The role of SPRTN protease in colorectal cancer chemotherapy by Peron, C

“…The first-line treatment of metastatic colorectal cancer (mCRC) is frequently based on combination chemotherapeutic regimens, where 5-fluorouracil is either associated with irinotecan (FOLFIRI) or oxaliplatin (FOLFOX). …”

Hollow microcapsules as periocular drug depot for sustained release of anti-VEGF protein by Radhakrishnan, Krishna, Vincent, Anita, Joseph, Rini Rachel, Moreno, Miguel, Dickescheid, Andreas, Agrawal, Rupesh, Venkatraman, Subbu S.

“…The current treatment regimen for such diseases involves repeated intravitreal injections of anti- Vascular Endothelial Growth Factor (VEGF) proteins. …”
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A systems biology approach to define SARS-CoV-2 correlates of protection in non-human primates by Brady, C

“…Novel predictors of protection included low peripheral intermediate monocyte prevalence during the vaccination regimen and low seasonal coronavirus IgG at baseline - parameters which also predicted high spike IgG titres post- vaccination. …”

Forces on oscillating uniform and tapered cylinders in a crossflow by Hover, F. S., Techet, A. H., Triantafyllou, M.S.

“…Calculation of the cross-correlation coefficient between forces at the two ends of the uniform cylinder reveals five distinct regimes as a function of the nominal reduced velocity Vrn: two regimes, for low and high values of Vrn, and far away from the value of VrS corresponding to the Strouhal frequency, show small correlation; two regimes immediately adjacent to, but excluding, VrS show strong correlation, close to 1; surprisingly, there is a regime containing the Strouhal frequency, within which correlation is low. …”
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In Vivo RNA Delivery to Hematopoietic Stem and Progenitor Cells via Targeted Lipid Nanoparticles by Shi, Dennis, Toyonaga, Sho, Anderson, Daniel G

“…However, these therapies have several limitations owing to the manufacturing complexities and toxicity resulting from required conditioning regimens. Here, we developed a c-kit (CD117) antibody-targeted lipid nanoparticle (LNP) that, following a single intravenous injection, can deliver RNA (both siRNA and mRNA) to HSCs in vivo in rodents. …”
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Knowledge and practice regarding medication use among elderly with chronic diseases in Felda Tembangau 2, Kemayan, Pahang by Farid, Aina Natasha Mohd

“…The elderly population, defined as those aged 60 and above, faces unique challenges in managing chronic diseases due to physiological changes, limited access to healthcare information, and barriers in understanding and adhering to medication regimens. The aim of this study was to determine the levels of knowledge and practice regarding medication use among elderly with chronic diseases in FELDA Tembangau 2, Kemayan, Pahang and to explore the correlation between these two variables. …”
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Criteria for Crack Formation and Air Invasion in Drying Colloidal Suspensions by Lilin, Paul, Bischofberger, Irmgard

“…We show that the pressure inside the deposit controls both the onset of crack formation and the onset of air invasion. Two distinct regimes of air invasion occur, which we can account for using the same model that further provides a quantitative criterion for the crossover between the two regimes.…”
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Elucidating the role of metabolic changes in modulating cell fate following treatment with anti-mitotic drugs by Wong, Alex Xing Fah

“…Better understanding of the cellular pathways underlying this escape from antimitotic drug-induced cell death, known as mitotic slippage, is crucial for development of combinatorial therapies that can enhance existing treatment regimen in patients. Mitotic slippage describes a phenomenon where cells escape mitotic arrest and cell death following treatment with anti-mitotic drugs, and "slip" into interphase without proper chromosome segregation and cytokinesis. …”
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Evaluating new malaria vaccine candidates by Noé, A

“…Liver-resident memory CD8+ T cells (TRM) are necessary for protection against rodent malaria by this vaccine regimen. Ultimately, to most faithfully assess immunological responses by these local, specialised, hepatic T cells, periodic liver sampling is necessary. …”

A comparative analysis of missing data imputation techniques on sedimentation data by Loh, Wing Son, Ling, Lloyd, Chin, Ren Jie, Lai, Sai Hin, Loo, Kar Kuan, Seah, Choon Sen

