, Walker, AS, McIlleron, H

“…<p><strong>Background:&nbsp;</strong>Determining a therapeutic window for maintaining antiretroviral drug concentrations within an appropriate range is required for identifying effective dosing regimens. The limits of this window are typically calculated using predictive models. …”

Maximizing the performance of badminton athletes through core strength training: Unlocking their full potential using machine learning (ML) modeling by Ma, Shuzhen, Geok Soh, Kim, Japar, Salimah, Xu, Simao, Zhicheng, Guo

“…Incorporating core strength training into regular regimens can improve athletes' overall strength, endurance, balance, control, and prevent injuries. …”
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Shedding Light on Chemoresistance: The Perspective of Photodynamic Therapy in Cancer Management by Viana Cabral, Fernanda, Quilez Alburquerque, Jose, Roberts, Harrison James, Hasan, Tayyaba

“…Photodynamic therapy (PDT) has emerged as a promising photochemistry-based approach to address chemoresistance in cancer regimens. PDT not only induces cell death but also primes surviving cells, enhancing their susceptibility to subsequent therapies. …”
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Treatment options to support the elimination of Hepatitis C: an open label, factorial randomised controlled trial by Cooke, G, Le Manh, H, Flower, B, McCabe, L, Vu Thu Kim, H, Vo Thi, T, Dang Trong, T, Nguyen Thanh, D, Le Thanh, P, Dao Bach, K, Nguyen Thi Chau, A, Pham Ngoc, T, Vu Thu Thu, H, Dang Thi, B, Nguyen Kim, T, Ansari, A, Le Ngoc, C, Vo Minh, Q, Nguyen Thi Ngoc, P, Le Thi, T, Nguyen Bao, T, Kestelyn, E, Kingsley, C, Van Doorn, R, Rahman, M, Pett, S, Thwaites, G, Barnes, E, Day, J, Nguyen Van Vinh, C, Walker, AS

“…No randomised trials have compared these regimens and high cure rates may be achievable with shorter durations of therapy.…”