“…A comparative analysis on the missing fine sediment data imputation performance was made based on four different techniques, namely the k-Nearest Neighbourhood (k-NN), Support Vector Regression (SVR), Multiple Regression (MR), and Artificial Neural Network (ANN), under the single imputation (SI) and multiple imputation (MI) regimes. Across different missing data proportions (10%-50%), the ANN demonstrated optimal results with consistent performance metrics recorded over both SI and MI regimes. …”
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The prevention and management of chronic kidney disease among patients with metabolic syndrome by Zhu, D, Judge, PK, Wanner, C, Haynes, R, Herrington, WG

“…In addition, statin-based regimens lower low-density lipoprotein cholesterol and reduce the risk of atherosclerotic disease (with no clinically meaningful effect on kidney outcomes). …”

Somatic gene mutation patterns and burden influence outcomes with enasidenib in relapsed/refractory IDH2-mutated AML by Risueño, A, See, WL, Bluemmert, I, de Botton, S, DiNardo, CD, Fathi, AT, Schuh, AC, Montesinos, P, Vyas, P, Prebet, T, Gandhi, A, Hasan, M

“…We recently reported results from the phase 3 IDHENTIFY trial (NCT02577406) showing improved response rates and event-free survival with enasidenib monotherapy compared with conventional care regimens (CCR) in heavily pretreated, older patients with late-stage R/R AML bearing IDH2 mutations. …”

Experimental study on sediment clump by Yang, Yang

“…A group of dense particles released instantaneously into stagnant ambient water is generally studied as thermal-like formation, experiences the classical three regimes of transition, namely the acceleration, thermal and dispersive regimes (Wilkinson & Rahimipour 1992). …”
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Dynamic friction model for tendon-sheath actuated surgical robots : modelling and stability analysis by Tjahjowidodo, Tegoeh, Lau, Michael Wai Shing, Phee, Soo Jay, Do, T. N.

“…In addition, transition between two regimes is guaranteed to be smooth without using any switching functions and it permits an arbitrary configuration of sheath, i.e. helical and spatial shape. …”
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Structure of mushy layers grown from perfectly and imperfectly conducting boundaries. Part 1. Diffusive solidification by Hitchen, JR, Wells, AJ

“…For an isothermal boundary we characterise different growth regimes depending on a concentration ratio, which can also be viewed as characterising the ratio of composition-dependent freezing point depression versus the temperature difference across the mushy layer. …”

Phonetic Faithfulness in Phonological Opacity by Kim, Yeong-Joon

“…The results of typological surveys encompassing 87 counterfeeding and 65 counterbleeding interactions across languages support this prediction, revealing that opacified processes are subject to a narrow range of markedness conditions, such as coarticulatory assimilation (e.g., palatalization) and durational adjustments (e.g., segmental weakening). Other types of phonological processes, particularly non-natural ones, are only rarely, if ever, opacified. …”
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Genomic profiling of mycobacterium tuberculosis strains, Myanmar by Aung, Htin Lin, Nyunt, Wint Wint, Fong, Yang, Biggs, Patrick J., Winkworth, Richard C., Lockhart, Peter J., Yeo, Tsin Wen, Hill, Philip C., Cook, Gregory M., Aung, Si Thu

“…Introducing new oral drugs to replace those currently used in treatment regimens for multidrug-resistant TB will also be useful for treating TB in Myanmar.…”
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Surface Friction and Spectroscopic Probes of New Physics with Trapped Ions by Counts, Ian T.

“…By varying transport speed and corrugation depth, experimental signatures of both regimes are measured and used to write a predictive Boltzmann model. …”
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Strongly out-of-equilibrium simulations for electron Boltzmann transport equation using modal discontinuous Galerkina approach by Singh, Satyvir, Battiato, Marco

“…Ultimately, these results predict that the modal DG approach is particularly effective in treating the strongly out-of-equilibrium regimes encountered like in ultrafast transport dynamics.…”
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MU'TAQAL Machine: Power, Gender and Identity in Egypt's Political Prisons, 1948-1981 by Ashmawi, HE

“…<p>This thesis charts the history and evolution of a mass-incarcerating regime of detention, disappearance and torture in Egypt between 1948 and 1981. …”